Articles tagged with Triglycerides
In a phase 2 trial, evinacumab significantly reduced triglyceride levels in patients with severe hypertriglyceridemia, particularly those with specific genetic mutations. The study found that the magnitude of response was highly dependent on the participant's genetic profile.
Research suggests that fish oil supplementation only lowers triglycerides in individuals with a specific genetic background (AG genotype), while those with the AA genotype may see increased triglycerides.
Adding icosapent ethyl to statin therapy may lower stroke risk by an additional 36% in people with high triglyceride levels and cardiovascular disease. The study, based on the REDUCE-IT trial, found that icosapent ethyl can benefit patients with heart disease, diabetes, or elevated triglycerides above 150mg/dL.
A team of international chemists identified valuable fatty acids in seeds of two popular medicinal plants. The study found that these plant oils contain unsaturated conjugated fatty acids with anti-tumor properties and help combat obesity and inflammation.
The Endocrine Society's Clinical Practice Guideline emphasizes the importance of evaluating high cholesterol and triglycerides in adults with endocrine disorders. The guideline provides recommendations for managing lipid abnormalities and cardiovascular risk in patients with hypothyroidism, menopause, and Cushing's syndrome.
Researchers at North Carolina State University have found that vitamin D deficiency during early development can disrupt the metabolic balance between growth and fat accumulation in zebrafish. The study suggests a linkage between vitamin D and metabolic homeostasis, leading to obesity and stunted growth.
A newly identified mutation in microsomal triglyceride transfer protein (MTP) may enable the development of more specific inhibitors to reduce triglyceride levels without intestinal side effects. This discovery has important public health implications for cardiovascular disease prevention.
Icosapent ethyl significantly reduces first and subsequent revascularizations, including coronary stenting and cardiac bypass surgery, in statin-treated patients with elevated triglycerides. The study found a 34% reduction in first revascularization events and higher reductions in subsequent events among statin-stabilized patients.
Researchers at Baylor College of Medicine and Princeton University have discovered the 3D structure and mode of action of diacylglycerol O-acyltransferase-1 (DGAT1), a key enzyme in triglyceride synthesis and fat absorption. This finding opens opportunities for designing novel strategies to manage obesity and other metabolic diseases.
Higher levels of omega-3 fatty acid EPA found to explain significant reductions in cardiovascular events and deaths among patients taking prescription fish oil. Achieved EPA levels on the drug strongly correlated with lower rates of cardiovascular events.
Researchers have successfully produced human protein Apolipoprotein A5 (APOA5) in the laboratory to metabolize and clear excess levels of triglycerides. The study demonstrates a potential pathway for developing drugs that trigger this process.
Researchers have visualized the first structure of a lipin enzyme, crucial for triglyceride production, revealing how it regulates fat storage and its role in diseases like heart disease and obesity. The study provides insights into mutations that lead to abnormal triglyceride production.
Scientists at CNRS have discovered that triglycerides interact with certain neurons in the brain's reward circuit, reducing their excitability and strengthening reward-seeking behavior. The study also found a correlation between blood triglyceride levels and brain activity in response to food odors.
A new study found that middle-aged and older adults who consumed sugary beverages daily had a higher risk of developing abnormal cholesterol and triglyceride levels compared to those who rarely drank them. The study suggests that limiting sugary drink intake may help maintain healthier blood cholesterol and triglyceride levels.
A new observational study published in the Journal of the American Heart Association found that drinking 12 ounces of sugary drinks more than once per day is linked to lower levels of HDL-C and higher levels of triglycerides. The study also found that regularly consuming sugar-sweetened beverages increases the risk of cardiovascular di...
Regulating lipid metabolism in neurons has been shown to promote axon regeneration, with triglyceride synthesis impeding and phospholipid synthesis promoting regrowth. This new direction for research may provide translational targets for CNS injury treatment.
Researchers have found a causal link between high blood triglycerides and chronic inflammation, leading to kidney damage and vascular disease. A diet low in fat can significantly extend the life expectancy of patients with diabetes or high blood pressure.
A new study found that leisure-time physical activity is associated with a healthier blood lipid profile in postmenopausal women. However, it did not completely offset the unfavorable changes seen during the menopausal transition.
Prescription omega-3 fatty acid medications are effective in reducing high triglyceride levels by 20-30% among most people. The American Heart Association advises using these medications safely in conjunction with statin medicines that lower cholesterol.
A new drug called volanesorsen has been shown to significantly reduce blood fat levels in people with a rare genetic disorder. In a Phase III clinical trial, participants experienced a 77% reduction in triglyceride levels, while those receiving a placebo saw a 18% increase.
A new study has found that women with low-density lipoprotein (LDL) cholesterol levels below 70 mg/dL may be at a higher risk of hemorrhagic stroke. The study also found that women with the lowest triglyceride levels had an increased risk of bleeding strokes compared to those with the highest triglyceride levels.
A new study shows that a 4 gram dose of icosapent ethyl significantly reduces the occurrence of ischemic events, including heart attacks, strokes, and related deaths. The drug also prevents subsequent cardiovascular events and may be a cost-effective way to prevent CV complications in patients with elevated triglycerides.
Researchers discovered lipid-filled particles (AdExos) released by adipocytes in mice that activate immune function and regulate metabolism. AdExos control the development of immune cells, inducing bone marrow cells to develop into macrophages that digest lipids.
Researchers found that high triglyceride levels were linked to lower risk of cognitive decline, frailty, and death in older adults. Current guidelines for lowering cholesterol may not be beneficial for this age group.
The REDUCE-IT trial found that icosapent ethyl reduced the risk of death due to cardiovascular causes, heart attack, and stroke by 25%, including a 20% reduction in death and 31% reduction in heart attack. This may set a new standard for patients with elevated triglycerides and increased cardiovascular risk despite statin therapy.
A study of 1,826 adolescents found that higher current total activity was associated with lower VLDL and triglycerides, while longer-term activity showed similar results. The findings suggest that it's never too late to benefit from physical activity, but maintaining regular engagement is key.
Researchers have identified specific lipid species in the blood and liver that correlate with healthy or fatty liver states. These findings suggest that measuring individual lipid species may provide a more accurate diagnosis of metabolic diseases such as NAFLD, diabetes, obesity, and metabolic syndrome.
A study of 800 participants who consumed milkshakes found new uncommon gene variants affecting patients' responses to a cholesterol drug. The variants were associated with changes in triglyceride and LDL-cholesterol levels after consuming high-fat meals and taking the medication.
Researchers found a significant link between pancreatitis in minority populations and severe levels of triglycerides, as well as gallstones and excessive alcohol intake. The study's findings may help physicians assess the risk of pancreatitis and develop early detection strategies.
A new study by the Intermountain Medical Center Heart Institute has identified protein pathways associated with changes in triglyceride and hemoglobin A1c levels in diabetic patients. The findings suggest a link between these pathways and increased risk of cardiovascular events, such as heart attack, stroke, or death.
A CRISPR-like gene editing technique has been shown to reduce blood triglyceride levels by up to 56 percent and cholesterol by up to 51 percent in a mouse model. This could potentially lead to new treatments for heart disease.
A new cholesterol calculation method has been shown to be more accurate than the standard method in nonfasting individuals. The method, developed by Johns Hopkins researchers, uses a chart with 180 different factors to calculate LDL cholesterol levels and individualize assessments.
Researchers found that genetic predisposition increases risk of high triglycerides, but maintaining a healthy body weight or changing diet can help reverse the risk. A specific gene mutation was associated with higher circulating triglycerides, but the correlation was dependent on BMI and dietary intake.
Researchers discovered that mTORC1 is essential for VLDL-triglyceride production, controlling lipid synthesis and storage in the liver. The study suggests targeting mTORC1 to prevent non-alcoholic fatty liver disease and cardiovascular disease associated with obesity and diabetes.
Researchers found an enzyme called DGAT1 that helps protect a key organelle within cells from toxic fatty acids. This discovery contributes to understanding common metabolic diseases like type 2 diabetes and fatty liver disease.
Research found that small amounts of house dust containing endocrine-disrupting chemicals can spur fat cells to accumulate triglycerides and divide, promoting weight gain. The study suggests that indoor dust is a likely exposure source of chemicals disrupting metabolic health, particularly in children.
A recent study by the University of Otago found that regular brisk walks and daily longer walks significantly lower levels of fatty acids in office workers' blood. This approach may improve metabolic health outcomes and reduce the risk of cardiovascular disease and death.
Researchers found that blocking ANGPTL3 activity with an injectable antibody reduced triglycerides by up to 76 percent and lowered LDL cholesterol 23 percent in human study participants. Carriers of mutations disabling ANGPTL3 had nearly 40 percent fewer incidents of coronary artery disease compared to non-carriers.
Researchers identified six people with hypertriglyceridemia whose bodies produce autoantibodies against GPIHBP1, preventing LPL from reaching capillaries. This newly discovered syndrome, dubbed the GPIHBP1 autoantibody syndrome, has life-threatening potential and may be treatable with immunosuppressive drugs.
A study published in the Journal of Nutrition found that eating peanuts with a meal can help prevent arterial stiffening and keep blood vessels healthy. The researchers observed a 32% reduction in triglyceride levels after peanut consumption compared to a control group.
A new study found that fenofibrate therapy may be beneficial in reducing cardiovascular events in patients with type 2 diabetes who take statins but still have high triglyceride levels and low HDL cholesterol levels. The study suggests a potential benefit of combining fenofibrate with statin treatment for this specific patient population.
Researchers at Saint Louis University found that silencing a protein in liver and adipose tissue significantly improves blood sugar levels and reduces body fat in animal models. This breakthrough could lead to new treatments for insulin-resistant obese or overweight patients.
A study published in JAMA Cardiology found that average total cholesterol, triglyceride, and LDL-C levels among US adults have decreased over the past two decades. The decline, which began between 1999 and 2010, continued through 2013/2014, with significant drops in triglycerides and LDL-C levels.
Researchers tested an injectable biologic drug therapy that inhibits Angiopoietin-like 3 (ANGPTL3) to lower triglyceride levels. The study showed a profound drop in triglyceride levels, with reductions of up to 73%, and dose-dependent reductions in cholesterol levels.
Researchers found that inhibiting Apolipoprotein C-III (ApoC-III) decreases triglyceride levels in blood by targeting similar pathways as LDL cholesterol. Treating mice with an ApoC-III inhibitor lowered triglycerides, but the effect was blocked in mice lacking key components of the LDL signaling pathway.
A study of over 300,000 individuals suggests that cholesterol levels are similar whether patients fast or not. This new guideline eliminates the need for fasting before cholesterol testing, benefiting patients and healthcare providers alike.
Researchers discovered a mutated ANGPTL4 gene that lowers triglyceride values in the blood, reducing the risk of coronary disease. This breakthrough may lead to new medications that simulate the effect of this mutation, providing a concrete goal for future research.
Researchers have identified two genes that, when altered, promote or undermine cardiovascular health. ANGPTL4 is associated with lower triglycerides and reduced risk of coronary disease, suggesting strategies to lower triglycerides could help prevent heart attacks. Future therapeutics targeting this pathway are in development.
A study by Finnish researchers found that removing a gene from mice protected them against arterial disease and obesity, due to increased activity of brown adipose tissue. The discovery suggests that inhibiting the USF1 gene might be a good strategy for treating cardiovascular disease and diabetes.
A recent study from the University of Eastern Finland found that a common gene mutation in healthy children improves blood lipid profiles while raising liver values. The TM6SF2 gene mutation was associated with lower triglyceride and LDL cholesterol levels, as well as higher ALT values indicative of changes in liver metabolism.
Research found that gut bacteria contribute to differences in body fat (BMI), blood lipids such as triglycerides and HDL, but have little relationship with bad cholesterol. The study used deep sequencing technology to identify 34 types of bacteria associated with these changes.
A Mayo Clinic study published in Pediatric Obesity found that excessive vitamin D supplementation in obese teenagers showed no benefits for their heart health or diabetes risk. The study, led by Dr. Seema Kumar, also found increased cholesterol and triglyceride levels in the teens during supplementation.
Researchers at the University of Montreal successfully block apoC-III gene expression, demonstrating significant decreases in triglyceride levels. This breakthrough could lead to precise interventions for severe hypertriglyceridemia, reducing cardiovascular risks.
Researchers have identified a genetic association between elevated triglyceride levels and decreased type 2 diabetes incidence. Triglyceride-increasing alleles were found to be associated with lower risk of developing type 2 diabetes, suggesting that these genetic variants may play a role in protecting against the disease.
A study by Spanish scientists confirms that exposure to persistent organic pollutants in the body is linked to higher levels of cholesterol, triglycerides, and obesity. The researchers analyzed nearly 300 men and women and found a correlation between pollutant levels and health risks.
Researchers discovered that triglyceride production in the liver is independent of insulin action, contributing to health risks in type 2 diabetics. The study's findings provide new insights into non-alcoholic liver disease and potential treatments.
Researchers identified rare APOA5 gene mutations linked to high triglycerides and increased heart attack risk. The study found that these mutations also raise LDL receptor mutation prevalence, underscoring the role of triglyceride metabolism in early-onset heart attacks.
Research suggests that spices and herbs, such as cinnamon and garlic, can lower triglyceride levels in the blood, which can lead to a reduced risk of heart disease. The use of high-antioxidant spice blends may be a potential way to reduce calorie intake without sacrificing flavor.
Research finds that individuals with a history of depression and hostile marital relationships experience reduced calorie burn and higher insulin levels after consuming high-fat meals, leading to potential weight gain and metabolic syndrome. The study highlights the importance of treating mood disorders in preventing obesity.
Researchers found large droplets of triglycerides within neurons of mice modeling the disease, leading to potential therapies and a new investigative strategy. The study points to triglyceride metabolism as a key factor in hereditary spastic paraplegia.