Articles tagged with Cell Cultures
A team led by Professor Satoshi Yamazaki has established a novel culture system that supports long-term ex vivo expansion of human hematopoietic stem cells (HSCs), overcoming previous limitations. The new system, which uses chemically-defined cell culture media, significantly improves HSC growth and proliferation.
Researchers have identified distinct senescence subpopulations and dynamic changes in the transcriptome of human cells undergoing senescence. The study provides new understanding of the heterogeneous nature of senescence and its impact on aging diseases.
Researchers have created a detailed map of human retinal organoid development, revealing information on cell types, proteins, and gene expression. The study uses advanced imaging techniques to visualize multiple proteins simultaneously and provides insights into retinal diseases such as retinitis pigmentosa.
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
A new liposome-based method aims to kill periodontitis-causing leukotoxin while protecting immune cells, providing an alternative treatment for aggressive gum infections. The approach has potential applications against a range of bacteria and could help combat antibiotic resistance.
Researchers found that exercise releases chemical signals that promote neuronal development in the hippocampus, a crucial area for learning and memory. Astrocytes play a critical role in mediating the effects of exercise on brain health, helping to regulate neuronal activity and prevent hyperexcitability.
Researchers at TUM have developed a method to create mini-hearts in Petri dishes using stem cells. The resulting organoids mimic the earliest stages of human heart development and can be used to investigate congenital heart defects, potentially leading to new treatment methods.
Researchers developed a 3D cell culture system to test fibroblast inhibitors with anti-cancer drugs. Combining nintedanib with cisplatin increased the latter's efficacy in suppressing cancer growth and invasion. The study provides a promising tool for preclinical drug testing.
Researchers at Hokkaido University discovered itaconate's modulatory effect on T helper and T regulatory cells, potentially leading to new treatments for autoimmune diseases. The study found that itaconate inhibits Th17 cell differentiation and promotes Treg cell development, reducing disease symptoms in mice models.
A new review paper suggests that selective protection of normal cells from chemotherapy could increase the therapeutic window and improve outcomes for cancer patients. The authors propose using antagonistic drug combinations to kill drug-resistant cancer cells, reducing side effects and improving quality of life.
Researchers explore cellular senescence's complex relationship with growth stimulation and cell cycle arrest, revealing potential anti-aging drug targets. Understanding these mechanisms is crucial for developing new treatments for age-related diseases.
The addition of antioxidants to cell cultures can improve the production of monoclonal antibodies by reducing oxidative stress and increasing cell viability. This has potential benefits for therapies targeting cancer and autoimmune diseases.
A team of researchers discovered that a mutation in the HMGB1 protein causes a rare disorder with severe malformations, suggesting a link between protein droplets and genetic disease. The study's findings could have implications for understanding congenital malformations, common diseases, and cancer.
A study reveals that big dynorphin, an endogenous opioid peptide, protects neurons against β-amyloid accumulation. The research suggests that big dynorphin can hinder the interaction between β-amyloid and form aggregates, promoting a neuroprotective effect.
Researchers from Tokyo Medical and Dental University developed a new approach to grow human intestinal mini-organs in the lab. They used cell culture plates and bioreactors to create robust and healthy intestine-like tissues that can be transplanted into mice, demonstrating the potential for regenerative medicine applications.
A new bioreactor system developed by KAUST scientists delivers gases to maintain physiological environments, reducing unpredictable shifts in cell growth. The system allows for more accurate and reproducible experiments in biomedical research.
A Collaborative Research Centre investigates animal navigation using the Earth's magnetic field. The study focuses on vertebrates, including birds and fish, aiming to protect endangered migratory species.
An international research team developed an animal-free testing battery to detect developmental neurotoxicity, using human cells instead of animals. The results show that the testing battery is technically feasible and already has a measurement sensitivity comparable to animal experiments.
Researchers have discovered a new gene, Schlafen11 (SLFN11), which correlates with chemotherapy response in medulloblastoma. The study's findings suggest SLFN11 can help improve treatment outcomes by increasing sensitivity to cisplatin.
A recent study identifies a specific gene, GNL3, that regulates neural proliferation in response to lithium, which is used to treat bipolar disorder. This gene plays an important role in brain function and has been implicated in risk for bipolar disorder, schizophrenia, and inter-individual variations in intelligence.
A study by Hokkaido University researchers found that low concentrations of cetylpyridinium chloride in mouthwash can inhibit SARS-CoV-2 infectivity and viral load, regardless of variant. This antiviral effect is thought to be due to disruption of the lipid membrane surrounding the virus.
Researchers at UVA Health System have made a groundbreaking discovery that could boost platelet production on demand to alleviate blood shortages. The finding offers hope for patients with thrombocytopenia and those receiving cord-blood transplants.
Researchers found that mTOR inhibition is crucial for p53-mediated tumor suppression, delaying cancer and increasing lifespan. In the absence of mTOR inhibition, cancer-promoting senescent cells drive tumor growth.
Researchers have discovered a new protein called MAIA, which is crucial for human fertilization. The protein helps draw sperm into the egg cytoplasm, paving the way for novel ways to treat infertility.
Researchers have developed a new method for 3D cell culture that accurately quantifies how breast cancer cells generate forces to spread within tissue. This study provides more accurate computational data on cellular forces during invasion by breast cancer cells, which may lead to more efficient and personalized drug development.
Researchers at Washington University have developed a hydrogel system that preserves biochemistry and mechanical environments of cultured podocyte cells. This allows researchers to identify new ways to control mechanisms used by cells to heal themselves, potentially leading to therapies for currently incurable diseases.
Researchers at Ritsumeikan University have created a technique to precisely control the concentration of chemicals in droplets using electrowetting-on-dielectric (EWOD). This allows for accurate drug screening and cell-based analysis, enabling the efficient handling of substances on a smaller scale than traditional pipettes.
Researchers at TUM have developed a cell-free production method for bacteriophages, which can be used to target and combat specific types of antibiotic-resistant bacteria. The new technology has the potential to produce personalized therapeutic phages for clinical trials, addressing multi-resistant germ infections.
A study by Goethe University Frankfurt found that antibodies against Omicron variants BA.1 and BA.2 decline rapidly, even after a second vaccination or booster shot, offering limited protection against infection.
A research team discovered that bacterial cellulose produced by Komagataeibacter bacteria survived on Mars-like conditions. The study found minor changes in the genome after reactivation on Earth, suggesting cellulose as a potential biomarker for extraterrestrial life.
Lab-grown plant material can be precisely controlled for physical and mechanical properties, such as stiffness and density. The researchers use a 3D bioprinting process to grow custom shapes and sizes of plant material.
A UC Davis study found a critical agent keeping KSHV dormant and undetected by the immune system. The virus is linked to various cancers and AIDS-related diseases. The researchers identified CHD4 as a key regulator of the latency-lytic switch, allowing the virus to stay silent.
Scientists at Osaka University created 3D human stem cell-derived lacrimal gland organoids that mimic the human tear duct. The organoids exhibited organization and branching patterns characteristic of the human lacrimal gland, demonstrating potential as a platform for regenerative therapies for dry eye syndrome.
Scientists have identified a retinoic acid-dependent hemogenic endothelial progenitor from human pluripotent stem cells, enabling the development of transcriptionally similar cells in tissue culture. This breakthrough method brings researchers closer to developing blood-forming stem cells for transfusions and cancer treatments.
University of Virginia professor Rachel Letteri's lab designs polymers for healthcare applications, using peptide fragments to create hydrogels with tunable stiffness and lifespan. The team aims to develop materials that can support cell growth and guide tissue regeneration, with potential applications in regenerative medicine.
Researchers from Goethe University and University of Kent found aprotinin effective against SARS-CoV-2 variants, including Delta and Omicron, by preventing virus entry into host cells. A recent phase III clinical study demonstrated the treatment reduced hospital stays by five days.
Researchers found that one viral protein suppresses infection with hepatitis E. However, experimental studies in mice revealed a different pattern, suggesting the two viruses affect each other in complex ways. Further analysis of liver cells is needed to shed light on the underlying causes of co-infection.
Researchers at Karolinska Institutet in Sweden have developed a novel strategy to identify potent miniature antibodies, so-called nanobodies, against emerging SARS-CoV-2 variants. The approach led to the discovery of multiple nanobodies that effectively blocked infection with different SARS-CoV-2 variants.
Researchers at Moffitt Cancer Center have developed patient-derived cells that can be used to study leptomeningeal disease, a rare complication of cancer. The cells provide a new opportunity for scientists to understand the disease and identify potential therapeutics.
Researchers at Tohoku University developed a new lab-based system to grow human muscle cells that contract vigorously. They found that muscle cells from patients with sporadic inclusion body mitosis (sIBM) have similar muscular properties to healthy humans but exhibit altered responses to exercise.
Researchers have discovered that the tumor suppressor protein pVHL degrades SMAD3, inhibiting the TGF-β signaling pathway and suppressing tumour cell growth. This finding opens up new opportunities for developing cancer therapies by regulating pVHL activity.
A new study reveals that the Omicron variant is sensitive to inhibition by the interferon response, an unspecific immune reaction present in all body cells. This provides the first explanation for why COVID-19 patients infected with Omicron are less likely to experience severe disease.
Researchers have created PicoShells, microscopic particles that can speed up the growth and analysis of microorganisms, including algae. This new tool enables faster identification of cell strains suitable for mass production, potentially shortening R&D timelines by months.
A clinical study and register studies have failed to confirm previous findings that a medicine blocking testosterone could help against COVID-19. The researchers found no discernible signs of the drug having any beneficial effect on participants' health status.
A study published in Allergy reveals the importance of PU.1 transcription factor in regulating CCL17 gene expression, which contributes to allergic diseases. The research found that suppressing PU.1 can reduce inflammation in asthmatic mice, paving the way for novel treatments.
Researchers at NTU Singapore have developed a new use for e-waste plastics by repurposing them as an alternative to laboratory cell culture containers. The team found that over 95% of human stem cells seeded on e-waste plastics remained healthy after a week, comparable to cells grown on conventional plates.
Heidelberg researchers have created a rapid process for 3D imaging of cells using soft X-ray tomography, enabling high-resolution images in just five to ten minutes. This technology provides valuable insights into viral diseases and their impact on infected cells.
Researchers created a disease map of genes involved in eye disorders, shedding light on how individual cells respond to external factors like injury. The study paves the way for regenerative medicine and cell replacement therapies for eye diseases.
Researchers have discovered molecules that could be candidates for contraceptives or fertility enhancers using human blastoid models. These models also show promise in improving the self-organization of stem cells during IVF procedures.
Researchers at UConn Health have discovered that eliminating senescent cells in human fat tissue can alleviate signs of diabetes and improve insulin sensitivity. The study suggests that clearing away these dysfunctional cells could lead to game-changing new treatments for Type 2 diabetes.
Researchers have developed a 3D cell culturing platform that allows study of lung fibroblasts and their microenvironment, enabling measurement of cell behaviors and microenvironment changes involved in IPF disease progression. The system's versatility enables personalized medicine and potential applications in studying other diseases.
DZNE researchers found that viral molecules facilitate the intercellular spreading of protein aggregates, which are hallmarks of brain diseases like Alzheimer's. The presence of viral ligands increases protein aggregate spreading between cells, potentially contributing to neurodegeneration.
Researchers found that Delta and Delta Plus infect lung cells with higher efficiency than the original virus, evading antibodies induced by infection and vaccination. The new variants were also resistant to some therapeutic antibodies, leading to reduced inhibition.
Researchers developed avidin-conjugated nanocellulose, enabling attachment of biotinylated molecules and promoting 3D cell culture. The material supports efficient integrin signaling and high cell viability, indicating its suitability for applications like cell differentiation and tissue engineering.
A study published in Nature Communications reveals the mechanisms of SARS-CoV-2 proteolysis and identifies key cellular substrates with therapeutic potential. The research provides a powerful resource for developing targeted strategies to inhibit the virus, which has caused over 227 million infections and 4.6 million deaths worldwide.
Scientists from Hungary, Russia, and Finland created SpheroidPicker, an AI device that selects cancer cells of specific shape and size. The system enables a more standardized approach to working with tumour samples, producing a more realistic response to treatments.
Researchers found that a family of proteins enhances the immune response to HIV, Ebola and Zika by boosting signals sent within immune cells. This discovery has implications for potential broad antiviral therapy.
Researchers have successfully cultivated complex retinal tissue from embryonic stem cells of medaka and zebrafish. The study, published in eLife, demonstrates the feasibility of growing retina-like structures in a Petri dish, offering new insights into retinal development and potential applications for human medicine.
A team of researchers has identified a novel splicing mechanism for human short introns, involving the distinct factor SPF45. This discovery sheds light on alternative splicing and its potential applications in cancer treatment.
Scientists at University of California San Diego School of Medicine have developed a method to keep cultured hematopoietic stem cells healthy, positive news for patients seeking stem cell transplants. The findings also hint at a new way to ward off aging by super-activating the heat shock pathway.