Articles tagged with Glucose
A recent study found that junk food diets can cause significant damage to the kidneys, similar to type 2 diabetes. The research used animal models and found that certain glucose transporters were present in higher numbers in rats with type 2 diabetes, but also increased after consuming high-fat or junk food diets.
A study from the Monell Center found that gut enzymes sucrase and maltase are also expressed in sweet taste cells on the tongue, breaking down complex sugars into glucose and fructose. This discovery may lead to the development of non-caloric sweeteners with a better sweet taste.
A Mayo Clinic study found that metformin does not limit the action of hormone glucagon, which may mitigate its ability to lower glucose production in the liver. The researchers discovered a compensatory increase of glucagon in prediabetic individuals taking metformin.
Researchers in China created a portable and high-performance device to detect glucose levels using fiber optic biosensors integrated with microfluidic chips. The device can detect glucose concentrations as low as 1 nM, making it an appealing technology for early diagnosis of diabetes via monitoring glucose content within sweat.
A team of Danish investigators manipulated the metabolic properties of yogurt-producing bacteria to create a sweeter, less-sweetened yogurt. They achieved this by modifying the bacteria to consume galactose instead of glucose, resulting in a product with reduced lactose and increased natural sweetness.
Salk researchers have found a hidden energy switch that powers up pancreatic cells to respond to glucose, enabling the production of functional human beta cells. The breakthrough could lead to a viable treatment for type 1 and 2 diabetes.
Researchers developed a new Liver-on-Chip device with glucose and lactate micro-sensors to track metabolic function in real-time, enabling detection of chemical toxicity before cellular damage. The technology has the potential to redefine studies on neurodegenerative diseases, cancer, and drug discovery.
Whey protein diet participants lost the most weight and experienced reduced hunger and glucose spikes compared to other diets. The study found that a high-protein breakfast containing whey protein induced greater satiety and reduction of glucose spikes after meals.
Researchers at Washington University in St. Louis discovered that cancer cells can synthesize lipids from non-glucose sources, contradicting the long-held glucose hypothesis. This finding raises questions about diagnostic methods and treatment strategies for cancer.
Scientists have repurposed portable glucose monitors to detect diseases using enzymes and liposomes. The method accurately detects thrombin levels, corresponding to restricted blood flow or heart disease. This approach could be used to detect other disease-associated proteins.
A study published in JACC found that drinking a high-carbohydrate shake can lower atrial natriuretic peptide (ANP) levels, which help regulate salt retention and blood pressure. Researchers discovered that glucose intake is the main driver behind this effect, mediated by the molecule miR-425.
Researchers found that replacing saturated fat with polyunsaturated fat slows diabetes progression in people with prediabetes whose muscles do not take up glucose properly. In contrast, reducing saturated fat had no effect on progress for those with liver-produced excess glucose.
Researchers at IBS created a wearable GP-based patch that allows accurate diabetes monitoring and feedback therapy using human sweat. The device enables systematic corrections of sweat glucose measurements by monitoring pH and temperature, reducing the need for painful treatments like insulin shots.
Scientists at Johns Hopkins Medicine discovered a new type of nerve cell that controls feeding behaviors in mice by signaling satiety. The discovery, confirmed through experiments, may lead to new tools for fighting obesity if replicated in humans.
A study of over 30,000 women found that genetically elevated maternal body mass index and blood glucose levels are associated with higher offspring birth weight. In contrast, elevated maternal systolic blood pressure is linked to lower birth weight.
A study published in Nature Medicine found that fuel-starved light receptors contribute to the development of age-related macular degeneration. The researchers discovered that photoreceptors need lipids, not just glucose, to function properly and that blocking a specific receptor can prevent abnormal vessel growth.
Researchers found that individuals with more brown fat had smaller fluctuations in blood sugar levels. Brown fat may act as a 'glucose buffer', lessening the variation in blood glucose and potentially diminishing metabolic stresses that could increase the risk of diabetes.
Researchers discovered that human brown fat cells show circadian fluctuations in glucose consumption, which may act as a glucose buffer and lessen the stress on the pancreas. Individuals with high brown fat abundance showed less variability in glucose levels over time.
A recent study by MIT biologists found that cancer cells use amino acids to build new cell mass, contradicting the long-held assumption that glucose is the primary source. The largest contributors to cell mass were amino acids, making up 20-40% of total mass.
Researchers at the University of Utah are developing a 'smart' insulin that can automatically lower blood sugar levels after consumption. The grant-funded project aims to create an insulin that deactivates when blood glucose drops below a certain level, reducing the risk of serious health threats associated with improper dosing.
A multinational trial found that injecting a new long-acting insulin with another drug, IDegLira, improved glucose control in Type 2 diabetes patients. Participants on the combination product lost weight and experienced fewer episodes of hypoglycemia compared to those receiving basal insulin alone.
A study published in The Journal of Experimental Medicine found that hyper-aggressive immune cells that consume glucose may drive the development of coronary artery disease. Blocking this glucose overconsumption prevented inflammation and atherosclerosis, suggesting new therapeutic interventions to prevent heart attacks.
Researchers found that mitochondria in brain cells rapidly change shape and function in response to high blood sugar levels, affecting peripheral tissue functions. The study suggests that alterations in this mechanism may be crucial for type 2 diabetes development.
A study of 399 participants found an association between higher mindfulness scores and healthier glucose levels. The researchers identified obesity risk and sense of control as potential mediators of this link, with mindful individuals being less likely to be obese and more likely to believe they can change their lives.
The study found that pregnant mice exposed to a high fructose diet developed higher peak glucose, insulin resistance, and obesity in their offspring. Female offspring were also heavier and had more visceral adipose tissue, indicating a potential link between maternal diet during pregnancy and childhood health.
Research published in Diabetologia reveals that each extra hour of daily sedentary time is associated with a 22% increased risk of developing type 2 diabetes. Participants with type 2 diabetes spent more time sedentary, highlighting the importance of reducing sedentary behavior in diabetes prevention.
The Stanford-Berkeley device is a noninvasive, wearable technology that analyzes sweat composition for continuous health monitoring. It provides insight into an individual's physiological state at molecular levels, allowing for real-time alerts on fatigue, dehydration, and other health problems.
The article discusses the development and future promise of Continuous Glucose Monitoring (CGM) technology, which combines CGM with an insulin pump and sophisticated algorithms for automating insulin control. Key challenges facing successful commercialization include cost, reimbursement issues, and lack of FDA approval for insulin dosing.
Scientists at the University of Montreal Hospital Research Centre have discovered an enzyme that can stop the toxic effects of sugar in various organs. The enzyme, glycerol 3-phosphate phosphatase (G3PP), plays a central role in controlling glucose and fat utilization and has been shown to detoxify excess sugar from cells.
VIB researchers identify PHD1 as a potential therapeutic target for treating brain infarction and ischemic stroke. Inhibition of PHD1 offers protection against stroke via an unexpected mechanism, reprogramming glucose utilization to detoxify toxic oxygen radicals.
Researchers at the University of Leicester have discovered that high blood sugar levels can cause blood vessels to contract more strongly, leading to higher blood pressure and potentially life-threatening complications. The study provides a potential therapeutic target for improving outcomes following a heart attack or stroke.
A workplace intervention program significantly reduced fasting blood sugar levels and led to greater weight loss compared to a control group. Participants who attended more group discussion sessions and monitored their food and physical activity lost more weight.
Researchers at MIT have developed a stretchy hydrogel material that can incorporate temperature sensors, LED lights, and drug-delivering reservoirs. The hydrogel can sense changes in skin temperature and release medicine as needed, making it a potential treatment for burns or other skin conditions.
Researchers have identified two coffee compounds, cafestol and caffeic acid, that contribute to the health benefit of drinking three to four cups of coffee per day in preventing type 2 diabetes. Cafestol increases insulin secretion and glucose uptake in muscle cells, matching the effects of a currently prescribed antidiabetic drug.
A new study published in The FASEB Journal suggests that low doses of abscisic acid can reduce glycemia and insulinemia in both rats and humans. This finding has implications for developing new pharmacologic approaches to prevent or treat diabetes.
A recent study monitored 800 participants' blood sugar levels in response to over 46,000 meals, revealing highly individual responses to different foods. The researchers developed an algorithm predicting individualized responses based on lifestyle and microbiome analysis, which was successfully applied to new participants.
A new study published in Cell Press found that the glycemic index of foods varies significantly between individuals, contradicting traditional dietary recommendations. The research, led by Eran Segal and Eran Elinav, used a large cohort of participants to demonstrate the power of personalized nutrition in managing blood sugar levels an...
Researchers analyzed competitors before the Ultraman competition and found that body fat percentage dropped significantly, but weight remained unchanged due to fluid retention. The study also revealed signs of muscle damage, elevated cortisol levels, and reduced insulin sensitivity.
The new system monitors five substances, including glucose and lactate, and can detect up to 40 molecules in real time. This reduces the need for invasive monitoring devices, providing a practical advantage for medical staff and loved ones.
Researchers have found a way to accurately screen for dehydration in older adults using routine blood tests for sodium, potassium, urea, and glucose. A simple mathematical equation can tell whether an older person is drinking enough fluid, reducing the risk of poor health outcomes such as disability and death.
A new synthesis method for glucosepane, a molecule implicated in diseases such as diabetes, has been developed by researchers. This breakthrough allows for the production of glucosepane's various forms, which may help uncover its role in health complications and potential countermeasures.
A new study found that elevated blood sugar levels in pregnancy are linked to an increased risk of congenital heart defects, including tetralogy of Fallot and dextrotransposition of the great arteries. High glucose levels were correlated with an increased risk of tetralogy of Fallot, but not dextrotransposition of the great arteries.
A team of researchers at the University of Virginia Health System is exploring the link between glucose metabolism and heart function. They aim to identify a therapeutic window where intervention can prevent cardiac dysfunction and subsequent heart failure.
Researchers found that people with a common genetic variant in MTNR1B may be more at risk for developing type 2 diabetes when taking melatonin close to mealtimes. The study suggests that genetics can impact blood sugar control, highlighting the need for caution when taking melatonin near meal times.
The Hong Kong Polytechnic University has developed a novel eco-friendly manganese dioxide ink for energy storage devices, which exhibits high capacity and power density. The MnO2 ink can be used to produce light, thin, flexible energy storage devices with improved performance and lower production cost.
A University of Iowa study reveals that disabling a critical biological checkpoint, Mitochondrial Pyruvate Carrier (MPC), reduces blood sugar levels in mouse models of type 2 diabetes. The research suggests that inhibiting MPC activity could be a new target for drugs to treat diabetes.
Researchers found that blocking glycolysis makes cancer cells more susceptible to death by starvation, potentially enhancing the effectiveness of taxol. This breakthrough could lead to new therapies against various cancers.
A recent study suggests that early transient newborn hypoglycemia may be associated with lower fourth-grade achievement test scores. The research, published in JAMA Pediatrics, found that newborns who experienced low blood sugar levels had decreased literacy and mathematics proficiency rates at age 10.
Studies have shown that an increase in muscle mass can lead to improved glucose metabolism and blood vessel dilation, even in obese mice. The researchers are now exploring the role of galectin-3 and Nox1 in this process to identify potential targets for intervention.
Researchers at Florida State University have uncovered a previously unknown activation mechanism for the glucokinase enzyme, which plays a crucial role in glucose regulation. This discovery sheds new light on how the enzyme's functional properties manifest in disease, including hyperinsulinemia and diabetes.
A high-protein breakfast containing 35 grams of protein prevented gains of body fat and stabilized glucose levels among overweight teens who skipped breakfast. Eating a high-protein breakfast also led to reduced daily food intake and improved feelings of hunger.
A new study reveals that skipping breakfast triggers major blood sugar spikes and impairs insulin responses in type-2 diabetics throughout the day. The researchers found that fasting until noon causes extraordinary glucose peaks after lunch and dinner, highlighting the importance of not skipping meals for diabetics.
A study published in JAMA Neurology found insulin resistance associated with reduced global and regional brain glucose metabolism in late middle-age adults at risk for Alzheimer's disease. Lower glucose metabolism was linked to poorer performance in immediate memory tasks.
Scientists at the University of Southampton have developed a molecule that acts as an exercise mimic, reducing fasting blood glucose levels and promoting weight loss in obese mice. The new compound 14 inhibits a cellular enzyme involved in metabolism, leading to improved glucose tolerance and reduced body weight.
A new approach to visualize glucose uptake activity in single living cells has been developed by Columbia University researchers. This technique uses stimulated Raman scattering imaging with a small alkyne tag to generate a strong Raman signal, allowing for high-sensitivity imaging of glucose uptake at the cellular level.
Researchers found that glucose and acetate can activate key tumor signaling molecule mTORC2, allowing tumors to resist targeted therapies like EGFR inhibitors. This discovery provides a potential window into treating glioblastoma, a deadly brain cancer with limited treatment options.
A gene mutation called ankyrin-B has been found to cause cells to absorb glucose faster, leading to fat storage and type 2 diabetes. The mutations are common among certain populations, including African Americans and Caucasians, and may provide a genetic link to modern diet-related diseases.
Scientists designed a new biochemical pathway in E. coli that can efficiently produce isobutyl acetate from both glucose and acetate, increasing its yield to 75 percent. This breakthrough could have significant applications in biotechnology, particularly in the production of flavoring agents, solvents, and fuels.
A study by University of Basel researchers found that fructose stimulates the reward system in the brain to a lesser degree than glucose, leading to increased satiety hormone levels and reduced feelings of fullness. This may contribute to the development of various disorders such as obesity, diabetes, and fatty liver disease.
Researchers at UT Southwestern Medical Center have identified a key enzyme, Protein Kinase C (PKC), that regulates glucose transport into cells. This process is critical for maintaining proper glucose levels, which are often abnormal in diseases such as diabetes and cancer. The findings may lead to new treatments for these conditions.