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JCI table of contents August 1, 2005

Researchers discover hemoglobin's novel function as a nitrite reductase, generating nitric oxide to regulate vasodilation. Separate studies reveal that M cells are not necessary for oral tolerance induction, while bacterial infections can break B cell tolerance by activating self-reactive B cells.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateJul 21, 2005

Imaging technique reveals new structure in retinal cells

A new imaging technique reveals the presence of a previously unknown organelle called a retinosome, which houses retinyl esters essential to the regeneration process. The discovery could lead to better understanding and treatment of congenital blindness caused by defects in the retinoid cycle.

SourceUniversity of Washington·JournalJournal of Cell Biology·DateFeb 17, 2004

Lipid abnormalities linked to Lou Gehrig’s disease

Researchers found elevated levels of ceramides and cholesterol esters in spinal cords of people with ALS, leading to motor neuron degeneration. Treating these lipids with a drug called ISP-1 may prevent this process.

SourceNIH/National Institute on Aging·JournalAnnals of Neurology·DateAug 21, 2002
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You Could Even Say It Glows

Researchers at the University of Maryland have developed a new method to detect chemical weapons by reacting with specific phosphate esters. The system uses molecules that selectively detect even small amounts of lethal phosphate esters, reducing false positives from benign chemicals like pesticides.

SourceAmerican Chemical Society·JournalJournal of the American Chemical Society·DateDec 1, 1998