Articles tagged with Glucose
Researchers have discovered that tPA can protect brain cells from oxygen and glucose loss after a stroke, even when its clot-dissolving powers are removed. A modified version of tPA could provide benefits to patients without increasing the risk of bleeding.
Researchers have identified a protein called α9β1, which inhibits airway smooth muscle contraction and may be used to develop treatment options for asthma. Additionally, studies have shown that LRH-1 plays a crucial role in glucose-sensing and coordinating glucose and lipid metabolism in the liver.
Researchers found that continuous glucose monitoring devices and insulin pumps improve blood sugar levels and reduce time spent with high levels in patients with type 1 diabetes. These new technologies offer a more convenient alternative to traditional methods, but adherence is key to effectiveness.
A new second-line treatment for Type 2 diabetes, linagliptin, has shown less hypoglycemia and weight gain compared to sulphonylureas. Patients treated with linagliptin experienced lower rates of cardiovascular events, but further studies are needed to confirm this finding.
Researchers at UCLA found that glucose starvation activates a metabolic and signaling amplification loop that leads to cancer cell death. The discovery reveals the power of systems biology in uncovering relationships between metabolism and signaling.
A new study finds that women with polycystic ovary syndrome (PCOS) who also have obstructive sleep apnea are at greater risk of metabolic disturbances, including prediabetes. The study's results indicate a strong relationship between sleep apnea severity and diabetes risk in PCOS patients.
USC researchers found that viewing pictures of high-fat foods stimulates appetite and reward centers in the brain, increasing hunger and desire for certain foods. Consuming sugary drinks also increases desire for savory foods, particularly fructose.
Researchers found that snacking on raisins significantly lowers postprandial glucose levels compared to common alternative snacks. The study, conducted among 46 participants, showed a 16% decrease in mean post-meal glucose levels with raisin consumption.
A study published in Archives of Neurology found that diabetes mellitus and poor glucose control are associated with worse cognitive function and greater cognitive decline in well-functioning older adults without dementia. Patients with diabetes who had higher hemoglobin A1c levels showed lower scores on cognitive tests.
MIT engineers have developed a fuel cell that runs on glucose, potentially powering brain implants to help paralyzed patients. The glucose fuel cell strips electrons from glucose molecules to create a small electric current, and its biocompatibility has been proven through platinum catalysts.
A systematic review found that aggressive blood sugar control can prevent diabetic neuropathy, a disabling condition affecting nerves in the feet and legs. However, the review suggests that optimal target levels for glucose control need to be established to balance benefits and side effects.
A study of over 12,500 people in 40 countries found that long-term insulin use does not increase the risk of heart disease or cancer. Participants who received daily basal insulin injections had a lower chance of developing type 2 diabetes even after treatment stopped.
A new study found that early and aggressive glucose-lowering treatment can significantly reduce the risk of progression to diabetes in people with prediabetes. The research analyzed data from over 3,000 patients who experienced periods of normal glucose regulation, revealing a 56% reduction in diabetes risk.
A new meta-analysis suggests that people with pre-diabetes are at increased risk of stroke, but the precise degree of this threat depends on the medical definition used. Researchers found that those with fasting glucose levels between 110-125mg/dL carry a 21% higher chance of suffering a future stroke.
Researchers at TUM and DIfE discovered the hTAS2R4 and hTAS2R14 receptors responsible for Stevia's bitter taste. The study found that the structure of glycoside molecules plays a key role in determining sweetness or bitterness in Stevia.
Researchers at Yale University found that intensively controlling glucose levels did not definitively reduce the risk of impaired kidney function, dialysis, or death from kidney disease. The study suggests that patients may not be better off with this approach and questions the benefits of aggressive glycemic control in Type 2 diabetes
Women referred to the telephone-based nurse management program had a lower risk of high baby birth weight and were more likely to have postpartum glucose testing, leading to earlier identification and management of postpartum glucose intolerance or diabetes. The study suggests that this program can improve outcomes for women with gesta...
A study published in CMAJ found that excess maternal weight before and during pregnancy is a significant predictor of larger-than-average babies. Researchers analyzed data from 472 women and found that maternal glucose levels and lipid levels also play a role, but to a lesser extent.
Researchers at the University of Cincinnati have identified apolipoprotein A-IV (apoA-IV) as a promising target for a new diabetes treatment. The study found that apoA-IV improves insulin secretion and reduces blood sugar levels in mice with impaired glucose tolerance.
Engineers developed glucose-sensing microbeads using droplet microfluidics, allowing for non-invasive monitoring of cell cultures. The technique enables detection of local glucose concentrations and gradual changes due to cell metabolism.
Scientists have created a new, inexpensive paper-based urine test to monitor glucose levels in areas with limited healthcare access. The device detects glucose levels using a simple enzyme reaction and can be built quickly, making it an ideal solution for rural India and other developing countries.
A small phase I study suggests that deep brain stimulation, a therapy used for Parkinson's and depression, may increase neuronal activity in people with mild Alzheimer's disease. The treatment showed promising effects on brain function, including sustained increases in glucose metabolism.
Research suggests that liver fat can be beneficial if stored in tiny coated droplets, reducing glucose intolerance and insulin resistance. Circadian rhythm regulation of histone deacetylase 3 may play a crucial role in metabolic management.
Research suggests a connection between blood sugar levels and mental health in diabetics, potentially impacting quality of life. Studies using continuous glucose monitoring data indicate that poor glycemic control may lead to negative moods and lower overall well-being.
A recent study has found that achieving Surgical Care Improvement Project (SCIP) benchmarks for glycemic control among patients undergoing coronary artery bypass graft (CABG) surgery may be irrelevant when perioperative continuous insulin infusion protocols are implemented. The researchers discovered that 6.6% of patients who received ...
A new study suggests that targeting the glucagon pathway could be an effective way to lower blood sugar levels without disrupting other functions of this hormone. Researchers found that blocking calcium signaling through CaMKII can regulate hepatic glucose production, leading to improved insulin sensitivity and reduced liver fat.
Researchers at Salk Institute discover molecular switch controlling liver glucose production, potentially offering new avenue for treating insulin-resistant type II diabetes. The discovery may lead to agents that can selectively damp down activity of the IP3 spigot and calcineurin accelerator to lower blood sugar levels.
Researchers have discovered a hormone that can be produced by fat stem cells to lower blood sugar levels and improve metabolism. The hormone appears to bypass the need for insulin, sending glucose out of the bloodstream and into muscle cells.
Research reveals that systemic inflammation causes an increase in depressive symptoms and metabolic changes in the brain's mood-regulating regions. This finding opens doors for testing potential treatments for depression in patients experiencing inflammatory-related symptoms.
A new study finds a protective gene in fat cells that helps regulate blood sugar and insulin levels, potentially leading to a new therapeutic strategy for preventing and treating type 2 diabetes. The discovery challenges popular notions of body fat and health.
Researchers at Gladstone Institutes discover p75NTR's role in controlling glucose metabolism, finding that blocking this receptor enhances insulin's effectiveness. This breakthrough may lead to new therapies for Type 2 diabetes, a global health problem affecting over 20 million Americans.
A study using integrative Personal Omics Profiling (iPOP) combines genome sequencing, disease risk analysis, and molecular measures to capture changes in human biology. The researchers observe tens of thousands of components over two years, revealing dynamic molecular-level changes that provide meaningful physiological information.
Pasireotide significantly reduced urinary cortisol levels and improved symptoms of Cushing's disease, cutting secretion by 50% and returning some patients' levels to normal. The drug, which blocks ACTH secretion by binding to somatostatin receptors on the pituitary tumor, showed promise in treating this rare endocrine disorder.
Scientists have developed a method to adapt personal glucose monitors for detecting DNA, allowing for rapid testing of viruses and bacteria in human body fluids and food substances. This technology has the potential to improve health and reduce costs, particularly in developing countries or rural areas with limited medical resources.
A new study published in The Lancet shows that TAK-875, a novel oral medication, significantly improves glycemic control in patients with type 2 diabetes without increasing the risk of hypoglycemia. The results suggest that targeting free fatty acid receptor 1 (FFAR1) may be a viable therapeutic target for treating type 2 diabetes.
Researchers found that short therapy with Pioglitazone can prevent the long-term effects of maternal obesity on offspring. The study shows a potential role for drugs activating peroxisome proliferator-activated receptors in preventing metabolic syndrome in adult offspring of obese mothers.
Researchers found that obese individuals' brains exhibit altered glucose metabolism in reward regions, leading to increased food cravings. The study suggests the brain plays a crucial role in obesity and weight gain, highlighting potential for new treatments.
Researchers at Brown University have developed a biochip that can measure glucose levels in saliva, providing a potential solution for non-invasive diabetes monitoring. The biochip uses surface plasmonics to detect glucose molecules in water, with results showing concentrations similar to those found in human saliva.
Research on low-dose X-ray irradiation reveals significant reduction in aerobic bacteria and mold/yeast populations, while maintaining sugar levels in asparagus. The study found that X-ray treatment can enhance consumer safety by decreasing the number of viable microorganisms.
A recent study found that elevated blood sugar levels are associated with an increased risk of colorectal cancer in postmenopausal women. Researchers observed nearly 5,000 women over 12 years and discovered that those with higher glucose levels were more likely to develop the disease.
Researchers developed a new MRI technique called Arterial spin labeling (ASL) to measure changes in brain function, potentially replacing the current standard PET scan. The study found that ASL-MRI is comparable to FDG-PET in detecting Alzheimer's disease and has the advantage of being non-invasive and widely available.
Scientists have developed an electrochemical sensor device that measures blood sugar levels from tears, potentially saving 350 million diabetes patients from finger-prick blood tests. The device tracks tear glucose levels, which correlate with blood glucose levels, allowing for multiple daily measurements without pain.
Researchers at Albert Einstein College of Medicine have demonstrated the brain's key role in regulating glucose metabolism in humans. The study found that drugs targeting the brain and central nervous system could be a novel approach to treating diabetes.
A new study identifies PKM2 as a critical enzyme for cancer cell survival under oxidative stress. Researchers found that activating PKM2 can sensitize cancer cells to ROS-induced death, opening up potential therapeutic avenues for cancer treatment. The study suggests that manipulating PKM2 activity could be a way to disrupt tumor growth.
A clinical practice guideline recommends continuous glucose monitoring for type 1 diabetes patients who can use devices daily, while also limiting risks of hypoglycemia. The guideline aims to improve glycemic control and reduce hypoglycemia risk in patients with type 1 and type 2 diabetes.
Scientists at UC Metabolic Diseases Institute discover that targeted inhibition of CB1 receptor can increase calorie burning in brown adipose tissue, leading to reduced body weight and blood glucose. Further study aims to find a safer and more effective drug strategy for glucose regulation and weight loss.
Scientists have found that nicotinamide mononucleotide, a naturally occurring compound, can reverse diabetes in mice by improving glucose tolerance and reducing cholesterol levels. The study suggests that this compound may one day be used to treat or prevent type 2 diabetes.
Research reveals a link between diabetes and cancer, showing that cancer-promoting proteins like Lin28a can increase insulin sensitivity in mice, while others with high let-7 levels become more resistant to diabetes.
Researchers at the University of Pittsburgh have identified a powerful molecular pathway regulating the liver's insulin management and new glucose production. FOX06, a protein family member, plays a crucial role in glucose production, leading to improved blood sugar levels when inhibited.
A study by Children's Hospital of Philadelphia found that optimal sleep duration for teenagers can help stabilize blood sugar levels and insulin secretion. The researchers discovered that 7.5-8.5 hours of sleep per night may protect against the development of type 2 diabetes in obese adolescents.
Researchers found that obese individuals' brains respond less to visual cues of high-calorie foods due to impaired glucose regulation. In contrast, non-obese individuals with normal glucose levels exhibit a stronger desire for these foods when triggered by food cues.
A study published by Yale University researchers found that when the brain's glucose levels drop, an area responsible for regulating emotions and impulses loses its ability to resist high-calorie food. This response is particularly pronounced in obese individuals, who exhibit a heightened desire for high-calorie foods.
Recent PET-measurements show that mobile phone signals suppress glucose metabolism in specific brain areas. The study, conducted on 13 young males, reveals a methodologically unique approach combining brain imaging, radiation measurements, and modeling.
A new treatment for alveolar rhabdomyosarcoma has been discovered by IDIBELL researchers, using 2-deoxyglucose to inhibit glucose metabolism and cause cell death in tumor cells. The molecule is similar to those used in PET imaging techniques and shows low toxicity at high doses.
A study by Sanford Burnham Prebys reveals that CDP138 is a crucial protein for insulin-stimulated glucose uptake in muscle and fat cells. The researchers found that optimal insulin response requires the correct insertion of GLUT4 into the cellular membrane, with CDP138 playing a key role.
University of Illinois scientists develop a new strain of yeast that converts seaweed into biofuel more efficiently, cutting production time in half. This breakthrough improves the economic feasibility of marine biofuels and offers a healthier product.
The Homburg Cream and Sugar study reveals a correlation between triglyceride and glucose tolerance with cardiovascular outcomes in patients with stable coronary artery disease. Postprandial triglyceride levels were found to be strongly correlated with glucose metabolism, particularly in those with normal glucose tolerance.
Researchers at the University of Missouri have found a link between inactivity and increased risk factors for Type 2 diabetes. In a study, participants who reduced their physical activity by half experienced doubled spikes in blood sugar levels after meals.
A new study from the University of Alberta found that combining metformin with exercise does not provide additional benefits for glucose control. In fact, it may trigger a counter-regulatory response in the body, leading to increased glucagon levels and reduced glucose control after exercise.
A new study found that high levels of fat interfere with key transcription factors, leading to diminished glucose sensing in pancreatic beta cells. This pathway is activated in type 2 diabetes and contributes to metabolic defects, including insulin resistance.