Articles tagged with Publishing Industry
Researchers found significantly higher levels of p16INK4a in young people with sickle cell disease, indicating accelerated cellular aging. This discovery may lead to new treatments targeting cell aging and improved quality of life for SCD patients.
Researchers have developed a new generation of cell-penetrating antibodies that can target cancer cells and deliver therapeutic molecules directly into tumor cells. The 3E10 antibody shows great promise for treating cancers with defective DNA repair pathways.
A new study by Lancaster University reveals that language in job ads can unintentionally reinforce or disrupt labour force gender/racial composition. Workforces with more women tend to use family-friendly policies in ads, while racial minority workers' ads lack impact, the research shows.
Researchers discovered that Prostaglandin E2 drives skin cells to age and enables some of these cells to become pre-cancerous, leading to increased cancer risk. The study found that blocking PGE2 reduced the chances of aged cells becoming precancerous.
PLOS has been awarded a $3.3 million grant from the Bill & Melinda Gates Foundation to transition towards APC-free publishing and promote open access options for authors without funding. The grant will also support improvements in funding metadata capture and peer review transparency.
Researchers at Chungnam National University have developed copper-zinc electrodes that can stabilize over time through recycling, preserving their catalytic effectiveness and selectivity for valuable hydrocarbons. This innovation has significant implications for the conversion of CO₂ into sustainable fuels or chemicals.
A new study from Tel Aviv University uses smartphone data to predict wildfire risk, overcoming individual device errors by averaging large amounts of public data. The method provides valuable insights into wildfire evaluation, especially in remote areas lacking traditional weather stations.
Researchers found that megakaryocyte conditioned media from younger mice was more effective at promoting blood vessel growth and improving healing. The study provides a potential approach for developing new therapies to speed up fracture recovery in older individuals, reducing pain and improving mobility.
Researchers have found that B7-H4 helps ACC tumors evade the immune system, leading to poor survival outcomes. A new drug targeting B7-H4 showed promising results in shrinking tumors in aggressive cases.
Mesenchymal stem cells (MSCs) show promise in delivering treatments directly to cancer cells and boosting the immune system's fight against cancer. However, ongoing research highlights challenges related to MSC behavior, including variability in their effects and potential to create conditions that support tumor growth.
Researchers analyzed seismic data from southern Israel and found weak ground motions caused by Hamas forces' unusual vehicle movement. This breakthrough highlights the potential of using seismic data to provide early warnings for future terrorist activities.
An investigation by The BMJ found over 180 medical articles funded by the fossil fuel industry, with ties to top journals including The BMJ and The Lancet. Experts demand stronger action against the industry's influence on research, citing similarities with tobacco companies in harm caused and tactics used.
This editorial introduces persistence landscapes as a mathematical method to identify and correct biases in medical imaging. Persistence landscapes offer a way to reduce random noise while preserving important details, making it easier for clinicians to focus on meaningful image parts.
Brian Gregory joins The Plant Cell editorial team with expertise in molecular biology, epigenetics, and RNA silencing. He will handle papers with conflicts of interest, develop focus issues, and oversee post-publication corrections.
Research highlights Nup93's critical role in endothelial cell function and vascular health, with promising findings for new treatments to slow down aging. Low Nup93 levels are associated with inflammation and cellular aging, while restoring its levels can reverse harmful effects.
Alex Zhavoronkov, Insilico Medicine's founder and CEO, was named Highly Cited Researchers of 2024. He has published over 40 peer-reviewed research papers, with a total H-index of 64, and led the development of Insilico's lead drug pipeline, ISM001-055.
A Tel Aviv University study finds that individuals who enhance their appearance are more likely to exhibit prosocial behavior, including donating to charity. The research suggests that feeling attractive can motivate people to engage in good deeds, with a significant impact on social consciousness.
This systematic review analyzes 33 biological clocks used for aging and mortality quantification, categorizing them into epigenetic and phenotypic clocks. Epigenetic clocks demonstrate precision in estimating chronological age through DNA methylation, while phenotypic clocks predict mortality using easily measurable clinical variables.
Researchers introduce persistence barcodes, a tool that reduces diagnostic bias and uncovers subtle details in medical images. The method preserves key structural details, enabling clearer insights into the data.
A new review highlights the differences in brain aging and Alzheimer's disease between humans and non-human primates, revealing that primate brains are more resistant to aging-related damage. The study suggests that tau tangles play a critical role in Alzheimer's progression, challenging the amyloid cascade hypothesis.
Industry and academic experts discuss the potential of new materials, configurations, and integration technologies to overcome bandwidth limitations and operational robustness issues in silicon photonic modulators. These advancements are expected to impact emerging applications such as data centers, AI, quantum information processing, ...
A new approach using topological data analysis (TDA) enhances the reliability and reduces bias in AI systems used for medical diagnosis in radiology. TDA captures intricate features and provides a holistic view of medical images, leading to more accurate diagnoses and equitable patient care.
Researchers explore potential synergies between chemotherapy, cannabinoids, and intermittent serum starvation in treating colorectal cancer. Combining these therapies could create a strong synergy by depriving cancer cells of glucose, making them more susceptible to treatment.
Professor Maarja Öpik will lead the journal's international board of Editors, focusing on all aspects of plant biology. She aims to maintain an active and engaging scientific community, publishing inspiring papers that contribute to strengthening New Phytologist.
The 2024 Guidelines for First Aid provide critical updates on recognizing and responding to mild, moderate, and life-threatening emergencies. The guidelines offer enhanced guidance on managing opioid overdoses, bleeding, and other conditions, as well as improved recommendations for emergency care involving children.
Researchers from Indiana University have uncovered how the EphA2 protein receptor contributes to cataract formation. The study found that canonical ligand-dependent EphA2 signaling remains stable in aging lens tissue, while non-canonical signaling increases with age, affecting lens fiber cell maturation.
The review explores the impact of extracellular matrix (ECM) geometry on immune cell behavior and treatment efficacy. Specific ECM configurations, known as Tumor-Associated Collagen Signatures (TACS), create physical barriers that limit immune cell access to tumors.
A new study introduces the Meuhedet Electronic Frailty Index (MEFI) to assess frailty in older people and identify those at risk for serious health outcomes. The index classifies individuals as 'fit,' 'mildly frail,' or 'severely frail' and has been shown to predict mortality and hospitalization with high accuracy.
The Collective Pathway to Open Publishing (CPOP) pilot program aims to support Humanities and Social Sciences (HSS) journals by combining OA agreements with 'read' income. CPOP will make all articles in participating journals open access if thresholds are met, expanding their international reach and impact.
AI models trained on limited data may misdiagnose certain populations, particularly those in underserved communities. Researchers propose six key strategies to develop fair AI models, including using diverse datasets and transparent decision-making processes.
INSEAD ranks third globally among international business schools and holds the top position among European institutions. The school's commitment to research excellence and the case method has been recognized with the #3 position in The Case Centre Impact Index 2024.
Researchers analyzed tumor samples from 64 SCLC patients, identifying promising results for biomarkers DLL3 and TTF-1. These biomarkers showed potential as targets for therapies like Tarlatamab and improved survival rates in patients with TTF-1-positive tumors.
Taylor & Francis joins DAISY Consortium’s Inclusive Publishing Partner program to advance accessibility in publishing. The company is committed to producing content accessible to all, regardless of reading requirements.
Research finds that Korean newspapers often focused on women learning Japanese for work and social purposes, not just reading novels. The ability to speak Japanese gave women new opportunities and challenged traditional roles in Korea.
Researchers discovered Werner syndrome gene WRN plays a crucial role in maintaining constitutive heterochromatin structure, essential for DNA stability. Loss of WRN function disrupts protein interactions, potentially accelerating aging due to cellular disorganization.
Researchers document remarkable response to pembrolizumab in patient with metastatic adenosquamous pancreatic cancer (ASCP) and KRAS G12C mutation. The study highlights potential shift in treatment of ASCP, a rare form of pancreatic cancer traditionally underserved by current therapies.
Researchers synthesizing AI with biomarker analysis aim to detect early signs of aging and enable targeted interventions to delay disease. This approach has the potential to slow, prevent or reverse certain effects of aging.
A recent study by Mizzou researchers found that infections are a significant problem for white-tailed deer on Missouri farms. The study identified the three most common types of bacteria causing pneumonia in farmed deer, providing actionable data for veterinarians and farmers to make informed decisions.
Researchers discovered that tumor dormancy in breast cancer can be triggered by specific signaling changes within small cell clusters, called tumor emboli. Key mechanisms include reduced activity of mTOR and structural shifts in E-cadherin, which are regulated by the PI3K pathway.
A remarkable clinical and metabolic response is reported in a metastatic BRAF V600E-mutated glomangiosarcoma treated with encorafenib and binimetinib. The combination of BRAF and MEK inhibitors achieves a long-lasting complete morpho-metabolic response in the patient.
A Colorado School of Public Health study reveals that gender affirming care patients experience disproportionately high levels of trauma, homelessness, and housing insecurity. Commercial insurance covers most treatments, but access to care varies by region.
Researchers propose a comprehensive biomarker-based approach to assess cardiovascular risk by combining markers of chronic inflammation with cardiac health indicators. This approach reveals the significant impact of aging-related inflammation, or 'inflammaging,' on heart health and opens new avenues for targeted interventions.
Researchers developed an in vitro model of murine peritoneal macrophage aging to study molecular mechanisms and develop innovative strategies. Chronic treatment with CB3 completely prevented the increase of p21CIP1 and maintained proliferative activity in day 14 macrophages.
Jan-Benedict E.M. Steenkamp, a renowned marketing expert, has been selected as the next Editor-in-Chief of the Journal of Marketing, effective July 1, 2025. With his extensive research experience and leadership skills, Steenkamp aims to expand the journal's tradition of high-quality research.
Researchers found that blood cancer cells rewired their gene regulatory networks to evade drug treatment in Acute Myeloid Leukemia (AML), disrupting normal differentiation and growth. The study identified key findings, including changes in open chromatin regions and the loss of binding of RUNX1 and AP-1 transcription factors.
Researchers used a mouse model to assess the impact of senolytic agents dasatinib and quercetin on pelvic organ prolapse. The study found that D+Q injections did not result in significant differences in prolapse development but reduced cellular senescence markers.
Researchers humanize the lupus-derived autoantibody 3E10, preserving its therapeutic efficacy, to create novel cell-penetrating antibodies targeting tumors and RAD51. Humanized variants exhibit faster cell uptake and superior in vivo tumor targeting.
A new study by Duke University researchers reveals that smaller, specialized science publications have a disproportionate impact on conservation efforts. The team found that journals focused on specific regions or organisms were often cited more frequently by federal agencies than high-impact journals.
A new study found that fibroblast growth factor 21 (FGF21) is an independent predictor of all-cause mortality in older adults. The Polsenior2 study revealed that middle and high FGF21 levels were associated with increased mortality risk, particularly when adjusted for age, co-morbidities, and blood parameters.
Research highlights molecular chaperones' role in maintaining tumor suppressor stability and functional integrity. This understanding is crucial for developing targeted therapies for multiple cancers.
A new proteomics study explores the relationship between protein and transcript levels in young-adult and old mice bones. The research identifies key targets associated with bone mineral density and aging, shedding light on protein-specific changes that occur with age.
TP53 mutations are commonly associated with therapy-related AML and complex cytogenetics. Researchers found improved long-term outcomes when allo-HCT was performed during Complete Remission 1 (CR1), despite limited effective therapies for TP53-mutated AML.
Researchers evaluated the efficacy and safety of using Zika virus for treating CNS tumors, finding that it reduces cell viability, inhibits growth, and decreases Bcl2 expression, potentially enhancing chemotherapy and radiotherapy effects. This ultimately led to significant tumor remission and improved long-term survival through an enh...
Recent research highlights microwave-induced synthesis as a transformative potential in drug discovery and development. This efficient technique enables rapid preparation of diverse N-heterocycles, including biologically active molecules such as pyrimidines, thiazoles, and quinolines.
Researchers identify modifiable determinants of cerebral blood flow (CBF) and arterial transit time (ATT) in older adults. A higher BMI was associated with lower CBF and longer ATT, while cardiorespiratory fitness linked to longer ATT in specific brain regions.
Recent clinical trials of neoadjuvant therapy before radical prostatectomy, such as the ACDC-RP trial, have struggled to show significant survival benefits. Researchers recommend maximal androgen blockade with an androgen receptor pathway inhibitor as the 'backbone' of neoadjuvant therapy trials.
Researchers review UBA1 loss of function in VEXAS Syndrome, a hematoinflammatory disorder characterized by severe inflammation, cytopenias, and oncogenicity. They explore therapeutic options, including clone-targeting drugs, to combat this challenging disease.
Researchers found high prevalence of frailty in breast cancer and hematopoietic cell transplant survivors, negatively impacting physical functioning and quality of life. The study supports an association between frailty and the senescence marker p16INK4a, highlighting the need for well-designed senolytic trials.
Researchers explore immune activation and tumor-promoting transcription factor FOXM1's role in CDK4/6-MEK resistance. They suggest targeting the oncogenic network of CDK4/6, MEK, PD-L1, and FOXM1 as future treatment options for MPNST patients.
Researchers found that single-housed adult fish exhibited a longer egg-laying period and slower aging process compared to group-housed counterparts. The study suggests that early-life social environment may influence life-long attributes beyond the typical relationship between growth rate and lifespan.