Researchers identified two closely related enzymes competing for the same metabolic precursor, driving distinct biochemical outcomes. The study reveals a molecular mechanism controlling saponin biosynthesis and offers new targets for improving medicinal plant products. Fine-tuned regulation by transcription factors optimizes resource a...
Researchers discovered GAME15, a crucial protein for controlling steroidal glycoalkaloids and saponin production in Solanum plants. The study also showed that steroidal saponins play an ecological role in insect defense, with GAME15 knockout plants being more susceptible to herbivores.
A study reveals the PgbHLH28 gene plays a crucial role in saponin biosynthesis in Platycodon grandiflorus, leading to enhanced medicinal value and potential for pharmaceutical industry applications. The findings provide a theoretical foundation for improving saponin content through genetic engineering and advanced cultivation practices.
A Philippine sea cucumber species has been found to contain diverse classes of valuable small molecules with potential biomedical applications. These bioactive compounds, including terpenoid glycosides and saponins, have reported anti-cancer benefits.
Researchers developed new methods for detecting drug-induced hepatotoxicity using 3D cell cultures and mass spectrometry imaging, identifying biomarkers and effective interventions. A zeolite-based protein corona method was also used to characterize plasma proteins, enabling the identification of low-abundance proteins and their potent...
Researchers found two Korean native plants' saponins inhibit SARS-CoV-2 entry into cells by blocking membrane fusion. These compounds show promise in treating COVID-19, especially for asymptomatic cases.
Researchers have discovered how sea cucumbers produce defensive chemicals using genome mining techniques. The animals' unique ability to biosynthesize toxins has been found to be linked to the diversion of a sterol-producing enzyme, resulting in the production of valuable medicinal compounds.
Scientists at La Jolla Institute for Immunology and MIT have discovered a new adjuvant called SMNP, which combines saponin and TLR agonist to boost the protective power of vaccines. The study found that SMNP triggers a strong immune response in mice, promoting lymphatic drainage and activating multiple parts of the immune system.
A research team at Osaka University has discovered a new enzyme that helps make valuable bioactive saponins, including glycyrrhizin, a potent natural sweetener with antiviral properties. The enzyme discovery opens novel routes for producing these high-value products commercially.
Researchers found that soy-derived isoflavones and saponins have anti-viral, anti-inflammatory, and anti-oxidant effects on pigs. These compounds promote growth and help pigs recover faster from PRRSV infection.
Scientists at the University of California, Davis have identified saponins in red wine as a potential cholesterol fighter. Saponins are found to contain higher levels in red wine than white wine and may work by binding to and preventing the absorption of cholesterol.