Articles tagged with Insulin Resistance
Researchers discovered that insulin sensitivity decreases by 32% among pubertal teens, while those who haven't started puberty experience increased sensitivity. The study suggests that changes during puberty contribute to lowered insulin sensitivity, with potential implications for preventing type 2 diabetes.
Researchers have developed a mouse model that replicates the clinical features of type 2 diabetes, enabling studies on pathogenesis and testing of new therapies. The strain of mice, generated by selectively mutating an insulin-like receptor in muscle cells, fully recapitulates the disease's progression.
New studies announce that AVANDIA (rosiglitazone maleate) may significantly reduce insulin resistance and lower cardiovascular risk in Type 2 diabetes patients. Insulin resistance is a fundamental cause of the condition, and targeting it with AVANDIA could lead to better outcomes.
A USC study found that administering a drug to lower insulin resistance in women at high risk for type 2 diabetes successfully prevents or stalls its onset. The study tested whether reducing the demands on beta cells could prevent diabetes in Latinas with recent gestational diabetes.
Researchers at Beth Israel Deaconess Medical Center found that fat cells can trigger insulin resistance in muscle and liver, leading to type 2 diabetes. The study, published in Nature, reveals a potential new target for diabetes treatment and prevention by disrupting the communication between fat cells and other tissues.
A new UB study reveals a significant association between breast cancer risk and physical characteristics of insulin resistance, including abdominal fat distribution and higher-than-normal male and female sex hormones. Women with increased waist-to-hip ratio and oily skin are at greater risk of developing breast cancer.
Researchers found that participants with high insulin resistance were more likely to develop high blood pressure, highlighting a potential new treatment target. The study also suggests that reducing insulin resistance may help prevent hypertension and cardiovascular disease.
Researchers found that female mice lacking IRS-2 protein are infertile due to defective ovaries and abnormal hormone production. The study suggests an evolutionarily conserved pathway linking energy metabolism and fertility in humans and animals, with potential implications for diabetes treatment.
Studies show Avandia reduces hepatic fat and increases subcutaneous fat without increasing intra-abdominal fat, a key factor in type 2 diabetes. The medication also decreases plasminogen activator inhibitor-1 levels, associated with cardiovascular risk factors.
Avandia targets both fundamental causes of type 2 diabetes by reducing insulin resistance and improving beta-cell function, providing enhanced glycaemic control. This dual therapeutic approach may delay disease progression and alter outcomes.
Insulin reduces expression of molecule promoting inflammation and clogging of arteries, increasing production of vasodilator nitric oxide. The study's findings indicate insulin may have an antiatherosclerotic role, potentially protecting people at risk of CVD.
Researchers found that Avandia had a lower rate of elevated alanine aminotransferase (ALT) levels compared to placebo and other treatments. This suggests that Avandia is a valuable option for patients with type 2 diabetes, as it can help improve blood sugar control and potentially slow disease progression.
A new study found that a high glycemic load diet, which includes foods like rice and potatoes, increases the risk of coronary heart disease in US women. Women with higher glycemic load were 1.57 times more likely to have CVD than those with lower glycemic load.
Researchers at UB School of Dental Medicine found a strong link between obesity and gum disease, with overweight individuals showing a 50% increased risk of severe periodontal disease. The study also suggests that bacteria in the mouth may contribute to insulin resistance, increasing the risk of Type 2 diabetes and heart disease.
Weizmann Institute researchers find a family of amino acid analogues that effectively regulate glucose levels in diabetic laboratory animals. The new compounds have greater antidiabetic potency than vanadium alone, offering a promising treatment option for type II diabetes.
Rosiglitazone reduces insulin resistance by 33% and improves pancreatic function in individuals with type 2 diabetes. The treatment also reduces insulin levels in the blood, potentially alleviating the need for regular insulin injections.
Researchers found that rosiglitazone treatment improved glycaemic control and reduced risk factors for coronary heart disease in patients with type 2 diabetes. The medication also showed promise in reducing protein excretion and triglycerides, while improving lipid profiles.
Scientists have identified a genetic defect linked to insulin resistance and adult diabetes, providing a target for potential new treatments. The Q allele of the PC-1 gene is three times more common among insulin-resistant people and twice as frequent among adult diabetics.
Researchers found that stress and coping measures can affect blood sugar control in people with diabetes. The study's biopsychosocial model suggests that psychological factors interact with biological factors to regulate blood sugar levels.
Scientists have identified a compound that mimics the effects of insulin in mice, offering hope for a pill-based treatment for diabetes. The new substance, L-783,281, is a nonpeptide molecule that can be absorbed through the bloodstream after being swallowed, potentially providing an alternative to insulin injections.
A recent study found that low-level inflammation in adults is connected to measures of insulin metabolism. The loss of sensitivity to insulin contributes to diabetes, which in turn is a major cause of heart disease. High levels of C-reactive protein indicate low-level inflammatory status and are associated with increased risk of cardio...
Research from the University at Buffalo School of Dental Medicine found a significant association between periodontal disease and insulin resistance in non-diabetics. The study also showed that individuals with severe gum detachment had a higher risk of developing chronic lung diseases.
A team of Canadian scientists identified a potentially useful target for drugs to treat type II diabetes and obesity by genetically engineering mice lacking a specific enzyme. The results showed that these mice resisted weight gain and insulin resistance on a high-calorie diet, suggesting a possible approach for treating the disease.
Researchers at Washington University School of Medicine found a strong link between genes and the accumulation of extra belly fat and insulin resistance. The study suggests that people with certain genetic traits are more likely to develop type II diabetes and abdominal visceral fat, even if they follow healthy lifestyles.
A recent study suggests that moderate drinking may protect against coronary heart disease by improving insulin sensitivity. Analysis of a large Italian database found that the prevalence of Syndrome X, a condition characterized by abnormal levels of triglycerides, HDL cholesterol, blood pressure, and glucose, was significantly higher a...
A new study reveals that insulin resistance, a precursor to diabetes, is caused by a cellular 'short circuit' triggered by excessive protein phosphorylation and TNF secretion, potentially explaining the link between obesity and insulin resistance.
Research reveals that insulin resistance is a significant risk factor for atherosclerosis in white and Hispanic populations, affecting up to 90% of diabetics and 10-20% of non-diabetics. In contrast, African Americans are not found to have the same association, despite being four times more likely to suffer from strokes.