Researchers discover hemoglobin's novel function as a nitrite reductase, generating nitric oxide to regulate vasodilation. Separate studies reveal that M cells are not necessary for oral tolerance induction, while bacterial infections can break B cell tolerance by activating self-reactive B cells.
SourceJCI Journals·JournalJournal of Clinical Investigation·DateJul 21, 2005
A new imaging technique reveals the presence of a previously unknown organelle called a retinosome, which houses retinyl esters essential to the regeneration process. The discovery could lead to better understanding and treatment of congenital blindness caused by defects in the retinoid cycle.
SourceUniversity of Washington·JournalJournal of Cell Biology·DateFeb 17, 2004
Researchers found elevated levels of ceramides and cholesterol esters in spinal cords of people with ALS, leading to motor neuron degeneration. Treating these lipids with a drug called ISP-1 may prevent this process.
SourceNIH/National Institute on Aging·JournalAnnals of Neurology·DateAug 21, 2002
A multicenter study published in the American Journal of Cardiology found that adding Benecol spread to a patient's diet can lower LDL-C and total cholesterol levels by 17% and 12%, respectively. The study also showed that the cholesterol-lowering effect of Benecol was evident as early as the second week of treatment.
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The NTP Center for the Evaluation of Risks to Human Reproduction will convene an Expert Panel to review seven phthalate esters. The meeting aims to complete integrated evaluation documents and draft summary statements on the chemicals' developmental and reproductive toxicity.
SourceNIH/National Institute of Environmental Health Sciences·DateNov 8, 1999
The NIH is evaluating seven widely used plasticizers for their potential reproductive and developmental effects. A panel of scientific experts will meet to assess the chemicals' impact on human health.
SourceNIH/National Institute of Environmental Health Sciences·DateAug 11, 1999
Researchers at the University of Maryland have developed a new method to detect chemical weapons by reacting with specific phosphate esters. The system uses molecules that selectively detect even small amounts of lethal phosphate esters, reducing false positives from benign chemicals like pesticides.
SourceAmerican Chemical Society·JournalJournal of the American Chemical Society·DateDec 1, 1998
Researchers identified Munc13-1 as a novel diacylglycerol target that regulates neurotransmitter release from nerve cells. This study reveals a new mechanism for neurotransmitter release beyond the well-known role of Protein Kinase C.
SourceMax-Planck-Gesellschaft·JournalNeuron·DateJul 27, 1998