Articles tagged with Glucose
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A study comparing NFL players' health to that of other healthy young men found lower incidence of impaired fasting glucose and similar prevalence of abnormal cholesterol levels. However, NFL players had a significantly higher prevalence of high blood pressure and prehypertension compared to the general population.
A meta-analysis of five trials found that more intensive glucose control in type 2 diabetes significantly reduces coronary events, including non-fatal heart attacks and coronary heart disease events. However, it has no significant effect on stroke rates or all-cause mortality.
Researchers from Institute for Clinical Evaluative Sciences found that even mild abnormalities in glucose testing during pregnancy increase the risk of developing type 2 diabetes. Women with these mild abnormalities are 2.5 times more likely to develop type 2 diabetes compared to those with normal glucose testing.
Researchers found that increased O-GlcNAc levels damage blood vessels by reducing nitric oxide production, increasing blood pressure and vessel contraction. This discovery could lead to new treatments targeting the O-GlcNAc pathway.
Researchers have discovered that yeast cells can extend their lifespan by up to 5-fold when converted to use glycerol instead of glucose for energy, offering an alternative to caloric restriction. This metabolic switch also enhances the cells' resistance to damage and may provide insights into human aging.
A recent study has found that the Humanin peptide protects against neuronal cell death and regulates insulin metabolism, significantly improving glucose levels in diabetic rats. The discovery provides new insight into the role of the brain in glucose metabolism and suggests a potential therapeutic approach to diabetes.
A LSUHSC student has developed a groundbreaking treatment for diabetes using ACE2 gene therapy, which improves pancreatic beta cell function and restores glucose stability in diabetic mice. The award recognizes the student's outstanding research contributions to the field of endocrinology and metabolism.
Recent studies show that short sleep can disturb appetite control, leading to overeating and increased risk of Type 2 diabetes. Researchers also found that chronic sleep deprivation can lead to glucose intolerance without weight gain.
Researchers found that sugary drinks and tasteless carbohydrates can significantly improve endurance event performance. Athletes given glucose or maltodextrin drinks outperformed those on 'disguised' water by 2-3%.
A new study led by NYU dental researcher Dr. Ananda P. Dasanayake found that pregnant women with periodontal disease are more likely to develop gestational diabetes. The study, conducted in Sri Lanka, eliminated smoking and alcohol use among participants to isolate the impact of gum disease on glucose levels.
A new study published in The New England Journal of Medicine suggests that intensively lowering blood glucose in critically ill patients increases the risk of death by 10%. The research, which followed over 6,000 ICU patients, found that targeting very low levels of blood glucose is not safe.
Researchers at the University of Michigan discovered that protein TBC1D1 plays a crucial role in glucose transport into muscle cells after exercise. This finding could lead to new drug therapies or more effective exercise protocols for preventing Type 2 diabetes and other health problems associated with high blood sugar.
Researchers studying the genetics of exercise have identified about 200 genes that play a role in adapting to physical activity. These genes may hold the key to understanding muscle diseases such as muscular dystrophy, and could lead to new treatments for individuals with limited genetic ability to adapt.
Researchers found that participants who slept less than six hours a night were 4.56 times more likely to convert from normal blood sugar levels to impaired fasting glucose compared to those getting six to eight hours of sleep. This association suggests a link between inadequate sleep and the development of type 2 diabetes.
Researchers found that cells' ability to sense glucose presence is key to lifespan extension. Decreasing glucose levels increased yeast cell lifespan, while eliminating glucose sensor significantly boosted it.
Recent studies using pure fructose are misinterpreted due to its absence of glucose, a critical factor in human diet. High fructose corn syrup and sugar have equal sweetenss and calorie content, with no meaningful difference in metabolism.
A recent study published in the Journal of Clinical Endocrinology & Metabolism found that pre-diabetic adults with post-challenge hyperglycemia have a higher risk of cardiovascular disease due to increased glucose and insulin levels, triglycerides, inflammation, and impaired blood vessel function. Routine glucose screening and preventi...
Researchers found that knocking out the protein tyrosine phosphatase 1B (PTP1B) gene improves cardiovascular function in genetically fat mice with diabetes. The study suggests that PTP1B contributes to insulin resistance, which can lead to impaired nitric oxide dilation and vascular remodeling. By improving fine control of blood glucos...
A team of researchers from Purdue University has developed a precise biosensor for detecting blood glucose and potentially many other biological molecules. The device, resembling a tiny cube-shaped tetherball, uses single-wall carbon nanotubes anchored to gold-coated nanocubes to conduct electrical signals.
A study published in Hepatology found that people on low-carbohydrate diets produce more glucose from lactate or amino acids, burning liver fat for energy. This suggests that optimizing diet may help manage and treat diseases such as insulin resistance, diabetes, and nonalcoholic fatty liver disease.
A new gene variant associated with fasting glucose levels influences insulin secretion via melatonin metabolism, implicating a previously unknown relationship between the sleep-wake rhythm and diabetes. Further studies will explore the role of melatonin in regulating insulin secretion and potentially lead to new treatment options.
A study found that CPAP therapy reduces sleeping and nocturnal hyperglycemia, improving glucose control and long-term prognosis in type 2 diabetics with OSA. Glucose levels decreased by approximately 20 mg/dl after 41 days of treatment.
A Tufts University study found that women on low-carb diets performed poorly on memory-based tasks compared to those on reduced-calorie diets with carbohydrates. Cognitive skills returned to normal when carbohydrates were reintroduced.
A new study by the University of Illinois found that fructose metabolism is more complex than previously thought, inducing a broader range of genes in the liver. This can lead to increased glycogen and triglycerides in the liver, as well as insulin resistance.
Researchers discovered 30 genetic variants associated with cholesterol levels, including 11 new ones, which could lead to more effective therapies. The study also found links between melatonin, sleep patterns, and small increases in glucose levels, increasing the risk of diabetes.
Researchers identified a gene involved in the body's response to the day-night cycle strongly linked to high blood sugar levels and type 2 diabetes. The melatonin receptor is implicated in conditions like jetlag and sleep disorders, suggesting that disrupted sleep patterns are connected to metabolic health.
A clinical tool called TAG-IT has been developed to assess the risk of undetected hyperglycemia, impaired fasting glucose, and undiagnosed diabetes in patients. By identifying high-risk patients early, clinicians can implement preventative strategies to minimize progression to diabetes and related diseases.
A new study reveals that the master gene SRC-2 plays a crucial role in regulating blood sugar levels. Mice lacking SRC-2 develop severe hypoglycemia and die within two days without food. The findings have significant implications for treating genetic diseases like Von Gierke's disease and adult-onset diabetes.
A new study by Joslin researchers found that a common genetic variant associated with an increased risk of coronary artery disease is also linked to poor glycemic control in people with diabetes. Those with the variant and poor glucose control experienced a four-fold increased risk for CAD relative to those without the variant and good...
Researchers found lactic acid is an important energy source for tumor cells and discovered a way to destroy hard-to-kill cells by preventing lactate delivery. Blocking lactate transport kills oxygenated cells that starve hypoxic cells, offering a novel approach to treating tumors.
Researchers have identified a potential new target for anticancer therapeutics by showing that well-oxygenated tumor cells use lactate as a fuel, while hypoxic cells use glucose. Inhibiting this protein MCT1 disrupts the symbiotic relationship between the two cell types, leading to decreased tumor growth in mouse models.
Researchers have discovered that the apelin protein can help regulate blood sugar levels in individuals with type II diabetes. Activation of this second pathway improves glucose regulation and offers a potential new treatment option.
A case report highlights the risk of thiamine deficiency disease after gastric bypass surgery for obesity, which can lead to severe neurological symptoms. Patients are advised to take multivitamins and monitor their thiamine levels to prevent this condition.
Researchers have identified SLC2A9 as a high-capacity urate transporter, playing a crucial role in controlling serum urate levels. The study suggests that genetic variants in SLC2A9 may contribute to increased serum urate levels and associated diseases such as gout.
Researchers at the Salk Institute have discovered a two-stage fasting-response mechanism that ensures glucose production in the brain is tightly regulated. CRTC2 and FOXO1 proteins play key roles in this process, with SIRT1 serving as a nutrient sensor that switches between them.
Researchers found that the brain utilizes lactate as fuel during intense physical activity, outpacing glucose usage. This discovery sheds light on the brain's energy needs and has potential implications for treatment and athletic performance.
Researchers discovered that existing anti-obesity drugs can inhibit viral replication by targeting fatty acid metabolism. The study found a thousand-fold reduction in HCMV replication when using drugs like TOFA and C75. This approach may provide an exciting antiviral treatment option.
Research found that chronic severe hepatitis B patients had significantly lower glucose oxidation rates and higher fat oxidation rates compared to acute hepatitis and cirrhosis patients. Upon recovery, patients showed improved energy metabolism, with increased glucose oxidation rates and decreased fat oxidation rates.
A new study found that a once-weekly diabetes treatment formulation provides better blood sugar control and weight loss compared to twice-daily dosing. Patients who received the once-weekly treatment had significantly improved HbA1c levels and greater reductions in body weight.
Research finds that intellectual work leads to a significant increase in calorie intake, with students consuming up to 253 more calories after mentally demanding tasks. The study suggests that fluctuations in glucose and insulin levels may trigger food overcompensation.
Studies show mixed results on blood glucose control and micro-vascular disease prevention, while oral drugs like metformin offer some benefits. Tight insulin control has limited proven success in reducing complications, emphasizing the need for longer-term studies.
A meta-analysis of randomized trials found that tight glucose control in critically ill adults is not associated with a reduced risk of death, but does increase the risk of hypoglycemia. The study challenges common practice guidelines recommending tight glucose control for these patients.
A study found that low-dose growth hormone treatment reduced visceral adipose tissue and improved blood pressure in HIV-infected patients with abdominal obesity. However, it also increased glucose levels during glucose tolerance testing, highlighting the need for caution when using growth hormone therapy in this population.
A low-dose growth hormone treatment reduced abdominal fat deposits and improved blood pressure and triglyceride levels in HIV patients with lipodystrophy. However, growth hormone treatment appeared to increase blood glucose levels, particularly in those with impaired glucose tolerance.
A commonly used diabetes monitoring test could be repurposed to screen for and diagnose diabetes, identifying millions of people with undiagnosed disease. The hemoglobin A1c test measures long-term glucose control, offering advantages over current testing methods that require fasting or are affected by recent meals and diet.
Researchers found that individuals with a maternal history of Alzheimer's disease exhibit progressive metabolic reductions in glucose usage, particularly in areas of the brain affected by AD. This study bolsters previous findings and suggests that maternal risk for AD may be mediated through reduced brain metabolism.
UC San Diego bioengineers identified a previously unknown mechanism allowing yeast to shut down galactose metabolism when glucose is present. This discovery provides new insights into gene regulation and could lead to understanding of human metabolic diseases like diabetes.
A recent study suggests that limiting fructose intake can lead to increased weight loss, as it is quickly converted into body fat in the liver. Dr. Elizabeth Parks' research found that even small amounts of fructose can contribute to greater triglyceride synthesis.
A study found that older people who engaged in endurance exercise training for a year had metabolically younger hearts. Women benefited more than men from the training, with improved glucose uptake and fatty acid metabolism.
Researchers at UCLA have solved the structure of sodium glucose co-transporters (SGLTs), which pump glucose into cells. This breakthrough may lead to improved treatments for diabetes and obesity.
A study at the Joslin Diabetes Center found that children with type 1 diabetes who closely adhered to prescribed dietary recommendations had lower A1C levels and reduced risk of diabetes-related complications. The study highlights the importance of dietary adherence in achieving optimal glucose control.
A new Canadian study found that the standard screening test for high blood sugar in children with risk factors misses nearly 3 times fewer cases of prediabetes than a longer test. The glucose stress test identified more cases of both prediabetes and metabolic syndrome. Early detection is crucial, as it can prevent or delay diabetes.
Researchers found that cells lacking iron reorganize their metabolism to use less efficient glucose-based pathways, producing lower energy levels. This mechanism may help explain human responses to iron deficiency and potentially aid in diabetes research.
Researchers at USC have identified a novel genetic association between fasting glucose levels and melatonin receptor 1B (MTNR1B), increasing the risk for type 2 diabetes. The study found a connection between MTNR1B and circadian rhythm regulation, suggesting potential links to sleep disorders.
Researchers found a previously unknown cooperation between pancreatic beta cells and alpha cells, crucial for glucose balance. The discovery may lead to better blood sugar regulation in diabetes patients by targeting the glucagon/glutamate pathway.
Researchers at USC identified a gene variant associated with fasting glucose levels, providing new insights into blood sugar regulation. The study found that genetic variation in the G6PC2 gene may be responsible for reducing insulin secretion and increasing glucose concentrations.
A team of researchers at The Scripps Research Institute identified molecular changes in the cerebrospinal fluid of monkeys infected with SIV, which can cause CNS damage. This approach may provide new information about other neurodegenerative and neuropsychiatric disorders.
A collection of state-of-the-art reports highlights the benefits of self-monitoring blood glucose (SMBG) in achieving improved glucose control. SMBG has been shown to significantly improve glucose control, complements A1C results, and guides patient self-management of diabetes at home.
Experts recommend revising current criteria for diagnosing diabetes, suggesting the use of hemoglobin A1c (HbA1c) as an alternative to fasting plasma glucose or oral glucose tolerance tests. This change may help identify more people with undiagnosed diabetes, reducing avoidable morbidity and mortality.
Researchers found that 'flat' carbonated drinks lack essential salts and sugars for oral rehydration solution. They contain too much sugar and not enough sodium and potassium, making them an inadequate alternative.