Articles tagged with Glucose
A study published in JAMA Neurology found insulin resistance associated with reduced global and regional brain glucose metabolism in late middle-age adults at risk for Alzheimer's disease. Lower glucose metabolism was linked to poorer performance in immediate memory tasks.
A new approach to visualize glucose uptake activity in single living cells has been developed by Columbia University researchers. This technique uses stimulated Raman scattering imaging with a small alkyne tag to generate a strong Raman signal, allowing for high-sensitivity imaging of glucose uptake at the cellular level.
A gene mutation called ankyrin-B has been found to cause cells to absorb glucose faster, leading to fat storage and type 2 diabetes. The mutations are common among certain populations, including African Americans and Caucasians, and may provide a genetic link to modern diet-related diseases.
Researchers found that glucose and acetate can activate key tumor signaling molecule mTORC2, allowing tumors to resist targeted therapies like EGFR inhibitors. This discovery provides a potential window into treating glioblastoma, a deadly brain cancer with limited treatment options.
Scientists designed a new biochemical pathway in E. coli that can efficiently produce isobutyl acetate from both glucose and acetate, increasing its yield to 75 percent. This breakthrough could have significant applications in biotechnology, particularly in the production of flavoring agents, solvents, and fuels.
A study by University of Basel researchers found that fructose stimulates the reward system in the brain to a lesser degree than glucose, leading to increased satiety hormone levels and reduced feelings of fullness. This may contribute to the development of various disorders such as obesity, diabetes, and fatty liver disease.
Researchers at UT Southwestern Medical Center have identified a key enzyme, Protein Kinase C (PKC), that regulates glucose transport into cells. This process is critical for maintaining proper glucose levels, which are often abnormal in diseases such as diabetes and cancer. The findings may lead to new treatments for these conditions.
Studies by Scripps Whittier Diabetes Institute found that poorly controlled blood sugar levels result in significantly longer and more expensive hospital stays. Care teams focused on managing diabetes during hospitalization can improve patient outcomes and reduce costs.
In silico experiments show that more accurate continuous glucose monitoring (CGM) systems can detect dangerously low blood sugar and reduce the frequency of hypoglycemic episodes. The technology improves glycemic control by providing more precise measurements, enabling better decision-making for individuals with diabetes.
A recent study at Beckman Institute for Advanced Science and Technology found that fructose causes significant weight gain, physical inactivity and body fat deposition when matched calorie for calorie with glucose. Fructose-fed mice displayed increased body weight, liver mass and fat mass compared to glucose-fed mice.
Researchers at EPFL have developed a chip placed under the skin that can detect multiple molecules, including glucose, lactate, cholesterol, and drugs, using induction-powered biosensors. The device has been successfully tested on mice with promising results, paving the way for clinical trials in humans within three to five years.
A new study by Ohio State University researchers suggests that skipping meals can lead to insulin resistance and increased abdominal fat gain in mice. Mice on restricted diets who fasted for extended periods developed metabolic issues, including inflammation and plumper fat cells, compared to those who ate regularly.
Researchers discovered that Escherichia coli bacteria can cooperatively share resources by breaking down glucose into acetate and exchanging it with other cells. This behavior emerged spontaneously in simulated colonies as oxygen levels decreased, allowing cells to adapt and thrive.
Researchers found that elevated blood sugar can rapidly increase amyloid beta levels in the brain, contributing to Alzheimer's disease. The study suggests a new connection between diabetes and Alzheimer's, providing a potential therapeutic target for treatment.
Researchers found that eating more protein at breakfast lowered post-meal glucose levels and prompted cells to increase insulin concentrations at the second meal. Consuming 25-30 grams of protein at breakfast may be beneficial for individuals with type 2 diabetes, according to Jill Kanaley.
Neurons, not astrocytes, consume glucose and produce lactate in the brain, according to a groundbreaking study published in Nature Communications. This discovery has significant implications for understanding neurological disorders, such as Alzheimer's and stroke.
Continuous glucose monitoring may help pregnant women with diabetes give birth to healthier children by detecting changes in glucose levels throughout the day. The study found that this technology can reveal distinct patterns of glucose associated with large-for-gestational-age infants.
A recent study by Virginia Tech researchers found that the body's muscle begins to process nutrients differently after just five days of a high-fat diet. This change can have dire consequences on the rest of the body and may lead to the development of diabetes and other diseases.
Researchers at Columbia University Irving Medical Center have found a defect in pancreatic cells that can lead to high blood sugar levels and impaired glucose balance. An experimental drug called Rycal has been shown to stop the leaky channels and normalize glucose levels in mouse models.
A study published in American Journal of Clinical Nutrition found that egg consumption was associated with a lower risk of type 2 diabetes. Men who ate four eggs per week had a 37% lower risk compared to those who ate one egg per week.
Researchers found that patients with stage I non-small cell lung cancer (NSCLC) and low tumor metabolic activity have increased overall survival. A diagnostic test using fluorodeoxyglucose positron emission tomography (FDG/PET) can help identify patients who may benefit from post-surgical chemotherapy.
Researchers have discovered a new class of potentially therapeutic lipids, FAHFAs, which are found at lower levels in people with insulin resistance. Administering FAHFAs to diabetic mice improved glucose metabolism and insulin secretion, suggesting a potential avenue for developing novel medications.
A new study suggests that eating a high-caloric breakfast and a more modest dinner can significantly reduce post-meal glucose surges and improve glycemic control in type-2 diabetics. By consuming a larger meal at breakfast and a smaller meal at dinner, participants experienced lower blood glucose levels and increased insulin sensitivity.
Engineers at Oregon State University have developed an improved type of glucose sensor for patients with Type 1diabetes, utilizing electrohydrodynamic jet printing. The new system is more precise, less intrusive, and cost-effective, with the potential to improve diabetes management and treatment.
Researchers found that young mice don't possess cellular machinery for regeneration after weaning, leading to reduced insulin secretion and replication of beta cells. A new developmental step in beta cell maturation is triggered by dietary change from high-fat milk to chow.
Scientists at MD Anderson Cancer Center discovered a vital connection between the Hippo pathway and glucose metabolism, which can be manipulated to regulate tumor growth. The study found that regulating blood sugar levels impacts the nutrient source of tumors, ultimately leading to cancer suppression.
A recent study found that quitting smoking has favorable metabolic effects, with reduced central fat distribution and improved hepatic glucose output. The study also showed a correlation between weight loss and increased glucose uptake and utilization of carbohydrate substrates.
A study from UT Southwestern Medical Center found that a single elevated random blood glucose value is a strong risk factor for diabetes. Individuals with values above 100 mg/dL were up to 30 times more likely to have undiagnosed diabetes, highlighting the importance of considering these often-overlooked values.
A new study published in Diabetologia found that statin use is associated with a 46% increased risk of developing type 2 diabetes. After adjusting for confounding factors, researchers discovered that statins decrease both insulin sensitivity and secretion, leading to an increased risk of diabetes.
A comprehensive health program with personalized coaching on exercise, nutrition, stress, and sleep helped people with prediabetes reverse their condition and improve overall health. Participants showed significant improvements in blood glucose levels, blood pressure, and other key risk factors.
Researchers developed bio-inks that react with chemicals, allowing the creation of reusable glucose sensors on skin and leaves. The pens can also detect pollutants and hazardous materials, enabling potential applications in healthcare, environmental monitoring, and security. Future steps include connecting sensors wirelessly to monitor...
Researchers found that habitual breakfast skippers had poorer glucose control after consuming a high-protein breakfast, while those who typically ate breakfast experienced improved glucose control. The study suggests that young women should gradually increase protein intake in the morning to improve glycemic control.
A new study published in Diabetologia shows that eating a high energy breakfast and a low energy dinner improves blood sugar control for individuals with type 2 diabetes. The study found significant reductions in post-meal glucose levels and insulin levels when participants followed the high-energy breakfast and low-energy dinner diet.
Patients undergoing duodenal switch experienced greater weight loss and improvements in blood lipids, but also faced higher rates of nutritional complications. In contrast, gastric bypass resulted in better health-related quality of life for patients with severe obesity.
The study identified 35 genetic factors associated with motion sickness, including those affecting balance, eye, ear, and cranial development, as well as glucose homeostasis. The findings suggest a role for the nervous system in motion sickness and may provide insight into other nausea-related conditions.
A study of 100 women with gestational diabetes found that a probiotic capsule intervention had no effect on glucose control, but did reduce total and LDL cholesterol levels. This suggests a potential role for probiotics in improving the metabolic profile of pregnant women at risk of future cardiovascular disease.
Researchers found that maternal glycemia is associated with some childhood anthropometric measures of obesity, such as skinfolds and subscapular/triceps ratio, but not body mass index or insulin resistance. Maternal obesity and Hispanic ethnicity were strongly linked to childhood obesity and metabolic dysfunction.
Researchers at Cornell University engineered a probiotic to secrete GLP-1, reducing high blood glucose by up to 30% in diabetic rats. The treatment mimics the function of pancreatic beta cells, shifting glucose control from the pancreas to the upper intestine.
A study published in Molecular Metabolism found that adropin, a hormone regulating fat and sugar metabolism during feeding and fasting cycles, can improve insulin action in obese mice. This suggests that it may work as a therapy for type 2 diabetes.
A temporary tattoo has been developed to extract and measure glucose levels in the fluid between skin cells, offering a promising step forward in noninvasive glucose testing. The device, which uses a flexible sensor, can detect glucose spikes after meals with high accuracy.
Scientists have developed an ultra-thin, flexible device that sticks to skin like a rub-on tattoo and can detect glucose levels. The device has the potential to eliminate finger-pricking for people with diabetes, eliminating a major pain point in managing the disease.
A new study reveals that fructose-glucose mixtures in high-fructose corn syrup are more toxic to female mice than sucrose, reducing reproduction and lifespan. In contrast, male mice showed no significant differences between the two diets.
A study of over 4,000 non-diabetic Mexican-Americans reveals shared and distinct genetic contributions to insulin signaling and glucose response. The findings identify potential novel genetic risk factors for type 2 diabetes, highlighting the complexity of the disease.
A study using fMRI found that fructose triggers greater activation in the nucleus accumbens and higher ratings of hunger compared to glucose, suggesting it may promote overeating. The findings have important public health implications for a society with high-sugar foods and tempting stimuli.
Activation of glucokinase in the arcuate nucleus of rodents increased food intake and body mass, as well as preference for glucose. Inhibition of glucokinase decreased food consumption and glucose intake, indicating that glucokinase dysfunction may underlie glucose cravings.
A team at Imperial College London identified a brain mechanism that senses glucose levels and prompts animals to seek more if it detects a shortfall. The researchers believe this mechanism may play a role in humans' preference for sweet and starchy foods.
EPFL scientists have found that replacing glucose with starch from rice can reduce the toxicity of the cholera bacterium, Vibrio cholerae, and may lead to a 30% reduction in cholera cases. Oral rehydration therapy using rice starch could significantly improve treatment outcomes.
Researchers are investigating a protein that may be key to disabling endothelial dysfunction, a major risk factor for vascular disease in diabetes. By blocking PTP1B expression, the study aims to improve nitric oxide production and reduce inflammation, potentially leading to more effective treatments for diabetes-related complications.
A recent study published in PNAS shows that young capillary vessels can rejuvenate aged pancreatic islets, suggesting a new way to treat age-dependent dysregulation of blood glucose levels. By replacing the islet vasculature with young capillaries, glucose homeostasis was fully restored.
A newly discovered signaling pathway in brown fat cells stimulates glucose uptake, potentially treating type 2 diabetes. The mTORC2 pathway, involving protein kinase mTOR, enhances GLUT1 transport to the surface of brown fat cells.
Researchers at Indiana University School of Medicine have identified Sestrin 3 as a critical regulator of glucose homeostasis and insulin sensitivity in the liver. Mice with the protein showed improved glucose tolerance, while those without it exhibited impaired glucose metabolism.
A new study led by Beth Israel Deaconess Medical Center found that fructose ingestion increases blood levels of the hormone FGF21, providing a reliable predictor for altered fructose metabolism. This discovery offers an avenue for further investigation into genetic and environmental determinants of metabolic response to fructose.
A new gene, Tpcn2, has been discovered as a key player in the development of diabetes. Variants in this gene have been associated with fasting glucose levels and insulin response in animal models, as well as human populations.
A new study found that rosuvastatin is more effective in reducing low-density lipoprotein subfractions in prediabetic patients than those with normal glucose levels. The medication led to a greater decrease in small dense lipoproteins, considered particularly harmful.
Researchers found that artificial sweeteners can induce glucose intolerance by changing the composition and function of the gut microbiota. The study used mice and human data to show that certain bacteria in the gut react to artificial sweeteners, leading to inflammation and metabolic changes.
Researchers found that excess glucose enters cells via inflammatory pathways, sparking escalating inflammation and damaging blood vessels. Lifestyle changes like exercise and weight reduction can reduce both blood sugar and inflammation.
A study by Harvard University scientists has identified a non-toxic way to target leukemia cells' metabolism without harming normal cells. This breakthrough could lead to new treatments for leukemia patients.
Researchers developed a new continuous glucose monitoring material that changes color as glucose levels fluctuate, offering higher sensitivity and precision than current point measurements. The color-changing material is simple, low-cost to manufacture, and can be used for short-term monitoring of patients in intensive care units.
New research finds children exposed to gestational diabetes are at increased risk of developing impaired glucose tolerance and type 2 diabetes. The study suggests a growing number of women with gestational diabetes will lead to an alarming rise in early childhood diabetes, emphasizing the need for preventive measures.
A new study led by Northwestern University anthropologists reveals that energy is funneled to the brain early in life, dominating metabolism and leading to slow body growth during childhood. The study finds that brain development peaks at age 5, when it consumes glucose at a rate comparable to 66% of the body's resting metabolic rate.