Articles tagged with Wound Healing
Dr. Mary Ann Stepp's research on corneal wound healing has been continuously funded for 32 years, with a new $2.8M grant continuing her studies on the role of nerves in wound healing. Her team uses the cornea to study cell migration and epithelial cell adhesion, shedding light on general wound healing and cancer metastasis.
A phase-1 clinical trial demonstrates that gene therapy can restore functional type-7 collagen protein expression and improve wound healing in patients with recessive dystrophic epidermolysis bullosa. The treatment appears safe and well-tolerated, with improved outcomes for patients who had not healed for five years.
A study has found that a protein-folding gene plays a new role in wound healing, accelerating closure in diabetic mice. The researchers used zebrafish to test the hypothesis that Hsp60 promotes inflammation and cell proliferation, leading to tissue regeneration.
Researchers have found that impaired insulin metabolism affects neighboring cells involved in wound healing, leading to slow and incomplete healing. This discovery opens up new possibilities for treating wounds in diabetics, with local treatment targeting insulin metabolism.
A new study shows early infant circumcision can be safely performed by trained nurses with low rates of adverse events. The procedure resulted in high maternal satisfaction and healed wounds within four weeks.
Researchers found that mixed bacterial-fungal biofilms in chronic wounds are associated with poor outcomes and longer healing times. The study identifies the most abundant fungi species, including Cladosporium herbarum and Candida albicans, which can hinder healing.
A NYIT researcher has won an NIH grant to investigate methamphetamine's impact on the body's inflammatory response and wound healing. The study aims to understand how meth causes overproduction of IL-6, delaying inflammation and healing.
Researchers discovered weaker electric currents in diabetic wounds, which can lead to delayed healing and increase the risk of complications. This finding opens up new avenues for managing diabetic patients and could have significant implications for reducing healthcare costs associated with chronic ulcers and wounds.
Researchers at Washington State University have observed skin cells altering proteins and moving to repair wounds, a process that could be manipulated to speed up healing. They found that the cells use their internal muscle-related proteins to generate forces needed to move, allowing them to 'walk' to the wound site.
Researchers found that electrical fields enhanced macrophage migration and phagocytosis, cleaning the wound site and boosting healing ability. This discovery may have wide-reaching implications for diseases where macrophages play a role.
Researchers discovered that English ivy's adhesive is made of arabinogalactan proteins, which can be used to create strong bio-inspired adhesives for wound healing and surface-coating applications. The study also found that the glue has unique properties such as being resistant to moisture and environmental conditions.
Researchers at NC State University have genetically engineered green bottle fly larvae to produce and secrete human growth factor-BB, a molecule that promotes cell growth and wound healing. The modified maggots show promise for cost-effective wound treatment that could save people from amputation.
Researchers at Ohio State University have identified a human gene product called MG53 that regulates wound healing and may control scarring. This discovery could help heal open wounds, decrease recovery time after surgery and reduce the spread of infections.
A new electrochemical detection strategy can identify bacteria in wounds in under a minute, allowing for targeted therapies and reduced healthcare costs. The method uses pyocyanin, a molecule produced by Pseudomonas bacteria, to detect infections.
A new seaweed-based solution has been developed to transport stem cells and treat wounds, offering a low-cost and effective alternative to current methods. The alginate gel protects the stem cells from environmental damage, preserving their viability for up to three days at room temperature.
A new Johns Hopkins study of over 930,000 patient records found that patients undergoing bariatric surgery during winter months fared worse than those in the summer due to lower vitamin D levels. The researchers also noticed a disproportionate number of complications occurred north of latitude 37 degrees.
Recent research reveals that all dividing human skin cells have the potential to switch between two modes of cell division, one for maintenance and another for wound repair. This finding explains how skin grafts work and may lead to new treatments for wound healing and cancer.
Researchers at the University of Notre Dame have discovered a compound that accelerates diabetic wound healing, opening doors to new treatment options. The study found that combining an MMP-9 inhibitor with enzyme MMP-8 enhances healing even further.
Researchers discovered that the behavior of monocytes, a type of white blood cell, can indicate how soon patients will recover after hip surgery. The study found that 50% of variation in recovery time could be predicted based on these cells' behavior, which could help doctors plan better post-surgery care.
Researchers found that combining meshed split skin autographs with autologous cultured proliferating epidermal cells resulted in better wound healing and less scarring. The treatment also showed improved pigmentation for the wounds treated with cultured ECs.
A cancer-causing parasitic worm has been discovered to drive wound healing and blood vessel growth, which could lead to accelerated recovery from chronic wounds such as diabetic ulcers. The growth factor secreted by the parasite also increases the risk of developing liver cancer over time.
Researchers at the University of Toronto have identified the process of endocytosis as a key driver of rapid embryonic healing, which coordinates cell movement to close wounds. This discovery holds promise for developing more efficient treatments for human wound repair.
A clinical trial at the VA Medical Center in Gainesville is testing maggot therapy for veterans with chronic diabetic ulcers. The treatment, which involves sterilized maggots feasting on dead tissue, has shown promise in clearing out wounds and reducing bacterial infections.
The new journal aims to publish current research on scars, burns, and healing from a range of clinical and academic authors. The partnership between SAGE and The Katie Piper Foundation seeks to improve the delivery of burns rehabilitation and scar management.
Researchers from the University of Arizona College of Medicine - Phoenix conducted a study on osteopathic manipulative therapy (OMT) in an in vitro setting. The results showed that OMT had profound effects on cellular processes, including proliferation, apoptosis, and cytokine production.
A study published in the Journal of Clinical Investigation found that microRNA-132 plays a critical role in regulating the transition from inflammation to proliferation during wound healing. The researchers identified miR-132 as a therapeutic target for promoting healing and developing new treatments for chronic skin wounds.
Researchers from Boston Children's Hospital discovered that body's own immune cells produce bacteria-trapping NETs, which slow healing in diabetic mice. Methods to prevent NET production or cleave them might alleviate wound healing problems in people with diabetes.
Researchers accelerate wound healing using electrical pulses, significantly reducing recovery time. The technology has potential to be applied to various situations where faster healing is desired.
A new study has identified a temporary, but potentially troublesome unintended consequence of male circumcision: an increased risk of infecting female sexual partners while the wound heals. The study found that nearly 30% of HIV-positive men were shedding the virus two weeks after surgery, compared to less than 10% before circumcision.
A study found that wound healing and lower plasma viral loads are associated with less HIV shedding from male circumcision wounds. The likelihood of viral shedding increases initially but decreases as wounds heal.
Researchers developed a topical gene regulation technology that uses spherical nucleic acids (SNAs) to silence the gene that interferes with wound healing in diabetic animals. The treatment improved healing and blood circulation at the wound site, reducing recovery time by 50%.
Many nursing home residents experience high mortality rates and functional decline after lower extremity revascularization. The study found that ambulatory function may not be the primary objective of treatment for these patients.
Researchers have discovered bioplastics with significant antibacterial properties that could reduce hospital-acquired infections and food contamination. Albumin-based bioplastics demonstrated complete inhibition of bacterial growth, making them a potential solution for wound healing dressings and drug delivery.
Researchers at Albert Einstein College of Medicine developed a nanoparticle therapy that reduces fidgetin-like 2 enzyme levels to promote wound healing. The treatment accelerated healing in mice with skin excisions or burns by over twice as much as untreated controls, showing promise for faster recovery from various types of wounds.
Scientists develop nanofibers from tilapia collagen and apply them to rat wounds, resulting in faster healing times and no immune reactions. The study suggests fish collagen could be a viable alternative for wound treatment, reducing the risk of transmitting diseases.
Researchers at National University of Singapore discover that cells exert directional forces to close gaps in protective epithelial barriers, even when underlying layers are damaged. This 'tug-of-war' mechanism drives mechanical forces responsible for gap closure.
Researchers at Penn Dental Medicine have identified Foxo1 as a critical molecule that impairs wound healing in diabetics. The study found that deleting Foxo1 in keratinocytes improved wound healing in diabetic mice, suggesting a potential target for therapies to boost healing.
Researchers have developed a safe and effective skin patch to deliver a drug that enhances the healing of diabetes-related ulcers. The patch has been shown to accelerate wound healing and prevent ulcer formation in mice, offering new hope for millions of people with diabetes.
Researchers found that moderate levels of free radicals are necessary for proper skin wound healing in laboratory roundworms. Increased ROS can even accelerate wound closure, suggesting a potential therapeutic target for improving wound healing in humans, particularly the elderly and those with diabetes.
A new paint-on, see-through 'smart' bandage glows to indicate tissue oxygenation concentration, enabling direct measurement for improved wound care. The bandage's phosphorescence emits light based on oxygen levels, allowing for non-invasive monitoring of wounds and burns.
Researchers identified Maresin-Ls, molecules that promote wound healing and reduce inflammation in patients with diabetes. The study restores reparative functions to diabetic macrophages, enabling better treatment of diabetic wounds.
A study published in The FASEB Journal identifies a salamander skin peptide called tylotoin that promotes wound healing by enhancing keratinocyte proliferation and releasing essential growth factors. This discovery could lead to the development of new treatments for human wounds.
Researchers found that mice lacking specific vascular system proteins developed normally but healed poorly from injuries. Increasing FGF signaling may improve wound healing, while inhibiting it in the eye could help patients with age-related macular degeneration or diabetic retinopathy.
Researchers at Ruhr-University Bochum discovered that sandalwood scent activates olfactory receptors in human skin cells, increasing cell proliferation and improving wound healing. The team identified the receptor OR2AT4 as responsible for this effect.
A new material has been developed to improve wound healing and prevent bacterial infections, leading to faster recovery times compared to existing commercial dressings. The material was tested on mice and showed complete wound healing within two weeks.
Molecular methods have improved identification of war wound infections, revealing new insights into microbial species associated with successful and unsuccessful healing. The study found that certain bacteria are linked to poor wound healing, while others are associated with successful recovery.
Researchers found that aspirin inhibits wound healing by reducing the production of 12-HHT, a molecule promoting epithelial layer restoration. A synthetic BLT2 agonist accelerated wound healing in diabetic mice, suggesting potential treatments for chronic wounds.
Researchers at JAX Laboratory have identified a protein involved in both wound healing and tumor growth as a potential therapeutic target. The study found that manipulating this protein could stimulate healing in wound patients while dialing back cancerous proliferation.
A study published in Advances in Wound Care highlights the promising role of interleukin-10 in scarless wound healing. Researchers found that IL-10 enables fetal skin to heal without scars, providing a potential therapeutic agent for anti-scarring treatments.
Scientists studying fetal stem cells that facilitate scarless wound healing aim to develop cell-based approaches to minimize scarring in adult wounds. Researchers have identified a new stem cell capable of participating in this process.
A new study finds that binge drinkers heal from wounds at a slower rate due to impaired immune function. Binge alcohol exposure reduces key immune system components, making wounds more susceptible to infection.
Researchers found that low-intensity vibration can accelerate wound healing in mice with diabetes by forming more granulation tissue and new blood vessels. The study suggests that this non-invasive technique could be easily translated to humans and is being tested in human trials.
Researchers at the University of California, Berkeley, used electrical current to direct the movement of epithelial cells, a breakthrough that could lead to controlled forms of tissue engineering. The study demonstrates the potential for 'smart bandages' that use electrical stimulation to aid wound healing.
University of Cincinnati researchers discovered that high-frequency electrical stimulus increased blood vessel network growth by up to 50%, leading to enhanced wound closure. The team developed a specialized antenna for localized application and filed a provisional patent for their design.
A Johns Hopkins systematic review of 66 research papers found most skin ulcer treatments are technically flawed, with weak evidence supporting some treatments over standard compression therapy. The review suggests a need for well-designed studies to compare current minimally invasive surgical interventions to gold standard care.
Chronic wounds affect millions of Americans at a high cost. Researchers found that reducing reactive oxygen species (ROS) levels can break the cycle of unhealing wounds. Antioxidant treatments can also reverse chronicity by disintegrating bacterial biofilms, leading to healthier tissue and wound healing.
Researchers have found that controlling levels of reactive oxygen species can break the cycle of wounds that refuse to heal. Antioxidant supplements such as vitamin E and N-Acetyl cysteine were able to normalize conditions and promote healing in chronically infected wounds.
A team of Wayne State University researchers identified transforming growth factor β (TGFβ) signaling as a major pathway affected by hyperglycemia in DM corneal epithelial cells. Adding TGFβ3 to the wound accelerated epithelial wound closure, providing new treatment options for diabetic wound healing.
Researchers have identified FOX01 as a critical molecule in the wound-healing process, providing a possible new target for pharmaceuticals. The study found that FOX01 plays an integral role in activating key growth factor TGF-β1 and protecting cells against oxidative stress.
Researchers at University of Notre Dame identified enzymes detrimental and beneficial to wound repair in diabetic individuals. Selective MMP-9 inhibitors showed 92% wound healing rate after 14 days, compared to 74% in untreated mice.