Articles tagged with Triglycerides
Researchers discovered four rare APOC3 gene mutations that lower blood triglyceride levels and reduce the risk of coronary artery disease by 40%. The study suggests a powerful strategy for developing new drugs against heart disease.
Researchers found that people with a specific gene variation have lower blood lipids and a reduced risk of arteriosclerosis. The study, based on two large population studies, suggests that inhibiting apolipoprotein C3 could be an effective target for new drugs to prevent cardiovascular disease.
Overweight children exposed to higher levels of perfluorinated chemicals show early signs of metabolic syndrome, a cluster of risk factors for heart disease, stroke, and diabetes. The study highlights the potential public health hazard of these industrial chemicals.
Research reveals that fetal exposure to nicotine increases long-term risk of obesity and metabolic syndrome in offspring, as the liver produces more triglycerides. The study found that pregnant rats exposed to nicotine had an increased risk of developing these conditions later in life.
Researchers have discovered a rare genetic variation that increases triglyceride levels, contributing to the risk of heart disease and other disorders. The ApoE R145C variant is estimated to affect up to 36 million sub-Saharan Africans worldwide.
A novel method to estimate LDL-C levels has been developed, providing more accurate risk classification for heart disease. The new approach uses a larger database of lipid profiles and applies an adjustable factor for triglyceride levels, resulting in improved accuracy, especially for patients with elevated triglyceride concentrations.
A recent study found that eating a large breakfast reduces the risk of obesity, diabetes, hypertension, and cardiovascular disease. Participants who ate a larger breakfast had significantly lower levels of insulin, glucose, and triglycerides throughout the day.
A bacterial supplement containing lipid-producing Rhodococcus opacus increased circulating triglycerides in weanling pigs, providing an alternative source of energy. This could help strengthen the immune system and fight off infections more efficiently during a critical stage of development.
Researchers found a link between a specific gene variant and lower triglyceride levels, as well as higher HDL cholesterol. Carriers of the variant tend to have lower risk of cardiovascular disease, particularly when consuming more polyunsaturated fat.
A recent study published in the University of Montreal found that consuming junk food meals damages artery health, whereas Mediterranean meals rich in good fats can even improve endothelial function. Participants with higher blood triglyceride levels showed greater benefits from healthy meals.
Researchers found that Mediterranean and low-carbohydrate diets improved lipid profiles and reduced triglyceride levels six years after the intervention period. The studies also showed that total cholesterol levels remained persistently lower in all diet groups.
Research reveals that activated macrophages accumulate triglycerides to support their function, leading to increased pathogen destruction. This finding provides new insights into the development of atherosclerosis and potential approaches to slowing its progression.
The Endocrine Society recommends screening adults for hypertriglyceridemia every five years to identify individuals at risk of cardiovascular disease. Treatment focuses on lifestyle changes and addressing secondary causes, such as obesity and endocrine conditions.
A genetic screen of roundworms identified two proteins required for the expansion of lipid droplets, which are associated with obesity and health hazards. The study reveals an anatomical link between these proteins and suggests that they act synergistically to allow cells to store more fat and expand lipid droplet size.
People of African descent may be at risk for cardiovascular disease despite normal triglyceride levels, highlighting a paradox known as the TG paradox. Researchers call for further study and development of new screening guidelines to better identify metabolic syndrome in this population.
Researchers found high triglyceride levels strongly predict ischemic stroke in postmenopausal women, exceeding the risk associated with cholesterol levels. The study analyzed data from over 900 women who experienced strokes, revealing a nearly two-fold increased risk for those in the highest triglyceride quartile.
A recent study published in Stroke journal found that high triglyceride levels are a stronger predictor of stroke risk in postmenopausal women than previously thought. Researchers analyzed data from over 90,000 women and discovered that those with the highest triglyceride levels were nearly twice as likely to suffer an ischemic stroke.
Researchers have identified a human receptor that can taste fat, suggesting individual variability in sensing fat's presence. People with a specific genetic variant of the CD36 gene are more sensitive to fat, making it easier to detect.
A study found that individuals carrying a mutant gene associated with high HDL cholesterol can more efficiently clear triglycerides from their system. This discovery provides new insights into the role of glycosylation in lipid metabolism and has implications for the treatment of heart disease.
A recent study published in the New England Journal of Medicine found that high-dose niacin did not further reduce cardiovascular events in patients with stable cardiovascular disease and low HDL levels. The trial, AIM-HIGH, involved 1,718 patients who received extended-release niacin or a placebo for two years.
Drinking two or more sugar-sweetened beverages daily can expand waistlines and increase heart disease and diabetes risk in women. The study found nearly four times more likelihood of developing high triglycerides among women consuming two or more drinks per day.
Researchers have discovered a new therapy that increases good cholesterol and lowers triglycerides, showing promise in combating cardiovascular disease. The treatment, which targets microRNA-33, has been shown to increase HDL cholesterol and lower triglyceride levels in non-human primates.
Researchers at NYU Langone Health have identified microRNA-33a/b as a novel therapeutic target to suppress triglyceride levels and increase high-density lipoprotein cholesterol (HDL-C). The study shows that inhibition of miR-33a/b markedly suppresses triglycerides and causes a sustained increase in HDL-C.
The Homburg Cream and Sugar study reveals a correlation between triglyceride and glucose tolerance with cardiovascular outcomes in patients with stable coronary artery disease. Postprandial triglyceride levels were found to be strongly correlated with glucose metabolism, particularly in those with normal glucose tolerance.
The National Institutes of Health stopped a clinical trial studying the combination of high-dose niacin and statin treatment after 18 months, finding it did not reduce the risk of cardiovascular events. The trial involved 3,414 participants with heart disease and low HDL cholesterol, who were assigned to receive either high-dose niacin...
A 33-year study by Danish researchers found that higher non-fasting triglycerides are associated with greater stroke risk in both men and women. The study suggests that levels of non-fasting triglycerides should be included in stroke prevention guidelines, currently focused on total cholesterol and LDL cholesterol levels.
A new study at UC Davis found that eating a high-fat meal can trigger inflammation in blood vessels, particularly in individuals with waist sizes over 32 inches and high triglyceride levels. This inflammation can lead to atherosclerosis and increase the risk of heart disease.
A study published in Archives of Dermatology reveals that nearly 40% of individuals with psoriasis also have features of the metabolic syndrome. The most common feature among individuals with psoriasis is abdominal obesity, followed by high triglyceride levels and low levels of HDL cholesterol.
A study published in CMAJ found that an increased waistline and high triglyceride levels during the first trimester are linked to higher glucose intolerance levels later in pregnancy. Researchers suggest that measuring waist girth in combination with triglyceride concentrations may be useful for early screening of gestational diabetes.
Research shows early metabolic abnormalities due to poor diet and exercise may increase risk of asthma in children, regardless of body weight. The study implicates metabolic disorders directly in the development of asthma, suggesting a new way of viewing diet and lifestyle as risk factors.
A global team of researchers has identified 95 regions of the human genome where genetic variants are associated with blood cholesterol and triglyceride levels, a major indicator of heart disease risk. The study found that many common variants discovered by the team also influence lipid traits across different racial and ethnic groups.
A study in mice with disrupted circadian rhythms found that triglyceride levels remain high throughout the day, unlike normal mice whose levels peak at night. The researchers suggest that activities disrupting the circadian rhythm may have real consequences for lipid metabolism.
A new study reveals that a combination of common and rare genetic variants contribute to hypertriglyceridemia. Researchers found that patients with high triglycerides had excess rare variants in four genes, adding up to 28% of cases.
A study published in CMAJ found that a larger waistline and high triglyceride levels significantly increase the risk of coronary heart disease. The combination of increased waist circumference and triglyceride levels was associated with the highest risk of developing the condition.
A study published in Cell Metabolism identifies GPIHBP1 as the key protein responsible for transporting lipoprotein lipase (LPL) into capillaries. This discovery offers new insights into the causes of hypertriglyceridemia, a risk factor for cardiovascular disease.
A study of 600 subjects found that consuming 67 grams of nuts per day significantly lowered total and LDL-cholesterol levels, as well as triglycerides. Pistachios' unique nutrient profile provides significant heart health benefits.
Genetic research suggests that elevated triglyceride levels are associated with a higher risk of heart disease. A major international consortium led by Dr Nadeem Sarwar and Professor John Danesh found this link in analysis of 350,000 people from 101 studies.
A new study found that daily volume of physical activity, measured by steps/day, is related to positive health outcomes and lower prevalence of MetS. Adults who maintain an active lifestyle by accumulating more steps are likely to have a lower risk of CVD factors.
A study of US adults found a significant association between high dietary added sugar intake and unfavorable lipid profiles, including lower HDL-C levels and higher triglyceride levels. The findings suggest that reducing added sugar consumption could help mitigate cardiovascular risk factors.
A study published in JAMA analyzed US government data and found that consuming more added sugar increases cardiovascular disease risk factors. The study suggests reducing daily added sugar intake could be beneficial for long-term health.
Consuming foods with high glycemic index increases the risk of coronary heart disease in women due to higher levels of blood glucose and triglycerides. A study found that a diet rich in high-glycemic index carbohydrates, rather than overall carbohydrate intake, is associated with greater risk of heart disease in women.
Research reveals that mice without an enzyme breaking down triglycerides exhibit improved metabolism with no negative effects, suggesting TGH as a promising therapeutic target. The liver compensates by synthesizing less fat and triglycerides are directed for oxidation.
The analysis found that hazard ratios for vascular disease were nearly identical with non-HDL-C and HDL-C measurements as those seen with apo B and apo AI. Moreover, triglyceride concentration was not independently related to CHD risk after controlling for HDL-C and total cholesterol levels.
Researchers found that elevated triglycerides are significantly more likely to result in worsening neuropathy over a year. Doctors can use this predictor to address lowering lipid counts with their diabetes patients with neuropathy, similar to pursuing glucose control.
Researchers at Oregon State University found that lipoic acid supplements can significantly reduce triglyceride levels in laboratory rats, lowering them by up to 60 percent. This natural compound may offer a new way to lower blood triglycerides and reduce the risk of atherosclerosis.
A study published in Archives of Internal Medicine found that high triglyceride levels are common in the US population, affecting 33.1% of participants. Lifestyle interventions, such as physical activity and weight management, are recommended as the primary treatment for hypertriglyceridemia.
Researchers identified acyl CoA: monoacylglycerol acyltransferase 2 as a critical enzyme in fat absorption. In mice genetically modified to lack this enzyme, high-fat diets failed to induce obesity and related symptoms.
A University of Illinois study found that a moderately high protein diet outperforms low-carb diets for weight loss and maintenance. Participants on the protein-rich diet lost more body fat and preserved muscle mass, reducing triglyceride levels and improving overall health.
A study by Monell Center researchers found that fructose-sweetened beverages increased triglyceride levels in obese individuals, even when consumed with meals. This effect was most pronounced in insulin-resistant subjects, who already had high triglyceride levels.
A new study uncovers 11 gene variants associated with three blood lipids measured to determine cardiovascular disease risk. Researchers believe that these variants could lead to precise dietary recommendations for individuals at risk, such as carriers of certain gene variants who may benefit from low-cholesterol or Mediterranean diets.
Researchers discovered a gene mutation that significantly reduces triglyceride levels and produces a favorable cholesterol profile in the Old Order Amish population. Carriers of this mutation have higher levels of HDL-cholesterol and lower levels of LDL-cholesterol, reducing the risk of cardiovascular disease.
Research reveals that obese children's neck artery plaque thickness is comparable to that of 45-year-olds, indicating a high risk of heart disease and stroke. The study found that children with obesity, abnormal cholesterol levels, and high triglycerides had advanced vascular ages.
Elevated nonfasting triglyceride levels are associated with an increased risk of ischemic stroke, according to a large population-based study. The study found that men and women with higher triglyceride levels had significantly increased risks of stroke, with the risk doubling or tripling for certain ranges of triglyceride levels.
Researchers at Monell Center found that changes in blood triglyceride levels after a high-fat meal can indicate susceptibility to diet-induced obesity. The study suggests that such a simple blood test could be used to identify individuals at risk, particularly children, and target obesity prevention resources.
A genetic variant found almost exclusively in individuals of Asian descent significantly increases the risk of elevated triglycerides. The study found that 15.1% of Chinese-Americans with high plasma TG carried at least one copy of the variant, corresponding to a 4.4 times greater risk.
Researchers at Harvard T.H. Chan School of Public Health discovered a molecule called XBP1 that regulates fat and cholesterol production in the liver. Turning off XBP1 dramatically reduced blood levels of cholesterol and triglyceride fats, with no apparent adverse effects on the liver.
A USC study found that genetic variants of FTO and Arachidonate 5-Lipoxygenase (5-LO) are associated with higher triglyceride levels and lower HDL cholesterol in Mexican-American participants. The study suggests that these genetic interactions may play a vital role in the development of disease, particularly diabetes.
Researchers at Children's Hospital of Pittsburgh have identified Forkhead Box O1 (FoxO1) as a potential target for treating hypertriglyceridemia. Inhibiting FoxO1 in the liver curbs triglyceride secretion in obese and diabetic animals.
Scientists have identified a region on human chromosome 1 that contributes to elevated blood triglyceride levels, increasing the risk of atherosclerosis and heart disease. Three genes, angiopoietin-like 3, leptin receptor, and sterol carrier protein 2, are promising candidates for further study.
A genome-wide study has identified 18 DNA variants associated with blood lipid levels, including six new regions never before linked to cholesterol and triglycerides. These findings hold promise for predicting genetic risk of heart disease and identifying novel targets for cholesterol-lowering therapies.