Articles tagged with Insulin Resistance
A recent study published in Life Metabolism found that impaired phosphorylation of SERCA2a plays a bidirectional role in myocardial insulin resistance, dysregulation of calcium homeostasis, and the early stages of DCM. This mechanism involves the regulation of protein stability and insulin receptor maturation.
Researchers at Washington State University identified eight proteins that regulate insulin sensitivity and resistance in hibernating bears, similar to human genes. The discovery could lead to the development of treatments for human diabetes.
Research suggests that arterial stiffness increases blood pressure in adolescents due to insulin resistance, not body fat. Healthy lifestyle choices like exercise and a balanced diet may help lower blood pressure in this age group.
Researchers found that endothelial cells in blood vessels drive the body's metabolism and produce nitrous oxide to regulate brown fat production. This discovery reverses long-held ideas about the relationship between diabetes, fat and cardiovascular disease.
A recent JAMA study found a positive association between high insulin dosage and cancer incidence among patients with type 1 diabetes. The study suggests that clinicians may need to balance cancer risk when treating patients on high insulin doses, with improving insulin sensitivity potentially being a preferred approach.
Individualized, comprehensive treatment approaches and risk stratification of patients are crucial for effective treatment of MAFLD. Lifestyle modifications and pharmaceutical therapeutics combining to treat the condition.
Arterial stiffness in adolescence is a novel risk factor for hypertension, insulin resistance, and type 2 diabetes in young adulthood and mid-adulthood. Risk factors include maternal smoking habits, early life smoking patterns, high salt intake, genetic inheritance, obesity, and elevated blood pressure from childhood.
A 20-year study found that Black adolescents living in poverty showed accelerated immune cell aging and higher insulin resistance at ages 25-29. The researchers also found associations between childhood poverty, perceived life chances, and premature immune cell aging.
Research found that acidic activated charcoal from Shinshu Ina's specialty Akamatsu tree suppresses weight gain due to a high-fat diet by increasing bile acid, cholesterol, triglyceride, and fatty acid excretion. No damage to the gastrointestinal mucosa or lungs was observed.
A long-term high-fat diet has been shown to cause significant weight gain and metabolic disorders in mice, leading to anxiety, depression, and worsening Alzheimer's disease. The study suggests a clear link between chronic obesity and diabetes with cognitive decline.
Researchers from Tianjin Medical University General Hospital review sarcopenic obesity's impact on liver disease, including nonalcoholic fatty liver disease and cirrhosis. The study aims to clarify the pathogenesis of sarcopenic obesity and identify potential therapeutic avenues.
Researchers at Beth Israel Deaconess Medical Center have identified a key enzyme involved in producing a new class of lipids with therapeutic effects for patients with diabetes. The discovery, published in Nature, could pave the way for new treatments to protect insulin-producing cells and improve blood sugar control.
Research led by Texas A&M AgriLife scientist Shaodong Guo found that estrogen protects female mice from cardiomyopathy and death, reversing the effects of insulin resistance. The study suggests that estrogen replacement therapy may be a feasible treatment option for diabetic cardiomyopathy.
A high-fat diet can lead to increased fructose metabolism in the small intestine, resulting in the release of glycerate into circulation. This can cause damage to insulin-producing pancreatic beta cells, increasing the risk of glucose tolerance disorders and Type 2 diabetes mellitus.
Researchers at Oregon State University have developed a new analytical method that reveals why some obese patients develop type 2 diabetes while others don't. The study found that a particular type of gut microbe leads to insulin resistance, and treatments targeting microbiota may be a new therapeutic strategy for the disease.
A University of Cincinnati study found that adding blueberries to middle-aged diets may lower the chances of developing late-life dementia. The researchers discovered that blueberries' high level of micronutrients and antioxidants helped improve cognitive function and metabolic function.
A novel therapy using sustained release of nitric oxide has been shown to ameliorate obesity and Type 2 diabetes in mice fed a high-fat diet. The therapy was found to decrease body weight, improve glucose tolerance, and stimulate the browning of adipose tissue.
A new study from Northwestern University found that once-weekly prednisone treatment improved exercise endurance, increased lean body mass, and reduced weight in obese mice. The treatment also promoted nutrient uptake into muscles and increased adiponectin levels, a hormone that helps protect against diabetes and insulin resistance.
Researchers investigate how mushrooms improve gut health and provide a preventive buffer against disease in Western-style diets. The study aims to understand the role of Turicibacter in dietary obesity and gut health, as well as the potential benefits of incorporating oyster mushrooms into diet.
Intermittent fasting produces mild to moderate weight loss and improves cardiometabolic risk factors, comparable to traditional calorie-restricted diets. The review also dispels myths about intermittent fasting, including the misconception that it leads to weakness and decreased concentration.
Researchers at Université Laval found that yogurt's health benefits for obesity may be due to its impact on the gut microbiota and production of branched chain hydroxy acids (BCHA). The study, published in Nature Communications, suggests that BCHA can help improve fasting glucose and liver function in obese mice.
Research suggests exercise can break the vicious cycle of inflammation that leads to diabetes and depression in people with Long COVID. A 30-minute session of moderate-intensity exercise, such as walking, can be beneficial.
A team of UTSA researchers has developed an innovative inhibitor that blocks the effects of cytochrome P450 8B1, a key enzyme linked to cholesterol absorption and obesity. The treatment shows promise in reducing glucose levels without affecting body weight, offering potential relief from obesity-associated metabolic disorders.
Researchers at University of Illinois Chicago identified changes in the gut microbiome that can lead to gestational diabetes. They found a specific metabolite, kynurenine, that is increased during pregnancy and contributes to insulin resistance.
Scientists at Nanyang Technological University have developed a novel therapeutic approach to tackle obesity, reducing body fat and improving blood markers through a hydrogel injection and near infrared light treatment. The treatment shows significant promise in lab trials, with mice experiencing reduced body mass and improved metabolism.
Researchers discovered that Black women have a greater relative abundance of Actinobacteria, associated with reduced insulin sensitivity and elevated inflammation. The study highlights the importance of understanding the role of gut microbiome in cardiometabolic health disparities among Black women.
Researchers discovered distinct gut microbiomes in Black and white US women, with potential associations to insulin resistance. The study highlights the importance of understanding individual microbiome variations in relation to metabolic health.
Researchers found that adolescent arterial stiffness may be a causal risk factor for hyperinsulinaemia and insulin resistance in young adulthood. Arterial stiffness also temporally precedes low HDL-cholesterol in young adults, with a positive association with triglyceride levels.
Researchers at Salk Institute have discovered a new molecular pathway that controls blood glucose levels independent of insulin, offering new avenues for treating diabetes and metabolic disorders. The hormone FGF1 suppresses lipolysis and regulates glucose production in the liver.
Individuals with high-risk prediabetes significantly improved their blood glucose levels through more exercise and healthy eating behavior, while those at low risk showed limited benefits from conventional lifestyle intervention. The study's findings support personalized interventions tailored to each patient's risk profile for effecti...
Researchers found that SGLT2 inhibitor empagliflozin can improve insulin sensitivity in the brain, leading to better glucose control and reduced liver fat content. This breakthrough discovery positions SGLT2 inhibitors as a potential treatment for insulin resistance in the brain.
Researchers at RIKEN have developed a healthier form of tapioca starch by suppressing multiple genes that increase its resistance to digestion. The resulting starch is composed of longer chains with fewer branches, making it harder to digest and potentially improving intestinal function and blood sugar control.
A study in mice suggests that transplanted brown fat can reduce type 2 diabetes risk factors after a heart attack by dampening gene activation linked to negative effects. The transplantation method could help researchers understand the mechanisms behind this protective effect and potentially lead to therapeutic applications.
Researchers at UConn Health have discovered that eliminating senescent cells in human fat tissue can alleviate signs of diabetes and improve insulin sensitivity. The study suggests that clearing away these dysfunctional cells could lead to game-changing new treatments for Type 2 diabetes.
A new study from Intermountain Healthcare found that low-frequency intermittent fasting raises galectin-3 levels, a protein tied to inflammatory response, and lowers rates of insulin resistance and metabolic syndrome. This suggests that even occasional fasting may have positive health effects.
Research supports strong relationship between ceramides and diseases in animals and humans. Ceramides are standalone biomarkers of cardiovascular disease, independent of cholesterol.
A VCU study found that people with advanced liver scarring caused by obesity and diabetes are dying from liver disease, underscoring the need for new treatments. The research provides a roadmap for future therapies to prevent liver transplants and save lives.
A recent study from the Okinawa Institute of Science and Technology Graduate University identified a crucial protein linked to increased appetite and obesity in mice. The researchers found that mice lacking this protein, XRN1, exhibited leptin resistance, leading to insatiable hunger and weight gain.
A review of 25 studies on intermittent fasting found that all forms produced mild to moderate weight loss, similar to traditional calorie-restrictive diets. Intermittent fasting regimens also showed benefits in decreasing blood pressure and insulin resistance, and improving appetite regulation.
New research identifies SGK as a key driver of insulin resistance in the liver, which can be targeted to prevent type 2 diabetes. Inhibiting SGK activity restores normal insulin action and helps block fat buildup in the liver.
Researchers found that COVID-19 patients with high blood sugar levels were more likely to develop severe lung dysfunction, require mechanical ventilation, and die. The study also suggests that SARS-CoV-2 may disrupt fat cells' production of adiponectin, a hormone regulating blood sugar levels.
Researchers at Boston University School of Medicine found that long-term use of insulin-releasing drugs may worsen insulin resistance in type 2 diabetes patients. This could lead to increased insulin levels and hyperinsulinemia, a precursor to the disease.
A Stanford study has linked insulin resistance to an increased risk of major depressive disorder. The research found that individuals with insulin resistance are twice as likely to develop the condition, even if they have never experienced depression before.
A Finnish study discovered a positive association between standing and improved insulin sensitivity in adults with increased risk of type 2 diabetes and cardiovascular diseases. The researchers found that increasing daily standing time can help prevent chronic diseases, even if physical activity recommendations are not met.
Researchers found that certain peptides associated with migraine pain can regulate insulin production in mice, potentially preventing type 2 diabetes. The study suggests that these peptides could be developed into therapeutic strategies to control blood sugar levels, while minimizing the risk of migraines.
Researchers at Karolinska Institutet discovered three different subtypes of mature fat cells in white adipose tissue, with only one subtype, Adipo PLIN, responding to insulin. The study suggests that changes in this specific subtype may contribute to metabolic diseases like Type 2 diabetes.
Researchers at Tohoku University have identified a new gene, CCDC152 (L-IST RNA), which inhibits selenoprotein P (SeP) levels, reducing insulin resistance and glucose metabolism issues associated with type 2 diabetes. EGCG supplements may help increase L-IST, offering potential treatment options for diabetic patients.
Researchers have identified five novel diabetes subgroups with distinct biomarker profiles, highlighting the importance of inflammation in diabetes-related complications. These differences may enable early detection and therapy in individual subgroups, particularly those with severe insulin resistance.
A new study suggests that starting the day with breakfast can help lower blood sugar levels and insulin resistance, potentially reducing the risk of developing type 2 diabetes. Researchers analyzed data from over 10,000 adults and found that eating earlier in the day was associated with improved metabolic health.
Researchers at Karolinska Institutet found that reducing apolipoprotein CIII levels can protect against high-fat diet-induced obesity, insulin resistance and liver damage. The study showed that a treatment targeting apoCIII reversed metabolic derangements in mice.
A Cornell University scientist is receiving a USDA grant to study the relationship between insulin, ceramide, and lactation in dairy cows. The goal of the research is to identify mechanisms that control insulin resistance in early lactation, with potential benefits for improving milk production efficiency and animal health.
Researchers discovered pancreatic beta cells secrete miR-29 family members to promote insulin resistance and enhance hepatic glucose output. This finding reveals a new mechanism linking obesity-induced insulin resistance in type 2 diabetes's pathogenesis.
Researchers identified pancreatic β cell-derived exosomal miR-29 family as a new mechanism that regulates glucose homeostasis through liver. Exosomal miR-29s negatively regulate insulin signalling pathway via targeting p85 α, attenuating the suppression of insulin on glucose output.
Research reveals a direct relationship between insulin resistance and severe lung inflammation and scarring in people with pre-diabetes or diabetes. High ozone exposure may exacerbate pulmonary fibrosis, particularly in individuals with poorly controlled diabetes.
A new study published in JAMA Network Open found that a plant-based diet increased after-meal calorie burn by 18.7% in overweight participants, leading to significant weight loss and cardiometabolic benefits. The study also showed reductions in fat mass, visceral fat volume, and liver and muscle cell lipid levels.
A study of over 25,000 female health professionals found that a Mediterranean-style diet was associated with a 30% lower risk of developing type 2 diabetes. The diet's impact on insulin resistance, body mass index, and inflammation were key factors in this reduced risk.
A new study from the University of Eastern Finland shows that physical activity and dietary counselling significantly reduces insulin resistance in normal-weight children, preventing type 2 diabetes. The intervention also boosts metabolism in skeletal muscles, adipose tissue, and the liver.
Researchers at Pennington Biomedical Research Center will investigate how the SGK1 enzyme regulates beta-cell mass when more insulin is needed. The study aims to understand how beta-cell growth mechanisms influence insulin release, potentially leading to new medications for diagnosing and treating metabolic diseases.
Researchers discover reduced glucagon sensitivity in people with fatty liver and type 2 diabetes, leading to increased glucose production. This finding opens up new possibilities for early detection and treatment of the diseases.
Yale researchers found a molecular connection between nonalcoholic fatty liver disease and liver insulin resistance. They identified diacylglycerols and ceramides as key players in this process.