Research on engineered particles at the nanoscale. Covers hyperspectral imaging, nanoparticle cancer therapy, gene-editing delivery, and heat-beating materials.
Sumit Sharma, assistant professor at Ohio University, has received a $511,902 NSF CAREER grant to investigate surfactant molecule adsorption on metallic nanoparticles. His research aims to develop a fundamental theory explaining the optimal surfactants for specific results.
The special issue explores the subtopics of in vivo fate of drug nanocarriers through review and research articles. Featured papers discuss intracellular uptake, impact of particle size and pH on protein corona formation, and in vivo dissolution of poorly water-soluble drugs.
Researchers at Scripps Research have unveiled an innovative Ebola virus vaccine design that stimulates a better protective immune response. The new approach involves tethering copies of the Ebola virus outer spike protein to a spherical carrier particle, resulting in a more stable and realistic-looking virus particle.
The review explores recent strategies in surface functionalization, their specific biomedical applications, and comparative toxicities with non-functionalized metallic nanoparticles. It discusses the challenges for metallic NPs to undergo human clinical trials due to their aggregation and toxic nature.
By vaporizing metals within a magnetic field, UC Riverside engineers direct the reassembly of metal atoms into consistent shapes and surfaces. The approach enables manipulation of particle assembly, producing string-like aggregates or globular clusters with tunable properties.
KAUST researchers have developed a robust catalyst that converts carbon dioxide into carbon monoxide gas with 100% selectivity, overcoming the limitations of precious metals. The innovative method uses MOFs to create mixed metal catalytic nanoparticles in a homogenous mixture.
Inkjet printing of metal nanoparticles forms layers with functional anisotropy, causing electrical conductivity to vary between horizontal and vertical directions. Researchers discover that organic chemical residues in the inks are responsible for this effect, enabling new techniques to overcome it.
The patented technology uses magnetic nanoparticles to capture lithium and other critical materials from brines, offering a more efficient and cost-effective process. This innovation has the potential to reduce energy consumption and create new domestic supply chains for these essential elements.
A new pan-coronavirus vaccine has proven effective in protecting monkeys and mice from various coronavirus infections, including SARS-CoV-2 and its variants. The vaccine triggers neutralizing antibodies via a nanoparticle and targets a cross-reactive site of vulnerability on the spike protein.
Researchers developed an uncrackable combination of invisible ink and artificial intelligence to encrypt messages securely. Using a carbon nanoparticle-based invisible ink and AI algorithms, they achieved 100% accurate decryption with UV light exposure.
Researchers at UTA are combining nanoparticles and light waves to treat traumatic brain injuries on the battlefield. The goal is to create a synergistic effect with improved healing outcomes.
A new strategy combines AIEgen-mediated photodynamic therapy with Poly(I:C)-based immunotherapy to enhance anti-tumor immune responses. The system induces tumor cell death and stimulates cytokine release, demonstrating potential for preventing tumor recurrence and metastasis.
Researchers develop Nanotraps that capture SARS-CoV-2 viruses within the body, utilizing the body's own immune system to destroy them. The therapy has shown promising results in early stages of testing and could potentially be administered via a nasal spray as a treatment for COVID-19.
Scientists developed zinc-modified aluminum oxide membranes for heavy metal removal, achieving high efficiency rates. The membranes showed antifouling properties and were reusable up to three cycles.
Researchers at Rice University reveal a two-step process by which silver ions are released from nanoparticles, with the possibility of stabilizing the alloy through gold manipulation. The discovery could lead to the development of new catalysts and materials for various applications.
Researchers develop nanoparticles that penetrate human cells and destroy bacteria, offering new hope against antibiotic resistance. The particles use cerium oxide to create reactive oxygen species that kill germs, reducing the likelihood of resistance development.
Researchers create nanostructured bimetallic catalysts with enhanced activity and stability, offering a cost-effective alternative to noble metal-based catalysts. The new material is stabilized on a conductive surface using a polymeric material, enabling predictable catalysis performance.
Scientists have developed a method to create crystalline exoskeletons around delicate liposomes and lipid nanoparticles, stabilizing them at room temperature for up to two months. This breakthrough could help address the need for COVID-19 vaccines to be kept at below-freezing temperatures during transport and storage.
Researchers used mirror SELFI to detect nanoparticles' size and location with nanometre resolution, enabling tracking of disease-causing viruses. This breakthrough could lead to new sensing methods for biomedical applications.
University of Central Florida researchers have developed a new screening technique using nickel-platinum nanoparticles to increase ELISA sensitivity for diseases like cancer, allowing for earlier diagnosis and potentially saving lives.
ITQB NOVA researchers have developed a new approach to produce hydrogen from light using non-photosynthetic microorganisms. The biohybrid systems combine high hydrogen-producing bacteria with self-produced cadmium sulfide nanoparticles, which capture light and enable direct energy transfer.
Researchers have developed next-generation influenza vaccines that protect against a wide variety of seasonal and pandemic strains, including avian viruses H5N1 and H7N9. These nanoparticle-based vaccines spur strong immune responses in animal trials, potentially lowering the risk of bad flu seasons.
Columbia Engineers use DNA nanotechnology to design nanoparticle-based 3D materials that can withstand extreme conditions. The new fabrication process results in robust and fully engineered nanoscale frameworks with a broad range of applications.
Researchers employed nanoparticles-based delivery systems to deliver AMPs for treating deep infections. Intelligent nanocarriers can achieve selective activation and target at infection sites, improving therapeutic efficacy against bacterial infections and reducing toxicity.
Researchers have developed a novel nanoparticle delivery system that enhances the effectiveness of neuroprotectant NA1 in treating stroke. The study found that nanoparticles carrying NA1 reduced stroke size by 69.8% and brain swelling by 60.3%, leading to improved survival rates.
Scientists have developed a new technique to manipulate nanoparticles with the same refractive properties as their background environment, overcoming a fundamental technical challenge. This breakthrough has huge potential in fields like medicine, enabling precise manipulation and measurement of microscopic objects inside cells.
Researchers successfully filmed and restored the 3D structure of nanoparticles that share structural similarities with viruses using X-ray free electron laser (XFEL) and machine learning. This breakthrough enables high accuracy and speed imaging of viruses, opening new avenues for understanding their structures.
Kytai Nguyen's research aims to reduce complications and improve quality of life for PAD patients by delivering plasmids that protect cells and promote new blood vessel growth. The project has the potential to offer hope to millions worldwide affected by this common malady.
Researchers at UC San Diego have created coronavirus-like nanoparticles to serve as positive controls for COVID-19 tests, ensuring reliability and accuracy. These new controls can be used with existing tests or adapted to newer assays, making them a valuable tool for mass testing in underserved areas.
Researchers have developed a new technique using bowl-shaped nanoparticles to study Alzheimer's disease amyloid beta protein aggregates. The findings confirm multiple forms of these aggregates co-exist and not all convert into brain plaques, opening possibilities for diagnostic and treatment applications.
A research team led by Berkeley Lab has captured high-resolution videos of nanoparticles forming solid-like layers at the interface between oil and water. The findings could help optimize liquid structures for advanced biomedical applications such as drug discovery and targeted cancer treatment.
A new virus detection method has been developed by KAUST researchers using magnetic nanoparticles, allowing for fast, safe and cheap testing of viruses in clinical and wastewater samples. The method rivals commercial viral-RNA extraction kits while lowering the risk of handling potentially infectious samples.
A new isolated lymphatic vessel lumen perfusion system was developed to evaluate the interaction between nanoparticles and lymphatic vessels. The system enables detailed examinations of nanomaterial movements and biological safety, paving the way for safe clinical applications.
Researchers developed a new strategy to destroy cancer cells using magnetic nanoparticles and constant magnetic fields. The combined effect of nanoparticles and magnetic fields reduced the viability of leukemia cells while sparing healthy cells, suggesting a selective therapeutic effect.
Scientists have developed a technology for obtaining magnetic nanoparticles using sweet flag extract, which exhibits antioxidant and antimicrobial properties. The new nanoparticles show antifungal activity against various species of fungi, demonstrating potential applications in agriculture and medicine.
Researchers uncovered dynamic details of a platinum-based catalyst's active site, resolving earlier conflicting reports. They found that only certain platinum atoms play an important role in the chemical conversion, which may lead to designing more efficient and cost-effective catalysts.
Scientists at NIST and University of Delaware developed a new method to create nanoparticle gels, which have potential uses in water filtration and smart windows. The resulting gel has a spongelike structure with interconnected microscopic channels, offering advantages for filtration and chemical reactions.
Researchers developed a next-generation nanotherapy that specifically targets injured regions of arteries in mouse models mimicking angioplasty. The nanoparticles containing an microRNA switch offer promising biotechnology to advance the fight against atherosclerotic cardiovascular disease.
A new nanoparticle-based drug can boost the body's innate immune system and make it more effective at fighting off tumors. Researchers found that the polymer-based nanoparticles activate STING even without a small molecule activator, causing a more sustained effect on the protein.
Scientists at Martin-Luther-University Halle-Wittenberg have fully determined the internal structure of single-chain nanoparticles (SCNPs) for the first time. The study reveals a 'nano-pocket' that protects dye or other molecules, enabling new imaging techniques and biomedical applications.
Researchers found that a previously overlooked phenomenon in chemical reactions can boost efficiency and reduce waste. The discovery, led by University of Illinois researcher David Flaherty, involves the formation of an organic residue that acts as a surface redox mediator, increasing reaction rates and hydrogen peroxide production.
Researchers found that silver nanoparticles in antimicrobial plastic can form in foods and beverages, especially in sweetened products. The study suggests that long-term storage of these packaged items could lead to the transfer of silver ions into food and drinks, potentially harming human health.
Researchers at Yale University have developed an injection treatment for skin cancer that uses polymer-based nanoparticles carrying chemotherapy agents. The treatment's bioadhesive properties allow it to kill cancer cells and stimulate the immune system, potentially eliminating the need for surgery.
Physicists have developed a new material for water desalination that can accelerate evaporation up to 2.5 times and detect hazardous substances. The material, made of titanium dioxide nanoparticles decorated with gold nanoclusters, absorbs light across the entire visible spectrum, converting it into heat.
Researchers have developed a unique combination of microscopy techniques to study the biological effects of nanoparticles and their interaction with human plasma. This approach allows for an unprecedented view of the nanoparticle's 'corona', also known as its biological 'crown', which contains clues about how nanoparticles interact wit...
Researchers at Ruhr-University Bochum have developed a method to control the direction of nerve fiber growth using magnetic nanoparticles. The team successfully implanted functionalized nanoparticles into model neurons, allowing them to guide axon growth and potentially promote regeneration in Parkinson's patients.
Researchers at Columbia University have developed the first nanomaterial that demonstrates photon avalanching, a process with extreme nonlinear optical behavior and efficiency. The realization of this phenomenon in nanoparticle form opens up new applications in sensing, imaging, and light detection.
A new class of crystalline material called avalanching nanoparticles (ANPs) overcomes the diffraction limit without heavy computation or a super-resolution microscope. ANPs enable real-time high-resolution bioimaging of cells' organelles and proteins, as well as ultrasensitive optical sensors and neuromorphic computing.
A new nanoparticle vaccine platform has been developed to protect against many strains of coronaviruses, including SARS-CoV-2. The vaccine, called a mosaic nanoparticle, presents the immune system with multiple different coronavirus variants at once, generating a diverse antibody response.
Researchers developed nanoparticles displaying SARS-CoV-2 RBD with diverse bat and pangolin betacoronavirus RBDs, eliciting cross-reactive immune responses in mice. The approach showed promise as a candidate vaccine against COVID-19 and emerging coronaviruses
Researchers at the University of Illinois Chicago developed a new catalyst made from 10 elements that can lower methane combustion temperatures by half. This could lead to a significant reduction in harmful greenhouse gases produced by burning natural gas in households, power turbines, and cars.
Researchers at NTU Singapore have developed oral insulin nanoparticles that can carry large amounts of insulin, making them a potential alternative to painful injections. The nanoparticles are stable and able to pass through the intestinal wall into the bloodstream, offering a promising solution for diabetic patients.
Researchers have developed a nanoparticle vaccine that elicits a virus-neutralizing antibody response in mice after just one dose. The spike/ferritin nanoparticles may be a viable strategy for single-dose vaccination against COVID-19, suggesting potential improvements over current two-dose regimens.
Researchers at Stanford University have created a nanoparticle vaccine candidate for COVID-19 that shows promise in inducing immunity after just one dose. The vaccine uses nanoparticles studded with the virus's surface spikes to trigger an immune response, offering a potential alternative to traditional viral-based vaccines.
Researchers from University of Illinois Chicago and Argonne National Laboratory developed alloy nanoparticles with high entropy, showing exceptional stability and durability during chemical reactions. These findings have potential applications in energy storage and conversion technologies, such as fuel cells and solar cells.
A novel nanoparticle platform facilitates therapeutically effective delivery of encapsulated agents to the brain, opening possibilities for treating neurological disorders. The technology showed three times more accumulation in brain than conventional methods and was therapeutically effective in mouse models.
The authors review future directions of nanomedicine development focusing on the mechanism of nanoparticle entry into tumors. Designing better nanoparticles to achieve efficient clinical transformation can be informed by a deep understanding of the mechanism of nanoparticle entry or the mode of action.
Researchers developed a new microscopy method to visualize the building blocks of 'smart' materials being formed at the nanoscale. The technique, called VC-LCTEM, allows scientists to see the reaction taking place in real time, enabling them to understand how to speed up and control the process.
Researchers from Siberian Federal University found that nanoparticles can dramatically change rock wettability characteristics, leading to increased oil recovery. The study showed that even small amounts of nanoparticles added to the liquid improved oil production efficiency by weakening capillary forces and reducing interfacial tension.
Researchers have developed nanoparticles that can breach cell barriers and kill tumor cells, reducing tumor sizes by 40-70% in mice. The highly selective toxicity of the particles offers new hope for treating aggressive cancers.