Articles tagged with Wound Healing
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Researchers at Texas A&M University have developed a clay-based platform that delivers therapeutic proteins to assist with the formation of blood vessels. The technology introduces nanosilicates to deliver growth factors, promoting sustained and controlled release.
Scientists have discovered a new relationship between the enzyme PDIA1 and Drp1 that drives endothelial cell damage in diabetes. Restoring a healthy balance of PDIA1 and Drp1 may provide new treatment targets for diseases associated with endothelial cell senescence.
Researchers at Tufts University have developed smart bandages with integrated pH and temperature sensors that can detect infection and inflammation. These bandages can deliver targeted drug treatments to improve the chances of healing for chronic wounds, which are a significant medical problem affecting millions of people worldwide.
A Northwestern University team developed a regenerative bandage that heals diabetic wounds 33% faster than current market products, leveraging the body's natural wound-healing process. The bandage uses an antioxidant hydrogel with a thermally responsive segment of laminin to facilitate tissue regeneration and counter inflammation.
Scientists have found that a specific protein called thrombospondin-2 (TSP2) is elevated in wounds of patients with diabetes and contributes to delayed wound healing. Removing or inhibiting TSP2 from mice with diabetes led to improved wound healing, suggesting it could be a target for new treatments.
A team of researchers from Texas A&M University has developed an injectable bandage using a gelling agent commonly used in pastries, which can stop bleeding and promote wound healing. The injectable hydrogels are made with kappa-carrageenan and nanosilicates to form a controlled release of therapeutics.
Patients with critical limb ischemia treated with JVS-100 did not experience faster wound healing compared to those receiving a placebo, despite being in a highly monitored environment. The study's findings highlight the need for additional therapies to aid patients' recovery.
A Lehigh University professor has received a prestigious NSF CAREER Award to explore the role of human mesenchymal stem cells in remodeling hydrogel materials for wound healing. Her research aims to develop new biomaterials with optimal properties for tissue regeneration and structural integrity.
The technology involves delivering a human chemokine on site in wounds, increasing immune cell recruitment and specialization to accelerate healing. In preclinical studies, the treatment demonstrated potent effects on acceleration of wound healing in mice and models of diabetes and peripheral ischemia.
The University of Texas at Arlington has received a $227,000 grant to develop the manufacturing process for the REHEAL glove, a bioengineered healing glove that delivers medicine to injured hands to speed up healing. The project aims to accelerate rehabilitation and improve patient care.
Peripheral nerve cells change their identity and distribute factors that support wound closure, reconstitution of the dermis, and chronic wound healing. Researchers found reprogrammed nerve cells in human skin wounds, which may lead to an effective treatment for chronic wounds.
A new study discovered how our body clocks impact wound healing, with wounds sustained at night taking up to 60% longer to heal compared to daytime injuries. The research found that skin cells move to the wound site faster during daylight hours, leading to increased collagen deposition and improved healing.
Patients with severe burns who have higher levels of vitamin D recover more successfully than those with lower levels. Vitamin D supplementation may be a simple treatment to improve wound healing and combat infection.
Researchers at Johns Hopkins Medicine have developed a topical gel made from common blood pressure pills that block inflammation pathways, speeding up the healing of chronic skin wounds. The gel was shown to be effective in accelerating wound healing in mice and pigs, with one concentration showing significant benefits.
Researchers found that Rapamycin significantly reduces heterotopic ossification (HO) in rats, mimicking blast-related limb injury, and decreases progenitor cells and gene expression associated with abnormal bone formation. The treatment has potential as a prophylactic strategy to prevent HO in combat casualties and civilians.
Researchers have designed a smart bandage that can deliver customized medication to promote better, faster healing of chronic wounds. The bandage uses electrically conductive fibers coated in a gel to release medications tailored to specific types of wounds.
Researchers at Nanyang Technological University developed a gel patch enriched with Angiopoietin-like 4, which speeds up wound healing while reducing scarring. The patch shows promise for treating hard-to-heal skin lesions in diabetic patients and post-surgical patients.
A study published in The FASEB Journal found that the salivary peptide histatin-1 promotes angiogenesis, a critical process for efficient wound healing. Histatin-1 was also shown to increase cell adhesion and migration, opening new avenues for understanding oral wound healing and potentially improving treatments for other types of wounds.
A new review examines the role of various stem cells in corneal wound healing, highlighting similarities and differences in the process. Stem cell transplantation may fine-tune wound healing and provide benefits for patients.
Researchers at Binghamton University developed a DNA coating that absorbs UV light more effectively the longer it's exposed. The film also keeps skin hydrated, slowing water evaporation and promoting faster wound healing rates in extreme environments.
Vitamin D deficiency may impair corneal healing in individuals with underlying health issues, such as diabetes. Research suggests that vitamin D plays a role in cell communication and connectivity, which is essential for proper wound healing.
Researchers found that celecoxib, an anti-inflammatory drug, protects stem cells from harsh inflammation during wound repair. The study showed that celecoxib promoted stem cell survival and differentiation into skin cells, leading to better wound healing outcomes.
Researchers have found that SkQ1, a mitochondria-targeted antioxidant, significantly enhances wound healing in a mouse model of diabetes mellitus type II. The study improves wound epithelization, granulation tissue formation, and vascularization, restoring disturbed blood circulation.
A molecule produced by a Thai liver parasite has been found to have the potential to supercharge healing and treat non-healing wounds in diabetics. The researchers have successfully produced a version of the molecule on a large enough scale to conduct laboratory tests, with promising results.
Researchers at Goethe University Frankfurt have developed light-inducible microRNA inhibitors that can target specific genes involved in slow-healing wounds. By injecting these inhibitors into the skin of mice, they were able to improve wound healing by blocking a particular microRNA that is frequently found in diabetes patients.
A study reveals that cognitive stimulation and social interactions increase lifespan in mice with colon tumors through a wound repair response. Environmental enrichment also reduces inflammation, improves tumor vasculature, and promotes immune cell activity to defend against cancer.
A new study found that patients with moderate anxiety or depression are at a higher risk of experiencing wound-related complications after surgery. The likelihood of such complications is 1.17- to 1.20-times greater for these patients, emphasizing the need for preoperative assessment of psychological state.
A new skin-graft harvesting system has been shown to significantly accelerate the healing process of chronic wounds in high-risk patients. The minimally invasive approach resulted in faster recovery times and reduced healthcare costs, with an average savings of $1,153 per patient.
New research from Organogenesis Inc. reveals that Apligraf can convert chronic venous leg ulcers into acute, healing wounds by modulating inflammatory and growth factor signaling. This breakthrough study published in Science Translational Medicine provides valuable insights for researchers and clinicians treating chronic wounds.
A team of researchers from the University of Toronto has developed a proprietary peptide-hydrogel biomaterial that promotes skin cells to 'crawl' together, closing chronic, non-healing wounds caused by diabetes. The treatment closed wounds 200% faster than no treatment and 60% faster than existing collagen-based products.
Researchers at Drexel University have developed a portable device that uses low-frequency ultrasound to heal chronic wounds. The device, which is battery-powered and compact, has shown promising results in clinical trials, with patients experiencing improved healing by 15% per week.
A new study published in Wound Repair and Regeneration found that patients with chronic wounds who never received opioids healed faster than those who did. The study, led by GW researcher Victoria Shanmugam, analyzed data from 450 subjects and found a significant association between opioid dose and total wound surface area.
New research clarifies why wounds heal more slowly with age by examining molecular changes in aging mouse skin. The results show that disruptions in communication between skin cells and immune cells slow down the healing process.
Dr. Mary Ann Stepp's research on corneal wound healing has been continuously funded for 32 years, with a new $2.8M grant continuing her studies on the role of nerves in wound healing. Her team uses the cornea to study cell migration and epithelial cell adhesion, shedding light on general wound healing and cancer metastasis.
A phase-1 clinical trial demonstrates that gene therapy can restore functional type-7 collagen protein expression and improve wound healing in patients with recessive dystrophic epidermolysis bullosa. The treatment appears safe and well-tolerated, with improved outcomes for patients who had not healed for five years.
A study has found that a protein-folding gene plays a new role in wound healing, accelerating closure in diabetic mice. The researchers used zebrafish to test the hypothesis that Hsp60 promotes inflammation and cell proliferation, leading to tissue regeneration.
Researchers have found that impaired insulin metabolism affects neighboring cells involved in wound healing, leading to slow and incomplete healing. This discovery opens up new possibilities for treating wounds in diabetics, with local treatment targeting insulin metabolism.
A new study shows early infant circumcision can be safely performed by trained nurses with low rates of adverse events. The procedure resulted in high maternal satisfaction and healed wounds within four weeks.
Researchers found that mixed bacterial-fungal biofilms in chronic wounds are associated with poor outcomes and longer healing times. The study identifies the most abundant fungi species, including Cladosporium herbarum and Candida albicans, which can hinder healing.
A NYIT researcher has won an NIH grant to investigate methamphetamine's impact on the body's inflammatory response and wound healing. The study aims to understand how meth causes overproduction of IL-6, delaying inflammation and healing.
Researchers discovered weaker electric currents in diabetic wounds, which can lead to delayed healing and increase the risk of complications. This finding opens up new avenues for managing diabetic patients and could have significant implications for reducing healthcare costs associated with chronic ulcers and wounds.
Researchers at Washington State University have observed skin cells altering proteins and moving to repair wounds, a process that could be manipulated to speed up healing. They found that the cells use their internal muscle-related proteins to generate forces needed to move, allowing them to 'walk' to the wound site.
Researchers found that electrical fields enhanced macrophage migration and phagocytosis, cleaning the wound site and boosting healing ability. This discovery may have wide-reaching implications for diseases where macrophages play a role.
Researchers discovered that English ivy's adhesive is made of arabinogalactan proteins, which can be used to create strong bio-inspired adhesives for wound healing and surface-coating applications. The study also found that the glue has unique properties such as being resistant to moisture and environmental conditions.
Researchers at NC State University have genetically engineered green bottle fly larvae to produce and secrete human growth factor-BB, a molecule that promotes cell growth and wound healing. The modified maggots show promise for cost-effective wound treatment that could save people from amputation.
Researchers at Ohio State University have identified a human gene product called MG53 that regulates wound healing and may control scarring. This discovery could help heal open wounds, decrease recovery time after surgery and reduce the spread of infections.
A new electrochemical detection strategy can identify bacteria in wounds in under a minute, allowing for targeted therapies and reduced healthcare costs. The method uses pyocyanin, a molecule produced by Pseudomonas bacteria, to detect infections.
A new seaweed-based solution has been developed to transport stem cells and treat wounds, offering a low-cost and effective alternative to current methods. The alginate gel protects the stem cells from environmental damage, preserving their viability for up to three days at room temperature.
A new Johns Hopkins study of over 930,000 patient records found that patients undergoing bariatric surgery during winter months fared worse than those in the summer due to lower vitamin D levels. The researchers also noticed a disproportionate number of complications occurred north of latitude 37 degrees.
Recent research reveals that all dividing human skin cells have the potential to switch between two modes of cell division, one for maintenance and another for wound repair. This finding explains how skin grafts work and may lead to new treatments for wound healing and cancer.
Researchers at the University of Notre Dame have discovered a compound that accelerates diabetic wound healing, opening doors to new treatment options. The study found that combining an MMP-9 inhibitor with enzyme MMP-8 enhances healing even further.
Researchers discovered that the behavior of monocytes, a type of white blood cell, can indicate how soon patients will recover after hip surgery. The study found that 50% of variation in recovery time could be predicted based on these cells' behavior, which could help doctors plan better post-surgery care.
Researchers found that combining meshed split skin autographs with autologous cultured proliferating epidermal cells resulted in better wound healing and less scarring. The treatment also showed improved pigmentation for the wounds treated with cultured ECs.
A cancer-causing parasitic worm has been discovered to drive wound healing and blood vessel growth, which could lead to accelerated recovery from chronic wounds such as diabetic ulcers. The growth factor secreted by the parasite also increases the risk of developing liver cancer over time.
Researchers at the University of Toronto have identified the process of endocytosis as a key driver of rapid embryonic healing, which coordinates cell movement to close wounds. This discovery holds promise for developing more efficient treatments for human wound repair.
A clinical trial at the VA Medical Center in Gainesville is testing maggot therapy for veterans with chronic diabetic ulcers. The treatment, which involves sterilized maggots feasting on dead tissue, has shown promise in clearing out wounds and reducing bacterial infections.
The new journal aims to publish current research on scars, burns, and healing from a range of clinical and academic authors. The partnership between SAGE and The Katie Piper Foundation seeks to improve the delivery of burns rehabilitation and scar management.
Researchers from the University of Arizona College of Medicine - Phoenix conducted a study on osteopathic manipulative therapy (OMT) in an in vitro setting. The results showed that OMT had profound effects on cellular processes, including proliferation, apoptosis, and cytokine production.
A study published in the Journal of Clinical Investigation found that microRNA-132 plays a critical role in regulating the transition from inflammation to proliferation during wound healing. The researchers identified miR-132 as a therapeutic target for promoting healing and developing new treatments for chronic skin wounds.
Researchers from Boston Children's Hospital discovered that body's own immune cells produce bacteria-trapping NETs, which slow healing in diabetic mice. Methods to prevent NET production or cleave them might alleviate wound healing problems in people with diabetes.