Articles tagged with Glucose
Researchers have discovered a compound that attacks cancer cells by depriving them of glucose, a process found in most rapidly dividing cells. The team tested the compound on kidney cancer cells and found it nearly halved glucose uptake and slowed tumor growth, with minimal side effects.
Research found no clear picture on risk of death and cardiovascular disease with intense vs conventional glucose control. Lower intensity levels may reduce small vessel damage, but increased risk of low blood sugar and death with more intensive control.
A recent study found that consuming high fructose corn syrup increases cholesterol and triglycerides, key indicators of heart disease risk. The study suggests the current upper limit of sugar consumption may need re-evaluation.
A study published in PLOS Biology found that a defect in brain glucose sensing contributes to obesity, while correction of this defect can treat the condition. The researchers discovered a novel role for hypoxia-inducible factor (HIF) in hypothalamic glucose sensing and whole-body energy balance regulation.
Researchers at the University of Illinois have developed a method to use glucose meters for detecting multiple targets in various samples. Functional DNA sensors enable the detection of vital metabolites, contaminants, and disease markers in a simple, low-cost, and portable manner.
A major international study reveals that the number of adults with diabetes has reached 347 million, more than double the number in 1980. The prevalence of diabetes has risen or remained unchanged in virtually every part of the world over the last three decades.
A new study found that diabetes prevalence has increased globally over the past three decades, with 350 million adults affected. The study also showed that high-income countries such as the USA and Western Europe have higher rates of diabetes than other regions.
New basal insulin analogs have improved diabetes management by reducing hypoglycemic episodes and improving blood glucose levels in type 2 diabetes patients. Modern physiological basal insulin replacement has made optimal blood sugar control a realistic target for diabetes management.
Researchers at Baylor College of Medicine found that a natural product called DLPC stimulates LRH-1 activity, improving regulation of glucose and fat within the liver. In mice with insulin resistance, DLPC decreased fatty livers and lowered glucose levels, suggesting it may provide a treatment for prediabetes.
Researchers at Salk Institute discover a unique fasting pathway that turns up glucose production in the liver when blood sugar levels drop, providing a novel way to treat metabolic disease. Inhibiting histone deacetylases (HDACs) may help regulate blood glucose levels and prevent type II diabetes.
A systematic review and meta-analysis found that structured exercise training, including aerobic and resistance exercises, significantly reduces hemoglobin A1c levels in patients with type 2 diabetes. Longer weekly exercise duration is also linked to greater HbA1c decreases.
Researchers at Mount Sinai School of Medicine found that patients with Alzheimer's disease have lower glucose utilization in the brain, detectable approximately 20 years prior to symptoms. The study suggests that novel therapies could prevent the onset of Alzheimer's by addressing mitochondrial impairment.
Researchers found sitagliptin effective in preventing prediabetes from progressing to diabetes. The drug reduced glucose levels after meals and increased insulin output while decreasing glucagon levels.
A new ultra-long-acting form of insulin, degludec, has shown improved glucose control when administered just three times a week, compared to daily injections. This reduces the risk of hypoglycaemia and improves patient adherence.
A new study reveals that taste cells have several additional sugar detectors beyond the previously known sweet receptor, indicating a complex mechanism for detecting sugars. The presence of these sensors may help regulate sensitivity to sweet taste under different nutritional conditions.
Researchers at the University of Pennsylvania School of Medicine found that protein p53 controls glucose metabolism, enabling cells to grow uncontrollably in tumors. This discovery may lead to new cancer therapeutics by targeting an inefficient metabolic pathway.
Scientists at Indiana University School of Medicine have identified the source of excessive phosphate buildup in glycogen, a chain-like molecule used to store energy. This finding sheds light on a possible route to treatment for Lafora disease, a rare and deadly condition caused by genetic mutation.
A study of elderly patients found a strong association between undiagnosed high blood glucose and increased hospital death rates. Researchers now recommend routine blood glucose testing on admission to prevent unnecessary deaths.
Researchers found increased brain glucose metabolism in regions closest to the phone antenna after 50-minute cell phone use. However, the clinical significance of this finding is unclear and further studies are needed.
A study identified blood glucose levels that predict the 10-year risk of retinopathy. Individuals with higher fasting plasma glucose and HbA1c levels were more likely to develop eye-related complications.
Researchers at Joslin Diabetes Center have found a molecular pathway that is activated in people with insulin resistance and type 2 diabetes. This pathway holds promise as a target for novel diabetes therapies, offering new hope for patients with the disease.
New research at OHSU finds that the brain responds differently to fructose and glucose, with fructose inhibiting activity in cortical brain control areas. This study supports animal research and links fructose to obesity, suggesting a potential explanation for the nation's growing obesity epidemic.
UT Southwestern researchers found that eliminating glucagon action can restore glucose tolerance to normal in mice with type 1 diabetes. This suggests a potential 'cure' for the disease, as insulin would no longer be necessary.
A newly engineered yeast strain can simultaneously consume glucose and xylose, reducing inefficiencies in current biofuel production methods. The new strain produces more ethanol and consumes less time than existing strains, making it a significant breakthrough in cellulosic biofuel production.
Researchers found that drinking sweetened lemonade boosted glucose levels, reducing aggressive behavior in college students. The study suggests a link between low glucose metabolism and increased aggression and violence, particularly among individuals with diabetes.
Researchers discovered SRC-1, a steroid receptor coactivator, plays a crucial role in regulating the liver's glucose production. The study found that mice lacking SRC-1 have impaired glucose production, leading to hypoglycemia.
Researchers have trained bacteria to efficiently convert sugars in agricultural bio-wastes into valuable chemicals for bioplastics. The optimized process enables the production of high-quality bioplastics from waste materials, reducing costs and increasing efficiency.
Australian scientists have developed a measure to assess embryo health and likelihood of successful pregnancy in IVF treatment. The research found that embryos with higher glucose uptake are healthier and more likely to result in successful pregnancies, with women's embryos consuming more glucose than men's.
Scientists have found a key protein regulating biological clocks also regulates glucose production in the liver, improving diabetic mice health. Altering this protein can open new treatments for obesity and type 2 diabetes.
Researchers at NIH used high-resolution microscopy to understand how fat cells absorb glucose in response to insulin. The findings may aid in identifying the interval when someone becomes at risk for developing type 2 diabetes.
A study by researchers at the University of Warwick has found that short sleep duration is associated with a significant increased risk of developing type 2 diabetes and heart disease. People who sleep less than six hours a night are three times more likely to develop impaired fasting glycaemia, a pre-diabetic state.
Researchers found that hormonal changes play a significant role in enabling the crabs to make their journey. The Crustacean Hyperglycaemic Hormone (CHH) enables the efficient use of stored energy and its conversion to glucose to fuel the migration.
Research found high glucose levels can form a 'sugar coating' that blocks immune receptors, increasing the risk of chronic bacterial and fungal infections in diabetes patients. This can lead to increased risks of viral infections like influenza and inflammatory conditions like cardiovascular disease.
Researchers identified a novel protein called SNARK, which plays a key role in regulating glucose transport during muscle contraction and exercise. The study shows that SNARK mediates contraction-stimulated glucose transport, providing an alternative pathway for increasing glucose uptake in individuals with insulin resistance.
A bioengineered implantable glucose sensor successfully monitored tissue glucose levels in animals for over a year, demonstrating its potential as an alternative to traditional glucose monitoring methods. The device could help people with diabetes adjust their insulin doses and reduce the risk of hypoglycemia.
A Tel Aviv University study finds that women who fail the glucose challenge test have a nearly 50% chance of developing Type II diabetes within ten years. The test's predictive power highlights the need for personalized counseling and intervention to prevent disease onset.
Researchers found a significant association between acute illness complicated with hyperglycaemia and the development of type II diabetes or glucose intolerance. Patients with hospital-acquired hyperglycaemia during critical illness are at increased risk of developing diabetes, suggesting regular monitoring is necessary.
In a study of over 10,000 adults with type 2 diabetes, intensive glucose control did not delay the progression to kidney failure, major vision loss, or advanced peripheral neuropathy. However, it reduced signs of damage, such as decreased protein leakage in urine and lower cataract surgery rates.
A national study called HEALTHY found that innovative PE programs, healthier food choices, and in-class lessons on healthy lifestyles can benefit children most at-risk for type 2 diabetes. After three years, students in intervention schools had a 21% lower rate of obesity and improved fasting insulin levels compared to comparison schools.
The DURATION-2 study found that once-weekly exenatide improved HbA1c levels by 1.5% compared to 0.9% for sitagliptin and 1.2% for pioglitazone, with significant weight loss in the exenatide group. The findings suggest that exenatide should be considered as an adjunct to metformin for improving glucose control and weight loss.
A laboratory study found that fructose makes fat cells in belly fat more mature and less responsive to insulin. The findings suggest a link between high fructose intake during childhood and increased visceral obesity, which raises cardiometabolic risk.
A University of Pennsylvania psychologist reanalyzes data suggesting that the brain does not consume extra glucose when exerting self-control, contradicting a popular model. The analysis also suggests that any potential decrease in glucose levels may be due to other factors, such as increased heart rate.
Research published in Archives of Disease in Childhood found that giving infants a small amount of sucrose or glucose before immunization significantly reduced crying and pain. Healthcare professionals are recommended to consider using these solutions as an analgesic during painful procedures.
A new study found that just one night of short sleep duration can cause significant changes in metabolic regulation, leading to impaired glucose tolerance and insulin resistance in healthy individuals. Researchers used the hyperinsulinemic euglycemic clamp method to measure insulin sensitivity before and after a night of either normal ...
Researchers found significant differences in hemoglobin A1c response to blood glucose between African-American and Caucasian children with diabetes. The study suggests that doctors may be misinformed about blood glucose levels in African-American patients, leading to life-threatening hypoglycemia and increased complications.
A new study by Duke University Medical Center scientists identifies a mechanism linking meal anticipation to Type 2 diabetes. Ankyrin-B gene mutation impairs insulin secretion, increasing blood sugar levels.
Researchers found that HbA1c levels accurately predict future diabetes and stroke, heart disease, and all-cause mortality. The study identified people with HbA1c levels between 5.0 to 5.5 percent as within the normal range, while those at a level of 6.5 percent or greater are considered diabetic.
A team of LMU researchers has created a genetically modified strain of pigs that consistently develop the essential symptoms of type 2 diabetes. The pigs' physiology is similar to humans', making them an ideal model system for studying the disease, testing new treatments and diagnostic methods.
A closed-loop 'artificial pancreas' system can improve blood sugar control in young patients with type 1 diabetes, reducing the risk of nocturnal hypoglycaemia and achieving good glucose levels. The study found that children with the artificial pancreas maintained normal blood glucose levels for 60% of the time.
Researchers at the Salk Institute have discovered that corticotropin-releasing factor (CRF) plays a part in the pancreas, increasing insulin secretion and promoting beta cell division. This finding may provide new insights into diabetes, particularly type 1, and suggest novel targets for drug intervention.
A study reveals that the absence of SIRT6 triggers a switch from cellular respiration to glycolysis, leading to increased glucose uptake and reduced mitochondrial energy production. This switch may contribute to tumor growth and provide new insights into treating type 2 diabetes.
Researchers at University of Florida have developed a tiny new sensor that can detect glucose levels in the breath and pH levels, offering a potential solution for non-invasive diagnosis and treatment. The sensor is made from widely used technology already in cell phones and other devices, making it inexpensive to produce.
Two large-scale studies found 13 new genetic variants influencing blood glucose regulation, insulin resistance, and beta cell function. Five variants increase the risk of type 2 diabetes, highlighting the role of beta cells in disease development.
A team of researchers identified ten new genetic markers associated with biological traits underlying type 2 diabetes and three new variants linked to raised glucose levels. The study helps unravel the complex biology of type 2 diabetes and paves the way for further research on treatments.
A major international study has identified 10 new gene variants associated with blood sugar or insulin levels, including two that increase type 2 diabetes risk. The study provides additional information on glucose regulation and potential therapeutic targets for the disease.
A study conducted by the University of Chicago found that obstructive sleep apnea (OSA) significantly worsens glucose control in patients with type 2 diabetes. OSA severity is associated with poorer glycemic control and increased HbA1c levels, which can negate the effects of anti-diabetic medications.
Researchers developed non-invasive technology using nanoparticles that react with glucose molecules in tears, changing color to alert users. The innovation has potential applications beyond biomedical devices, including food packaging and biodegradable materials.
Researchers at UAB have discovered that restricting glucose consumption can extend the life of healthy human-lung cells and speed the death of precancerous cells. The study found that calorie reduction aids the body's natural ability to kill off cancer-forming cells through epigenetic control of telomerase and p16 expression.
Researchers at the University of North Carolina found genetic variations that lead to less efficient glucose metabolism in African-American patients compared to whites. These findings suggest a link between diet and environment in shaping genetic predispositions to diabetes.
Researchers found that gestational glucose intolerance during pregnancy predicts an increased likelihood of metabolic syndrome at 3 months postpartum. This study suggests women with this condition may be at high risk for future cardiovascular disease.