Articles tagged with Insulin Resistance
A recent study has identified mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 (mtGPAT1) as a trigger for insulin resistance in the liver. The researchers found that mice lacking this enzyme were protected from fatty liver and liver insulin resistance, suggesting mtGPAT1 as a potential therapeutic target.
A study found that insulin resistance is a predictor of congestive heart failure (CHF) in elderly men, independent of diabetes and other established risk factors. Insulin resistance was also associated with more severe disease and a worse prognosis in patients with CHF.
A new study found that adult lifestyle, particularly body fat and waist-hip ratio, is a significant risk factor for insulin resistance and Type 2 diabetes. Childhood factors such as birth weight and nutrition have limited impact on the development of insulin resistance in adulthood.
Researchers found that variations in four genes controlling inflammation are associated with insulin resistance in Mexican Americans. These findings may enable physicians to identify patients at high risk for developing diabetes and design therapies targeting these genes.
Researchers found that taking pioglitazone for three years significantly reduced the risk of developing type 2 diabetes in women who had previously had gestational diabetes. This is promising news for preventing and treating type 2 diabetes, as it may help stabilize beta-cell function.
A recent study reveals that grandsons and granddaughters of female rats fed an inadequate diet during pregnancy and/or lactation are more likely to become obese and insulin resistant. The research extends previous findings on the negative effects of poor maternal nutrition, now showing a two-generation impact.
Research highlights that body mass index is just one aspect of ischemic heart disease risk, with insulin resistance syndrome playing a significant role. Metabolically healthy obese men and metabolically unhealthy lean men have been found to have different heart disease risks.
A new study found that the ENPP1 gene variant is associated with an increased risk of developing type 2 diabetes. The variant, which affects insulin action, was more common in people with type 2 diabetes and those at high risk for the disease, regardless of ethnicity.
Researchers have discovered that a compound called HPMC, commonly used as an additive in foods and drugs, may help prevent diabetes in people who frequently consume high-fat fast foods. The compound works by regulating metabolic genes and slowing down the absorption of fats, potentially reducing the risk of developing insulin resistance.
Research at Joslin Diabetes Center reveals that prenatal undernutrition can lead to impaired insulin production and higher blood glucose levels, setting the stage for type 2 diabetes. The study found that low-birth-weight mice had abnormal insulin secretion patterns, leading to permanent impairment.
Researchers found that deleting pro-inflammatory enzyme IkB kinase â (Ikk-â) from immune cells' macrophages improves insulin sensitivity, offering hope for new type II diabetes treatments. The study suggests targeting myeloid cells and their macrophages as a potential strategy for treating the disease.
The Insulin Resistance Intervention after Stroke (IRIS) trial aims to investigate the effectiveness of pioglitazone in reducing recurrent stroke and myocardial infarction among eligible participants. The trial will enroll 3,136 participants over three years and tests the hypothesis that pioglitazone reduces risk by 20 percent.
Research found significant insulin resistance and impaired glucose effectiveness in non-obese patients treated with clozapine, olanzapine, or risperidone. This may increase the risk for diabetes mellitus in vulnerable individuals.
A US study found a strong link between frequent fast-food consumption and weight gain, as well as increased insulin resistance in young black and white adults. The study of over 3000 participants showed that those who ate at fast food restaurants more frequently gained more weight and developed insulin resistance.
A 15-year study found that frequent fast food consumption is associated with a significant increase in body weight and insulin resistance, even after accounting for other lifestyle factors. The study suggests that reducing fast food intake may help mitigate the risk of type 2 diabetes.
A 15-year study found that eating at fast-food restaurants more than twice a week is associated with significant weight gain and increased insulin resistance. The study highlights the importance of healthy eating habits to mitigate these risks.
A new study links resistin to inflammation, insulin resistance, and obesity. Resistin levels increase in human macrophages treated with endotoxin or cytokines, suggesting a role in promoting diabetes through insulin resistance.
A randomized, double-blind, placebo-controlled trial found that DHEA replacement therapy significantly decreases both visceral and subcutaneous abdominal fat in elderly men and women. The therapy also improves insulin action, correlating with the reduction in visceral fat.
A study by Johns Hopkins Medicine found that new-generation antipsychotics olanzpine, quetiapine, and risperidone can induce insulin resistance in children, even at moderate doses, leading to increased risk of Type 2 diabetes and heart disease.
A large study found that teenagers with insulin resistance are at a higher risk of developing high blood pressure as adults. Insulin resistance, a precursor to diabetes, was linked to increased systolic blood pressure and obesity in the long-term study.
Researchers identified a mechanism for beta-cell growth during insulin resistance, which occurs as a normal protective response to delay type 2 diabetes onset. PDX-1 plays a crucial role in regulating this growth, and modulating key proteins involved may enhance beta cell replication or transplantation
Researchers at Cold Spring Harbor Laboratory discovered a lean gene, C/EBPbeta, which helps mice live longer and weigh less. The gene's activation may help jump-start metabolism in fat cells, preventing fat accumulation. Another study found that targeting the JIP1 protein can effectively protect against obesity and insulin resistance.
Research finds connection between cytokine IL-4 signaling impairment and type 2 diabetes. Hyperinsulinemia triggers serine phosphorylation, impacting insulin receptor substrates and leading to neuroimmune response.
Research finds that rosiglitazone effectively treats PCOS symptoms, while valproate increases incidence of PCOS in women. Carotid artery thickness is also linked to increased risk for heart disease in women with PCOS. Furthermore, sleep apnea may increase risk for diabetes in women with PCOS.
A recent study published in the Proceedings of the National Academy of Sciences found that overexpressing a selenium-containing enzyme in mice led to insulin resistance and obesity. The researchers suggest that antioxidants, like selenium, may be harmful by neutralizing free radicals necessary for insulin signaling.
ACTOS therapy has favorable effects on dyslipidemia, including reductions in triglycerides and increases in HDL cholesterol. Additionally, ACTOS was found to have beneficial effects on non-HDL cholesterol and A1C levels.
A recent study published in the New England Journal of Medicine found that nearly 50% of severely obese youth develop metabolic syndrome. The condition is associated with worsening body mass index and insulin resistance, increasing risk for type 2 diabetes and cardiovascular disease.
Researchers have found that women with visceral fat experience increased lipolysis, the breakdown of fat cells, which can lead to weight loss. The study suggests that this type of fat may be particularly responsive to diet and exercise.
Researchers at UCSB are studying cinnamon's effects on mice with diabetes, finding a compound that has insulin-like activity and may help alleviate the condition. The study aims to explore the potential of cinnamon as a natural treatment for type II diabetes, which affects over 170 million people worldwide.
Researchers at the Eleanor Roosevelt Institute have patented a new treatment for type II diabetes, focusing on regulating insulin resistance by manipulating melanocyte-stimulating hormone (MSH) levels. The approach has shown promise in genetically engineered mice and may offer a new direction in understanding and treating the disease.
Researchers will examine inflammatory process in obese patients to understand how it contributes to cardiovascular disease. High levels of free fatty acids in the blood stream may trigger inflammation, which increases risk of atherosclerotic disease in obese patients with diabetes.
Researchers develop vaccine that prevents tumor growth in mice, while also reversing cardiac dysfunction through gene therapy. These breakthroughs demonstrate the potential of combinatorial approaches to vaccination and gene therapy for treating neoplastic lesions and heart disease.
Research at Joslin Diabetes Center reveals that insulin resistance in the brain may contribute to the development of Alzheimer's disease. Studies using genetically altered mice found a marked reduction in insulin signaling proteins, leading to excessive phosphorylation of tau protein, a hallmark of brain lesions in Alzheimer's.
Researchers found that insulin-resistant young offspring of type 2 diabetics have increased muscle cell lipid content and reduced mitochondrial energy production. This study suggests a potential genetic cause of insulin resistance in young people with type 2 diabetes.
Studies identify specific tissue sites where abnormal cells lead to insulin resistance and Metabolic Syndrome. PPARgamma in fat tissue affects adipose cell function, while defective muscle tissue causes profound insulin resistance.
Cedars-Sinai researchers found a link between lipoprotein lipase (LPL) and insulin resistance in Mexican-Americans. The study used precise diagnostic tests and genetic analysis to identify two LPL haplotypes associated with high or low levels of insulin resistance.
A new study finds that obese mice require the MSH hormone to develop diabetes, increasing resistance to insulin. Researchers believe this may lead to more effective preventive treatments for Type 2 Diabetes.
Understanding insulin-regulatory pathways is crucial to identifying health-enhancing and disease-endangering manipulations. Research has identified components of key insulin-controlled signaling pathways, including IRS1 and IRS2, which regulate body growth, glucose homeostasis, and female fertility.
Scientists discovered a chemical relay that controls whether the body burns sugars or fats for energy. The discovery may help design better treatments for insulin resistance and ultimately prevent adult-onset diabetes.
Monitoring waistline fat, insulin levels, and lipid particles can detect early signs of heart disease in women. Targeted interventions can be initiated to prevent progression of the disease.
A study by Joslin Diabetes Center has identified a family of metabolic genes associated with type 2 diabetes risk. The research found that 55 genes showed altered activity in both people with diabetes and those at high risk for prediabetes, suggesting a continuum from normal to diabetic states.
Researchers found that pioglitazone reduced the risk of developing type 2 diabetes by 55 percent, with only one woman out of 76 participants developing diabetes after a year. The study suggests that pioglitazone can protect women from developing insulin resistance and related health issues.
Researchers found lower levels of metabolic activity in mitochondria of older people, underlying insulin resistance. Physical activity can enhance mitochondrial number in muscle through activation of AMP kinase.
A new study suggests that type 1 diabetics can develop insulin resistance, increasing their risk of heart disease. Insulin resistance occurs when the body fails to use insulin properly, leading to high blood sugar levels and a greater risk of cardiovascular events.
Researchers found that simvastatin, a cholesterol-lowering statin, prevents diet-induced arterial hypertension and metabolic insulin resistance in mice by stimulating nitric oxide bioavailability. This effect appears to be related to stimulation of vascular NO availability.
A study of 289 teenagers found that cardiovascular fitness and lower body fat are independently associated with greater insulin sensitivity. Improving fitness or reducing body fat could protect high-risk children from developing insulin resistance, a precursor to diabetes.
Research finds that eating breakfast daily lowers rates of obesity and insulin resistance syndrome, a key factor in type 2 diabetes and heart disease. Whole-grain cereals also appear to have protective effects, with daily consumption associated with a 15% reduced risk of the syndrome.
A Keck School of Medicine study finds that black and Hispanic children are more insulin-resistant, but their bodies cope differently with resistance. Insulin resistance can worsen over time, leading to type 2 diabetes.
Researchers found strong relationships between nephropathy and insulin resistance throughout follow-up, unlike other risk factors such as blood pressure and blood fats. Lifestyle changes like proper diet, exercise, and smoking cessation may help people with type 1 diabetes avoid kidney disease.
Researchers found that early treatment with insulin-resistant drugs saves about 30% more beta cells than late intervention, preventing type 2 diabetes. The study suggests that lessening the workload on beta cells can prevent or slow disease onset.
Researchers identified the AGPAT2 gene as the cause of congenital generalized lipodystrophy, a rare disorder characterized by extreme lack of body fat at birth. The disorder leads to severe diabetes, insulin resistance, and metabolic complications in affected individuals.
Researchers found that extra sugar on proteins can cause insulin resistance in cells. The discovery provides a potential target for developing new strategies to treat or prevent diabetes.
Researchers found that women who develop preeclampsia have reduced levels of SHBG protein in their first-trimester blood tests. The association remains even in lean or overweight women, suggesting insulin resistance as a true risk factor.
Men with shorter legs are more likely to develop insulin resistance, a precursor to diabetes and an increased risk of heart disease. Leg length is linked to nutritional and environmental factors during childhood, suggesting it as a key indicator for disease risk.
A survey of practice nurses found that 85% are underestimating the prevalence of insulin resistance in type 2 diabetes patients. This lack of awareness can lead to inadequate treatment and education, highlighting the need for increased understanding of insulin resistance as a fundamental cause of type 2 diabetes.
A survey found that nearly two-thirds of GPs are unaware that insulin resistance is present in 92% of people with type 2 diabetes. This lack of understanding can lead to suboptimal treatment, as insulin resistance improves glycaemic control and reduces cardiovascular complications.
Researchers discovered that insulin sensitivity decreases by 32% among pubertal teens, while those who haven't started puberty experience increased sensitivity. The study suggests that changes during puberty contribute to lowered insulin sensitivity, with potential implications for preventing type 2 diabetes.
Researchers have developed a mouse model that replicates the clinical features of type 2 diabetes, enabling studies on pathogenesis and testing of new therapies. The strain of mice, generated by selectively mutating an insulin-like receptor in muscle cells, fully recapitulates the disease's progression.
New studies announce that AVANDIA (rosiglitazone maleate) may significantly reduce insulin resistance and lower cardiovascular risk in Type 2 diabetes patients. Insulin resistance is a fundamental cause of the condition, and targeting it with AVANDIA could lead to better outcomes.
A USC study found that administering a drug to lower insulin resistance in women at high risk for type 2 diabetes successfully prevents or stalls its onset. The study tested whether reducing the demands on beta cells could prevent diabetes in Latinas with recent gestational diabetes.