Articles tagged with Wound Healing
A new study reveals that Surgical Site Infection (SSI) is a major financial burden on health services in LMICs, with patients experiencing higher costs for postoperative care. Investing in health technologies to reduce SSI could help improve healthcare quality and save lives.
A new study presents a chronic wound murine model that characterizes the role of persistent senescent cell accumulation in delayed wound closure. The molecular profiles of senescent cells demonstrate the adverse influence of SASP factors, highlighting a potential root-cause-driven therapeutic strategy.
A two-component system designed by MIT engineers has shown promising results in stopping internal bleeding in mouse models. The system, which mimics the body's natural clotting process, uses a nanoparticle and polymer to recruit platelets and form blood clots at injury sites.
Researchers at Linköping University developed a nanocellulose wound dressing that reveals early signs of infection through pH monitoring. This technology can lead to more efficient care and reduce unnecessary antibiotic use.
A team of researchers has developed a method that uses electric stimulation to accelerate wound healing, making it possible for wounds to heal up to three times faster. The technique involves applying an electric field to damaged skin, which helps guide skin cells in the same direction, promoting faster healing.
A 3-year-old girl was infected with M. marinum after being bitten by an iguana while on holiday in Costa Rica. The toddler developed a ganglion cyst and eventually responded to treatment with rifampin and clarithromycin.
The PROMISE II clinical trial showed that LimFlow therapy enabled 76% of patients to avoid amputation and experience wound healing. This minimally invasive procedure bypasses blocked arteries in the leg and rushes blood back into the foot through the veins, providing a unique alternative to major amputation.
Scientists developed an injectable biomaterial with improved adhesion, stretchability, and toughness, making it ideal for surgical wound sealing. The material showed superior adhesive strength, stability, and biocompatibility in physiological conditions.
Researchers found that cocklebur fruit extracts encouraged collagen production, sped wound healing, and exerted a protective effect against UVB radiation. However, high doses of the extract can be harmful and further research is needed to determine its safe use in cosmetic applications.
A study published in Lasers in Surgery and Medicine suggests that light therapy, known as photobiomodulation (PBM), can improve heart function and reduce the thickness of the cardiac wall in middle-aged mice. The research also found improved neuromuscular coordination and a significant survival rate among mice with severe heart disease.
Researchers developed smart bandages that can monitor wound conditions and deliver medication to treat inflammation and infection. The bandages have shown promising results in animal models, offering real-time updates and speed healing of chronic infected wounds.
A team of researchers developed a transfer-tattoo-like cell sheet that can be directly applied to targeted surfaces, facilitating cutaneous wound healing and promoting skin tissue regeneration. The system leverages natural cell migration between surfaces, eliminating the need for external stimuli and detachment processes.
Researchers used a biomimetic model to study wound healing in burn and laceration wounds. Fibroblasts were found to clear away damaged tissue before depositing new material, but this process was slower in burn wounds due to more tissue damage. Therapies that promote wound clearance could accelerate healing.
Researchers develop a novel combination therapy using mitoxantrone and vancomycin to treat vancomycin-resistant Enterococcus faecalis (VRE) infections. The therapy stimulates the host immune system, accelerating wound healing and killing bacteria more effectively.
Researchers at Northwestern University developed a first-of-its-kind small, flexible, stretchable bandage that accelerates healing by delivering electrotherapy directly to the wound site. The bandage healed diabetic ulcers 30% faster than in mice without the bandage.
Researchers developed a neural network model that uses terahertz time-domain spectroscopy data to predict burn healing outcomes with high accuracy. The new approach improves upon existing methods by reducing training data requirements, making it more practical for processing large clinical trials.
A new antibacterial spray and coating can kill antibiotic-resistant bacteria, reducing the risk of infection in wounds and medical devices. The innovative material has been shown to be effective against MRSA and other resistant bacteria, offering a promising solution to combat antibiotic resistance.
A new study finds that andiroba oil accelerates wound healing, increases contraction rates, and promotes local re-epithelialization. The oil also presents a similar potential to low-level laser therapy (LLLT) in treating oral mucositis, a common side effect of chemotherapy.
Research suggests that avoiding or withdrawing from tough conversations can lead to emotional distress, bad feelings about the relationship, chronic inflammation, and lowered immune function. Couples who exhibit negative communication patterns report fewer positive emotions and slower wound healing.
Researchers have developed a system using microvesicles from algae that promote skin cell proliferation and migration, leading to increased collagen synthesis. The findings show promising results for the treatment of wounds and skin regeneration.
Scientists discover a way to train healthy immune cells to acquire tumor cells' skills for accelerating diabetic wound healing. TAMs-educated macrophages promote cell proliferation, resolve inflammation and orchestrate vasculature.
Researchers developed a customizable, strontium-loaded scaffold that promotes wound healing by stimulating gingival fibroblast activity. The scaffold increased cellular activity of isolated cells while showing minimal toxicity over four days.
A recent study found that patients undergoing abdominal ostomy surgery have high rates of hospital readmissions and emergency department visits, often due to ostomy-related complications. The study analyzed data from nearly 28,000 patients and found that 42% were readmitted within 120 days after initial hospitalization.
Researchers at RMIT University have developed an AI-powered system to predict how leg ulcers will heal based on thermal images from the first assessment. This innovation enables nurses to identify chronic wounds during the first visit, allowing for specialized treatment up to four weeks earlier than the current gold standard.
The 13th International Conference on Skin Ageing & Challenges will be held in Lisbon, Portugal, with over 61 communications and innovations presented. Key findings include the impact of olfactory receptors on microbiota & wound healing, as well as recent artificial intelligence developments for skin cancer detection.
The 13th Annual Meeting on Skin Challenges 2022 will address key skin ageing and challenges such as skin microbiome, cancer, inflammation, wound healing, and more. The event will feature experts from industry and academia presenting their research on these topics.
Researchers found that changing gloves and instruments just before closing wounds can prevent as many as 1 in 8 cases of Surgical Site Infection. A new toolkit also helps hospitals prepare for pandemics, heatwaves, and natural disasters.
A landmark study published in The Lancet found that chlorhexidine gluconate and povidone-iodine aqueous solutions are equally effective in preventing surgical site infections in patients with open fractures. This finding has significant implications for healthcare practitioners and may reduce costs associated with accessing these antis...
A new American Heart Association scientific statement emphasizes the importance of managing PAD based on a person's experience of symptoms, rather than relying solely on clinical measures. This approach aims to improve patient-centered care and outcomes, particularly for individuals with severe limb ischemia or comorbidities.
A new skin-stretching device called EASApprox has been successfully used to treat large scalp defects in 12 patients, providing enough skin for direct closure using sutures or gradual healing. The procedure showed good functional and cosmetic results with acceptable scarring and no serious complications.
The study found that a combination of NOX1, loss of function, and TNF leads to an abnormal increase in microfold cells, driving increased recruitment of immune cells. Reversing the defect with reactive oxygen species restored healthy gut balance. Further studies on reactive oxygen species-stem cell modulation therapy are proposed.
A new, dissolvable hydrogel developed by Mass General Hospital promotes wound healing for second-degree burns while minimizing pain and trauma. The biomaterial is highly absorbent, based on green chemistry approaches, and can be dissolved in under five minutes.
Researchers at Washington University in St. Louis are developing a new wound dressing to overcome obstacles to healing in people with diabetes, including chronic inflammation and delayed growth of new blood vessels.
A recent study by Medical University of Vienna researchers has identified a crucial dual function of neutrophils in liver regeneration after partial hepatectomy. The findings suggest that these immune cells produce factors necessary for liver growth, enabling the organ to recover quickly from tissue damage.
Researchers at NTU Singapore and Cuprina have developed a new clinical-grade collagen made from discarded bullfrog skin, which is leapfrogging from the lab bench to clinics soon. This sustainable innovation aims to reduce waste and provide an affordable yet effective wound-care solution.
Researchers have identified a key chemical controlling hair follicle cell division and death, shedding light on a potential cure for baldness. The discovery also holds promise for speeding up wound healing by harnessing the regenerative properties of stem cells found in hair follicles.
Researchers at Indiana University School of Medicine used tissue nanotransfection (TNT) technology to edit genes in chronic wound tissue, rescuing wound healing. The study found that gene silencing due to DNA methylation was a critical barrier to wound closure.
Researchers at Ben-Gurion University have found a phytochemical derived from broccoli that breaks down biofilms protecting antibiotic-resistant pathogens, enabling eradication rates of up to 94% when combined with antibiotics. The compound also accelerates wound healing and is being further developed for commercialization.
The 13th Annual Meeting on Skin Challenges 2022 will discuss recent advances in skin ageing, focusing on extracellular vesicles and their therapeutic potential. Experts will also share findings on the skin microbiome and its role in age-related diseases.
Researchers have developed unique self-regulating footwear for persons with diabetes, featuring snapping mechanisms that distribute pressure evenly. The sandals can be customized to an individual's foot dimensions and walking style, promoting faster healing of injured regions and preventing further injuries.
Researchers developed e-bandages producing hydrogen peroxide to treat wound infections, reducing MRSA biofilm bacteria by 99 percent. This alternative method to antibiotics has the potential to improve wound healing and reduce antibiotic resistance.
Researchers from the University of Tokyo have created a controllable robotic finger covered with living skin tissue that can heal itself. The development could lead to new possibilities in advanced manufacturing industries, such as automation and cosmetics, reducing costs, time, and complexity of research.
Researchers discovered that dermal contact with nicotine concentrations found in thirdhand smoke and electronic cigarette spills can impair wound healing, increase susceptibility to skin infections, and cause oxidative stress in skin cells. The study suggests that even a short exposure of 24 hours is sufficient to cause skin damage.
Researchers developed a biopolymer film that combines anti-bacterial properties, inflammation dampening, and release of active pharmaceutical ingredients in a targeted manner. The film adheres to sensitive surfaces without damaging tissue, speeding up healing process and completely dissolving by itself.
Researchers developed new method to visualize CNS fibroblasts and their intercellular interactions in the CNS. The technique provides a detailed picture of CNS fibroblasts, including their location, size, morphology, and gene/protein expression patterns.
Researchers found that a blueberry phenolic extract improved vascularization and cell migration in live wounds, leading to a 12% increase in wound closure. The study suggests wild blueberries have the potential to enhance wound healing, particularly for patients with chronic wounds.
Researchers have found that autophagy helps form epithelial syncytia during wound healing, a process previously only observed in muscle and placenta development. This discovery highlights the importance of understanding autophagy's role in disease mechanisms.
Researchers at Osnabrück University observe chimpanzees applying insects to their own and others' wounds, sparking interest in potential anti-inflammatory or antiseptic properties. The team aims to investigate the social dimension of this behavior and its possible transmission through social learning.
The University of Cincinnati College of Medicine has developed an ointment called AB569 that kills virtually all pathogenic bacteria, including multidrug resistant Pseudomonas aeruginosa. This study shows the topical drug enhances wound healing in various burn injuries.
A new smart wound dressing has been developed that can bind wounds together, ward off infection, and monitor the wound's condition directly to doctors' computers. The dressing is made of a biocompatible polymer that heals itself in under three seconds.
Researchers at University of Göttingen investigate tight junctions' importance in cell movement and their consequences when missing. The findings suggest a 'tug of war' scenario between cells with unequal contraction and stretching, affecting tissue mobility and biological functions.
Researchers at UCI found that PIEZO1, an ion channel mechanosensor, regulates keratinocyte migration and wound healing speed. In mice lacking PIEZO1, wounds heal faster than those with increased PIEZO1 function.
Scientists from Japan discover IL-36Ra plays a pivotal role in wound healing, and Cl-amidine normalizes exacerbated I/R injury. The study's findings suggest IL-36Ra as a potential therapeutic target for cutaneous I/R injuries.
Researchers aim to provide digital histopathology images and quantitative information without invasive biopsies, addressing a common challenge in wound healing. The project combines metabolic imaging, deep learning techniques, and collaboration with experts in the field.
A new 'smart bandage' has been developed to track wound moisture levels wirelessly, enabling doctors to monitor wounds without removing the bandage. The technology could help improve wound healing rates by detecting optimal moisture levels, reducing the risk of disruption to the healing process.
A study published in the Journal of Cell Biology found that skin stem cell motility is crucial for wound healing and skin regeneration. The researchers discovered that a specific molecule, EGFR, drives skin stem cell movement and coordinates the production of collagen COL17A1.
A new hydrogel treatment kills drug-resistant bacteria, including MRSA, and induces the expression of naturally-existing antimicrobial peptides in human skin cells. The gel is non-toxic, biodegradable, and scalable.
Scientists from Hefei Institutes of Physical Science create a novel approach to synthesizing silver nanoparticles and reduced graphene oxide composite material using plasma technology. The resulting AgNPs@rGO nanomaterial shows excellent disinfection effects and bio-compatibility, making it suitable for wound healing band-aids.
Researchers at IOCB Prague have developed a novel antibacterial material called NANO-LPPO that can prevent infection and facilitate treatment of skin wounds. The material combines lipophosphonoxins with a nonwoven nanotextile, which releases active substances in response to bacterial presence.
A new study provides evidence supporting the involvement of aquaporins in corneal cell proliferation and nerve regeneration, suggesting AQP5 induction as a potential therapy to accelerate corneal defect resurfacing. The study found that AQP5 deficiency can slow down corneal epithelial repair, but its specific mechanism remained unclear.