Research finds that inefficient breakdown of fats in fat cells predicts later weight gain and metabolic complications such as type 2 diabetes. An algorithm based on clinical and blood measures can detect impairments in hormone-stimulated lipolysis, identifying women at high risk of becoming overweight or obese.
A UK-based research team found that prolonged antidepressant use is associated with a sustained increase in weight gain over at least five years. The study analyzed data from over 300,000 adults and showed that patients prescribed any of the 12 most commonly used antidepressants were more likely to experience weight gain.
Researchers at King's College London found that patients prescribed antidepressants were 21% more likely to experience weight gain than those not taking the drugs. The risk of weight gain remained elevated for up to six years, with peak risk periods after two to three years of continued use.
A systematic review of protein supplement studies found that consuming protein with meals helps maintain body weight while decreasing fat mass. Snacking on protein supplements may not be as effective for weight control and can even lead to increased calorie intake.
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Researchers have discovered a molecule directly linked to thermogenesis in beige fat cells, which can be activated by nicotine and acetylcholine molecules. The study suggests that CHRNA2 receptor proteins play a role in energy metabolism, potentially leading to new approaches for combating weight gain after smoking cessation.
A mouse study found that time-restricted feeding maintains normal food intake and reduces weight gain in obese mice. The researchers discovered that restricting food availability to one half of the day resets the normal timing of satiety signals, leading to less weight gain.
Research reveals that underweight and very obese women should aim for specific weight gain ranges during pregnancy for a balanced risk of having small or large babies. An online calculator has been developed to provide personalized recommendations based on individual BMI.
A systematic review found that consuming protein supplements with meals was associated with greater reductions in fat mass and improvements in lean to fat mass ratio compared to consuming them between meals. This strategy may be beneficial for adults looking to improve their health status through resistance training.
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Researchers found that black women with obesity burned fewer calories during pregnancy, leading to more retained baby weight. This could influence calorie intake recommendations for pregnant women, particularly those from underrepresented groups.
A new study published in Diabetes Care found that a tailored letter with personalized weight-gain recommendations improved pregnancy weight gain among women with gestational diabetes. The intervention, delivered via electronic health record data, resulted in a higher proportion of women meeting national weight-gain guidelines.
Researchers found that female POMC neurons fire faster than male's due to the expression of gene TAp63, leading to increased energy expenditure and protection against weight gain. This novel mechanism may facilitate future gender-specific therapeutic strategies for obesity and related disorders.
Research by Stanford University School of Medicine researchers provides the first molecular understanding of why people gain weight due to chronic stress and disrupted circadian rhythms. The team identified key molecules involved in controlling fat-cell maturation and found that the timing of glucocorticoid pulses controls weight gain.
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A study conducted at the University of Helsinki found that eating regularly, rather than dieting, is crucial for successful long-term weight management in both women and men. Factors such as physical activity, education level, and mental wellbeing also play a significant role.
A recent study published in the International Journal of Obesity found that parenting style and a baby's temperament have a significant impact on their weight gain. Babies with a surgent temperament are more likely to be offered food as a comfort measure, leading to overeating and a higher risk of obesity.
A recent study published in Science Immunology highlights a crucial immune cell type involved in healthy weight gain, removing excess fat and regulating blood sugar levels. The discovery offers new insights into the complications of obesity and potential therapeutic strategies to mitigate its effects.
A five-year research project aims to help new bus operators succeed early in their driving careers and avoid health pitfalls. The study will assess working conditions, measure the impact of driving on eating, exercise, sleep, and weight, and provide tools for operators to stay healthy.
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A study published in PLOS Medicine found that perfluoroalkyl substances (PFASs) may interfere with human body weight regulation, leading to greater weight gain after dieting. Higher blood levels of PFASs were linked with lower resting metabolic rates, which can result in slower metabolism and increased calorie burn.
A new trial shows that family-integrated care in neonatal intensive care units leads to improved weight gain, breastfeeding rates, and reduced parental stress among preterm infants. The program also may have long-term benefits for neurodevelopmental outcomes.
A new study found that standing burns more calories than sitting, with a 65 kg person losing 10 kg in 4 years by substituting standing for sitting for 6 hours a day. Standing is linked to lower rates of heart attacks, strokes, and diabetes.
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A Stanford-led study found that even modest weight gain causes significant changes in the human microbiome, cardiovascular system, immune system, and gene expression. When participants lost the weight, most systems recalibrated back to normal states.
A study published in The BMJ found that improving diet quality leads to greater weight loss in people with a high genetic risk of obesity. The research analyzed data from two large studies and found that adhering to healthy dietary patterns can attenuate the genetic association with weight gain.
A study of women with rheumatoid arthritis found that weight gain, not loss, was associated with a lower mortality risk. Those who experienced severe unintentional weight loss had the highest risk of death decades later.
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Researchers found that weight loss, particularly severe unintentional weight loss, increases the risk of death in patients with rheumatoid arthritis. In contrast, healthy weight gain has no effect on mortality risk for these patients.
A James Cook University study found nearly three quarters of office workers believe there is a negative relationship between sitting down all day and their health. The study suggests that education on the benefits of standing and buy-in from management are crucial to implementing effective behavior change strategies.
A growing proportion of public monies are being diverted to profit margins, warns Professor Neena Modi. She argues that a mixed system reduces healthcare effectiveness and calls for 'visionary leadership' and investment in the NHS to address its challenges.
A new study reveals that C-section births in mice result in less developed gut microbiota and significant weight gain. Vaginal-born mice demonstrated a leaner body type and normal microbiome maturity, while C-section born mice showed no major changes in microbiome structure but gained 33% more weight after weaning.
A study published in Science Advances found that mice born by C-section gained an average of 33% more weight than those born vaginally over the course of 15 weeks after weaning. The researchers also discovered significant differences in bacterial species in their guts, with mice born by C-section having a less mature microbiome structure.
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Midlife women experience significant weight gain, mainly in the midsection, increasing cardiovascular disease risk. Researchers recommend primary care providers screen for overweight and establish behavioral interventions, including psychological support and physical activity.
A new method targets the appetite-stimulating hormone ghrelin to prevent post-diet weight gain in mice. Mice treated with a virus expressing butyrylcholinesterase (BChE) gene therapy showed reduced weight regain and improved glucose tolerance after switching back to an unrestricted diet.
A new study by Allina Health found that using a combination of education and a tracking tool improves communication about gestational weight gain during prenatal care. Patients at intervention clinics were more likely to remember provider advice on weight gain and report a target weight within guidelines.
University of Tasmania researchers found that taking a 2-week break during dieting can lead to greater weight loss and less weight regain. The study showed participants who alternated between dieting and regular eating for 30 weeks lost an average of 8 kg more than those who continued with continuous dieting.
A first-of-its-kind study reveals that expanding waistlines and body fat distribution are key factors contributing to obesity in individuals with psychotic disorders. The research found that nearly two-thirds of those with schizophrenia and more than half of those with bipolar disorder were obese 20 years after their first hospitalizat...
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A new study at Drexel University found that female college students who weighed themselves daily lost body fat and experienced modest BMI changes, while those who did not saw little change. The researchers suggest that daily self-weighing can motivate healthy eating and exercise behaviors.
A new study found that consuming high energy-density foods increases obesity-related cancer risk among normal-weight women, independent of body mass index. The study suggests that metabolic dysregulation caused by high-energy-density diets may be a contributing factor to obesity-related cancers.
A Norwegian study found that increasing Body Mass Index above one unit from first to second pregnancy drastically increases the risk of developing gestational diabetes mellitus (GDM). Women with BMI less than 25 in first pregnancy showed a strongest risk associated with weight gain, while overweight women who reduced their BMI by more ...
A new study published in PLOS Medicine found that women who gained more than one BMI unit between pregnancies had a doubled risk of developing gestational diabetes. The increased risks were strongest in women with a low BMI, and evidence suggested that reducing weight between pregnancies can help prevent GDM.
A study published by The BMJ finds that healthy eating and physical activity during pregnancy limits weight gain and lowers the odds of having a caesarean section. The benefits are consistent regardless of age, ethnicity, BMI, or underlying medical conditions.
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A study published in JAMA found that weight gain from age 18 to 55 is associated with a higher risk of type 2 diabetes, hypertension, cardiovascular disease, and death. Weight gain as little as 11 pounds during this period can lead to increased risks of major chronic diseases.
Prevention of young adult obesity can significantly impact US rates of obesity and related diseases, costs, and premature death. Interventions targeting this age group may also reduce prevalence in children, making it an essential focus for reversing the epidemic.
A new study by Harvard T.H. Chan School of Public Health finds that cumulative weight gain over the course of early and middle adulthood may increase health risks later in life, including a higher risk of type 2 diabetes, hypertension, cardiovascular disease, and premature death. The study suggests that even moderate weight gain can ha...
A systematic review of 37 studies found a link between artificial sweetener consumption and higher risks of weight gain, obesity, high blood pressure, diabetes, and heart disease. The evidence suggests that artificial sweeteners may have negative effects on metabolism and gut bacteria, although the evidence is conflicting.
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A recent study published in Cell Metabolism found that brain-resident immune cells called microglia play a crucial role in driving overeating and weight gain in mice fed high-fat diets. The study suggests that targeting microglia could provide a novel approach to treating obesity, potentially avoiding side effects of existing medications.
Adolescent weight gain has been linked to a long-term increased risk of stroke in adulthood, according to new research. Children who returned to a normal BMI by age 20 had no such increased risk.
A daily fiber supplement has been shown to decrease body fat and improve intestinal bacteria profiles in children with overweight or obesity. The study found a 19% reduction in triglycerides and significant weight gain reductions compared to a placebo group.
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A systematic review and meta-analysis found that women who gained more than the recommended weight during pregnancy were at a higher risk of small for gestational age, preterm birth, and cesarean delivery. In contrast, those who gained less than the recommended weight had a lower risk of large for gestational age and macrosomia.
Researchers discovered a brain subgroup that triggers binge-like eating when activated, leading to weight gain. Stimulation of this area with specific neurons or hormones increased food intake, but reduced it after stimulation stopped.
A study tracking body mass index over 16 years found that women who are divorced, separated, or widowed and smokers are at high risk of becoming overweight or obese. Measuring rates of weight gain between 18-23 years old could help identify those who need assistance with prevention.
Researchers found that years of gradual weight gain more than doubles the risk of hypertensive disorders, including high blood pressure and pre-eclampsia, during pregnancy. Women who gained moderate to high annual weight gains had a higher risk of developing hypertensive disorders.
A new study identifies erythritol as a biomarker for increasing fat mass in young adults during the transition to college life. Researchers found that students who gained weight had fifteenfold higher blood erythritol levels compared to those who were stable or lost weight.
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Researchers at SISSA discovered that weight gain after deep brain stimulation is associated with an increased desire for food and level of impulsiveness. The study also found a link between the duration of Parkinson's disease and reduced pharmacological treatment, highlighting potential preventative measures.
A study by University of Michigan researchers found that preschoolers who recognize food brand logos are more likely to be overweight. The study showed that children with higher BMI percentiles recognized unhealthy foods like M&M's and Coca-Cola more often than healthy-weight peers.
A new anti-rejection drug, Everolimus, has been found to reduce weight gain and enhance outcomes for liver transplant recipients. Researchers compared Everolimus to Tacrolimus in a randomized international multi-center study of over 700 patients, finding that those taking Everolimus gained less weight.
Researchers identified DNA-dependent protein kinase, an enzyme that promotes fat accumulation and exercise capacity loss with age. The study's findings suggest a genetic program driving mid-life weight gain and lower fitness levels.
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Research tracked over 3,000 women and found that small weight gains within the healthy BMI range doubled their risk of gestational diabetes compared to those with stable weights. Women who gained more than 2.5% of their body weight each year had almost triple the risk of developing gestational diabetes.
A study of 129 kangaroo offspring found that those spending time with their mothers grew faster and gained more weight, while those alone had higher survival rates. Social interaction also allows young kangaroos to avoid harassment from adult females.
A new study published in PLOS ONE found that pre-pregnancy body mass index (BMI) is directly linked to excess weight gain during pregnancy, especially among young mothers. The research also showed that Hispanic women are less likely to experience excessive weight gain compared to non-Hispanic women.
Research by Jillian Trabulsi and Julie Mennella investigates the effects of infant formula on infant weight gain. The study found that babies fed cow's milk formula gained weight faster than those fed hydrolyzed protein formula or breastfed, highlighting the importance of choosing a suitable formula for infants.
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A study published in JAMA found that the percentage of overweight and obese adults trying to lose weight declined between 1988-1994 and 2009-2014. The decline was most pronounced among black women, who saw a significant reduction in reporting efforts to lose weight.
A Swedish study found that insufficient weight gain during pregnancy is associated with a higher risk of nonaffective psychosis, including schizophrenia spectrum disorders, in children. The study of 526,042 individuals born between 1982 and 1989 found that mothers who experienced extremely inadequate gestational weight gain were more l...
Physical activity is most important lifestyle change to reduce breast cancer recurrence risk, with at least 30 minutes of moderate exercise per day recommended. Avoiding weight gain and maintaining adequate vitamin D levels also play a crucial role in reducing the risk of cancer recurrence.