Reducing malarial transmission in Africa
A randomized trial in Uganda found a six-dose regimen of co-artemether significantly reduced gametocyte levels and mosquito infectivity. However, limitations include patient compliance and absorption issues.
Parasites
Articles tagged with Parasites
Life Sciences
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
447,757
articles
2542
topics
Health and Medicine
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
431,843
articles
751
topics
Social Sciences
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
260,756
articles
745
topics
Physical Sciences
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
257,913
articles
1552
topics
Applied Sciences and Engineering
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
225,386
articles
998
topics
Scientific Community
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
193,043
articles
157
topics
Space Sciences
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
29,662
articles
175
topics
Research Methods
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
21,889
articles
139
topics
Mathematics
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
3,023
articles
113
topics
Molecular models advance the fight against malaria
Researchers developed disease models using yeast to test resistance to atovaquone and created a practical tool to design new anti-malarial drugs. This study provides the first quantitative explanation for malaria's drug resistance, enabling the development of new treatments within 3-5 years.
Researchers unmask malaria parasite's cloaking mechanism
Scientists found that P. falciparum uses gene silencing to mask its presence by packaging DNA into tight forms and preventing expression. The study also revealed the role of protein SIR2 in this process, suggesting new avenues for developing novel drugs for malaria.
Researchers reveal the infectious impact of salmon farms on wild salmon
A recent study reveals the far-reaching impact of salmon farms on wild juvenile salmon, with sea lice infections increasing by 73 times near the farm and extending 30 km beyond. The research sheds light on the critical threat posed to dwindling wild salmon populations in British Columbia.
Ecological destruction fuels emerging diseases
Dr. Brooks' research highlights the link between biodiversity decline and emerging human and wildlife diseases, such as West Nile Virus and avian flu. He argues that understanding parasite life cycles is crucial to preventing these diseases.
Scientists reveal molecular secrets of the malaria parasite
Scientists have identified key genes and gene regulation mechanisms in malaria parasites, which could lead to the development of new vaccines. The study's findings may help researchers understand when different genes switch on and off as the parasite metamorphoses through its complex life cycle.
MIT team engineers new approaches to understanding malaria, more
Researchers at MIT used nanotechnology to study how malaria affects human blood cells, revealing new insights into the disease's impact. The study could lead to better treatments for malaria and other diseases by understanding how parasites affect cell behavior and function.
Dream home: Malaria parasite renovates to suit its tastes
Researchers identified a subset of proteins vital to malaria parasite's survival in host red blood cells and a unique mechanism for protein export. This discovery allows for focus on key proteins for developing antimalarial drugs.
'Signal' identified that enables malarial parasites to target blood cells
Scientists at Northwestern University have identified a signal on exported parasite proteins that enables the malaria parasite to target red blood cells. This discovery provides a new understanding of the complex mechanisms underlying malaria infection and offers promising leads for developing new treatments.
A puzzle posed by black-headed ducks yields to persistent biologists
Researchers found that black-headed duck eggs are often rejected from host nests of red-gartered and red-fronted coot species, which employ defenses against their own species' brood parasites. This rejection is due to coots' adaptations to counter intraspecific brood parasitism, leaving the ducks evolutionarily stranded.
Gene exchange between species is aided by parasitism
Indiana University researchers found that genes can move from plant parasites to host plants, establishing parasitism as a medium for horizontal gene transfer. The discovery complements previous findings showing the opposite process, and suggests that plant parasitism has been a key mechanism of gene exchange between species.
HIV-1 protease inhibitors: Effective against malaria?
Researchers found that HIV-1 protease inhibitors, such as saquinavir and ritonavir, effectively inhibit P. falciparum growth and demonstrate anti-malarial activity. The study builds on previous findings of antiretroviral agents reducing parasite adhesion to endothelial surfaces.
Fly gut's 'sticky spot' for leishmaniasis parasite
Researchers found a specific region in the fly's gut wall where the parasite attaches and feeds on nutrients. This unique structure enables the parasite to survive and multiply within the insect host.
Genetically modified parasite lets researchers probe immune system's memory
Scientists have created a genetically modified parasite to study the immune system's memory, which could aid in developing vaccines for Leishmania major, AIDS, and tuberculosis. Researchers found that central memory T cells remain primed to fight new infections even after initial infection has cleared.
Rutgers-Newark scientist: Mosquitoes may carry lethal parasite
A Rutgers-Newark scientist has found that mosquitoes may carry a lethal parasite called B. algerae, which can invade human muscle tissue and cause death. The parasite is typically found in the tissues of mosquitoes and can be transmitted to humans through mosquito bites.
Excess levels of nitrogen, phosphorus linked to deformed frogs
Excess nitrogen and phosphorus from farming activities cause eutrophication, creating a food web that imperils frogs. A parasite, Ribeiroia ondatrae, infects tadpoles, causing deformities.
Inadequate vaccines can help breed more vicious malaria strains
A laboratory-based study suggests that inadequate vaccines could lead to the emergence of more virulent malaria strains, potentially making them more dangerous to non-immunized populations. The research found that immunity accelerates the evolution of virulence in malaria parasites, even after mosquito transmission.
Study helps explain island populations' susceptibility to exotic diseases
Researchers found that larger islands with more native parasites have weaker bird immune responses, making them ill-prepared for invasive infections. This study sheds light on how island populations respond to exotic disease introduction through human activities.
Nutrients cause increase in parasites and frog deformities
A study found that high nutrient levels lead to increased rams horn snail populations, which in turn cause more parasite infections and deformities in frogs. This research may help explain the recent increase in amphibian malformations and suggest control strategies.
Choice of food helps hungry caterpillar
Researchers found that a caterpillar's adaptation to a specific fruit's chemical composition allows it to survive without triggering the plant's defense mechanism, providing a stable food supply. This unique dietary preference also shields the caterpillar from parasites, enabling it to thrive in an otherwise hostile environment.
Plant-like enzyme acts as key life cycle switch in malaria parasite
Researchers identified a plant-like enzyme, CDPK4, essential for malaria parasite transmission to mosquitoes. The findings provide a promising new target for developing safe and effective anti-malarial drugs.
First target for childhood malaria vaccine
Researchers have identified a new protein target for a universal childhood malaria vaccine, which causes infected red blood cells to stick inside blood vessels. This protein is expressed on the surface of red blood cells during severe childhood malaria but not during adult infections, making it an ideal candidate for vaccination.
Mosquitoes vs. malaria: How we can win the fight
Researchers have discovered two mosquito proteins, TEP1 and LRIM1, that kill the malaria parasite. Eliminating these proteins could block the parasite-mosquito cycle, potentially decreasing malaria prevalence.
Out-of-balance ecosystems play role in demise of amphibian populations
Out-of-balance ecosystems play a significant role in the demise of amphibian populations. Human activities, parasites, and environmental changes are contributing factors. The research highlights the importance of managing landscapes and water bodies to prevent further declines.
Parasite's enzyme structure helps address a public health issue
Scientists have solved the puzzle of DHFR-TS, an enzyme needed by Cryptosporidium for reproduction. The study's results will help researchers design targeted drugs to combat the parasite and better understand related protozoan families.
History of frog deformities suggests emerging disease
Research reveals a significant rise in frog deformities over the past three decades, with a notable correlation to trematode parasites. Historically documented cases suggest an ongoing issue, while recent findings indicate increased occurrences and severity across more than 50 hotspots in North America.
Novel delivery system devised for toxoplasmosis treatment
A new delivery system uses short chains of arginine to ferry drugs across membranes and into cysts of Toxoplasma gondii, a single-celled microorganism that causes toxoplasmosis. The discovery opens the possibility of treating active and latent infections in the eye by applying a lotion containing triclosan.
TIGR posts sequence data for parasite that causes trichomoniasis
The Institute for Genomic Research has released sequence data for the Trichomonas vaginalis parasite, which causes trichomoniasis and is linked to increased HIV transmission. The larger-than-expected genome holds promise for finding new treatments and prevention strategies.
Hormones and drugs that control blood pressure also control malaria infection
Researchers identified a key process in malaria infection involving G proteins in red blood cells, which can be blocked with beta-blockers to prevent parasite entry. By targeting this process, new approaches for treating malaria may be developed using existing drugs.
Fat chance for hosts
A new study reveals that parasitic flatworms use light to locate hosts, while water temperature increases their swimming speed. The findings suggest that the larvae's movement is largely controlled by themselves rather than environmental factors.
Leishmania mutant provides insight into disease and may lead to a vaccine
A Leishmania mutant parasite has been developed to study persistent infections without triggering disease. The research may provide a breakthrough in understanding how the parasite interacts with the immune system, potentially leading to the development of a vaccine.
Monitoring malaria: Genomic activity of the parasite in human blood cells
A recent study published in PLOS Biology tracked the genomic activity of Plasmodium falciparum in human red blood cells, revealing a surprisingly simple pattern of gene expression. This finding could lead to the identification of the biological function of unknown genes and provide new insights into the life cycle of malaria parasites.
Study of leishmania parasite may lead to vaccine, new treatments
Researchers engineered a strain of leishmania parasites without lipophosphoglycan, which increased their vulnerability to immune defenses. The findings could help develop new treatments for the deadly disease, affecting 12 million people worldwide.
Scientists discover 'drive shaft' in mechanism that propels parasite into cells
Researchers identified a previously unknown protein-aldolase interaction that drives the parasite's movement into cells. This discovery may lead to the development of small molecules blocking this mechanism and treating diseases like toxoplasmosis and malaria.
U.Va. researcher reports on advances in treatment of a leading parasitic killer
A U.Va. researcher has made significant breakthroughs in treating the parasite that causes amebiasis, a disease responsible for millions of cases and deaths globally each year. The researcher's team developed an FDA-approved diagnostic test to improve diagnosis accuracy and a potential vaccine based on immunity in children.
They’re healthier: With fewer parasites, invaders gain competitive edge over native species
Two studies found that invasive species have significantly fewer parasites than their native competitors, allowing them to outcompete and devastatingly impact native ecosystems. This advantage is due to the poor match between parasite hosts in new environments.
Researchers find invasive species are healthy species –– They leave their parasites behind
Research finds that invasive animals typically have fewer parasites in new habitats, allowing them to dominate native populations. This advantage is attributed to the lack of matched parasites, enabling introduced species to outcompete less fit native species.
Researchers decipher cause of parasite’s worldwide spread
A study published in Science reveals that Toxoplasma parasites can rapidly adapt to new hosts, allowing them to infect a wide range of animal species and spread worldwide. This discovery raises the possibility of other parasites undergoing similar changes, potentially presenting new threats of infection.
Kiss mistletoe goodbye this season for better tree health
Researchers at the Texas Agricultural Experiment Station have discovered a promising new treatment for eliminating mistletoe from urban trees. The plant hormone has shown to be effective in controlling up to 90% of mistletoe infestations, with potential applications for widespread use across the United States.
Genetic variant protects people against malaria
A genetic variant in the NOS2 gene boosts nitric oxide levels, protecting against malaria disease. This trait explains why some people with malaria have mild symptoms and recover fully.
Scientists decode mosquito/malaria parasite genomes
International collaboration sequences mosquito genome, revealing gene functions and immune system adaptations that help understand why only a few species transmit human malaria. The findings provide a head start for researchers to develop new therapies against the disease.
Parasite, mosquito genomes complete malaria picture
The sequencing of both P. falciparum and its insect vector heralds a new era in the fight against malaria. This detailed map of the parasite's 5,300 genes will enable investigators to design targeted anti-malarial drugs.
Gene's role in malaria drug resistance proved
Researchers have identified a specific gene mutation that confers chloroquine resistance in Plasmodium falciparum malaria parasites, allowing scientists to develop targeted treatments, and also increasing susceptibility to artemisinin and quinine.
New discovery in malaria
Researchers have found genes in Anopheles mosquitoes that enable them to resist infection by the deadly malaria parasite. The discovery could lead to new strategies to prevent malaria transmission by spreading the parasite-blocking genes among mosquito populations.
Slightly stressed carp succumb easily to parasite
Researchers found that stressed carp are easily infected by the single cell parasite Trypanoplasma borreli due to high levels of cortisol. The study revealed that cortisol inhibits crucial proteins that protect fish from parasites, rendering them more susceptible to infection.
From parasitism to mutualism
A study by Johnstone and Bshary found that the threat of leaving by clients can prevent cleaners from exploiting them. In asymmetric interactions, this 'partner control' model matches existing data on cleaner and client behavior.
New approach to malaria vaccine effective in mice
Researchers have identified a toxin, glycosylphosphatidylinositol (GPI), that contributes to malaria's virulence and is now being explored for use in a vaccine. The anti-GPI vaccine has shown promise in mice, eliciting an antibody response and reducing immune reactions to the malaria parasite.
Promising vaccine may provide long-lasting protection against malaria
A new vaccine targets the parasite's deadly toxin, potentially providing longer-lasting protection against malaria. The vaccine has shown promise in animal trials, with mice surviving after being infected with the parasite when vaccinated against the toxin.
Genetic studies shed light on the malaria parasite's origins and drug resistance
Researchers found that chloroquine-resistant parasites arose in multiple geographic locations and rapidly spread across continents, contradicting long-held theories. The genetic diversity of the malaria parasite suggests it has evolved over a timeframe coincident with human population expansion out of Africa.
UC study links parasites in freshwater runoff to sea otter deaths
A recent UC study found that 42% of live sea otters and 62% of dead sea otters were infected with Toxoplasma. The researchers suggest that land-based freshwater runoff is a source of the parasite, likely transported by surface runoff from fields and yards to coastal areas.
'Nature' report: Researchers genetically alter mosquitoes to impair malaria transmission
Researchers at Case Western Reserve University have created genetically altered mosquitoes that prevent the passage of malaria from one individual to the next. The mosquitoes were engineered to produce a protein that interferes with the development of the parasite in the mosquito, reducing transmission by about 80%.
Widespread amphibian deformities caused by parasite
Researchers found a strong link between amphibian deformities and parasites, particularly those carried by snails, which thrive in human-altered habitats. The study surveyed over 60% of sites in Oregon, where deformities were linked to the presence of Ribeiroia parasite.
Protein research illustrates how drugs fight malaria, other diseases
Researchers have discovered a new standard for selectively targeting malaria-causing parasites, which could lead to breakthroughs in treating other diseases such as HIV, cancer, and Alzheimer's. By understanding how proteins like DHFR are regulated, scientists can develop more effective and non-toxic treatments.
Amphibians and crippling parasites
A new study found a striking connection between malformed amphibians and the presence of Ribeiroia, a parasitic infection. The parasite was linked to limb malformations in over 12,000 amphibians across 11 species, with Pacific treefrogs exhibiting the greatest number of abnormalities.
Parasitic worms 'read' the body’s immune condition and reproduce accordingly
Researchers discovered that parasitic worms develop normally into adults when in contact with specific immune cells in their host's liver, producing fewer eggs if disconnected. This adaptation allows the worms to thrive by exploiting their host's immune response.
Hookworms may prevent asthma
A recent study found that individuals with hookworm infections were half as likely to develop asthma compared to those without the infection. The researchers suggest that hookworms may alter the body's response to allergens, leading to reduced inflammation and increased resistance to asthma.
Component of fly saliva makes promising Leishmaniasis vaccine
A novel vaccine has been developed to protect against Leishmaniasis, a disease caused by the single-celled parasite Leishmania. The vaccine targets a component of sand fly saliva, dubbed SP15, which appears to induce natural immune responses in mice.
Across the countryside: How ecology predicts the movement of parasites and disease
Researchers explore how ecological principles, such as the dilution effect, predict the movement of parasites and diseases in various ecosystems. Studies examine the impact of animal diversity on disease transmission, with findings highlighting the importance of community diversity in preventing the spread of infectious diseases.
Banning animals from the bedroom could reduce Chagas Disease risk, say Science researchers
Keeping chickens and dogs out of bedrooms can reduce Chagas disease risk by reducing the bug population, say Science researchers. Removing infected dogs from households nearly wipes out transmission of the parasite.
Health threat to travellers from ticks at home and abroad
A study found that tick-borne diseases are a major concern for travelers, with over 100 viruses and bacteria transmitted through ticks. The most serious problem is posed by hard ticks, which can cause mild irritation but also transmit fatal diseases like Lyme disease and tick-borne typhus.