Articles tagged with Parasites
Researchers discover how malaria parasites hijack red blood cells and develop a new strategy to block them using propranolol. The finding opens the possibility for important new drugs that won't become resistant, addressing the growing problem of drug-resistant malaria.
The scientists' achievement provides new avenues for diagnosing and treating this sexually transmitted disease, affecting an estimated 170 million people worldwide. The genome contains genes and proteins not found in humans, which can help expand drug options and devise a diagnostic test.
Recent studies published in major scientific journals reveal the molecular mechanisms behind Toxoplasma gondii's severity and its link to AIDS patients' dementia. The research provides a model for studying toxoplasmosis and related diseases, with potential applications for developing more effective treatments.
Researchers discovered a single Toxoplasma protein, ROP16, that travels to the host cell nucleus and blocks normal responses to invasion. This finding has wide-ranging implications for diseases caused by other parasites, including malaria.
Researchers developed a malaria vaccine that prompts the immune system to eliminate the parasite from an area's mosquitoes. The vaccine was tested in mice and showed promise by eliminating the parasite from the digestive tract of infected mosquitoes.
Researchers found that snail hosts arriving from Japan led to novel disease outbreaks in North America. Genetic analysis revealed distinct invasion pathways for two cryptic species of trematode parasites, one arriving with the snails and the other historically dispersed by migratory birds.
A comprehensive genetic analysis of an invasive marine host and its parasites reveals the accidental introduction of Japanese seed oysters carrying parasitic flatworms, leading to widespread disease in the region. The study highlights the importance of identifying and mitigating disease outbreaks in a globalized economy.
A single gene, ROP18, accounts for 90% of Toxoplasma gondii's virulence, making it a key target for identifying and treating the parasite's most dangerous strains. Researchers hope to develop new treatments using existing kinase inhibitors.
Researchers at Stanford University School of Medicine have identified two proteins, ROP16 and ROP18, that are critical to Toxoplasma's ability to infect and reproduce inside human cells. The study found that changes in these proteins can ramp up damage to the host by 10,000-fold.
A genome-scale map of genetic variation in the malaria parasite has been completed, revealing nearly 47,000 specific genetic differences among parasites worldwide. This study provides a critical foundation for dissecting the functions of important parasite genes and tracing the global spread of malaria.
A massive effort to sequence and compare complete or partial genomes of Plasmodium falciparum has revealed nearly 47,000 genetic variations. This data will help researchers understand the parasite's evolution and study malarial drug resistance. New antigens identified may be potential targets for new therapeutics or vaccines.
A new study provides a reliable way to diagnose cerebral malaria in children through changes to the retina. This discovery could greatly reduce child mortality rates from this major childhood killer.
A CU-Boulder research team has discovered over 200 suspected parasite burrows in a well-preserved duck-billed dinosaur, indicating the presence of tiny worms similar to annelids and nematodes. The findings provide evidence for interactions between dinosaurs and invertebrates.
Research by S. Kankova and colleagues found that Toxoplasma positive mothers give birth to more boys than negative women, with a probability of up to 72 boys in every 100 children born. The increased survival of male embryos may be attributed to the parasite's modulating effects on the immune system.
Researchers discovered that parasitic plants like Cuscuta pentagona sense and respond to volatile chemicals emitted by potential host plants. They found that dodder seedlings grew towards tomato plants in a specific direction, indicating a directed growth response.
Researchers at Karolinska Institutet in Sweden and Makerere University in Uganda have identified how the malaria parasite conceals itself in the placenta, paving the way for a potential vaccine. The study found that several receptors on the placenta are involved in binding to the parasite, contrary to previous laboratory studies.
Scientists at Johns Hopkins have identified a previously unknown way the trypanosome parasite that causes African sleeping sickness makes fatty acids. The discovery of this unique biochemical pathway could lead to the development of new drugs to treat the illness.
Chagas' disease kills 50,000 people annually, with 18 million already infected and 100 million at risk. The disease has no initial symptoms, expensive prevention methods, and limited treatment options, prompting The Lancet to call for increased research attention.
A research team at the University of Georgia has identified a crucial metabolic pathway in Toxoplasma gondii that is essential for its survival. This discovery could lead to the development of new drugs to control the parasite's effects on humans and animals, particularly pregnant mothers and those with compromised immune systems.
Researchers used real-time imaging to track malaria infections in live mice, discovering that the parasite uses dead liver cells to cloak and transport itself back into the bloodstream. The study provides insights into the parasite's complex life cycle and potential ways to treat malaria.
Researchers suggest that Toxoplasma gondii, a common cat parasite, may influence human behavior and cultural aspects such as ego, money, and work. High prevalence of the parasite in certain regions is associated with higher neuroticism scores and differences in masculine sex roles.
Researchers found that parasites dominated the links between species in food webs, with a significant impact on ecosystem stability. The study also revealed new patterns, including increased vulnerability of mid-trophic level animals to parasites and predators.
A study by Ohio State University researchers found that mice lacking a specific gene produce fewer parasites in their livers, preventing the disease from developing. This discovery may lead to the creation of new drugs to treat different diseases affecting the liver.
A recent study by Scripps Research Institute has identified novel immunogens and genes involved in the development of drug resistance, which could lead to new vaccine targets. The research uses gene-chip technology to analyze the genomes of Plasmodium falciparum parasites.
Researchers examined the mosquito immune system and found that it employs similar factors to defend against different Plasmodium species. Boosting the mosquito's capacity to fight malaria parasites could be achieved through exposure to certain microbes or compounds.
Researchers are using California horn snails as a 'data logger' to monitor trematode populations and infer predator-prey relationships in wetland ecosystems. The study found that higher parasite counts were associated with more bird species, indicating the effectiveness of this method for assessing biodiversity.
Researchers discovered a new function for glycolipids in responding to cell stress, which may lead to treatment development for diseases like human African trypanosomiasis. The study also uncovered a pathway for protein movement in trypanosomes that could be relevant to human cells.
Researchers at VIB have made a significant breakthrough in combating African sleeping sickness by developing a nanobody that carries an ApoL-1 variant to the surface of the parasite. This treatment has shown promising results in mice, with infected animals surviving after a single treatment and the parasite being removed from their blood.
Researchers have discovered the structure of Anopheles gambiae's 3-hydroxykynurenine transaminase, a key enzyme in its oxidative defense mechanism. This finding could lead to the development of novel antimalarial agents by inhibiting this enzyme and disrupting the malaria parasite's lifecycle.
After five years of mass treatments, rates of filarial infection have sharply declined in Egypt. The Egyptian campaign to eliminate these infections has achieved its goals in most areas, with the parasite's transmission efficiency being low enough for remaining infections to die out on their own.
Mass drug administration has led to sharp falls in infection rates and transmission in both study areas. The Egyptian national programme is likely to be successful if sentinel villages are representative of communities included in the programme.
Human activities are disrupting the balance of diseases in oceans, causing harm to sea lions, marine mammals, and humans. Coral diseases, linked to sugars from sewage and run-off, are also on the rise, threatening coral reefs.
Researchers used mathematical modeling tools to document the spread of sea lice from commercial salmon farms to wild Pacific salmon. The study found that a single farm could lead to a massive increase in parasite load, affecting the health of young fish.
Scientists from five institutions identify five vaccine targets for an East Coast fever subunit vaccine, which triggered a strong immune response in lab tests. The researchers used the genome sequence of the parasite responsible for the disease to develop the vaccine.
Researchers found that up to 25% of injected malaria parasites stop in lymph nodes close to the bite site, where they can interact with immune cells and degrade. While partially developed or destroyed parasites may not contribute to symptoms, their presence could affect how the immune system responds to infection.
Scientists have identified the DNA sequence controlling the malaria parasite's ability to change its disguises, a key virulence factor. This breakthrough could lead to the design of a drug candidate molecule that freezes the parasite's disguise capability, allowing the human immune system to respond effectively.
Researchers at Howard Hughes Medical Institute have determined how P. falciparum parasites can turn on one cloaking gene and keep dozens of others silent until needed. This discovery reveals the mechanism behind the parasite's survival and has implications for developing new therapies to interfere with its immune evasion strategies.
Researchers have discovered a unique architecture of the Duffy-Binding Like (DBL) domain that allows the malaria parasite to bind to red blood cells. This finding may lead to the development of specific drugs that can target the parasite without affecting healthy blood cells.
A team of researchers has discovered a parasite enzyme, PfSUB2, that sheds sticky surface proteins, allowing the parasite to invade red blood cells. The discovery could lead to the development of new antimalarial drugs that target this enzyme.
New study in Cameroon confirms declining effectiveness of malaria drugs like sulfadoxine-pyrimethamine and amodiaquine, highlighting need for alternative treatments. Researchers highlight importance of monitoring resistance and patient adherence to effective treatment regimens.
Researchers discovered that two proteins in HDLs work synergistically to kill the Nagana parasite in humans. This finding contradicts a long-held hypothesis and provides new information for treatments of parasitic infections like malaria.
Researchers found that a specific gene, SPRN6, is switched on in mosquitoes infected with the malaria parasite, allowing them to defend against it. By knocking out this gene, they observed increased parasite development in some mosquito species and delayed parasite lysis in others.
A new mathematical model developed by researchers at Imperial College London can help reduce the numbers affected by river blindness. The model measures exposure by analyzing how often people were bitten by flies carrying the parasite, providing a better understanding of the role of exposure in the fight against the disease.
Researchers used microscopy and fluorescent tags to study malaria parasite release from infected red blood cells. They found that membranes fold into small vesicles allowing parasites to infect neighboring cells through pressure build-up.
A study by Professor IV Yannas suggests that adults have a dormant regenerative potential that can be reactivated with the right agents. This discovery may lead to new treatments for organ regeneration and increased longevity. The emerging field of Regenerative Medicine is based on this new treatment.
The study reveals the malaria parasite's release mechanism from infected red blood cells, contradicting previous theories. The findings provide new insights into the disease and its potential targets for treatment.
Researchers have identified two genes that enable P. falciparum parasites to switch from sugar-dependent to sugar-independent invasion of red blood cells. The PfRh4 gene is required for this switching mechanism, which provides the parasite with adaptability in the face of receptor changes and immune system responses.
An international team of scientists has discovered the gene PfRh4 that allows the malaria parasite to switch between potential invasion points on red blood cells. The inactivation of this single protein could block multiple entry points currently open to the parasite, paving the way for new anti-malarial vaccine designs.
A study found that mass treatment interventions in Uganda had no significant impact on reducing the prevalence of human infective T b rhodesiense parasites. Since 1998, over 428 new cases have been diagnosed in the Sorotic district, with an additional 300 cases likely going undiagnosed.
Researchers discovered a gene, PfRh4, that enables P. falciparum parasites to switch between two invasion pathways, increasing their adaptability in the face of immune responses and host changes. This finding has important implications for the design of anti-malaria vaccines.
Researchers develop new method to detect sequestered malaria parasites in red blood cells. The study found that patients with severe malaria have six times higher parasite burden than those without severe symptoms.
Researchers discovered a new compound, LMP-420, that potently reduces activation of endothelial cells and inflammation in cerebral malaria. This finding offers a promising avenue for treating the condition, which has a high fatality rate despite existing treatments.
Researchers found that mosquitoes were significantly more attracted to children with infectious stages of malaria, whereas treatment with antimalarial drugs showed no difference in attractiveness.
A new canine vaccine has shown complete protection against visceral leishmaniasis in a successful trial, with laboratory experiments confirming the activation of immune cells to eliminate parasites. The vaccine uses antigen proteins excreted by the parasite and has potential for reducing transmission to humans.
Researchers found that parasitic fly larvae alter tiger moth caterpillar taste organs, favoring toxic plants containing protective chemicals. This change in behavior helps caterpillars escape parasites and survive.
Researchers found that parasite costs and virulence depend on the infection status of competitors, with infected individuals doing better when paired with an infected competitor. High prevalence of infection in a population means healthy larvae face less competition, leading to improved development and survival.
The genome sequences of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major have been completed, providing a blueprint for developing new drugs. The shared core of genes among the three parasites offers potential targets for a class of drugs that can target all three diseases.
Researchers at UGA have conducted the first global survey of protein expression in Trypanosoma cruzi, a parasite that causes Chagas disease. The study identified patterns of protein expression across the parasite's four lifecycle stages, providing new criteria for selecting vaccine targets and potential drug candidates.
Eight Melbourne scientists, including six from WEHI, have been awarded five-year grants to tackle infectious and parasitic diseases like malaria. The $23.3 million international program aims to understand disease mechanisms, identify new drug targets, and develop vaccines.
The WEHI team will conduct research on parasite behavior, drug targets, and vaccine development to combat malaria and leishmaniasis. The ultimate goal is to prevent infection or reduce illness severity with effective treatments.