Articles tagged with Glucose
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Researchers at M. D. Anderson Cancer Center found that EGFR stabilizes a protein channeling glucose to cancer cells, saving them from starvation. This discovery may require targeting both EGFR's growth-inducing kinase activity and its glucose-related role to effectively treat epithelial cancers.
Researchers have found that cancer cells use glucose to avoid programmed cell death and maintain survival through the protein Akt. By exploiting this mechanism, cancer cells can bypass normal safeguards and continue to grow even without growth factors.
Two studies suggest that Diabetinol, a natural citrus supplement, improves blood glucose numbers and LDL-cholesterol levels in people with type 2 diabetes. The supplement shows promise in lowering blood glucose levels after meals and improving heart health, potentially reducing diabetic complications.
Chronic hyperglycemia disables the molecular switch that normally shuts off glucose production in the liver, leading to insulin resistance and complications. Inhibiting the hexosamine biosynthetic pathway may provide a new therapeutic target for lowering glucose levels and reducing long-term diabetes complications.
Scientists have discovered a single molecule regulating both glucose and fatty acid metabolism in cells. This finding has the potential to revolutionize our understanding of diabetes and develop new therapeutic agents.
Researchers tracked participants' glucose levels over 72 hours to find that consuming caffeine increased average daily sugar levels by 8%. Eliminating caffeine from the diet might be a good way to manage blood sugar levels for people with type 2 diabetes.
Researchers discovered the rumi gene's effect on bristles in fruit flies, finding a subtle loss of Notch activity at 25 degrees C. The protein associated with rumi is an O-glycosyltransferase that adds glucose to the Notch protein.
A recent study found that suppressing slow-wave sleep in healthy young adults significantly decreases their ability to regulate blood-sugar levels. After only three nights of selective slow-wave sleep suppression, subjects became less sensitive to insulin, resulting in reduced tolerance to glucose and increased risk for type 2 diabetes.
Researchers at UT-Houston have discovered an association between genes regulating glucose metabolism and spina bifida, a birth defect that affects the spine. The study found variants in three glucose metabolism genes were linked to an increased risk of spina bifida.
A systematic review and meta-analysis found that active smoking is associated with a 44% increased risk of type 2 diabetes. The association was strongest for heavy smokers, suggesting that smoking may contribute to insulin resistance or inadequate compensatory insulin secretion responses.
Research suggests glucose powers self-control, which wanes when exercised. Replenishing blood sugar through sugary drinks can improve subsequent self-control efforts.
A new study published in the journal Sleep found that short sleep duration is associated with an increased risk of developing type 2 diabetes. The study, which followed over 8,992 subjects for eight to ten years, revealed that those who slept less than five hours or more than nine hours per night were more likely to develop diabetes.
A team from the University of Illinois identified SgrS, a 200-nucleotide-long RNA molecule, which performs two functions to regulate glucose metabolism in bacteria. The molecule binds to messenger RNA to inhibit new glucose transporter production and codes for a protein that retards existing transporter activity.
Researchers have developed a glucose-powered fuel cell that uses sunlight to convert glucose into hydrogen, producing several hundred millivolts. This innovative device has the potential to reduce our reliance on fossil fuels by utilizing biological resources such as food waste and managed high-energy crops.
Scientists reveal that the adiponectin hormone plays a key role in increasing lifespan by burning fatty acids instead of glucose, reducing free radical damage. Meanwhile, researchers identify a new protein in spider silk, which could revolutionize our understanding of its mechanical properties.
A recent study published in Gastroenterology found that high glucose levels are a strong risk factor for colorectal cancer. Patients with elevated insulin and glucose levels had a 50% increased risk of recurrence of colorectal tumors. Maintaining a healthy glycemic index may help reduce this risk.
A new study suggests that avoiding sweets may spell a longer life. Researchers found that worms lived up to 20% longer when unable to process glucose, increasing mitochondrial activity and oxidative stress. This finding raises questions about the effects of sugar on human lifespan and treatment for type 2 diabetes.
A new study by UMass Medical School researchers found that certain popular weight-loss plans significantly outperform others in reducing cardiovascular disease risk. The Ornish, Weight Watchers High Carbohydrate, and New Glucose Revolution plans scored highest due to their emphasis on whole grains, fruits, and vegetables.
Researchers discovered a link between impaired brain glucose sensing and type 2 diabetes development in mice. A high-fat diet may contribute to this impairment by disrupting ATP production, leading to reduced glucose-sensing ability.
Researchers at Mount Sinai School of Medicine have identified taste receptors in the human intestines that sense glucose and regulate appetite. These receptors may lead to new treatments for obesity and diabetes by controlling blood sugar levels.
Researchers create nanoreactors with enzymes and plastic membranes to run three different enzymatic reactions simultaneously without interference. The system allows small molecules to pass through while trapping larger ones, enabling precise control over reaction cascades.
A study by University at Buffalo endocrinologists found that flavonoids in orange juice suppress destructive oxygen free radicals, reducing oxidative stress and inflammation in healthy participants. The two types of flavonoids, hesperetin and naringenin, inhibited ROS generation by 52% and 77%, respectively.
A new study found that cane sugar and high fructose corn syrup have similar effects on appetite and food intake in beverages. Researchers compared four caloric beverages and found no differences in how they affected hunger and calorie consumption.
Researchers at the University at Buffalo discovered that high levels of cystatin C can predict an increased risk of developing pre-diabetes. The study, based on the Western New York Health Study, found a three-fold association between cystatin C levels and progression to pre-diabetes.
Researchers at the University of Warwick discovered a glycation process that creates a metabolic memory in diabetes, persisting even after glucose levels are corrected. The study suggests early tight control of glucose and antioxidant use can mitigate complications, but long-term antioxidants may have health problems.
Two studies identify smoking, low formal education, and glucose tolerance as independent predictors of rheumatoid arthritis. Smoking is associated with a higher risk, while better glucose tolerance is linked to a lower risk, suggesting alternative mechanisms may be at play.
Researchers at PNNL have successfully converted glucose and fructose into a promising chemical precursor for fuels, polyesters, and other industrial chemicals. The breakthrough uses a novel non-acidic catalytic system and an ionic liquid solvent to achieve high yields with minimal impurities.
A new study published in Journal of Biological Chemistry reveals that glucose enables the development of healthy beta cells, which secrete insulin. Understanding how to switch on genes crucial for beta cell development may enable the creation of insulin-producing cells from stem cells.
A new study found significant sex differences in cardiac performance and metabolism in rainbow trout. Female trout prefer carbohydrates and tolerate lower oxygen levels better than males. The study also revealed distinct layer structures in the ventricle, with males having a larger epicardium-to-endocardium ratio.
Researchers identified TXNIP as a key regulator of glucose homeostasis in humans. Elevated TXNIP levels inhibit glucose uptake in muscle and fat cells, contributing to type 2 diabetes. Modulating TXNIP activity may help break the cycle leading to diabetes.
A UCLA study suggests that lactate may be a key fuel for the brain after traumatic injury, potentially replacing glucose. Researchers found that the brain takes up and utilizes lactate more than at any other time after injury, making it a faster and more efficient source of energy.
Researchers at San Francisco VA Medical Center found that administering glucose to treat hypoglycemia actually causes brain damage in rats, contrary to previous assumptions. Oxidative stress is triggered by the sudden return of glucose, leading to neuron death.
Researchers have discovered that a transcription factor KLF15 controls glucose production in the liver. Mice deficient for KLF15 experience severe hypoglycemia due to an inability to produce glucose through gluconeogenesis, a process dependent on amino acids and enzymes.
A study published in JCI Journals found that glucose reperfusion triggers more extensive neuronal death in hypoglycemic mice than prolonged hypoglycemia itself. Gradual increase of blood glucose levels may be a better approach to treat individuals in hypoglycemic coma, but the findings are subject to further clarification.
Researchers found that hypoglycemic neuronal death is triggered by glucose reperfusion and activation of NADPH oxidase. Treatment with CD40Ig allows rats to accept heart grafts from non-genetically identical donors by enhancing regulatory immune cells.
The St. Jude study found that cells shift their biochemical activities to conserve energy by increasing glucose production and recycling CoA, a key player in metabolism. The researchers also showed that PanK controls the concentration of CoA in specific locations within the cell.
A recent study by Joslin researchers has identified the glucose transporter 2 (Glut2) protein as a key contributor to the development of birth defects in children born to mothers with diabetes. Glut2 enables high blood glucose levels to enter embryonic cells, increasing the risk of malformations.
Researchers at Harvard University developed a new class of rapid tests that can carry out several biological tests simultaneously on a single drop using patterned paper. The tests are highly practical, inexpensive, and unaffected by contamination.
Researchers at VBI have identified a potential target for inhibiting excessive glucose production in type 2 diabetics by modulating the activity of key enzyme phosphoenolpyruvate carboxykinase. This approach could lead to the development of novel therapeutics to slow down but not eliminate glucose overproduction.
A new study conducted at Brandeis University and Malaysia found that a modified fat replacing trans fat causes an increase in blood glucose levels and depresses insulin in humans. The researchers discovered that this interesterified fat had a similar impact on cholesterol levels as trans fat, but with weaker effects.
Researchers have identified a new 'glucose sensor' that plays a crucial role in glucose metabolism and fat synthesis, potentially leading to new treatments for obesity and diabetes. The discovery highlights the significance of the Liver X Receptors (LXRs) in regulating gene expression linked to cholesterol and fat metabolism.
Scientists have engineered yeast to improve ethanol production efficiency by increasing tolerance to high ethanol levels and producing more ethanol during fermentation. The new strain of yeast can survive elevated ethanol concentrations and produces 50% more ethanol in a shorter period.
A new hypothesis proposes that a deficiency in the enzyme Pancreatic Endoplasmic Reticulum Kinase (PERK) during fetal development can lead to permanent neonatal diabetes. The research found that PERK-deficient mice have impaired beta cell proliferation, differentiation, and clustering, resulting in reduced insulin production.
Researchers have developed a highly sensitive NMR probe to analyze small samples, unlocking volumes of information from tiny amounts of venom. This breakthrough could aid in finding natural substances for medicines and advance understanding of Alzheimer's disease.
A study at the University of Chicago Medical Center found that short or poor quality sleep is associated with reduced control of blood-sugar levels in African Americans with diabetes. The research suggests that improving sleep duration and quality may be an inexpensive way to improve health outcomes for patients with type 2 diabetes.
A new study suggests that taking rosiglitazone, a medication for type 2 diabetes, can prevent the disease in people at high risk. The three-year trial found that this combination reduced the risk by about two-thirds, preventing around 144 cases of diabetes per 1000 people.
Researchers at Carnegie Institution for Science have developed a new technology to monitor glucose levels in leaf and root tissues of Arabidopsis thaliana, revealing extremely low sugar levels in roots. The breakthrough enables studies on sugar metabolism in plants and has potential applications for engineering higher crop yields.
Researchers discovered that a protein called ChREBP initiates fat storage when carbohydrates are present. Disabling this protein reduces obesity and improves glucose control in obese mice. The study suggests a potential new approach to treating type 2 diabetes.
Researchers analyzed data from 11 studies and found that blacks with diabetes had about 0.65% less A1C levels, a measure of blood sugar control, compared to whites. This disparity contributes to higher rates of diabetes complications among blacks.
Researchers found that suppressing telomerase, a key enzyme in cancer cell growth, can inhibit the spread of melanoma. By reducing glucose metabolism, cancer cells lose their ability to metastasize and regain lost pigmentation.
The study suggests a novel approach for duplicating leptin's actions when the body no longer responds to the hormone. STAT3 production is essential for leptin's best-known action: acutely reducing food intake. Activating STAT3 may allow normalizing appetite and producing health benefits for obesity, diabetes and infertility.
Researchers at U of T confirm the GI's reliability as a predictor of blood glucose levels, despite concerns over unpredictable outcomes. The study found that 90% of variation was explained by carbohydrate content and GI values, validating the concept's effectiveness in managing blood glucose.
Blocking the conversion of glucose to lactate in mammary tumor cells impaired mitochondrial function and hindered tumor cell proliferation in low oxygen conditions. Alterations in glucose metabolism are linked with changes in mitochondrial physiology, highlighting LDH-A's critical role in tumor growth.
Researchers identify abnormal fasting glucose levels as a risk factor for neuropathy, suggesting an earlier stage of disordered glucose metabolism. The study's findings support the hypothesis that impaired glucose tolerance may be a milder precursor to neuropathies associated with diabetes.
Researchers at Johns Hopkins Medicine have discovered a protein called GCN5 that plays a crucial role in controlling blood sugar levels. By altering the activity of another protein, PGC-1alpha, GCN5 can turn off pathways leading to glucose release from liver cells.
Scientists at the University of Manchester have identified a previously unknown mechanism by which glucose blocks brain cells responsible for regulating wakefulness. This finding has implications for understanding and treating disorders such as narcolepsy, obesity, and addiction.
A nationwide survey shows a significant gap in understanding of type 2 diabetes management, with patients feeling knowledgeable about their condition but not following treatment regimens as prescribed. The Diabetes Roundtable advocates for a team-centered approach involving patients, physicians, and educators to improve care outcomes.
A new mechanism explains how glucose inhibits neurons that regulate wakefulness, revealing a role for previously unknown potassium ion channels. Glucose levels affect the firing rate of these neurons, shedding light on cellular pathways regulating vigilance states and energy balance.
A Joslin-led study has discovered that insulin signals to the liver differently for glucose and lipid metabolism, opening the door to developing targeted therapies. The research reveals new insights into phosphoinositide 3-kinase (PI3K) pathway, which regulates insulin's action in the liver.
A recent study found that blocking ghrelin may improve insulin sensitivity and glucose control in mice, potentially providing a new approach for treating type 2 diabetes. However, the study also raised concerns about potential long-term risks of increasing ATP production by pancreatic cells.