Articles tagged with Insulin Resistance
A genetic variant in SCN10A modifies cardiac expression of SCN5A, essential for conduction. An inflammatory feedback loop activates STAT3, repressing miR-34a and promoting EMT in colorectal cancer cells. Insulin resistance in bone disrupts glucose homeostasis through decreased active osteocalcin.
A study identifies a key role for RBP4 in insulin resistance and inflammation of fat tissue, leading to an increased risk of diabetes. Researchers found that elevated RBP4 levels activate immune cells, triggering chronic inflammation and metabolic dysfunction.
A study of 1,358 children found that preterm infants had higher plasma insulin levels at birth and in early childhood, indicating a potential link between preterm birth and insulin resistance. This association may suggest that preterm birth is a risk factor for the development of type 2 diabetes.
Research from the University of East Anglia found that high intakes of flavonoids lower insulin resistance and inflammation, reducing the risk of diabetes. Flavone compounds also improved blood glucose regulation.
Researchers at Lund University are studying the connection between type 2 diabetes and dementia, specifically focusing on insulin resistance and pericyte cells in the brain. They hope to discover new biomarkers that can signal early stages of dementia in diabetes patients, allowing for potential treatment targets.
A recent study published in the Journal of Clinical Investigation has shed new light on the relationship between type 2 diabetes and mitochondrial function. Researchers found that heat shock protein 60 (HSP60) is crucial for appropriate mitochondrial function and insulin responses, while leptin plays a key role in regulating HSP60.
Researchers at Emory University discovered that hemin injection causes labored breathing and rapid death in sickle mice, but not in control mice. Hemopexin treatment was effective in preventing hemin-induced lung injury. These findings suggest targeting hemin and TLR4 signaling may be a valuable approach for treating acute chest syndrome.
A study by researchers at the Hebrew University of Jerusalem found that women with PCOS who ate a big breakfast had improved glucose levels, insulin resistance, and fertility rates. This suggests that timing of calorie intake may play a crucial role in overcoming reproductive difficulties.
A recent study published in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that young women are better equipped to deal with the negative effects of insulin resistance. This biological ability may explain why women typically develop heart disease 10 years later than men.
A recent study published in Nature Communications suggests that the body's production of fructose from non-fructose containing carbohydrates may be a key factor in obesity and insulin resistance. Researchers found that mice converted glucose to fructose in the liver, leading to the development of fatty liver and insulin resistance.
Researchers found that weight loss significantly improved vascular function in obese individuals, particularly those with high insulin levels. The study suggests that reversing insulin resistance and endothelial dysfunction may represent key therapeutic targets for cardiovascular risk reduction.
A study published in Clinical Science found that a meal plan prioritizing breakfast intake can reduce insulin resistance, lower testosterone levels, and increase ovulation frequency in women with PCOS. This natural therapy may provide new hope for those struggling with fertility issues associated with the disorder.
A recent study published in JAMA Neurology investigated the association between glucose intolerance and insulin resistance with brain β-amyloid burden. The research found no significant link between these conditions and AD pathology. Long-term therapeutic trials may be necessary to further elucidate this issue.
Researchers have discovered a protein, Neu1, that regulates insulin signaling in body cells, potentially helping to prevent type 2 diabetes. The study's findings, published in the journal Diabetes, suggest that restoring Neu1 levels and function could improve insulin absorption, reducing the need for insulin therapy.
Researchers found that lower fitness levels in middle-aged South Asian men contribute to higher blood sugar levels and increased diabetes risk. To mitigate this, physical activity guidelines may need to be adjusted to account for ethnicity.
Researchers found a conserved phospholipid enzyme, PIKfyve, crucial for insulin signaling in muscle cells, leading to glucose intolerance and insulin resistance. The study's mouse model exhibits metabolic defects similar to human prediabetes, offering new insights into treating these conditions.
A new study has found that the directed in vitro technique, ICSI, may increase the risk of insulin resistance among children. The study used metabolomics to assess the risk of developing obesity and metabolic syndrome, finding significant differences in 38 metabolites between ICSI and non-ICSI conceived children.
A clinical study found that insulin resistance is associated with weakened bones and a higher risk of bone fractures. The study, presented at The Endocrine Society's annual meeting, showed that bone strength decreased by 10-14% for every doubling of insulin resistance.
A new study has found that skipping breakfast can lead to acute insulin resistance in overweight women, a condition that increases the risk of developing type 2 diabetes. After just one day of skipping breakfast, insulin levels were significantly higher and glucose levels more elevated than after eating breakfast.
A recent clinical trial has found that impaired heart function among obese children and adolescents is associated with an increased risk of future heart disease. The study suggests that obese youth who exhibit insulin resistance and lower adiponectin levels are at higher risk for long-term heart disease.
Researchers found that insulin-resistant individuals exhibit lower natural dopamine release in response to glucose ingestion compared to healthy controls. The study suggests a possible link between abnormal eating behaviors and the onset of type 2 diabetes.
Researchers found that Africans develop type-2 diabetes through increased insulin resistance, while East Asians develop it through lower insulin-secretion ability. This understanding could lead to more targeted therapies for the disease.
A new study published in Diabetologia found that growing up in areas with high air pollution increases the risk of insulin resistance in children. The research used data from two prospective German birth cohort studies and found a significant association between air pollution exposure and increased levels of insulin resistance.
Researchers at Sanford-Burnham discovered an imbalance between neutrophil elastase and its inhibitor causes inflammation, obesity, insulin resistance, and fatty liver disease. In mouse models and human studies, reversing this imbalance protected against weight gain, metabolic problems, and inflammation.
Researchers found high activity levels of miR-93 in fat cells of women with PCOS and insulin resistance, contributing to glucose impairment. This study provides a new molecular mechanism for PCOS and insulin resistance, pointing towards targeted therapies.
A study of 207,954 veterans found that PTSD significantly increases the risk of developing insulin resistance and metabolic syndrome. Early detection and treatment of these conditions can prevent long-term medical and psychiatric adverse events related to PTSD.
Researchers found that insulin action follows a 24-hour circadian rhythm, with mice becoming insulin-resistant during the day. Mice unable to keep the time of day get stuck in an obesity-prone mode.
A new study published in Science Translational Medicine has found a strong link between binge drinking and the development of insulin resistance, which can lead to Type 2 diabetes. The research suggests that alcohol disrupts insulin-receptor signaling, causing inflammation in the brain and increasing the risk of metabolic disorders.
Retaining certain compounds normally excreted by the kidneys can cause insulin resistance in kidney disease patients. Treating mice with a prebiotic reduces these compound levels, preventing insulin resistance and related lipid abnormalities.
Researchers found an inverse association between low adiponectin plasma levels and the risk of pancreatic cancer. The study suggests that metabolism plays a role in the pathophysiology of pancreatic cancer, potentially leading to improved survival rates with early detection and therapeutic interventions.
A new mouse study challenges the widely held view that obesity is caused by high insulin levels. Instead, it suggests that chronically low insulin levels can help prevent weight gain on a high-fat diet. The research provides direct evidence in mammals that circulating insulin drives obesity.
A diabetes drug initially used to treat insulin resistance has shown promise in improving cognitive performance in some people with Alzheimer's disease. Researchers found that rosiglitazone enhanced learning and memory while normalizing insulin resistance by reducing the negative influence of Alzheimer's on brain-signaling molecules.
Overeating can cause a malfunction in brain insulin signaling, leading to increased fatty acid levels, inflammation, and worsened insulin resistance. The study suggests that the brain's response plays a crucial role in developing type 2 diabetes, making it a potential target for improving insulin function.
A new study suggests that teenagers who get extra sleep can improve their insulin resistance and prevent the future onset of diabetes. The research found a significant association between shorter sleep duration and higher insulin resistance levels in healthy adolescents.
Researchers at Karolinska Institutet have made a major breakthrough in type II diabetes treatment by inhibiting VEGF-B. The study shows that VEGF-B inhibition can prevent and treat insulin resistance, which is related to the storage of fat in muscles, blood vessels, and heart.
A study found that 20-40 minutes of daily exercise reduces the risk of diabetes and body fat in children, with longer periods providing greater benefits. Children who exercised for 40 minutes had a 22% reduction in insulin resistance compared to those who exercised for 20 minutes.
A recent study published in JAMA found that obese adults with excess visceral fat and biomarkers of insulin resistance are at a higher risk of developing type 2 diabetes. In contrast, those with higher amounts of total body fat and subcutaneous fat did not have this increased risk.
A new study published today reveals the extent of type 2 diabetes problems in black and minority ethnic populations in the UK. By age 80, approximately half of all South Asians, Africans, and African Caribbean individuals will develop diabetes, with twice as many British South Asian, African, and African Caribbean men and women diagnos...
A recent study found that Mexican-Americans with an ancestral link to Amerindian tribes have higher insulin resistance levels, a key indicator of several chronic conditions. The research suggests that ethnicity information is crucial in identifying individuals at high risk of disease, and that genetic markers can be used for personaliz...
Researchers found that mice exposed to methyl-glyoxal, a heat-processed food compound, developed abdominal weight gain, insulin resistance, and type 2 diabetes. A diet high in MG reduced SIRT1 and AGER1 levels, impairing glucose metabolism.
A team of researchers has shown a link between low levels of adropin, a hormone that regulates glucose and fatty acid metabolism, and increased risk of metabolic diseases such as type 2 diabetes. The study found that low adropin levels were associated with obesity, insulin resistance, and other metabolic syndrome risk factors.
Researchers found that CCR9 is abundant in early stage colon cancer but lacks in invasive and metastatic cancer, suggesting its role in reducing cancer spread. Activation of NOTCH promotes degradation of CCR9, inhibiting the chemokine-induced signaling pathway.
Researchers found that neutrophil elastase impairs insulin signaling and boosts resistance. Deletion of NE in obese mice improved insulin sensitivity. Neutrophils may hold the key to developing treatments for insulin resistance and diabetes.
Research from Drexel University School of Public Health found that obese individuals with low vitamin D levels had insulin resistance 32 times more common than the general population. The combination of obesity and vitamin D deficiency may put people at a greater risk of developing Type 2 diabetes.
A large study found a direct association between the presence of a small genetic alteration in a hormone receptor and increased body fat and insulin resistance. The BclI polymorphism, which makes the glucocorticoid receptor more sensitive to glucocorticoids, was linked to greater effects with similar hormone levels.
A clinical study published by The Endocrine Society reveals that over half of type 2 diabetes patients are aspirin resistant, increasing the risk of blood clots causing heart attacks and strokes.
A recent study has found that exposure to the fungicide tolylfluanid can induce insulin resistance in fat cells, providing new evidence of the link between environmental pollutants and diabetes. This discovery raises concerns about the potential health risks of using this chemical on farm crops.
Fruit flies developed insulin resistance by overloading on carbs and protein, mimicking Type 2 diabetes. The flies' lifespan shortened and fertility decreased with both diets, offering a new model for studying human disease.
Researchers found that deleting GPR21 improves insulin sensitivity in diet-induced obese mice by reducing inflammation. The study suggests that GPR21 inhibitors could be promising treatments for type 2 diabetes.
A University of Michigan Health System study reveals that Bcl10 is necessary for the harmful effects of high-fat foods on insulin action and blood sugar regulation. The findings suggest that even short-term changes in diet can induce insulin resistance, highlighting the importance of understanding the body's response to indulgent eating.
Research suggests that liver fat can be beneficial if stored in tiny coated droplets, reducing glucose intolerance and insulin resistance. Circadian rhythm regulation of histone deacetylase 3 may play a crucial role in metabolic management.
A recent study from the University of Edinburgh found that low testosterone levels in men can increase their risk of developing diabetes. The research discovered that testosterone plays a crucial role in regulating insulin sensitivity, and its impairment is linked to insulin resistance.
A new Joslin study contradicts long-held assumptions about the relationship between hyperinsulinemia and atherosclerosis. Hyperinsulinemia is associated with atherosclerosis in humans due to insulin resistance, but research suggests that excess insulin alone does not cause atherosclerosis.
A new study finds that brain insulin resistance contributes to cognitive decline in Alzheimer's disease, independent of diabetes status. Insulin-sensitizing medicines may have therapeutic potential to correct insulin resistance and slow down or improve cognitive decline.
Research published in JCI suggests a connection between insulin resistance and Alzheimer's disease, highlighting potential new therapeutics for treatment. The studies found that defective insulin signaling is a common feature of Alzheimer's disease and that treatment with a new anti-diabetic drug normalized insulin signaling and improv...
Research suggests a connection between insulin resistance and Alzheimer's disease, with defective insulin signaling potentially impacting cognitive function. Studies show that treating Alzheimer's disease with anti-diabetic drugs can normalize insulin signaling and improve cognitive function.
A study found that catch-up growth with different diets and resveratrol intervention can improve bone status. Re-feeding with normal chow showed a greater degree of improvement in mineral density than high-fat diet, while resveratrol had protective effects on bone health.
Researchers found that metformin treatment prevented growth of calcium deposits in coronary arteries and reduced insulin resistance in HIV-infected patients with metabolic syndrome. Lifestyle modification did not significantly impact calcification, but improved cardiovascular risk factors.
A recent study published in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that elderly people with the metabolic syndrome are at a higher risk of chronic kidney disease. Insulin resistance and high blood glucose levels were also linked to rapid decline in renal function.
Scientists discovered that problems controlling blood sugar in the intestines can lead to chronic inflammation and insulin resistance. Researchers found a link between fatty acid synthase enzyme defects and diabetes, suggesting potential new targets for therapy.