Articles tagged with Parasites
Researchers used 2-photon microscopy to study granulomas formed in mice infected with Leishmania donovani, identifying how killer T lymphocytes interact with infected cells. The findings provide insights into the biology of granulomas and may help improve vaccines and treatments for this neglected disease.
A research program aimed at understanding malaria infection and developing effective treatments and vaccines has been awarded $12.7 million. The program will investigate the parasite's ability to evade the immune system and develop resistance to existing drugs.
A UCR researcher has identified a mechanism by which the malaria parasite replicates in human red blood cells, intensifying its infectious cycle. The 'histone crash' process involves the massive breakdown of histones, allowing for rapid gene transcription and multiplication.
Using transcriptional profiling, NTU researchers uncovered the gene functions for almost the entire Plasmodium falciparum genome, better understanding its response to existing compounds. This breakthrough could lead to the development of more potent drugs or a vaccine for malaria, potentially saving millions of lives.
Researchers at the University of Copenhagen have synthesized the entire protein responsible for life-threatening malaria in pregnant women and their unborn children. A protein-based vaccine is planned to trigger antibodies protecting against malaria, saving over 200,000 lives annually.
Researchers have discovered a key enzyme that allows the malaria parasite to take over human red blood cells. Plasmepsin V is essential for the parasite's ability to secrete proteins into the host erythrocyte.
Researchers at Walter and Eliza Hall Institute have identified Plasmepsin V as a key survival protein used by the malaria parasite to transform human red blood cells. This discovery offers a clear target for developing a new class of anti-malarial drugs that destroy the parasite, providing hope for combating the disease.
A multinational team of researchers has identified a plan to develop new treatments for malaria by targeting the parasites' digestive enzymes. By blocking these enzymes, the parasites can no longer survive within human red blood cells, offering new hope for millions affected by global spread of drug-resistant parasites.
Researchers detect Plasmodium falciparum and two new species of malaria parasites in gorillas, complicating efforts to eradicate the disease. The findings could aid vaccine development and further understanding of infectious disease transmission from animals to humans.
Walter and Eliza Hall Institute researchers have discovered proteins that could form the basis of an effective vaccine against malaria. The findings support the development of a vaccine against the blood-stage of malaria, which is transmitted by mosquitoes and caused by the Plasmodium falciparum parasite.
Galapagos finches develop antibodies against two parasites that invaded the islands, suggesting they can fight off alien invaders. The immune system recognizes these parasites and produces specific antibodies, which may help the birds resist the threats.
Professor Alan Cowman's research on Plasmodium falciparum has led to a better understanding of the malaria parasite's evasion of the human immune system and its invasion of red blood cells. He is being recognized for his contributions to identifying vaccine and drug candidates against malaria.
Researchers at Heidelberg University Hospital discovered that malaria parasites alternate between phases of rapid gliding and firm adhesion to surface. This 'stick-slip' mechanism enables the parasite to move rapidly over a long time, necessary for successful transmission of the disease.
Researchers at Tufts University have discovered how the parasite Trypanosoma cruzi prolongs its life in human host cells by activating anti-apoptotic molecules, enabling it to evade death. This study provides new insights into the mechanisms behind Chagas' disease.
Malaria parasites adapt their molecules to evade the host's immune response, with different approaches used in children and adults. Researchers discovered a limit to severe disease-causing variants and found evidence for a vaccine against this deadly form of malaria.
A study found higher Anisakis spp presence in anchovies from Atlantic South East coast and Mediterranean North West coast. Freezing or cooking fish can reduce the risk of anisakiasis.
Malaria eradication remains an elusive goal despite progress in controlling the disease, requiring multiple activities, interventions, and approaches. Scientists must adapt their strategies to address changing parasite behavior and distribution, developing new tools and interventions to keep ahead of emerging challenges.
A team of scientists has gained a better understanding of how Leishmania donovani parasites evade the human immune system, leading to chronic infection. This breakthrough could potentially lead to new treatments for visceral leishmaniasis, a fatal disease affecting millions worldwide.
Researchers have charted extreme genetic differences in the malaria parasite, which could make it difficult to develop a broadly protective vaccine. The study found that certain regions of the protein are recognized by the immune response, allowing researchers to narrow their focus and reduce the number of immunologically important types.
Researchers at McGill University Health Centre discovered a key molecule, GP63 protease, that neutralizes macrophages' defences and hinders the body's innate inflammatory immune response. The study provides a promising approach to treating leishmania as well as other infectious diseases.
Scientists have discovered a gene behind malaria-resistant mosquitoes, which could lead to new tools for controlling malaria transmission in endemic areas. The study found that a single section of one chromosome contains a gene called TEP1 that promotes the killing of malaria parasites in mosquitoes.
A recent study published in Clinical Infectious Diseases reveals key laboratory and clinical features of human P. knowlesi infections, confirming the potentially deadly nature of the disease. The research found that P. knowlesi malaria can cause a wide spectrum of disease, including breathing difficulties and kidney problems.
A new study published in PLOS Pathogens shows that Leishmania parasites use a gel to persuade immune cells called macrophages to feed them instead of killing them. This trick enables the parasites to establish an infection and infect the skin, highlighting a crucial step in leishmaniasis transmission.
Researchers at Instituto Gulbenkian de Ciencia discover that an enzyme called heme oxygenase-1 (HO-1) protects mice from developing severe forms of malaria. An anti-oxidant drug, N-acetylcysteine (NAC), has the same effect on Plasmodium-infected mice.
Researchers found that daily temperature fluctuations significantly impact malaria parasite growth and transmission rates. In areas with cooler temperatures, a fluctuation of 45 degrees Fahrenheit reduces the parasites' incubation period, making them infectious nearly two weeks earlier.
Researchers believe a parasite found in chimpanzees in equatorial Africa is the original source of malignant malaria, transmitted to humans through a single mosquito around 5,000 years ago. This discovery could aid the development of a vaccine for malaria, which affects 500 million people annually.
Scientists developed a novel immunization method that induces complete protection against the life-threatening malaria parasite in humans. The method allowed the human immune system to target the parasite at an earlier stage of its life cycle, resulting in significant improvement over other experimental malaria vaccines.
Researchers found malaria parasites in western Cambodia resistant to artemisinin-based therapies, making them less effective and a potential game-changer for malaria control. The study's findings highlight the need for swift action to contain the spread of resistant parasites.
Scientists have created a weakened strain of the malaria parasite that will be used as a live vaccine against the disease. The vaccine, developed in collaboration with researchers from the US, Japan and Canada, will be trialled in humans from early next year to provide protection against deadly malaria.
Biologists discovered that parasites drive snails to reproduce sexually, increasing genetic diversity and resistance to infection. The study supports the Red Queen Hypothesis and Geographic Mosaic Theory, showing that host species can adapt to avoid parasite coevolution by producing genetically variable offspring.
Research finds freshwater snails reproduce more when infected with trematode parasites in shallows, supporting the Red Queen hypothesis and Geographic Mosaic Theory. Parasites enhance sexual reproduction by increasing selection on species interactions over small spatial scales.
The complete genome sequence of Schistosoma mansoni, a parasitic worm causing devastating disease, has been published. Researchers have identified potential new drug targets and explored ways to treat and eradicate the disease.
The genomes of two parasitic flatworm species causing schistosomiasis have been sequenced, revealing potential drug targets and enzymes that can be targeted with drugs. The research may lead to new treatments for the debilitating disease.
Researchers at Duke University have found that variation in a single gene influences baboons' susceptibility to a closely related parasite, similar to its impact on humans. The study's findings provide a unique example of how the same genetic mechanism can confer resistance to different parasites.
A new study found that parasites evolve to be less aggressive when scattered among isolated clusters of hosts, favoring the survival of the group. This discovery suggests that as human activity makes the world more connected, natural selection will favor more virulent and dangerous parasites.
UT Southwestern researchers accelerate efforts to eradicate worm infections by targeting a biochemical system that controls development and reproduction in parasitic nematodes. The compound dafachronic acid sends signals for the worms to mature from infective to feeding stages, making hosts sick.
Researchers from Heidelberg University Hospital have discovered that combining methylene blue with newer malaria medications is twice as effective in curbing the spread of malaria parasites than standard therapy. This new approach has significant implications for eradicating the disease, particularly among children under five who are m...
Researchers at the University of Leeds have developed chemicals that kill the deadliest malaria-causing parasite, Plasmodium falciparum, and those resistant to existing drugs. These compounds work by preventing an enzyme essential to the parasite's growth, resulting in its death.
Researchers discover that Trypanosoma brucei breaks its DNA to change its surface coat, a key strategy for avoiding immune cells. This finding suggests a common mechanism for DNA rearrangement in parasites and humans.
Researchers have found a way to induce sex in the disease-causing parasite Leishmania by cramming enough parasites into the gut of an insect, potentially leading to new treatments for deadly infections.
Researchers at the University of Pennsylvania have found a new way to combat malaria by trapping parasites inside host cells. They identified an enzyme called calpain-1, which parasites use to break out of infected cells, and developed a method to block it, leaving parasites trapped.
The study provides a comprehensive map of global malaria endemicity, revealing areas where malaria control can be improved and areas where elimination may be possible. The map uses model-based geostatistics to incorporate data from local surveys, providing an important resource for policymakers and researchers.
Researchers identified a molecular pathway that triggers an immune response in multiple mosquito species, blocking the development of malaria-causing parasites. By activating transcription factor Rel 2, mosquitoes were able to mount an efficient defense against Plasmodium falciparum.
Scientists at the University of Leeds have discovered a link between toxoplasmosis and schizophrenia, suggesting that the parasite affects dopamine production in the brain. The study provides new insights into the development of schizophrenia and its potential connections to other neurological disorders.
Researchers have discovered a new way the malaria parasite interacts with human red blood cells, identifying the EBL-1 molecule as the attachment site. This finding could lead to the development of a vaccine cocktail to combat malaria.
Researchers discovered that mosquitoes use proteins called LRIM1 and APL1C to detect and destroy malaria parasites. The study found that 80-90% of parasites are killed, but only a few manage to evade detection, allowing the disease to be transmitted to humans.
A team of researchers found that the malaria parasite breaks down essential amino acid arginine to trigger a more deadly phase of the disease. By depleting this substance, the parasite may be able to 'switch off' human immune functions that threaten its survival.
Climate change is altering malaria patterns due to daily temperature fluctuations, which can affect the incubation period of malaria parasites in mosquitoes. This can lead to changes in transmission rates, with warmer temperatures potentially increasing the risk of infection.
Researchers at UGA have discovered a protein essential for Toxoplasma gondii's growth and division. The study reveals that disrupting this protein leads to the death of the parasite, providing a new working model for understanding parasitic diseases.
Researchers at Monash University have made a breakthrough in treating malaria by deactivating the parasite's digestive machinery. The discovery could provide treatment for millions of people worldwide and offers hope against drug-resistant malaria.
Researchers found that reed warblers employ a defense-in-depth strategy by mobbing model cuckoos at high-risk nests, reducing parasitism rates. Mobbing is adaptive in contexts where brood parasitism varies spatially and temporally.
Researchers found that Plasmodium falciparum relies heavily on the Pcalp protein, which is essential for its cell cycle progression. By manipulating Pcalp levels, they revealed the parasite's vulnerability to inhibition.
Researchers study how Toxoplasma gondii infects mice and finds that infected cells fuse with endoplasmic reticulum to present parasitic peptides. This process, called cross-presentation, helps the parasite evade immune detection.
Research reveals that California sea otters living in coastal areas with limited resources are more susceptible to diseases caused by parasites. The study found that diet diversity among individual otters can lead to higher infection rates, highlighting the importance of habitat quality for maintaining healthy populations.
Researchers at Johns Hopkins Malaria Research Institute identified saglin and TRAP as essential proteins for Plasmodium's invasion of the Anopheles mosquito salivary gland, a critical step in transmitting malaria to humans. This discovery could lead to novel approaches for disrupting the parasite's lifecycle and preventing malaria spread.
Researchers at American Museum of Natural History found a close evolutionary relationship between malarial parasites in rats and humans, including Plasmodium falciparum. The study suggests that the most deadly form of malaria may have originated from rodents.
Aphids leave behind their old exoskeletons, called exuviae, to act as decoys for parasitoid wasps. This behavior helps aphids escape from parasitic attacks by giving other aphids time to flee while the wasps investigate the empty shells.
Researchers at Centenary Institute in Australia used high-powered multi-photon microscopy to visualize the spread of a parasite through the body, gaining insights into how pathogens are recognized by the immune system. This discovery has potential to improve current vaccinations and inform vaccine design.
Researchers have developed nematode-resistant varieties of bell peppers, such as Charleston Belle and Carolina Wonder, which can be used as viable alternatives to methyl bromide for managing southern root-knot nematode. These varieties are stable in sub-tropical climates and can increase the availability of parasite-resistant vegetables.
A team of researchers has characterized a large number of parasite proteins that may prove useful in the development of a human malaria vaccine. These proteins are essential for sporozoite development, which can be genetically inactivated to stimulate an immune response.