Articles tagged with Planar Cell Polarity Pathway
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Researchers found that defects in the planar cell polarity pathway play a significant role in the pathogenesis of yellow nail syndrome (YNS). The study identified the CELSR1 gene as a principal candidate disease-causing gene with autosomal recessive inheritance.
Scientists at the University of California San Diego have discovered that planar cell polarity is a widely used mechanism for forming and maintaining glutamatergic synapses. The study found that Prickle protein plays a crucial role in stabilizing these synapses, which are essential for neuronal communication.
Researchers at UC San Diego have discovered the main components driving amyloid beta-associated synapse degeneration in Alzheimer's disease. They found that blocking a toxic signaling pathway can protect synapses and preserve cognitive function, offering a potential therapeutic agent.
Researchers identified how Wnt proteins orchestrate cell communication and patterning of body axis, revealing the role of Vangl2 in regulating cytoneme formation. Long and branched cytonemes reinforce distant Wnt signalling, leading to altered body axis patterning.
Researchers at HKUST have discovered a new mechanism that regulates planar cell polarity, a process crucial for development and organ function. The study reveals a critical protein interaction that enables efficient delivery of PCP proteins to the cell surface, offering a potential therapeutic strategy for cancer treatment.
Researchers have discovered how polarized cells coordinate heart tube remodelling through tissue-scale polarisation of actomyosin activity. A disrupted PCP signalling pathway alters cytoskeleton structure, leading to impaired heart formation and most congenital heart diseases.
Researchers at UC San Diego discovered that Wnt proteins stimulate planar cell polarity signaling in growth cones, guiding nerves to their proper targets. This finding provides critical understanding of brain wiring mechanisms and may pave the way for nervous system repair and regeneration.