Articles tagged with Glucose
Researchers at Huntsman Cancer Institute have discovered that restricting glutamine availability can halt tumor growth by blocking glucose utilization. This breakthrough could lead to the development of new drugs targeting glutamine utilization or MondoA/ TXNIP.
Researchers at Duke University Medical Center found that carnitine supplementation improves glucose tolerance in obese rats by restoring their cells' fuel-burning capacity. This breakthrough offers potential therapy options for people with type 2 diabetes, prediabetes, and kidney disease.
A novel function of a gut hormone was discovered that can potentially lower glucose levels in diabetes by activating specific receptors. The study found that CCK peptide hormone rapidly lowers blood glucose by triggering a signal to the brain and liver.
Researchers found that a gut hormone called cholecystokinin (CCK) activates receptors to regulate glucose levels via a gut-brain-liver neuronal axis. CCK's effects depend on activation of CCK-A receptors, which slow down glucose production in the liver.
Researchers at the University of Illinois have developed a new method using electrolyzed water to pretreat ethanol waste products, producing an acetone-butanol-ethanol fuel mix. The traditional chemical-based method is eliminated, reducing inhibitor production and increasing sugar yield.
A study published in the Archives of Internal Medicine found that intensive glucose control halves the rate of eye and kidney damage in people with longstanding type 1 diabetes. The study also showed lower rates of cardiovascular disease events and improved vision loss rates compared to conventional control.
Researchers found that diabetic patients with heart failure who have blood glucose levels slightly higher than recommended have the lowest risk of death. In contrast, those with levels too high or too low are at increased risk of mortality.
A study published in The Journal of Bone and Joint Surgery found that controlled glucose levels significantly reduce complications after total joint replacement surgery for diabetic patients. Patients with uncontrolled glucose were more likely to experience surgical complications, infection, blood transfusions, and longer hospital stays.
The glucose challenge test is an accurate, convenient, and inexpensive way to screen the general population for unrecognized diabetes and prediabetes. The study screened 1,573 participants and found that 4.6% had previously unrecognized diabetes and 18.7% had prediabetes.
A recent phase II study found aleglitazar to be safe and well-tolerated, reducing HbA1c levels in patients with type 2 diabetes. The medication also showed a favorable lipid profile without significant cardiovascular risks.
A study published in The Lancet found that metabolic changes, including increased fasting glucose levels and decreased insulin sensitivity, occur several years before the onset of type 2 diabetes. By identifying these changes, it may be possible to delay or even prevent diabetes diagnosis.
Researchers found that routine diabetes screenings can lead to significant cost savings for healthcare systems. The study suggests that screening and preventive management can be a cost-effective approach to managing the disease.
Researchers at UCLA's Brain Injury Research Center are re-examining the standard treatment for traumatic brain injury (TBI), suggesting that fueling the brain with glucose may not be the best approach. Instead, they propose using alternative compounds like pyruvate and beta-hydroxybutyrate to optimize recovery.
A Finnish study found that low glycogen levels predict forthcoming violent offending among antisocial male offenders. Low glycogen stores may contribute to impulsive violent behavior during alcohol intoxications.
A special supplement of Diabetes Technology & Therapeutics reviews the latest research findings and critical analysis of continuous glucose monitoring (CGM) technology. CGM devices have been shown to improve glucose control, but limitations and drawbacks include finicky technology and limited physician knowledge.
Researchers at UCSF have identified a specialized protein called CHC22 that controls the formation of GLUT4 storage compartments in human muscles. This discovery highlights key differences between humans and mice and has implications for developing better models for studying type 2 diabetes.
A study comparing NFL players' health to that of other healthy young men found lower incidence of impaired fasting glucose and similar prevalence of abnormal cholesterol levels. However, NFL players had a significantly higher prevalence of high blood pressure and prehypertension compared to the general population.
A meta-analysis of five trials found that more intensive glucose control in type 2 diabetes significantly reduces coronary events, including non-fatal heart attacks and coronary heart disease events. However, it has no significant effect on stroke rates or all-cause mortality.
Researchers from Institute for Clinical Evaluative Sciences found that even mild abnormalities in glucose testing during pregnancy increase the risk of developing type 2 diabetes. Women with these mild abnormalities are 2.5 times more likely to develop type 2 diabetes compared to those with normal glucose testing.
Researchers found that increased O-GlcNAc levels damage blood vessels by reducing nitric oxide production, increasing blood pressure and vessel contraction. This discovery could lead to new treatments targeting the O-GlcNAc pathway.
Researchers have discovered that yeast cells can extend their lifespan by up to 5-fold when converted to use glycerol instead of glucose for energy, offering an alternative to caloric restriction. This metabolic switch also enhances the cells' resistance to damage and may provide insights into human aging.
A recent study has found that the Humanin peptide protects against neuronal cell death and regulates insulin metabolism, significantly improving glucose levels in diabetic rats. The discovery provides new insight into the role of the brain in glucose metabolism and suggests a potential therapeutic approach to diabetes.
A LSUHSC student has developed a groundbreaking treatment for diabetes using ACE2 gene therapy, which improves pancreatic beta cell function and restores glucose stability in diabetic mice. The award recognizes the student's outstanding research contributions to the field of endocrinology and metabolism.
Recent studies show that short sleep can disturb appetite control, leading to overeating and increased risk of Type 2 diabetes. Researchers also found that chronic sleep deprivation can lead to glucose intolerance without weight gain.
Researchers found that sugary drinks and tasteless carbohydrates can significantly improve endurance event performance. Athletes given glucose or maltodextrin drinks outperformed those on 'disguised' water by 2-3%.
A new study led by NYU dental researcher Dr. Ananda P. Dasanayake found that pregnant women with periodontal disease are more likely to develop gestational diabetes. The study, conducted in Sri Lanka, eliminated smoking and alcohol use among participants to isolate the impact of gum disease on glucose levels.
A new study published in The New England Journal of Medicine suggests that intensively lowering blood glucose in critically ill patients increases the risk of death by 10%. The research, which followed over 6,000 ICU patients, found that targeting very low levels of blood glucose is not safe.
Researchers at the University of Michigan discovered that protein TBC1D1 plays a crucial role in glucose transport into muscle cells after exercise. This finding could lead to new drug therapies or more effective exercise protocols for preventing Type 2 diabetes and other health problems associated with high blood sugar.
Researchers studying the genetics of exercise have identified about 200 genes that play a role in adapting to physical activity. These genes may hold the key to understanding muscle diseases such as muscular dystrophy, and could lead to new treatments for individuals with limited genetic ability to adapt.
Researchers found that participants who slept less than six hours a night were 4.56 times more likely to convert from normal blood sugar levels to impaired fasting glucose compared to those getting six to eight hours of sleep. This association suggests a link between inadequate sleep and the development of type 2 diabetes.
Researchers found that cells' ability to sense glucose presence is key to lifespan extension. Decreasing glucose levels increased yeast cell lifespan, while eliminating glucose sensor significantly boosted it.
Recent studies using pure fructose are misinterpreted due to its absence of glucose, a critical factor in human diet. High fructose corn syrup and sugar have equal sweetenss and calorie content, with no meaningful difference in metabolism.
A recent study published in the Journal of Clinical Endocrinology & Metabolism found that pre-diabetic adults with post-challenge hyperglycemia have a higher risk of cardiovascular disease due to increased glucose and insulin levels, triglycerides, inflammation, and impaired blood vessel function. Routine glucose screening and preventi...
Researchers found that knocking out the protein tyrosine phosphatase 1B (PTP1B) gene improves cardiovascular function in genetically fat mice with diabetes. The study suggests that PTP1B contributes to insulin resistance, which can lead to impaired nitric oxide dilation and vascular remodeling. By improving fine control of blood glucos...
A team of researchers from Purdue University has developed a precise biosensor for detecting blood glucose and potentially many other biological molecules. The device, resembling a tiny cube-shaped tetherball, uses single-wall carbon nanotubes anchored to gold-coated nanocubes to conduct electrical signals.
A study published in Hepatology found that people on low-carbohydrate diets produce more glucose from lactate or amino acids, burning liver fat for energy. This suggests that optimizing diet may help manage and treat diseases such as insulin resistance, diabetes, and nonalcoholic fatty liver disease.
A new gene variant associated with fasting glucose levels influences insulin secretion via melatonin metabolism, implicating a previously unknown relationship between the sleep-wake rhythm and diabetes. Further studies will explore the role of melatonin in regulating insulin secretion and potentially lead to new treatment options.
A study found that CPAP therapy reduces sleeping and nocturnal hyperglycemia, improving glucose control and long-term prognosis in type 2 diabetics with OSA. Glucose levels decreased by approximately 20 mg/dl after 41 days of treatment.
A Tufts University study found that women on low-carb diets performed poorly on memory-based tasks compared to those on reduced-calorie diets with carbohydrates. Cognitive skills returned to normal when carbohydrates were reintroduced.
A new study by the University of Illinois found that fructose metabolism is more complex than previously thought, inducing a broader range of genes in the liver. This can lead to increased glycogen and triglycerides in the liver, as well as insulin resistance.
Researchers identified a gene involved in the body's response to the day-night cycle strongly linked to high blood sugar levels and type 2 diabetes. The melatonin receptor is implicated in conditions like jetlag and sleep disorders, suggesting that disrupted sleep patterns are connected to metabolic health.
Researchers discovered 30 genetic variants associated with cholesterol levels, including 11 new ones, which could lead to more effective therapies. The study also found links between melatonin, sleep patterns, and small increases in glucose levels, increasing the risk of diabetes.
A clinical tool called TAG-IT has been developed to assess the risk of undetected hyperglycemia, impaired fasting glucose, and undiagnosed diabetes in patients. By identifying high-risk patients early, clinicians can implement preventative strategies to minimize progression to diabetes and related diseases.
A new study reveals that the master gene SRC-2 plays a crucial role in regulating blood sugar levels. Mice lacking SRC-2 develop severe hypoglycemia and die within two days without food. The findings have significant implications for treating genetic diseases like Von Gierke's disease and adult-onset diabetes.
A new study by Joslin researchers found that a common genetic variant associated with an increased risk of coronary artery disease is also linked to poor glycemic control in people with diabetes. Those with the variant and poor glucose control experienced a four-fold increased risk for CAD relative to those without the variant and good...
Researchers found lactic acid is an important energy source for tumor cells and discovered a way to destroy hard-to-kill cells by preventing lactate delivery. Blocking lactate transport kills oxygenated cells that starve hypoxic cells, offering a novel approach to treating tumors.
Researchers have identified a potential new target for anticancer therapeutics by showing that well-oxygenated tumor cells use lactate as a fuel, while hypoxic cells use glucose. Inhibiting this protein MCT1 disrupts the symbiotic relationship between the two cell types, leading to decreased tumor growth in mouse models.
Researchers have discovered that the apelin protein can help regulate blood sugar levels in individuals with type II diabetes. Activation of this second pathway improves glucose regulation and offers a potential new treatment option.
A case report highlights the risk of thiamine deficiency disease after gastric bypass surgery for obesity, which can lead to severe neurological symptoms. Patients are advised to take multivitamins and monitor their thiamine levels to prevent this condition.
Researchers have identified SLC2A9 as a high-capacity urate transporter, playing a crucial role in controlling serum urate levels. The study suggests that genetic variants in SLC2A9 may contribute to increased serum urate levels and associated diseases such as gout.
Researchers at the Salk Institute have discovered a two-stage fasting-response mechanism that ensures glucose production in the brain is tightly regulated. CRTC2 and FOXO1 proteins play key roles in this process, with SIRT1 serving as a nutrient sensor that switches between them.
Researchers found that the brain utilizes lactate as fuel during intense physical activity, outpacing glucose usage. This discovery sheds light on the brain's energy needs and has potential implications for treatment and athletic performance.
Researchers discovered that existing anti-obesity drugs can inhibit viral replication by targeting fatty acid metabolism. The study found a thousand-fold reduction in HCMV replication when using drugs like TOFA and C75. This approach may provide an exciting antiviral treatment option.
Research found that chronic severe hepatitis B patients had significantly lower glucose oxidation rates and higher fat oxidation rates compared to acute hepatitis and cirrhosis patients. Upon recovery, patients showed improved energy metabolism, with increased glucose oxidation rates and decreased fat oxidation rates.
A new study found that a once-weekly diabetes treatment formulation provides better blood sugar control and weight loss compared to twice-daily dosing. Patients who received the once-weekly treatment had significantly improved HbA1c levels and greater reductions in body weight.
Research finds that intellectual work leads to a significant increase in calorie intake, with students consuming up to 253 more calories after mentally demanding tasks. The study suggests that fluctuations in glucose and insulin levels may trigger food overcompensation.
Studies show mixed results on blood glucose control and micro-vascular disease prevention, while oral drugs like metformin offer some benefits. Tight insulin control has limited proven success in reducing complications, emphasizing the need for longer-term studies.
A meta-analysis of randomized trials found that tight glucose control in critically ill adults is not associated with a reduced risk of death, but does increase the risk of hypoglycemia. The study challenges common practice guidelines recommending tight glucose control for these patients.
A study found that low-dose growth hormone treatment reduced visceral adipose tissue and improved blood pressure in HIV-infected patients with abdominal obesity. However, it also increased glucose levels during glucose tolerance testing, highlighting the need for caution when using growth hormone therapy in this population.
A low-dose growth hormone treatment reduced abdominal fat deposits and improved blood pressure and triglyceride levels in HIV patients with lipodystrophy. However, growth hormone treatment appeared to increase blood glucose levels, particularly in those with impaired glucose tolerance.