Articles tagged with Insulin Resistance
Researchers at Pennington Biomedical Research Center will investigate how the SGK1 enzyme regulates beta-cell mass when more insulin is needed. The study aims to understand how beta-cell growth mechanisms influence insulin release, potentially leading to new medications for diagnosing and treating metabolic diseases.
Researchers discover reduced glucagon sensitivity in people with fatty liver and type 2 diabetes, leading to increased glucose production. This finding opens up new possibilities for early detection and treatment of the diseases.
Yale researchers found a molecular connection between nonalcoholic fatty liver disease and liver insulin resistance. They identified diacylglycerols and ceramides as key players in this process.
Researchers found that deleting a key gene in mice just their fat tissue made them insulin resistant and had other effects. The findings shed light on Type 2 diabetes and could have implications for human disease.
A new study by Mount Sinai researchers found that insulin resistance is a key factor mediating racial disparities in breast cancer prognosis. Black women with invasive breast cancer had higher rates of insulin resistance and more aggressive tumors than white women.
Type 2 diabetes patients exhibit elevated glucagon levels due to α-cell resistance to insulin. Glucagon counteracts insulin's effects, exacerbating high blood sugar levels.
The REVITA-2 study found that Revita DMR therapy significantly improved blood glucose levels, insulin sensitivity, and liver measures in patients with poorly controlled type 2 diabetes. The treatment, which involves duodenal mucosal resurfacing, reduced insulin resistance and improved metabolic health.
Research published in the Journal of the American Heart Association found that longer sitting times were associated with higher levels of heart disease risk among overweight and obese post-menopausal women. The study revealed a strong negative link between sitting time and insulin resistance, particularly among Hispanic women.
Scientists at UC Berkeley have identified a molecular 'switch' that controls chronic inflammation, which can contribute to devastating diseases. Removing a small bit of molecular matter through deacetylation switches off the immune machinery, potentially reversing age-related conditions.
Good aerobic fitness is not linked to lower risk of insulin resistance in obese children. Instead, more physical activity and less sedentary time were associated with reduced insulin resistance regardless of body fat percentage. The study suggests that more physical activity plays a key role in preventing type 2 diabetes in childhood.
Researchers are testing whether changing brain's fuel source from glucose to ketones could potentially save neurons and neural networks over time. The study, funded by a $2.5 million grant, aims to understand how ketones affect brain cells and connectivity in the face of insulin resistance.
Researchers have discovered that avocatin B, found only in avocados, counters incomplete oxidation in skeletal muscle and the pancreas, reducing insulin resistance. The study found significant weight loss and improved insulin sensitivity in mice fed with a high-fat diet supplemented with AvoB.
A study by researchers at the University of California, San Francisco found that a workplace ban on sugared drinks led to a 48.5% reduction in consumption and improvements in insulin resistance and total cholesterol levels among participants.
Researchers at the University of Tsukuba found that deleting Elovl6 specifically in liver cells protects mice from developing insulin resistance due to excessive sugar consumption. However, this deletion has no effect when combined with a high-fat diet, highlighting the complexity of lipid metabolism in the liver.
A new study found that even short-term reduction in physical activity led to decreased cardiorespiratory fitness, increased waist circumference, and insulin resistance in healthy adults. Resuming normal activity levels reversed these effects, highlighting the importance of staying physically active to offset negative consequences.
Scientists at University of Utah Health and Merck Research Laboratories found that altering the production of ceramides can reverse insulin resistance and fatty liver disease in obese mice. By deactivating an enzyme called DES1, they lowered total ceramide levels, improving metabolic health.
A collaborative study by Connecticut researchers shows that food insecurity is linked to insulin resistance and the development of type 2 diabetes in Latinos. The study found that households with food-insecure individuals had higher levels of inflammation, stress hormones, and insulin resistance compared to those who were food secure.
A pilot study found that Montmorency tart cherry juice reduced systolic blood pressure and lowered insulin levels in adults with metabolic syndrome. The study also showed improvements in arterial stiffness after consumption of the juice.
Researchers have discovered a significant link between insulin resistance and fibromyalgia, enabling the use of metformin medication to reduce pain levels. The study found that most patients with fibromyalgia can be identified by their A1c levels, which reflect average blood sugar levels over two to three months.
A new study published in the Journal of Nutritional Biochemistry found that green tea extract reduced weight gain and inflammation in mice fed a high-fat diet. The researchers also discovered improved gut health, including more beneficial microbes and less permeability in the intestinal wall. These findings suggest that green tea may h...
Individuals taking statins may experience higher insulin levels and insulin resistance, leading to a greater risk of developing type 2 diabetes. The analysis found a 38% increased risk among those who used statins for 15 years or more.
A study found that over a quarter of healthy six-year-old children have metabolic risk factors for cardiovascular disease. Insulin resistance and waist circumference were stronger markers than body mass index.
Researchers found that SHBG levels at baseline can predict insulin resistance years later in both men and women. Lower SHBG levels are associated with higher insulin resistance, a precursor to type 2 diabetes.
A new genomic study reveals five distinct groups of DNA sites driving unique forms of type 2 diabetes, with potential implications for personalized treatment approaches. The research identifies subtypes based on genetics and physiology, which could help physicians tailor interventions to individual patients.
Researchers found that low-dose BPA exposure can trigger an insulin response in humans, similar to animal studies showing insulin resistance. The study suggests that exposure to endocrine-disrupting chemicals like BPA may contribute to the development of Type 2 diabetes.
Scientists discover that expanding subcutaneous white fat tissue can improve insulin sensitivity and reduce inflammation in obese individuals. A microRNA called miR-30a plays a crucial role in this process, protecting fat cells from inflammation and leading to improved metabolic health.
Research suggests ketogenic diets may cause an increased risk of Type 2 diabetes in the early stage of the diet, particularly through insulin resistance. The study found that fatty acids from a ketogenic diet can have signaling roles in the brain.
A new study suggests that nighttime light exposure during sleep can disrupt metabolic function, leading to increased insulin resistance. The researchers found that just one night of light exposure acutely impacts measures of insulin resistance, which is a diminished ability of cells to respond to insulin.
A novel adipokine, WISP1, secreted by abdominal fat promotes insulin resistance and systemic inflammation. Researchers identified a link between poor oxygen supply and increased WISP1 production, which could lead to improved insulin action and alternative treatment approaches for obesity-related diseases.
Fasting every other day impairs insulin function, leading to potential long-term health risks, including type-2 diabetes. This study found that even in normal-weight rats, intermittent fasting diets can cause damage to the pancreas and increase insulin resistance.
A Stanford study found a link between early-life obesity and depression in children's brains, revealing abnormalities in reward-processing areas. Young people with both conditions had lower volumes in the hippocampus and anterior cingulate cortex.
Researchers found that a liver enzyme increases abdominal fat inflammation in obese mice, leading to insulin resistance. Soothing this inflammation improves insulin sensitivity without affecting weight.
Researchers studying cavefish found that they can live healthy lives with high blood sugar levels, contrary to what is seen in humans. The fish have insulin resistance but no apparent harm from chronically elevated glucose levels.
A new study published in the Journal of Hepatology links high consumption of red and processed meat to non-alcoholic fatty liver disease and insulin resistance. High meat eaters had a higher risk of developing NAFLD and insulin resistance, regardless of saturated fat intake.
A study found that sleep restriction leads to insulin resistance in men, which can be mitigated by controlling testosterone and cortisol hormones. This imbalance may explain the increased risk of type 2 diabetes in sleep-deprived men.
Researchers found that elevated methylglyoxal levels lead to insulin resistance, obesity, and high blood sugar levels in flies, challenging the conventional view of type 2 diabetes. This discovery raises questions about the molecular causes of the disease.
A new classification of diabetes has been discovered, which can predict the risk of serious complications and provide tailored treatment suggestions. The study, published in The Lancet Diabetes & Endocrinology, reveals that type 2 diabetes consists of several subgroups, each with unique characteristics.
A new study found that people who regularly eat nuts have a significantly lower risk of colon cancer recurrence and mortality. Nuts also improve disease-free survival and overall survival rates by reducing insulin resistance. Regular nut consumption is associated with being leaner, contrary to concerns about high fat content.
A 3-day bed rest study is being conducted to investigate the effects of prolonged weightlessness on human metabolism, specifically insulin resistance. The study's findings could lead to the development of rehabilitation exercises to mitigate these effects and improve astronaut fitness for future Mars missions.
Researchers from UNIGE have identified a key role for the liver in the development of type 2 diabetes, linked to obesity and inflammation. By targeting the protein PTPR-γ, scientists may uncover new therapeutic strategies to prevent insulin resistance and related metabolic conditions.
A study found that captive bears fed a diet high in saturated fats and low in polyunsaturated fats did not develop insulin resistance or other diseases. However, mild inflammation and heart strain were observed, raising concerns about the long-term health of bears in the wild that feed on human refuse.
Scientists at Columbia University Irving Medical Center have identified several compounds that selectively inhibit FOXO1, improving insulin sensitivity and reducing glucose production in the liver. These findings offer a promising approach to developing new, safer treatments for diabetes.
The University of Illinois Chicago is conducting a $3 million study on inflammation's role in polycystic ovary syndrome (PCOS), which affects one in seven women. The research aims to test whether nonsteroidal anti-inflammatory drug salsalate can improve ovarian function and reduce inflammation.
Researchers have identified a key molecular connection between inflammation and insulin resistance in type 2 diabetes. The discovery sheds light on how chronic inflammation increases the risk of developing insulin resistance, which can lead to full-blown diabetes.
Researchers found that increasing BMP4 levels can improve metabolic health in lean mice by promoting beige fat cell activity, but overweight mice showed reduced effectiveness. Gene therapy with BMP4 also protected against insulin resistance in both lean and overweight mice.
A new study suggests that High-Intensity Interval Training (HIIT) is an efficient way to combat high insulin resistance, a warning sign for diabetes. HIIT improved blood pressure and glucose levels in women at risk of type 2 diabetes, with the greatest benefits seen in those with higher insulin resistance.
A new study published in The FASEB Journal suggests that green tea's EGCG may alleviate high-fat diet-induced insulin resistance and cognitive impairment. Researchers found that mice fed with a high-fructose diet and given EGCG showed improved cognitive function and reduced weight gain.
A clinical trial found that an Alzheimer's medication, galantamine, reduces inflammation and insulin resistance in patients with metabolic syndrome. The study showed a 25% decrease in inflammatory markers and improved insulin levels.
Researchers discovered that physical activity offers health benefits against insulin resistance, a precursor to type 2 diabetes. The study found that exercise's ability to remove damaged cellular materials and enhance mitochondrial quality is more effective in preventing insulin resistance than previously thought.
A new study finds that tamoxifen reduces food intake and prevents fat accumulation, insulin resistance, and fatty liver deposits in female mice fed a high-fat diet. Tamoxifen's protective effects are attributed to the activation of ER°-AF1, opening up possibilities for new therapies.
A new review suggests calorie restriction prolongs life by increasing ketone bodies, which decrease malignancies and insulin resistance in mice. Calorie restriction also reduces muscular weakness and blood glucose levels, supporting the theory's potential longevity benefits.
Joslin Diabetes Center researchers found impaired insulin effects boost cancer risks in mice with genetically modified intestinal tumors and blood vessels. Insulin resistance may impair blood vessel health and share biological mechanisms with cardiovascular disease.
A recent study found that high-calorie diets cause similar levels of bone loss in mice regardless of fat content. Glucocorticoid signaling in the skeleton plays a crucial role in diet-induced metabolic disturbances. Disrupting this signaling pathway may protect against obesity and related health issues.
Researchers at Joslin Diabetes Center identified a lipid molecule that signals brown fat cells to activate in mice, improving metabolism. The molecule, 12,13-diHOME, may also be used as a biomarker for brown fat activation in humans.
Research published in Archives of Disease in Childhood found a strong association between daily screen time of 3+ hours and increased risk factors for type 2 diabetes in children, including adiposity and insulin resistance. The study suggests that reducing screen time may be beneficial in reducing these risk factors.
Researchers at Kanazawa University discovered that sulforaphane can lower body weight gain rates and reduce visceral fat. The compound also improves energy consumption and fat burning, likely due to its effects on the gut microbiome.
A single high-fat meal can reduce the body's sensitivity to insulin, leading to increased fat deposits in the liver and changes in energy metabolism. This study found that even a small amount of palm oil triggers insulin resistance, which can contribute to the development of type 2 diabetes and fatty liver disease.
Researchers found that even modest levels of physical activity decreased insulin resistance and biomarkers of inflammation, while sedentary time increased levels of satiety-related chemicals in the blood. The study suggests that physical activity and inactivity may operate through different pathways to modulate disease risk.
A single episode of high fat intake caused immediate increases in fat accumulation and alterations in liver metabolism. Insulin resistance, elevated triglycerides, and increased glucagon levels were also observed.
Insulin resistance is a key mechanism in the pathogenesis of PCOS, leading to metabolic abnormalities and clinical burden. Lifestyle changes and specific medications can improve insulin sensitivity, but personalized treatment approaches are essential.