Articles tagged with Notch Pathway
Researchers found that an inhaled drug may provide a new therapeutic for asthma by inhibiting Th2 cell inflammatory responses. Additionally, hematopoietic stem cell transplantation enabled infused tumor-reactive T cells to expand and increase tumor regression in mice.
Researchers discovered that stem cells communicate with niche cells through the Notch pathway, leading to increased niche cell production and larger stem cell populations. This two-way dialogue enables stem cells to maintain an active niche, which is essential for their self-renewal and differentiation into specialized cells.
Researchers at the University of Pennsylvania School of Medicine have identified Notch as a key regulator of Th2 immune responses, which are impaired in mice lacking this signaling pathway. This study suggests that inhibiting Notch signaling may be beneficial for treating diseases characterized by excessive Th2 responses, such as asthm...
Researchers discover that Cut, a DNA-binding protein, plays a crucial role in regulating cell proliferation by accurately transcribing Notch signals. Inaccurate transcription leads to unregulated growth and can be linked to various diseases such as Alzheimer's, cancer, and genetic disorders.
A team of researchers at the University of Manchester has discovered that cell communication signals can be more complicated than previously thought. This breakthrough should help scientists better investigate what happens when these signals go wrong, potentially leading to new cancer treatments.
Researchers at RIKEN Center for Developmental Biology identified Nedd4 as a key player in protecting the Notch receptor from activation. The study found that Nedd4 works as an antagonist of Notch signaling, suppressing its activity and preventing molecular loose cannons from fouling the precisely ordered workplan.
The Notch molecule is found to be crucial for kidney development, particularly in the formation of podocytes. The study reveals that Notch signaling tells some cells to become podocytes from non-specialized epithelial cells. After a certain amount of time without Notch signaling, cells can recover and form podocytes again.
Researchers identify Notch signaling pathway involved in switching from brain cell growth to stability, which could lead to new treatments for neurological disorders. The study provides a clue on how the transition from growth to stability occurs in the brain.
The Notch signaling pathway is a key regulator controlling the proper development of many different cell types. In mice without Jagged2, there is a significant increase in hair cell density and a decrease in supporting cells.
Research at The Jackson Laboratory reveals the Lunatic fringe gene's essential role in regulating somite formation during embryonic development. Notch signaling pathway disruption leads to segmental body plan implementation challenges in mammals and other organisms.