Articles tagged with Insulin Resistance
A new study found that postmenopausal women with higher testosterone levels are three times as likely to have coronary heart disease and the metabolic syndrome compared to those with lower testosterone levels. Insulin resistance is also more common in these women.
Researchers have discovered that saturated fatty acids can 'anger' the immune system by hijacking Toll-like receptor 4 (Tlr4) on blood cells, leading to chronic inflammation. This interaction may be the key to understanding obesity-related metabolic consequences, and a new class of insulin sensitizers is being explored.
A new study found that South Asians are more likely to develop insulin resistance and type 2 diabetes due to their body composition, specifically higher total body fat and lower muscle mass. Researchers measured insulin levels in four ethnic groups and discovered a strong association between body fat distribution and diabetes risk.
Researchers at University of Texas Medical Branch at Galveston have found that increasing insulin levels can restore impaired muscle-building processes in elderly individuals. This breakthrough suggests a novel approach to addressing age-related muscle loss and has implications for developing new treatments.
A new study from the University of Gothenburg reveals that middle-aged women with large abdominal fat cells are at higher risk of developing type 2 diabetes. The study uses waist circumference divided by body height as a predictor, suggesting a simpler and faster way to identify those at risk.
A new UT Southwestern study suggests that fat from certain foods makes its way to the brain, causing it to send messages to cells warning them to ignore hunger signals. The researchers found that palmitic acid, a type of saturated fatty acid, is particularly effective at triggering this mechanism.
The ERC is funding top researchers, including Sanna Lehtonen's group, to study the development of albuminuria and diabetic nephropathy. They aim to identify novel drug leads to treat insulin resistance and combat early stages of kidney disease.
A breakthrough discovery identifies a new gene called Insulin Receptor Substrate 1 (IRS1) that affects how the body responds to insulin, leading to insulin resistance. The study found a single-nucleotide polymorphism in the IRS1 gene that reduces its activity by 40%, making it harder for insulin to work effectively.
A new study reveals that angiopoietin-like protein 2 (Angptl2) is a primary contributor to chronic inflammation in fat tissue, exacerbating conditions like diabetes and cardiovascular disease. Elevated Angptl2 levels have been found in obese individuals and those with insulin resistance.
Pittsburgh researchers have found a molecular link between insulin resistance and inflammation, suggesting a novel target for diabetes treatment. The study reveals that protein Fox01 stimulates inflammatory white blood cells, leading to increased production of cytokine IL-1B, which interferes with insulin signaling.
A Virginia Tech-led research team is designing a program to help pre-diabetic adults begin and maintain resistance training. The goal is to improve insulin and glucose metabolism, reducing the risk of diabetes. A five-year study will test theory-based approaches to encourage long-term adherence to resistance training.
Researchers found that a gut hormone called cholecystokinin (CCK) activates receptors to regulate glucose levels via a gut-brain-liver neuronal axis. CCK's effects depend on activation of CCK-A receptors, which slow down glucose production in the liver.
PEDF, secreted by fat cells, leads to insulin resistance and dyslipidemia. Blocking PEDF action may reverse health complications associated with obesity.
Researchers found that mothers with elevated blood pressure during pregnancy increased the risk of PCOS in their daughters, while a family history of cardiovascular disease in either parent was also linked to an increased risk. Brothers of women with PCOS are also at greater risk of developing insulin resistance or diabetes.
Researchers at Salk Institute discover how obesity triggers diabetes by activating ER stress, leading to abnormal glucose production in the liver. CRTC2 plays a key role in this process, with ATF6a competing for its binding site.
Researchers found that nicotine induces prediabetes in mice, which may contribute to the high prevalence of heart disease among smokers. The study suggests that reducing tissue glucocorticoid levels or decreasing insulin resistance may help reduce heart disease risk.
Researchers found that nicotine promotes insulin resistance, raising blood sugar levels higher than normal. This condition increases the risk of cardiovascular disease in smokers.
A new study finds that optimal medical therapy is equally effective as revascularization procedures like bypass surgery or angioplasty in lowering the risk of death and cardiovascular events in patients with diabetes and stable coronary heart disease. Insulin-providing and insulin-sensitizing drugs are also shown to be equally effective.
A new study published in Cell Metabolism suggests that a fat-derived inflammatory factor, CXCL5, plays a key role in insulin resistance and obesity-related diseases. The researchers found that CXCL5 is produced by fat tissue and is linked to the development of various conditions, including pulmonary disease, lung cancer, and arthritis.
A new study from Duke University Medical Center suggests that high protein intake with fat consumption may contribute to insulin resistance in obese individuals. The research found that the combination of branched-chain amino acids and high-fat diets caused changes at the cellular level that can lead to insulin resistance.
A new study reveals that high-fat diets supplemented with extra branched chain amino acids can lead to insulin resistance and diabetes in rats. The researchers found that BCAA tend to climb along with insulin resistance, and its effects are exacerbated when combined with high fat consumption.
Researchers at UT Southwestern Medical Center found that African-Americans tend to store fat in subcutaneous adipose tissues, which may protect them from insulin resistance and non-alcoholic fatty liver disease. This fundamental difference in lipid metabolism could lead to targeted therapies for populations prone to NAFLD.
Researchers at the University of Michigan discovered that protein TBC1D1 plays a crucial role in glucose transport into muscle cells after exercise. This finding could lead to new drug therapies or more effective exercise protocols for preventing Type 2 diabetes and other health problems associated with high blood sugar.
Two studies found that SOX9 renders melanomas sensitive to retinoic acid, stopping tumor growth and offering new hope for effective treatment. Additionally, researchers identified two enzymes crucial for ureter-bladder connection during development, which may hold key to treating congenital anomalies.
Researchers at the Salk Institute found a protein called CREB that promotes insulin resistance in obese mice. Blocking CREB's activity improved insulin sensitivity and reduced inflammation, suggesting a potential therapeutic target for type II diabetes. The study provides hope for new treatments that don't require weight loss.
A new study in mice reveals that a gene called PGC-1b plays a key role in the development of insulin resistance caused by high fructose intake. The researchers found that blocking PGC-1b activity improved metabolic profiles and reversed fructose-induced insulin resistance.
Researchers have found that blocking the 'fasting signal' in fat tissue can prevent insulin resistance in obese mice. The discovery suggests targeting therapies to adipose tissue could have therapeutic benefits for insulin-resistant states.
A study published in the World Journal of Gastroenterology found that telmisartan significantly improved insulin resistance, reduced liver inflammation and fibrosis, and showed promise as a treatment for nonalcoholic steatohepatitis. In contrast, valsartan had no effect on liver histology or plasma lipids.
Researchers have identified two causes of critical illness hypeglycemia in children: peripheral insulin resistance and primary beta-cell dysfunction. The study found that those with respiratory failure only had CIH caused by elevated insulin resistance, while those with both respiratory and cardiovascular failure had CIH caused by prim...
A new study published in Hepatology found that African-Americans are more resistant to fatty liver disease and insulin resistance, particularly when it comes to triglyceride levels. The research suggests an 'insulin resistance paradox' where African-Americans exhibit lower insulin sensitivity despite similar body fat distributions.
Researchers found increased PAI-1 expression in the heart of mice with diabetes leads to profibrotic effects, including increased fibrosis and functional derangements. This link may contribute to the high incidence of heart failure after myocardial infarction in people with diabetes.
Researchers discovered that omega-3 fatty acids protect against liver damage and insulin resistance caused by obesity. The study found that lipids called protectins and resolvins derived from omega-3 fatty acids reduced the incidence of liver complications in obese mice, leading to improved insulin tolerance.
Researchers found a genetic variation in the HGF gene that increases breast cancer risk, suggesting shortening of a DNA region called DATE could be a useful marker. A study also revealed that high-fat diets can lead to insulin resistance by damaging mitochondria and increasing oxidative stress, but antioxidants may mitigate this effect.
Researchers found that fat molecules clog up muscle cells' cytosol but not mitochondrion. By increasing mitochondrial ability to burn fat, muscles become more responsive to insulin. The discovery opens doors to developing new therapies for Type 2 diabetes.
A randomized clinical trial involving sedentary obese older adults found that a combination of resistance and aerobic exercises improved insulin resistance and functional limitations. The study showed greater improvements with combined exercise compared to individual types of exercise.
A study by Wajahat Mehal and colleagues found that aspirin reduces liver damage caused by acetaminophen overdose. In contrast, glucocorticoid therapy may cause varying levels of brain injury in neonates, depending on the type of steroid used. These findings have important implications for treatment strategies.
A study found that sleep apnea is strongly associated with decreased glucose metabolism and pancreatic function, independent of body fat. Another study linked chronic intermittent hypoxia from sleep apnea to liver disease progression in severely obese patients.
A gene variant that protects against weight gain and insulin resistance becomes a bad actor on high-fat diets, new research suggests. Mice with the Ala12 variant show improved insulin sensitivity and better plasma lipid profiles on balanced diets but worsen these outcomes when fed a diet high in fat.
New research suggests that excess liver fat is a key contributor to metabolic problems, including high blood pressure and cardiovascular disease. The study found that children with fatty liver disease had abnormalities in glucose and fat metabolism, including lower levels of HDL cholesterol.
A three-year study found that vitamin K supplementation improved insulin resistance in elderly men, while worsening it in women and those not given supplements. Vitamin K may help regulate glucose metabolism by storing in fat tissue.
Researchers at IRB Barcelona have discovered the relation between genes that affect a cell's capacity to generate energy. The study highlights the importance of Mitofusin 2 (Mfn2) in regulating mitochondrial fusion, which is crucial for insulin resistance and type 2 diabetes.
A new study reveals that fructose consumption can induce leptin resistance, leading to weight gain when combined with a high-fat diet. Leptin resistance developed silently, without obesity, and was associated with higher triglyceride levels in the blood.
A study found that vitamin A's carrier protein, retinol-binding protein (RBP), was significantly lower in obese subjects than nonobese subjects. This suggests a potential link between RBP and insulin resistance in obesity. Further research is needed to determine the role of apo-RBP, an unbound form of RBP, in mediating insulin signaling.
A study published in Diabetes Care found that young men with type-2 diabetes have significantly lower levels of testosterone, which can impact fertility, muscle development, and increase the risk of heart disease. The study also highlights the potential clinical implications of low testosterone in these individuals.
Research indicates that obesity can be metabolically benign, with some obese individuals having a lower risk of heart disease and diabetes. The studies found that visceral fat accumulation was more important than total body fat in determining the beneficial phenotype in obesity.
A new study found that targeting liver CB1 receptor may treat obesity-related conditions without brain-side effects, reversing severe insulin resistance and fatty liver in mice fed high-fat diets. The research indicates liver-specific CB1 is necessary for high-fat diet-induced fatty liver and related hormonal changes.
Researchers found insulin resistance in young girls with PCOS mother, suggesting high risk of disease; future studies aim to identify earliest sign of susceptibility. Excessive insulin may be primary culprit behind reproductive abnormalities.
A study found that higher levels of liver protein fetuin-A are associated with an increased risk of developing type 2 diabetes in older adults. The researchers measured fetuin-A levels in 519 diabetes-free individuals aged 70-79 years and found a significant association between fetuin-A and the development of diabetes.
Researchers found that rats on diets enriched with industrial or natural trans-fats showed no significant changes in insulin or glucose responses. The study also confirmed these findings in cell culture studies, indicating that muscles can utilize trans-fatty acids without increasing the risk of insulin resistance and diabetes.
Research conducted by University of Melbourne's Dr Anne Cust and colleagues found that overweight and insulin-resistant women are about 50% more likely to be diagnosed with an advanced stage of breast cancer. The study, published in Breast Cancer Research and Treatment, tracked over 60,000 Swedish women for 20 years.
A Finnish study of identical twins found that physical inactivity and acquired obesity impair the expression of genes involved in energy production, contributing to insulin resistance. The study suggests that lifestyle factors play a significant role in developing diabetes and heart disease.
A new study found that chronic alcohol abuse can decrease levels of genes needed for brain cells to respond to insulin/IGF, leading to neurodegeneration. Insulin resistance in the cerebellum and frontal lobe was associated with loss of neurons and decreased levels of neurotransmitters.
A study found that metformin treatment delayed menstruation and decreased insulin resistance in young girls at risk of early puberty. The treatment also reduced abdominal fat and improved cholesterol levels, lowering the risk of future heart disease.
A new study finds that pregnant women with high insulin resistance are at a higher risk of pregnancy complications, including preeclampsia, premature rupture of membranes, and cesarean sections. Babies born to these women also face increased risks of macrosomia and hypoglycemia.
A USC study found that progressive weight gain in Hispanic women is a key factor in the decline of beta cell function, leading to rising glucose levels and an increased risk of developing diabetes. The study's findings highlight the importance of reducing excess fat to prevent or delay diabetes.
A team of researchers found that the protein TORC2 is crucial for glucose production and fat storage in Drosophila, a genetic switch that regulates metabolism in both flies and human livers. Without functional TORC, fly lifespan was cut in half and their ability to store energy was impaired.
Researchers have found that tricyclic antidepressants can restore vagal function and reduce intestinal inflammation in individuals with inflammatory bowel disease, particularly those who are also depressed. Genetic mutations linked to permanent neonatal diabetes mellitus have been identified, and bacteria can blunt the responses of inv...
Researchers followed Minneapolis school children from ages 11 to 19 to track the emergence of cardiovascular risk factors. By age 19, boys were at greater cardiovascular risk despite gaining muscle mass and losing fat during puberty.
A new study from Ohio State University found that conjugated linoleic acid (CLA) may need to be paired with the hormone leptin to prevent side effects of rapid weight loss. The study used mice genetically engineered to have no leptin, finding that CLA diets can result in weight loss but also insulin resistance.
Researchers at Joslin Diabetes Center have found that insulin inhibits a master gene regulator protein, SKN-1, which controls the Phase 2 detoxification pathway. Increased SKN-1 activity increases lifespan, providing potential insights into increasing resistance to chronic diseases and influencing longevity.