Articles tagged with Wound Healing
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Developed by Cardiff University, the test identifies a wound type based on its gene signature with an initial accuracy rate of 98%. It has the potential to transform service provision and provide the right treatment at the earliest possible opportunity.
The Johns Hopkins Wound Center and the Evidence-based Practice Center are conducting an evidence-based review of wound care to determine what is known and unknown about it. This study aims to inform health care providers and patients about effective state-of-the-art wound care treatments, ultimately improving outcomes for six million p...
Researchers at Cornell University have developed dermal templates made of type 1 collagen that promote vascular growth and encourage healthy skin to invade wounded areas. The templates are designed to improve healing outcomes and reduce the need for invasive surgeries.
Researchers discovered that injecting DKK2 improved vascular regeneration in a mouse model of myocardial infarction. This suggests potential for pharmacological manipulation to treat various vascular diseases.
A new study examines recurrent wound botulism among injection drug users in California, finding that nearly three-quarters of reported cases are linked to this condition. The study highlights the risk of repeated cases despite potentially developing protective immunity against botulism.
Researchers found that certain immune system cells can hinder wound healing, leading to chronic ulcers. Supressing these cells may speed up the healing process.
Massachusetts General Hospital researchers developed nanoparticles containing keratinocyte growth factor that accelerate wound healing in diabetic mice. The fusion protein retained wound-healing properties and efficiently delivered growth factors to deeper tissues.
Researchers have identified markers associated with breast cancer outcomes and found a protein linked to tumor spread. Additionally, a new therapeutic target for tumor suppression has been discovered, while gene therapy shows promise for improving wound healing in diabetic patients.
Researchers found that natural killer T (NKT) cells impede the healing process, leading to slower wound closure. Inactivating these cells using an antibody is being tested as a potential treatment.
Scientists have discovered that a tiny piece of RNA in cells lowers protein production needed for skin cell growth, suggesting new treatment strategies for chronic wounds. Researchers used an experimental drug to silence the RNA segment and saw increased protein levels and skin-cell growth.
A team of researchers has created a new in vitro model for studying the effects of light on wound healing. They found that exposure to blue-violet light increases mitochondrial activity, cell proliferation, and growth factor secretion in human epidermal keratinocytes. These results suggest that blue light may be useful in enhancing epi...
Researchers found that maggot 'biosurgeons' used to treat chronic wounds are vulnerable to deadly bacteria Pseudomonas aeruginosa, which can kill the maggots within 20 hours. This discovery could lead to more effective treatment of wounds and development of novel antibiotics.
A new wound treatment has received $529,450 in funding to speed up healing of chronic wounds like burns and ulcers. The treatment uses antibodies to suppress a protein that restricts wound healing, promising benefits for the aged, obese and diabetics.
The National Science Foundation grant will help scientists study the response of amoebae to electric fields, which could reveal genes and molecules responsible for detecting these signals. This knowledge could have implications for wound healing and tissue engineering, as well as basic science research.
The androgen receptor, crucial for male hormones like testosterone, also plays a significant role in the body's ability to heal wounds. Blocking this receptor accelerates wound healing by reducing inflammation.
Researchers at Binghamton University identified specific types of chronic wound bacteria producing cell-cell signaling molecules AI-2 and AHLs. The 'good' bacteria produce AI-2, while pathogenic species produce AHLs, which can be targeted to improve wound healing.
A probiotic bacterium, Bacillus polyfermenticus, has been shown to effectively treat colitis in mice by promoting the growth of new blood vessels. The study found that the bacteria increased angiogenesis, a process necessary for wound healing, and reduced inflammation in affected tissues.
Researchers at Ohio State University have developed a mathematical model of ischemic wound healing, simulating both non-ischemic and ischemic wounds. The model predicts that ischemic wounds will heal in about 20 days, but only 25% will be healed by then.
Researchers at NIST have developed a microfluidic palette to produce multiple, steady-state chemical gradients for studying complex biological mechanisms. The device uses diffusion instead of active mixing, allowing cells to remain in the microchamber without disruption.
Researchers discovered that high glucose levels in diabetic tissue lead to reduced vascular endothelial growth factor production and impaired HIF-1a function. Deferoxamine, an iron-binding drug, has been shown to improve wound healing by restoring HIF-1a-p300 interaction, leading to increased growth factor production.
Researchers studied dorsal closure in fruit flies to gain insights into human wound healing, discovering that the actin cable acts as a ratchet to guide epithelial cells over gaps. This mechanism could apply to developing tissues beyond dorsal closure and wound healing.
A new model suggests mechanical forces play a crucial role in blood vessel growth, challenging previous assumptions about chemical gradients. This finding opens up new possibilities for treating diseases such as tumors, rheumatism, and eye disorders.
Researchers found that providing rats with nest-building materials significantly improved wound healing and altered gene expression in the brain, leading to faster healing rates and reduced stress effects. The study suggests a novel approach to improving physical health through environmental stimulation.
Researchers found that giving rats living in isolation the opportunity to build nests led to faster and more complete healing of burn injuries than isolation-reared rats without nest-building materials. This effect was associated with altered gene expression in stress-associated brain structures.
Researchers have identified a key signaling pathway, Notch, that stimulates endothelial cells to form new blood vessels in wounds. This discovery has significant implications for treating chronic skin wounds in diabetic patients and those with morbid obesity.
A study by the American Society of Plastic Surgeons found that malnutrition significantly increases surgical complications in massive weight loss patients. Pre-surgery nutritional supplements can accelerate wound healing, improve scar quality, and boost patient energy levels, according to the ASPS.
Researchers discovered a compound in human saliva, histatin, that accelerates wound healing. Histatin was found to close almost completely after 16 hours in the wound model.
A recent study found that omega-3 fatty acids in fish oil supplements increase levels of proteins associated with inflammation, delaying wound healing. The researchers discovered a gender difference in cytokine production, with men experiencing higher levels of inflammatory proteins than women.
Researchers at UVA Health System are conducting studies on the use of fat grafting to improve wound healing and minimize scarring in severely injured soldiers. The goal is to enhance recovery outcomes and reduce long-term functional deficits.
A study published in Circulation Research reveals that flexing muscles send biochemical signals through nearby matrix proteins, increasing blood flow and potentially reversing poor circulation and healing chronic wounds. The discovery sheds light on the role of extracellular matrix proteins like fibronectin in controlling bodily function.
New research reveals that timing of IL-7 treatment is crucial for enhancing antiviral immunity. Additionally, studies on cardiac development and wound healing have identified novel genes and mechanisms, offering potential therapeutic targets for chronic viral infections and cutaneous wounds.
Researchers developed a new wound dressing using hair follicular cells that increased wound closure rates by two times compared to control subjects. The technique provides an effective biodressing that maintains structural strength during healing, promising early-stage wound healing improvements.
Researchers investigate various aspects of wound healing, including exercise, compression therapy, and medication. Studies show that patients with leg ulcers often lack physical activity and use inadequate compression therapy, while medication may have a protective association against leg ulcers. Additionally, injection drug use is lin...
The partnership aims to widen the journal's audience, reducing reviewing time and increasing access to online features, including a comprehensive search engine and e-mail alerts. The Tissue Viability Society will continue to receive print copies as a benefit of membership.
Scientists have developed a novel method for capturing and genome-wide screening of blood vessel cells in their actual disease state, advancing potential for genetic research. The technique allows for precise cell-specific information and has implications for diseases such as cancer and chronic wounds.
The clinical effectiveness of topical negative pressure therapy for wound healing is unclear, according to a review by the BMJ Specialty Journals. The technique has been used to treat various types of wounds, but many studies have been flawed, casting doubt on its validity and reliability.
A study by University of Cincinnati researcher David Hom found that treating skin wounds with a concentrated topical gel of the patient's own blood platelets resulted in faster healing. The gel showed a statistically significant increased wound closure compared to antibiotic ointment, with some sites closing up to two days earlier.
A preliminary study suggests that autologous platelet gel can enhance wound closure in acute full-thickness dermal wounds, with statistically increased closure rates compared to controls. The gel is rich in platelets important for blood clotting and appears to promote healing by increasing new tissue appearance.
Researchers have found that mice lacking organic cation transporter 1 (OCT1) exhibit reduced metformin effects on AMPK phosphorylation and glucose control. Additionally, seven mutations in OCT1 were identified in humans, which reduce metformin uptake, indicating the importance of OCT1 in mediating metformin's therapeutic effects.
Research by UCSD School of Medicine reveals that Vitamin D3 plays a crucial role in controlling the body's innate immune response and protecting against infections. Fluctuations in vitamin D3 levels affect the healing process of skin wounds, with lower concentrations linked to increased susceptibility to infection.
Researchers at Montana State University's Center for Biofilm Engineering have received a $2.9 million grant to study the role of biofilms in chronic wounds. Biofilms, which are bacteria that form protective slime, can interfere with the healing process and contribute to amputations in diabetics.
A team of UCI researchers, led by Ken Muneoka, will focus on harnessing the body's natural healing process to heal deep wounds involving bone, muscle, nerves and other soft tissues. The goal is to recreate a regeneration process in mouse models that could lead to breakthroughs in wound healing and limb regeneration.
A study published in Nature sheds light on how the body repairs wounds, revealing that a 'scaffolding' protein plays a crucial role in signaling proteins that lead to new protein manufacture and cell growth. Additionally, research in Genes and Development reveals a novel role for this protein in promoting hair follicle growth.
Honey's antibacterial quality rapidly clears existing infection, while also protecting wounds from additional infections. The sweetener stimulates the growth of granulation and epithelial tissues to speed up the healing process.
A recent Ohio State University study found that exercise significantly speeds up wound healing in older adults, with wounds healing an average of 10 days faster in the exercising group. The study suggests that exercise may play a role in regulating cortisol levels, which could be a key biological pathway for enhanced wound healing.
Researchers at Ohio State University found that stress and hostility can significantly slow the healing process, taking up to two days longer for wounds to heal. Cytokine levels also increased in highly stressed couples, leading to chronic inflammation and age-related illnesses.
Researchers found that hair follicle stem cells quickly mobilize to generate new cells that migrate into the wound area, contributing to wound healing. The study suggests a therapeutic target for developing drugs to enhance wound healing and treat patients with wounds.
Beta-glucan, a soluble fiber found in oat kernels, has been shown to penetrate the skin naturally, promoting wound healing and reducing scarring. The compound works through the inter-cellular lipid matrix to enter lower levels of the skin, making it a potential alternative to Botox for non-invasive treatments.
Chronic wounds like bedsores affect millions in US, causing widespread infections and limb amputations. Researchers found skin cells get stuck in healing process due to overabundance of c-myc, a molecule that suppresses cell migration and causes thickened layers around the wound.
A study published in Science identifies the master gene grainyhead as essential for wound repair in both fruit flies and mice. The researchers found that grainyhead is required to activate genes involved in cuticle repair, which then regenerate injured patches of skin.
A small study found that maggot-treated wounds had a significantly lower infection rate compared to untreated wounds. Maggots' unique properties make them an effective treatment option for preventing post-operative wound infections.
A new study found that social bonding has a positive effect on wound healing in monogamous mice but not in those with multiple partners. Corticosterone levels, a stress hormone, were lower in socialized monogamous mice and showed no difference in non-monogamous mice.
Researchers found that socially isolated hamsters healed wounds at a slower rate than those paired with a sibling, which also reduced stress hormone cortisol levels. Oxytocin treatment improved wound healing in stressed and non-stressed animals.
New prosthetic fitting system offers improved match for knee arthritis patients, while researchers find nearly 80% of patients satisfied with brace treatment. Meanwhile, studies on traumatic brain injury research reveal legal and ethical concerns, as well as effective wound healing methods using electrical stimulation.
A study published in PLOS Biology discovered a common genetic signature linked to the progression of various cancers, including prostate and liver cell carcinomas. Patients with tumors carrying this signature had an increased risk of metastasis and death compared to those without it.
Pregnant women exhibit enhanced odor sensitivity and unpleasantness, which may help protect against stress. A study also found that brain areas mediating 'reward' are stimulated by pup suckling in rat mothers, suggesting a potential link between smell, reward, and maternal bonding.
Researchers at UC San Diego discovered that a protein essential for fruit fly embryonic development also plays a crucial role in mammalian wound healing. The study reveals that the loss of this protein causes skin cells to bunch up and stall, leading to slower wound healing rates.
MIF is a crucial intermediary in uncontrolled inflammation and impaired wound healing. In estrogen-deficient mice, MIF expression increased, leading to excessive inflammation and delayed healing. Therapeutics that inhibit MIF may accelerate wound healing.
The new mat mimics natural clotting processes by creating fibers of similar dimensions to those found in the body. It can be used for minor cuts or severe battlefield wounds, promoting clotting and eventual absorption by the body.
A study by Ohio State University found that topical oxygen therapy significantly improved healing rates for difficult-to-treat wounds, including diabetic hand ulcers and bedsores. The therapy, which involves applying pure oxygen to the wound, showed a 75% healing rate for acute traumatic injuries.