Articles tagged with Parasites
Researchers have developed an approach to identify parasite genes associated with severe infection in pregnant women and children, offering new understanding of childhood malaria. Additionally, studies found that niacin can inhibit progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells.
Researchers have developed a method to profile malaria-causing parasite P. falciparum, identifying genes associated with severe infection in pregnant women and children. The study aims to provide new understanding of childhood malaria severity.
Researchers use OMX 3D SIM super resolution microscopy to visualize malaria parasite invasion, revealing key molecular and cellular events. This technology may pave the way for developing new treatments for malaria.
The study found that a specific protein called GRA15 triggers inflammation in the host, leading to brain damage. Researchers hope to develop new drugs or vaccines to block this process and prevent chronic infections.
Researchers found that the ROP18 protein disables host cell proteins that protect against infection, allowing the parasite to thrive. This discovery could lead to new treatments for Toxoplasmosis and other parasitic infections.
Malaria-infected red blood cells stiffen up to 50 times more than healthy ones, blocking capillaries and impeding nutrient and oxygen delivery. This deformation changes blood viscosity and flow, potentially leading to severe organ damage.
A new UC Davis study concludes that sea lice from salmon farms have no significant impact on the productivity of wild pink salmon populations. The research analyzed 10 years of farm fish counts and 60 years of wild fish counts, contradicting earlier reports linking farm salmon to the 2002 population crash in western Canada.
Two Portuguese researchers are awarded $100,000 to develop a novel approach to combat malaria. By harnessing the power of human antibodies against gut flora, they aim to prevent infection immediately after mosquito bites. The project's innovative method has the potential to revolutionize malaria prevention and eradication efforts.
Researchers discovered that dendritic cells trigger the immune system's defence against invading parasites in mice infected with snail fever. The breakthrough could lead to new treatments for chronic illness caused by this condition.
Dr. Karine Le Roch is investigating how malaria parasite multiplies in red blood cells using a $1.7 million NIH grant. The goal is to develop more effective strategies against this devastating disease, with potential new drug strategies also being explored.
The 'malaria map' has shrunk by over 150 years, with 32 countries nearing elimination and many more in controlled low-endemic states. The fight against malaria involves two main parasite species, <i>Plasmodium falciparum</i> and <i>Plasmodium vivax</i>, highlighting the need for improved diagnostic tests and radical treatment options.
Countries seeking to eliminate malaria must adopt a new approach, prioritizing proactive case detection, treatment with effective drugs like primaquine, and preventive measures. Effective elimination strategies are needed despite operational challenges and high costs.
A Danish study reveals that schistosomiasis causes sores in women's reproductive organs, making them more susceptible to HIV infections. Younger women with the parasite are more likely to receive effective treatment and prevention programs.
Scientists at The University of Nottingham have pinpointed 72 molecular switches controlling the malaria parasite's three key stages. Their research, funded by Wellcome Trust and MRC, is a significant breakthrough in finding cheap and effective solutions to stop malaria transmission.
Researchers found that parasites can adjust their survival strategy in response to the host's immune system, leading to faster growth rates and increased reproduction. This insight may help inform the design of future vaccines against parasitic diseases such as elephantiasis and river blindness.
Researchers at the University of Missouri are using X-ray diffraction to study a unique enzyme found in the 'kissing bug' parasite and Aspergillus fumigatus fungus. The goal is to develop drugs that can inhibit the enzyme's activity, which could lead to breakthroughs in treating pulmonary diseases and Chagas disease.
A WCS study found that higher temperatures and rainfall in Argentina result in more parasitic fly larvae, leading to increased mortality and impaired growth for chicks. The researchers also found a positive correlation between climate variables and parasite loads on nestlings.
Researchers from the Institute of Tropical Medicine Antwerp successfully restored a sleeping sickness parasite's susceptibility to drugs, potentially alleviating economic losses. The discovery involves combining antibiotics with an existing medicine, ISM, which could lead to more effective treatments for both cattle and humans.
Researchers at The Walter and Eliza Hall Institute have discovered a new pathway used by malaria parasites to infect human cells, providing a potential vaccine target. Blocking both the glycophorin and CR1 pathways results in a 90% decrease in parasite infection, suggesting an effective vaccine could significantly reduce malaria cases.
Researchers at the Walter and Eliza Hall Institute are investigating different aspects of parasite biology, with a focus on developing new treatments. Dr Chris Tonkin is studying Apicomplexan parasites to understand their invasion mechanisms and identify potential targets for drugs.
Scientists have identified a potential new treatment for toxoplasmosis, an infection affecting almost 2 billion people worldwide. Triclosan, commonly found in soaps and toothpastes, has shown promise as a guiding light for developing effective medications.
Toxoplasma gondii parasite triggers stress response mechanism to survive outside host cells, enabling it to find new hosts and infect them. Researchers identify critical pathway that helps the parasite overcome environmental stresses, offering potential new treatments for toxoplasmosis infection.
Researchers have identified a gene mutation that confers resistance to the antibiotic clindamycin in malaria parasites. The findings suggest that current diagnostic tests may be inadequate and highlight the need for new treatment strategies. This study contributes to our understanding of the genetic basis of drug resistance in malaria.
A new study found that a Peruvian parasite population had significant genetic instability near the telomere, leading to missed diagnoses from rapid diagnostic tests. The researchers also identified a gene mutation that confers resistance to clindamycin, a commonly administered drug for treating malaria in pregnant women and infants.
Researchers found that adding primaquine to fixed-dose artemisinin combination treatments significantly reduces gametocyte carriage, a key factor in malaria transmission. The artesunate-mefloquine regimen showed the highest cure rate and lowest rates of reinfection.
A chemical compound, NITD609, has shown promising results in clearing malaria parasites from mice after a single oral dose. The compound targets a parasite protein not attacked by existing malaria drugs and has desirable features for a new malaria therapy.
Researchers have found that African trypanosomes avoid human immune systems by mutating surface protein receptors, reducing TLF-1 uptake. This discovery may lead to the development of new therapies against the disease-causing parasites.
Researchers have made progress on a vaccine for Ich, a parasitic disease that causes significant losses in commercial fish farms and home aquarium hobbyists. The study found that vaccination with live Ich theronts and trophonts stimulated production of protective antibodies in channel catfish.
A 48-million-year-old fossilized leaf has revealed evidence of a fungus taking control of ants to turn them into zombies. The discovery sheds light on the evolution of parasitic manipulation in animals.
A study found that infection with malaria parasites during antibiotic treatment developed a vaccine-like immunity against re-infection. Antibiotics can prevent malaria parasite replication in the liver, allowing the immune system to mount a robust defense against future infections.
Researchers have identified a unique metabolic pathway in Plasmodium falciparum, the deadliest malaria parasite, which could be targeted with anti-malarial drugs. The discovery, published in Nature, reveals that the parasite uses a double-branched pathway to generate acetyl-CoA, a crucial molecule for its survival.
Researchers discovered that cancer drugs can inhibit Leishmania's survival and infection ability by targeting its TOR kinase proteins. The study highlights the potential of repurposing existing cancer treatments to combat this debilitating parasite.
Researchers successfully engineer mosquitoes immune to malaria parasite, rendering them ineffective vectors for human infection. The breakthrough has significant implications for global health, with an estimated 1 million fatalities annually due to the disease.
A MSU-led research team will use the grant to create new prevention and control strategies for malaria in Malawi, focusing on identifying factors contributing to the disease's incidence and prevalence. The team aims to tailor strategies to specific seasons and locations.
Researchers and graduate students from low-income countries can apply for conference bursaries to attend the Parasite to Prevention conference in Edinburgh, UK. The bursaries cover travel, accommodation, and conference registration costs.
A Ph.D. student has received a fellowship to study the enzyme UDP-galactopyranose mutase, which produces a sugar absent in humans, offering a potential target for drug treatment. The research aims to understand the chemical mechanism and develop new treatments for Chagas' disease.
Researchers used DNA barcoding to reveal that parasites infecting freshwater fish mostly specialize on specific hosts, except for those targeting the eyes which can infect many different species and even frogs. This discovery may have practical benefits for wildlife managers and fish farmers.
A recent study published in Current Biology reveals that malaria is tens of thousands of years older than previously thought, evolving alongside anatomically modern humans. The research found a clear correlation between the geographic spread of malaria and human migration patterns, suggesting a shared origin and route of spread.
Researchers have identified the complement receptor 1 (CR1) as an alternative protein used by the malaria parasite to invade red blood cells. This finding has significant implications for the development of a vaccine against malaria, and may help prevent the proliferation of parasites that rely on this pathway.
A study by Instituto Gulbenkian de Ciência has identified the first genetic risk factors for cerebral malaria in Angolan children, a severe form of malaria infection. The research found that variants in two genes, TGFB2 and HMOX, increase susceptibility to cerebral malaria.
Researchers discovered how the parasite survives in a fly's gut, triggering an enzyme response that adapts its body. This reaction has a corresponding part in human cells, potentially leading to greater understanding of inherited diseases like Zellweger syndrome.
Researchers have discovered a new parasite, Edwardsiella, living on the American comb jellyfish that causes skin irritation in humans. The parasite's larvae may be problematic for Swedish sea bathers during late summer beach season.
Researchers at Walter and Eliza Hall Institute identify heparin-like carbohydrates that block malaria parasite's attachment to red blood cells, offering new potential for anti-malarial drugs. The study provides hope for developing effective treatments against the disease, which affects millions worldwide.
Parasites in invasive species can cause significant harm to local invertebrates, fish stocks, and ecosystem services. The discovery challenges previous thinking that parasites-free invaders do well in new locations.
A rare parasitic infection called paragonimiasis has been diagnosed in six people who ate raw crayfish from Missouri streams, according to Washington University School of Medicine. The infection causes fever, cough, chest pain, and fatigue, but is easily treated with an oral drug, praziquantel.
A signaling protein in parasites has been identified as a key regulator of movement and infectivity. By disabling this protein, scientists may be able to prevent parasite infections and develop new treatments.
Researchers have discovered a new twist on a potential malaria drug target, which traps malaria parasites within infected red blood cells. This breakthrough identifies an essential step in the biology of the most common and severe malaria parasite and offers a new direction for fighting one of the world's most deadly infections.
Researchers found ultra-small microbes, dubbed ARMAN, with tiny genomes and unusual interactions with other Archaea, living in acidic mine drainage. The microbes have unique cellular extensions that pierce other cells, blurring the lines between parasitism and symbiosis.
A team of researchers from McGill/MUHC has developed a novel screening tool to diagnose Chagas disease, a parasitic disease affecting over 10 million people in the Americas. The new approach uses mass spectrometry technology to identify specific biological markers left by the parasite, enabling rapid and reliable diagnosis.
Researchers have discovered the molecular signals used by Toxoplasma gondii to control cell behavior, paving the way for new treatments and vaccines. By disabling these signals, scientists can liberate cells from parasite takeover, potentially improving immune responses and treatment outcomes.
Scientists have confirmed that ovale malaria is caused by two distinct but similar species of parasite. The discovery was made using DNA technology, revealing the parasite's unique characteristics and potential impact on global health.
Researchers have generated a high-quality draft genome sequence for the strain of T. brucei responsible for human African trypanomiasis, a chronic disease affecting the central nervous system. The study found that the parasite's ability to infect humans is linked to subtle genetic differences, including changes in VSG genes.
A recent study reveals Toxoplasma gondii is prevalent among Iberian Lynx, with 81 of 129 sampled felids testing positive for antibodies. The parasite was also found in captive breeding centers, highlighting the need for prevention measures.
A new three-in-one test can detect Chagas' disease, leishmaniasis, and sleeping sickness in under an hour. The low-cost test uses special dyes that reveal the presence of parasite markers.
Researchers found that 10% of Duffy-negative people in Madagascar were infected with P. vivax, contradicting the long-held assumption of resistance. The study suggests that population mixing and disease evolution have led to the emergence of new parasite strains that can infect Duffy-negative red blood cells.
A new oral treatment has been shown to be effective in 95% of cases against head lice, providing a real therapeutic alternative to conventional anti-lice lotions. The study used oral Ivermectin administered at 400 μg per kilogram and found significant improvements compared to traditional malathion lotion treatments.
Researchers used 2-photon microscopy to study granulomas formed in mice infected with Leishmania donovani, identifying how killer T lymphocytes interact with infected cells. The findings provide insights into the biology of granulomas and may help improve vaccines and treatments for this neglected disease.
A research program aimed at understanding malaria infection and developing effective treatments and vaccines has been awarded $12.7 million. The program will investigate the parasite's ability to evade the immune system and develop resistance to existing drugs.
A UCR researcher has identified a mechanism by which the malaria parasite replicates in human red blood cells, intensifying its infectious cycle. The 'histone crash' process involves the massive breakdown of histones, allowing for rapid gene transcription and multiplication.
Using transcriptional profiling, NTU researchers uncovered the gene functions for almost the entire Plasmodium falciparum genome, better understanding its response to existing compounds. This breakthrough could lead to the development of more potent drugs or a vaccine for malaria, potentially saving millions of lives.