Articles tagged with Glucose
Researchers at the University of Cincinnati have identified apolipoprotein A-IV (apoA-IV) as a promising target for a new diabetes treatment. The study found that apoA-IV improves insulin secretion and reduces blood sugar levels in mice with impaired glucose tolerance.
Engineers developed glucose-sensing microbeads using droplet microfluidics, allowing for non-invasive monitoring of cell cultures. The technique enables detection of local glucose concentrations and gradual changes due to cell metabolism.
Scientists have created a new, inexpensive paper-based urine test to monitor glucose levels in areas with limited healthcare access. The device detects glucose levels using a simple enzyme reaction and can be built quickly, making it an ideal solution for rural India and other developing countries.
A small phase I study suggests that deep brain stimulation, a therapy used for Parkinson's and depression, may increase neuronal activity in people with mild Alzheimer's disease. The treatment showed promising effects on brain function, including sustained increases in glucose metabolism.
Research suggests that liver fat can be beneficial if stored in tiny coated droplets, reducing glucose intolerance and insulin resistance. Circadian rhythm regulation of histone deacetylase 3 may play a crucial role in metabolic management.
Research suggests a connection between blood sugar levels and mental health in diabetics, potentially impacting quality of life. Studies using continuous glucose monitoring data indicate that poor glycemic control may lead to negative moods and lower overall well-being.
A recent study has found that achieving Surgical Care Improvement Project (SCIP) benchmarks for glycemic control among patients undergoing coronary artery bypass graft (CABG) surgery may be irrelevant when perioperative continuous insulin infusion protocols are implemented. The researchers discovered that 6.6% of patients who received ...
A new study suggests that targeting the glucagon pathway could be an effective way to lower blood sugar levels without disrupting other functions of this hormone. Researchers found that blocking calcium signaling through CaMKII can regulate hepatic glucose production, leading to improved insulin sensitivity and reduced liver fat.
Researchers at Salk Institute discover molecular switch controlling liver glucose production, potentially offering new avenue for treating insulin-resistant type II diabetes. The discovery may lead to agents that can selectively damp down activity of the IP3 spigot and calcineurin accelerator to lower blood sugar levels.
Researchers have discovered a hormone that can be produced by fat stem cells to lower blood sugar levels and improve metabolism. The hormone appears to bypass the need for insulin, sending glucose out of the bloodstream and into muscle cells.
Research reveals that systemic inflammation causes an increase in depressive symptoms and metabolic changes in the brain's mood-regulating regions. This finding opens doors for testing potential treatments for depression in patients experiencing inflammatory-related symptoms.
A new study finds a protective gene in fat cells that helps regulate blood sugar and insulin levels, potentially leading to a new therapeutic strategy for preventing and treating type 2 diabetes. The discovery challenges popular notions of body fat and health.
Researchers at Gladstone Institutes discover p75NTR's role in controlling glucose metabolism, finding that blocking this receptor enhances insulin's effectiveness. This breakthrough may lead to new therapies for Type 2 diabetes, a global health problem affecting over 20 million Americans.
A study using integrative Personal Omics Profiling (iPOP) combines genome sequencing, disease risk analysis, and molecular measures to capture changes in human biology. The researchers observe tens of thousands of components over two years, revealing dynamic molecular-level changes that provide meaningful physiological information.
Pasireotide significantly reduced urinary cortisol levels and improved symptoms of Cushing's disease, cutting secretion by 50% and returning some patients' levels to normal. The drug, which blocks ACTH secretion by binding to somatostatin receptors on the pituitary tumor, showed promise in treating this rare endocrine disorder.
Scientists have developed a method to adapt personal glucose monitors for detecting DNA, allowing for rapid testing of viruses and bacteria in human body fluids and food substances. This technology has the potential to improve health and reduce costs, particularly in developing countries or rural areas with limited medical resources.
A new study published in The Lancet shows that TAK-875, a novel oral medication, significantly improves glycemic control in patients with type 2 diabetes without increasing the risk of hypoglycemia. The results suggest that targeting free fatty acid receptor 1 (FFAR1) may be a viable therapeutic target for treating type 2 diabetes.
Researchers found that short therapy with Pioglitazone can prevent the long-term effects of maternal obesity on offspring. The study shows a potential role for drugs activating peroxisome proliferator-activated receptors in preventing metabolic syndrome in adult offspring of obese mothers.
Researchers found that obese individuals' brains exhibit altered glucose metabolism in reward regions, leading to increased food cravings. The study suggests the brain plays a crucial role in obesity and weight gain, highlighting potential for new treatments.
Researchers at Brown University have developed a biochip that can measure glucose levels in saliva, providing a potential solution for non-invasive diabetes monitoring. The biochip uses surface plasmonics to detect glucose molecules in water, with results showing concentrations similar to those found in human saliva.
Research on low-dose X-ray irradiation reveals significant reduction in aerobic bacteria and mold/yeast populations, while maintaining sugar levels in asparagus. The study found that X-ray treatment can enhance consumer safety by decreasing the number of viable microorganisms.
A recent study found that elevated blood sugar levels are associated with an increased risk of colorectal cancer in postmenopausal women. Researchers observed nearly 5,000 women over 12 years and discovered that those with higher glucose levels were more likely to develop the disease.
Researchers developed a new MRI technique called Arterial spin labeling (ASL) to measure changes in brain function, potentially replacing the current standard PET scan. The study found that ASL-MRI is comparable to FDG-PET in detecting Alzheimer's disease and has the advantage of being non-invasive and widely available.
Scientists have developed an electrochemical sensor device that measures blood sugar levels from tears, potentially saving 350 million diabetes patients from finger-prick blood tests. The device tracks tear glucose levels, which correlate with blood glucose levels, allowing for multiple daily measurements without pain.
Researchers at Albert Einstein College of Medicine have demonstrated the brain's key role in regulating glucose metabolism in humans. The study found that drugs targeting the brain and central nervous system could be a novel approach to treating diabetes.
A new study identifies PKM2 as a critical enzyme for cancer cell survival under oxidative stress. Researchers found that activating PKM2 can sensitize cancer cells to ROS-induced death, opening up potential therapeutic avenues for cancer treatment. The study suggests that manipulating PKM2 activity could be a way to disrupt tumor growth.
A clinical practice guideline recommends continuous glucose monitoring for type 1 diabetes patients who can use devices daily, while also limiting risks of hypoglycemia. The guideline aims to improve glycemic control and reduce hypoglycemia risk in patients with type 1 and type 2 diabetes.
Scientists at UC Metabolic Diseases Institute discover that targeted inhibition of CB1 receptor can increase calorie burning in brown adipose tissue, leading to reduced body weight and blood glucose. Further study aims to find a safer and more effective drug strategy for glucose regulation and weight loss.
Scientists have found that nicotinamide mononucleotide, a naturally occurring compound, can reverse diabetes in mice by improving glucose tolerance and reducing cholesterol levels. The study suggests that this compound may one day be used to treat or prevent type 2 diabetes.
Research reveals a link between diabetes and cancer, showing that cancer-promoting proteins like Lin28a can increase insulin sensitivity in mice, while others with high let-7 levels become more resistant to diabetes.
Researchers at the University of Pittsburgh have identified a powerful molecular pathway regulating the liver's insulin management and new glucose production. FOX06, a protein family member, plays a crucial role in glucose production, leading to improved blood sugar levels when inhibited.
A study by Children's Hospital of Philadelphia found that optimal sleep duration for teenagers can help stabilize blood sugar levels and insulin secretion. The researchers discovered that 7.5-8.5 hours of sleep per night may protect against the development of type 2 diabetes in obese adolescents.
Researchers found that obese individuals' brains respond less to visual cues of high-calorie foods due to impaired glucose regulation. In contrast, non-obese individuals with normal glucose levels exhibit a stronger desire for these foods when triggered by food cues.
A study published by Yale University researchers found that when the brain's glucose levels drop, an area responsible for regulating emotions and impulses loses its ability to resist high-calorie food. This response is particularly pronounced in obese individuals, who exhibit a heightened desire for high-calorie foods.
Recent PET-measurements show that mobile phone signals suppress glucose metabolism in specific brain areas. The study, conducted on 13 young males, reveals a methodologically unique approach combining brain imaging, radiation measurements, and modeling.
A new treatment for alveolar rhabdomyosarcoma has been discovered by IDIBELL researchers, using 2-deoxyglucose to inhibit glucose metabolism and cause cell death in tumor cells. The molecule is similar to those used in PET imaging techniques and shows low toxicity at high doses.
A study by Sanford Burnham Prebys reveals that CDP138 is a crucial protein for insulin-stimulated glucose uptake in muscle and fat cells. The researchers found that optimal insulin response requires the correct insertion of GLUT4 into the cellular membrane, with CDP138 playing a key role.
University of Illinois scientists develop a new strain of yeast that converts seaweed into biofuel more efficiently, cutting production time in half. This breakthrough improves the economic feasibility of marine biofuels and offers a healthier product.
The Homburg Cream and Sugar study reveals a correlation between triglyceride and glucose tolerance with cardiovascular outcomes in patients with stable coronary artery disease. Postprandial triglyceride levels were found to be strongly correlated with glucose metabolism, particularly in those with normal glucose tolerance.
Researchers at the University of Missouri have found a link between inactivity and increased risk factors for Type 2 diabetes. In a study, participants who reduced their physical activity by half experienced doubled spikes in blood sugar levels after meals.
A new study from the University of Alberta found that combining metformin with exercise does not provide additional benefits for glucose control. In fact, it may trigger a counter-regulatory response in the body, leading to increased glucagon levels and reduced glucose control after exercise.
A new study found that high levels of fat interfere with key transcription factors, leading to diminished glucose sensing in pancreatic beta cells. This pathway is activated in type 2 diabetes and contributes to metabolic defects, including insulin resistance.
Researchers have discovered a compound that attacks cancer cells by depriving them of glucose, a process found in most rapidly dividing cells. The team tested the compound on kidney cancer cells and found it nearly halved glucose uptake and slowed tumor growth, with minimal side effects.
Research found no clear picture on risk of death and cardiovascular disease with intense vs conventional glucose control. Lower intensity levels may reduce small vessel damage, but increased risk of low blood sugar and death with more intensive control.
A recent study found that consuming high fructose corn syrup increases cholesterol and triglycerides, key indicators of heart disease risk. The study suggests the current upper limit of sugar consumption may need re-evaluation.
A study published in PLOS Biology found that a defect in brain glucose sensing contributes to obesity, while correction of this defect can treat the condition. The researchers discovered a novel role for hypoxia-inducible factor (HIF) in hypothalamic glucose sensing and whole-body energy balance regulation.
Researchers at the University of Illinois have developed a method to use glucose meters for detecting multiple targets in various samples. Functional DNA sensors enable the detection of vital metabolites, contaminants, and disease markers in a simple, low-cost, and portable manner.
A new study found that diabetes prevalence has increased globally over the past three decades, with 350 million adults affected. The study also showed that high-income countries such as the USA and Western Europe have higher rates of diabetes than other regions.
A major international study reveals that the number of adults with diabetes has reached 347 million, more than double the number in 1980. The prevalence of diabetes has risen or remained unchanged in virtually every part of the world over the last three decades.
New basal insulin analogs have improved diabetes management by reducing hypoglycemic episodes and improving blood glucose levels in type 2 diabetes patients. Modern physiological basal insulin replacement has made optimal blood sugar control a realistic target for diabetes management.
Researchers at Baylor College of Medicine found that a natural product called DLPC stimulates LRH-1 activity, improving regulation of glucose and fat within the liver. In mice with insulin resistance, DLPC decreased fatty livers and lowered glucose levels, suggesting it may provide a treatment for prediabetes.
Researchers at Salk Institute discover a unique fasting pathway that turns up glucose production in the liver when blood sugar levels drop, providing a novel way to treat metabolic disease. Inhibiting histone deacetylases (HDACs) may help regulate blood glucose levels and prevent type II diabetes.
A systematic review and meta-analysis found that structured exercise training, including aerobic and resistance exercises, significantly reduces hemoglobin A1c levels in patients with type 2 diabetes. Longer weekly exercise duration is also linked to greater HbA1c decreases.
Researchers at Mount Sinai School of Medicine found that patients with Alzheimer's disease have lower glucose utilization in the brain, detectable approximately 20 years prior to symptoms. The study suggests that novel therapies could prevent the onset of Alzheimer's by addressing mitochondrial impairment.
Researchers found sitagliptin effective in preventing prediabetes from progressing to diabetes. The drug reduced glucose levels after meals and increased insulin output while decreasing glucagon levels.
A new ultra-long-acting form of insulin, degludec, has shown improved glucose control when administered just three times a week, compared to daily injections. This reduces the risk of hypoglycaemia and improves patient adherence.
A new study reveals that taste cells have several additional sugar detectors beyond the previously known sweet receptor, indicating a complex mechanism for detecting sugars. The presence of these sensors may help regulate sensitivity to sweet taste under different nutritional conditions.
Researchers at the University of Pennsylvania School of Medicine found that protein p53 controls glucose metabolism, enabling cells to grow uncontrollably in tumors. This discovery may lead to new cancer therapeutics by targeting an inefficient metabolic pathway.
Scientists at Indiana University School of Medicine have identified the source of excessive phosphate buildup in glycogen, a chain-like molecule used to store energy. This finding sheds light on a possible route to treatment for Lafora disease, a rare and deadly condition caused by genetic mutation.
A study of elderly patients found a strong association between undiagnosed high blood glucose and increased hospital death rates. Researchers now recommend routine blood glucose testing on admission to prevent unnecessary deaths.