Articles tagged with Insulin Resistance
Insulin resistance is a key mechanism in the pathogenesis of PCOS, leading to metabolic abnormalities and clinical burden. Lifestyle changes and specific medications can improve insulin sensitivity, but personalized treatment approaches are essential.
New research published in The FASEB Journal suggests that IL-10 may protect against the normal insulin resistance associated with aging. Scientists used transgenic mice to show that IL-10 helped reduce inflammation and insulin resistance in skeletal muscle, a significant step toward improving quality of life as people age.
A large-scale genetic study found a strong link between the inability to safely store excess fat and increased risk of type 2 diabetes and heart disease. The study identified 53 regions of the genome associated with insulin resistance, highlighting the importance of peripheral fat tissue in energy storage.
A team of researchers at UC San Diego School of Medicine successfully reversed diabetic insulin resistance and glucose intolerance in mouse models by removing the protein galectin-3 (Gal3). This finding suggests that Gal3 inhibition could be an effective way to treat type 2 diabetes.
A University of Michigan study found that low-carb meals significantly lower insulin resistance by over 30 percent within 24 hours, while high-carb meals sustain it. Exercise before meals also failed to lower insulin resistance, and may even increase blood sugar levels.
Researchers found that obese individuals with insulin resistance showed improvement by avoiding AGEs, a byproduct of dry heat-cooked foods. A diet low in AGEs reduced insulin resistance, body weight, and AGE levels.
A study published in the Journal of Physiology found that fish oil pills can prevent and counter the negative effects of a high-fat diet. Mice fed fish oil had lower body fat and improved insulin resistance compared to those on a high-fat diet.
A study led by Daniel Kelly identified MondoA as a regulator of key pathways controlling glucose uptake and fat accumulation in muscle cells. Deactivation of MondoA resulted in enhanced glucose uptake and insulin signaling in mice, indicating potential therapeutic targets for preventing and treating obesity-related insulin resistance.
Researchers at Sanford Burnham Prebys Medical Discovery Institute have identified a potential target for preventing type 2 diabetes by blocking the cellular glucose sensor MondoA in muscle, improving insulin responsiveness. This study suggests that MondoA regulates genes involved in fat synthesis and inhibits insulin signaling.
Women with polycystic ovary syndrome (PCOS) may benefit from incorporating soy isoflavones into their diets, according to a new study. The study found that consuming soy isoflavones regularly can lower levels of insulin in the blood and improve metabolic health.
Researchers found cavefish have high body fat levels and insulin resistance but remain healthy. They may hold the key to understanding human diseases like non-alcoholic fatty liver disease and type 2 diabetes.
Research reveals specific gut microbiota imbalances contribute to insulin resistance, a precursor to type 2 diabetes. The study identified two bacteria, Prevotella copri and Bacteroides vulgatus, as key drivers of BCAA production, leading to insulin resistance in mice.
A new study published in Diabetes suggests that age and dopamine receptors may play a role in the preference for sweet foods in people with normal weight, but not in those with obesity. The researchers found that insulin resistance could contribute to the altered brain response in obese individuals.
Researchers compare model predictive control (MPC) and proportional integral derivative (PID) algorithms for an artificial pancreas. MPC outperformed PID in regulating glucose levels, with the former keeping participants within safe range 74% of the time.
A new study found that bright light exposure increases insulin resistance compared to dim light exposure in both the morning and evening. This could lead to excess blood glucose, weight gain, and a higher risk of diabetes over time. The study suggests that lighting impacts health outcomes.
Researchers at Joslin Diabetes Center have identified the role of natural killer cells in abdominal fat inflammation and insulin resistance. By modulating NK cell activity, they found that inflammation in abdominal fat is suppressed and insulin resistance improves.
Researchers developed a pharmacological approach to improve pancreatic beta cell growth and function. Trimeprazine, an antihistamine, was found to increase IRS2 in human islets and promote pancreatic beta cell growth and function in mice, suggesting its potential as a diabetes therapeutic.
A team of Penn researchers discovered a new mechanism linking amino acids to insulin resistance in type 2 diabetics. The study found that high levels of certain amino acids can cause fat accumulation in muscles, leading to insulin resistance.
A global study suggests that pioglitazone, a diabetes drug, can prevent recurrent stroke and heart attacks in people with insulin resistance but without diabetes. The Insulin Resistance Intervention after Stroke (IRIS) trial found a 24% relative decrease in stroke or heart attack risk among patients taking pioglitazone.
Researchers found that boys who experience a greater decline in slow-wave sleep during adolescence are at higher risk for developing insulin resistance, type 2 diabetes, and impaired attention. In contrast, girls showed no significant associations between SWS loss and health outcomes.
Research suggests that frequent shifts in sleep timing are associated with higher insulin resistance and body mass index (BMI) in midlife women. Irregular bedtimes were linked to impaired glucose regulation, while consistent sleep schedules showed better metabolic health.
Researchers analyzed competitors before the Ultraman competition and found that body fat percentage dropped significantly, but weight remained unchanged due to fluid retention. The study also revealed signs of muscle damage, elevated cortisol levels, and reduced insulin sensitivity.
Aging mice with a new type of diabetes have high levels of immune cells called T regulatory cells in their fat tissue, leading to insulin resistance. Blocking these cells may hold the key to treating this age-related form of diabetes.
A 12-week randomized study found that pioglitazone, an insulin-sensitizing drug, alleviated depression symptoms in insulin-resistant patients. The study suggests a link between insulin resistance and depression, with improved antidepressant effects seen in more insulin-resistant participants.
Scientists from Université de Genève found that depleting the gut microbiota triggers a metabolic mechanism that transforms white fat cells into beige fat, reducing obesity and insulin resistance. This discovery could lead to new anti-obesity treatments.
Researchers discovered that the TCF7L2 gene variant impairs glucose balance by suppressing glucagon, raising blood sugar levels. This finding sheds light on the novel mechanism of predisposition to diabetes and may lead to new therapies.
Australian researchers have defined key characteristics of metabolically healthy obesity, shedding light on the paradox. They found that obese individuals sensitive to insulin in muscle or liver are metabolically healthier, with lower blood pressure and less deep abdominal fat. This discovery provides significant insight into human ins...
Researchers found that insulin resistance is associated with a significantly worse prognosis for metastatic breast cancer patients. Lifestyle changes, such as diet and exercise, may help improve outcomes. Insulin targeting therapies could also be beneficial.
A Wayne State University research team, led by Zhengping Yi, aims to discover the abnormality in protein phosphatase 1 contributing to insulin resistance and type 2 diabetes. The $2.58 million NIH grant will support clinical studies, in vitro cell studies, and proteomics research.
Research shows that people carrying specific genetic variants of vitamin D metabolism can benefit from a high-protein weight loss diet, leading to improved insulin resistance and blood sugar control. The study found significant interactions between the DHCR7 variant and dietary protein, but not with other genetic variants or dietary fat.
Researchers at Karolinska Institutet have discovered a mechanism that explains how insulin-producing cells can be both insulin-resistant and insulin-sensitive at the same time. The study identifies a key factor, PI3K-C2α, that causes a switch in signaling pathways, leading to beta cell proliferation.
Researchers found altered mitochondrial DNA in pre-diabetic individuals with insulin resistance, who had lower amounts of mitochondrial DNA and higher methylation levels. This discovery may help prevent Type II diabetes by identifying a biomarker for early intervention.
Research published in Diabetologia found that insulin resistance is associated with poorer verbal fluency in women, a sign of cognitive decline. The study also discovered that higher insulin resistance is linked to slower reaction times and increased risk for Alzheimer's disease in this demographic.
A study found that physical activity reduces insulin resistance in early-teens, but not at age 16. The findings suggest targeting the early-teens for more effective interventions to prevent type 2 diabetes.
A new Iowa State University study found a strong association between insulin resistance and memory function decline, increasing the risk for Alzheimer's disease. Insulin resistance is common in people who are obese, pre-diabetic or have Type 2 diabetes, and can lead to cognitive decline at any age.
A new study has found a significant association between high blood pressure and the presence of phthalates in children and adolescents. The chemicals were used as replacements for DEHP, which was previously linked to detrimental effects on human health.
Researchers at UNC School of Medicine have discovered two biomarkers - oxidized LDL cholesterol and fructosamine - that are strongly correlated with the development of severe coronary disease in females. Elevated levels of these biomarkers were found to be a strong predictor of severe heart disease, particularly in women.
Research suggests that targeting the gut immune system with a commonly used anti-inflammatory drug may be an effective way to treat insulin resistance and lower blood sugar levels in humans. The study found that mice fed a high-fat diet had larger amounts of pro-inflammatory immune cells in their bowels, leading to insulin resistance.
A new study identifies N-acetyltransferase 2 as a key gene variant linked to insulin resistance, increasing the risk of type 2 diabetes and cardiovascular disease. Inhibition of NAT2 in a mouse model decreased insulin sensitivity, highlighting its role in complex diseases.
Research on mice by UC Riverside scientists reveals that genetically modified soybean oil is just as unhealthy as conventional soybean oil, inducing obesity, diabetes, and fatty liver. However, GM soybean oil does not cause insulin resistance, unlike regular soybean oil.
A new study by the Endocrine Society finds that accumulating just 30 minutes of sleep debt on weekdays can lead to significant effects on obesity and insulin resistance at follow-up. The research suggests that avoiding sleep debt could have positive benefits for waistlines and metabolism.
Scientists at USC Leonard Davis School of Gerontology discovered a new hormone, MOTS-c, that restores insulin sensitivity and counteracts diet-induced and age-dependent insulin resistance. The hormone targets muscle tissue and suppresses weight gain and insulin resistance in mice fed a high-fat diet.
Researchers at UC San Diego found that LTB4 promotes insulin resistance in obese mice, but blocking the LTB4 receptor improves insulin sensitivity. Genetic deletion or drug inhibition of the receptor prevents and reverses type 2 diabetes in this model.
A new study from the University of New Hampshire has found that flame retardants can cause metabolic and liver problems in laboratory rats, leading to insulin resistance. The researchers discovered that fat cells in these rats became more sensitive to hormones, similar to those experienced by people who are overweight.
Researchers have identified two transcription factors, GR and VDR, that play a crucial role in the development of insulin resistance. Epigenomic modifications, such as changes in DNA structure, can be passed from cell to cell and between generations, and this study provides insights into how these modifications contribute to the condit...
A new study confirmed that people born weighing 6 pounds or less face an increased risk for type 2 diabetes as adults. The research identified specific biomarkers with relative predictive value, giving doctors potential new tools to understand individual risk among low birthweight women.
Researchers have identified a new class of lipid molecules that enhance insulin sensitivity and blood sugar control, offering a promising direction for preventing and treating type 2 diabetes. The fatty acid hydroxyl fatty acids (FAHFAs) are produced and broken down inside the human body and may serve as an early marker for the risk of...
Research suggests physical activity reduces type 2 diabetes risk, but its effect may vary by genetic factors. Women at high genetic risk show weaker protective effect of physical activity compared to men.
A new study by Joslin Diabetes Center shows that Asian Americans who followed a traditional high-fiber, low-fat diet for 16 weeks lowered their insulin resistance and improved their LDL cholesterol levels. In contrast, those on a typical western diet experienced greater increases in insulin resistance.
A new study by Sanford-Burnham researchers identifies the NBR1 protein as a critical regulator of obesity-induced inflammation, which leads to metabolic disease. The study suggests that blocking this signal may protect against the development of metabolic disease and type 2 diabetes.
A new study found that soy protein supplements containing phytoestrogens do not reduce testosterone levels in men with Type 2 diabetes. Instead, they improve diabetes control and cardiovascular risk factors. The supplements also show promise in reducing the risk of heart disease.
Researchers at UC San Diego School of Medicine discovered that a lack of oxygen in fat cells leads to inflammation and insulin resistance in obesity-induced diabetes. Inhibiting key proteins like ANT2 and HIF-1alpha may provide therapeutic targets for prevention or reversal.
Research reveals a key role for HIF-1 alpha in insulin resistance, type 2 diabetes, and obesity-related inflammation. The protein's inhibition shows promise as a potential treatment for these conditions, including its application to cancer.
Researchers at Karolinska Institutet identified the EBF1 gene driving unhealthy adipose tissue development, associated with increased risk of insulin resistance and type 2 diabetes. The study found that individuals with large fat cells had lower EBF1 expression, altered lipid mobilization, and insulin resistance.
Rapamycin, an immunosuppressant approved for use about 15 years ago, appears to mimic the ability of dietary restriction in helping animals live both longer and healthier. New research identifies why rapamycin increases insulin resistance and suggests a combination with metformin may provide benefits without unwanted side effects.
Research reveals that increasing heart failure severity is associated with a higher risk of developing diabetes. Patients with more severe heart failure were found to be three times more likely to develop diabetes than those with milder cases.
Research found that brief, intense exercise 'snacking' before meals improved blood sugar control more effectively than one 30-minute session of moderate exercise. The study showed a 12% reduction in mean post-meal blood glucose concentration with exercise snacking compared to traditional continuous exercise.
Scientists studying high-altitude trekkers found increased insulin resistance and inflammation markers after prolonged exposure to hypoxia. The study suggests possible interventions to reduce progression towards full-blown diabetes.
Scientists have identified DOR protein as a plausible target against muscle deterioration in certain diseases. The researchers found that inhibition of DOR would only partially reduce autophagy, maintaining beneficial levels for cells.
A new study provides direct evidence that the fetus's brain response to glucose is associated with the mother's insulin sensitivity. Research found that women with lower insulin sensitivity had fetuses that reacted more slowly to sounds, while those with higher insulin sensitivity had faster reactions.