A novel nanoparticle platform facilitates therapeutically effective delivery of encapsulated agents to the brain, opening possibilities for treating neurological disorders. The technology showed three times more accumulation in brain than conventional methods and was therapeutically effective in mouse models.
The authors review future directions of nanomedicine development focusing on the mechanism of nanoparticle entry into tumors. Designing better nanoparticles to achieve efficient clinical transformation can be informed by a deep understanding of the mechanism of nanoparticle entry or the mode of action.
Researchers developed a new microscopy method to visualize the building blocks of 'smart' materials being formed at the nanoscale. The technique, called VC-LCTEM, allows scientists to see the reaction taking place in real time, enabling them to understand how to speed up and control the process.
Researchers from Siberian Federal University found that nanoparticles can dramatically change rock wettability characteristics, leading to increased oil recovery. The study showed that even small amounts of nanoparticles added to the liquid improved oil production efficiency by weakening capillary forces and reducing interfacial tension.
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Researchers at Duke University have created a new method to concentrate and separate nanoparticles using sound waves, working in under a minute instead of traditional centrifugation methods which take hours or days. The technique can be used for precision bioassays, cancer diagnosis, and more.
Researchers have developed nanoparticles that can breach cell barriers and kill tumor cells, reducing tumor sizes by 40-70% in mice. The highly selective toxicity of the particles offers new hope for treating aggressive cancers.
Scientists create tiny Janus balls that change color under a magnetic field, potentially used in inks for anti-counterfeiting tags. The technology could help manufacturers stay one step ahead of sophisticated counterfeiters.
Researchers from SUTD and MIT developed a procedure to link large-scale assembly processes to molecular simulations, allowing them to study the movement and interactions of atoms and molecules. They successfully simulated a large-scale virus, M13, with nanoparticles for fifty nanoseconds, overcoming previous limitations.
Researchers have developed a new technique to analyze the properties of individual cobalt oxide particles, enabling more efficient catalysts for hydrogen production. The method allows for the selection of particles under an electron microscope and their placement on a nanoelectrode for electrochemical analysis.
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Chemists from RUDN University synthesized biopolymers based on chitin from crab shells, forming effective catalysts for organic reactions. The new catalysts can be reused over ten times without reducing yield or damaging nanoparticles.
Researchers from RUDN University have synthesized new chitin-based antibiotics with enhanced antibacterial activity, outperforming existing compounds like ampicillin and gentamicin. The newly created substances also exhibit non-toxicity and potential as catalysts in organic synthesis.
Optical tweezers have been extended to trap nanoscale particles by exploiting a particular property of light diffraction at the interface between a glass and a liquid. The device uses 'Arago spots' and 'total internal reflection' to confine particles in a donut-shaped wave, enabling precise manipulation without physical contact.
KAIST researchers have synthesized nanoparticles that emit multiple wavelengths of light from a single particle, allowing for the control of these particles' properties and creation of environmentally responsible displays and lighting. The discovery also sheds new light on the mechanisms governing the optical properties of carbon dots.
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A Penn State research team conducted field tests on three commonly used mineral-based aerosol sunscreens, finding trace nanoparticles but at safe levels. The study suggests that the canister design and active ingredients are unlikely to produce vastly different amounts of nanoparticles.
Researchers have demonstrated a way to control nanoparticles to lase at low power, producing sharp signals for biosensing and bio-imaging. This breakthrough reduces tissue damage and improves the accuracy of sensing indicators, holding promise for early-stage disease detection.
Researchers at Harvard have developed an ionic forcefield coating that allows nanoparticles to bypass the immune system's first line of defense. In mouse experiments, coated nanoparticles survived longer in the body and reached their target location with increased efficiency.
Researchers developed an animal-free method to predict nanoparticle toxicity, enabling safer industrial materials production and reducing environmental risks. The new approach identifies key cellular events triggering inflammation, allowing for high-throughput testing and connectable with in silico modeling.
The study introduces a new generation of multifunctional materials created by adding carbon nanoparticles to polymer matrices, allowing for self-sensing properties. This technology has the potential to replace sensors in weight-critical systems and manufacture electrically conductive materials for various applications.
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Scientists create technique to remotely manipulate heat sources and associated fluid flows using laser light. This enables new functionalities in optofluidics, such as selective delivery of nano-objects and analytes. The method also demonstrates programmable control over optical propulsion forces and fluid streams.
Researchers at Duke University have developed a simplified method to calculate the attractive forces between nanoparticles, allowing for faster simulations and potentially leading to breakthroughs in fields like solar energy and catalysis. The new approach has been shown to be accurate within 8% of the actual results.
A Brazilian company developed a plastic film that eliminates 79.9% of SARS-CoV-2 particles in three minutes and 99.99% in up to 15 minutes, making it a promising material for food packaging protection against the novel coronavirus. The film contains silver and silica nanoparticles and has been successfully tested in laboratory settings.
A new optical imaging technology called PANORAMA has been developed to detect and study nanoscale objects as small as 25 nanometers in diameter. This technology uses unscattered light to monitor changes in transmission and determine the target's characteristics, making it possible to view nanoparticles directly without labeling.
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Researchers have developed a novel method to synthesize sub-nanoparticles (SNPs) with controlled composition and size, enabling the discovery of unique properties. The team found unusual electronic states and oxygen content in SNPs with an indium-to-tin ratio of 3:4, leading to different optical properties.
The University of Connecticut has licensed its groundbreaking continuous manufacturing technology for pharmaceutical nanoparticles to DIANT Pharma Inc. This technology offers several advantages over conventional batch manufacturing approaches, including highly controlled particle size, high-throughput production, and a smaller footprin...
Researchers demonstrate a solvent-assisted ligand exchange-hydrogen reduction strategy for selective encapsulation of ultrafine metal nanoparticles within the shallow layers of MOF. This approach reduces mass transfer resistance and enhances metal dispersion, promoting highly efficient hydrogenation reactions.
A new study has identified the coral skeleton growth mechanism, revealing that controlling water temperature is crucial for restoring reefs. The research suggests that corals regulate their internal ion concentrations by pumping calcium and carbonate ions from seawater through coral tissue.
Researchers have developed nanoparticles that can cross the blood-brain barrier and be captured by neuronal cells, enabling direct drug delivery to the brain. This breakthrough finding holds promise for improved treatment of neurodegenerative diseases affecting millions of Canadians.
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A new ultrapotent COVID-19 vaccine candidate, designed via computer, has been shown to produce virus-neutralizing antibodies in mice at levels ten times greater than those seen in people who have recovered from COVID-19 infections. The vaccine candidate also elicited a strong B-cell response after immunization.
Researchers have developed a novel method to convert carbon dioxide to carbon monoxide at room temperature using localized surface plasmons. This process eliminates the need for high heat, reducing energy requirements and costs in industrial production.
Researchers at University at Buffalo have discovered a method to convert a coronavirus protein into a nanoparticle, which could lead to more effective vaccines against COVID-19. High antibody levels were induced in laboratory mice and rabbits after immunization with the RBD particles.
Researchers from China University of Petroleum have designed ultra-small hollow alloy nanoparticles that exhibit excellent electrocatalytic activity and stability for the hydrogen evolution reaction. The unique structure provides abundant active centers, reducing the cost of platinum-based electrocatalysts.
Researchers developed a plastic film containing silver-silica nanoparticles that inactivates the novel coronavirus on contact, reducing SARS-CoV-2 particles by almost 100%. The film is made by Brazilian company Nanox and has been approved as a PPE mask for COVID-19 protection.
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Researchers have developed an ultra-sensitive hybrid nanothermometer that can detect small temperature changes in ambient conditions. The device uses a nitrogen-vacancy center in diamond and a magnetic nanoparticle to measure thermal signals with a precision of 76 microkelvin per second.
University of Delaware researchers develop tiny cargo-carrying systems that can selectively bind to degrading collagen, providing site-specific medicine delivery over longer periods. These nanoparticle carriers have the potential to improve treatment for diseases like osteoarthritis and rheumatoid arthritis.
Researchers developed tiny optically powered machines that self-assemble and can manipulate tiny cargo for applications like nanofluidics and particle sorting. The machines use circularly polarized light from a laser to create a nanoparticle array acting like a gear, influencing nearby particles to orbit the array.
Researchers discovered markers of Alzheimer's, Parkinson's and motor neurone disease in the brains of young Mexico City residents exposed to dirty air, linked to particulate pollution. Tiny nanoparticles were also found, which can cause inflammation and oxidative stress.
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Researchers discover a new method for making nanoparticles that can efficiently capture over 95% of proteins, DNA, or small molecule drugs. The process uses a self-assembling polymer to create a nanonet that collapses into nanogels, trapping therapeutics with high efficiency.
A new study reveals that nanoparticles can damage human cells when combined, even if individual types do not cause harm. Researchers call for more studies on the effects of lifelong exposure to nanoparticles, which are used in various products and manufacturing processes.
Researchers used zebrafish embryos to visualize the interactions between nanoparticles and cells, revealing that protein coronas can make nanoparticles appear non-self to cells. This understanding could lead to improved targeted drug delivery systems.
Researchers from Peter the Great St. Petersburg Polytechnic University successfully created silver nanoparticles in an ion-exchanged glass using infrared nanosecond laser pulses. The nanoparticles demonstrate surface plasmon resonance, enabling signal enhancement of up to 10^6 times in Raman spectroscopy.
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Researchers at TU Wien and DESY discovered a material that can be switched between two states: one is catalytically very active, the other less so. The switching is controlled by tiny iron nanoparticles on the surface, which change between metallic and oxidic states depending on the voltage applied.
This study investigates the antimicrobial effect of rosemary and ginger essential oil-based nano-sized formulations on colistin-resistant K. pneumonia clinical isolates. The results show that oil-loaded chitosan nanoparticles exhibit high antimicrobial and antibiofilm activity, inhibiting the expression of the biofilm gene mrkD.
Scientists at Tokyo Institute of Technology create alloyed metal nanoparticles using the atom hybridization method, achieving superior catalytic activity and stability. The sub-nanoparticles (SNPs) exhibit high reactivity even under mild conditions, producing unique compounds and hydroperoxides.
Researchers at Ohio State University have discovered that RNA nanoparticles exhibit elastic and rubbery properties, enabling them to target tumors by slipping through tumor blood vessels. The particles are also excreted from the body quickly via urine, reducing toxicity.
Researchers developed a non-toxic nanofluid using commercially available sodium, achieving 80% oil recovery in lab tests. The nanofluid works through multiple mechanisms, including generating heat and reducing viscosity, making it a game-changing technology for oil recovery.
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Scientists at Argonne National Laboratory developed a new nanocatalyst that uses gold to eliminate platinum dissolution, increasing fuel cell durability. The discovery is a breakthrough for PEMFC-powered transportation, offering a solution to the current performance limitations.
Researchers are co-developing a new, rapid-acting, long-lasting disinfectant spray that instantly kills viruses without harsh chemicals. The spray uses UCF-developed cerium oxide nanoparticles, which have shown therapeutic properties against various diseases.
Researchers at Skoltech have developed a simple and efficient method to convert silicon wafers into nanoparticles in an aqueous solution, providing a new source of sustainable materials. The process enables controlling particle sizes and has implications for optics, photonics, medicine, and other fields.
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A researcher has received a five-year, $1.8 million grant to develop and improve oral drug delivery systems for poorly water-soluble molecules. The goal is to increase the effectiveness of these drugs, which currently have limited technology options.
Researchers developed a simple, low-cost method to synthesize silver nanoparticles using habanero peppers. The process utilizes the antioxidant properties of the peppers to reduce silver ions, resulting in stable nanoparticles with potential applications in optics, biosensing, and antimicrobial coatings.
Using tattoo ink and food dyes, researchers have developed new imaging contrast agents that can illuminate cancers, allowing for better differentiation between cancer cells and normal adjacent cells. This breakthrough aims to improve early cancer detection and localization.
Researchers created silicon-based batteries with improved stability and capacity, allowing for faster charging times and increased efficiency. The breakthrough could enable the use of lighter batteries in spacesuits and satellites, reducing mission costs and increasing energy storage capabilities.
Scientists have developed a plasmonic photocatalyst with a nanocavity that accumulates charges, improving the efficiency of water oxidation reactions. The discovery could lead to more efficient conversion of renewable sunlight into useful fuels and chemicals.
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Researchers developed a novel spectroscopic technique to study stibnite nanostructures, revealing their potential as high-optical-quality waveguides. The technique allows for the measurement of spectrally resolved intensity profiles within individual nanodots, demonstrating that they can support four modes over a 200-nm bandwidth.
Researchers developed a machine learning workflow to streamline the analysis of liquid-phase electron microscopy videos, enabling the extraction of valuable information from nanoparticle dynamics. The new technique has potential applications in medicine, energy, environmental sustainability, and biomaterials research.
Scientists have engineered a tiny therapeutic delivery system using lipid-based nanoparticles that safely solve genetic problems in mice. The treatment successfully produced a protein to treat hemophilia and reduced gene activity to lower cholesterol levels, offering hope for targeted therapies.
Researchers at UCI are learning about resilience from the mantis shrimp, which has a uniquely designed nanoparticle coating that absorbs and dissipates energy. This finding has significant implications for engineered materials in various industries.
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Researchers have developed a new type of cerium nanoparticle formulation that can prevent plaque and cavities from forming, without killing oral bacteria. The nanoparticles inhibit the growth of biofilms by 40% compared to silver nitrate, reducing the risk of tooth decay.
Swimming microparticles have the potential to improve coolant performance by accelerating heat transfer from hot surfaces. This innovative technology could lead to faster, smaller devices with reduced energy consumption, benefiting industries such as electronics, automotive, and renewable energy.
Researchers develop innovative method to fabricate high performance lenses in monolayer two dimensional transitional metal dichalcogenide (TMDC) material using femtosecond laser. The lens provides subwavelength resolution and high efficiency, enabling diffraction-limited imaging.