Articles tagged with Clinical Research
A systematic analysis of cancer cells identifies 370 candidate priority drug targets across 27 cancer types. Researchers used machine learning methods to find promising targets and linked them to specific biological markers and genetic features.
A study by researchers at University of California - San Diego reveals a connection between the skin microbiome and signs of aging, including crow's feet wrinkles. The analysis found positive associations with diverse skin microbiomes and negative correlations with moisture loss, suggesting potential new directions for skincare solutions.
A new task force launched by C-Path aims to accelerate drug development for mitochondrial and inherited metabolic diseases. The task force will leverage C-Path's expertise in data management standards, biomarkers, and regulatory science to generate solutions and contribute to regulatory decision-making.
Researchers found that small declines in blood lead levels were associated with long-term cardiovascular health improvements, including reductions in systolic blood pressure and markers of hypertrophic cardiomyopathy and heart failure. This study suggests that even small decreases in blood lead levels can have meaningful health outcomes.
Researchers found a combination treatment involving high doses of radiation and chemotherapy to be safe and effective in treating locally advanced non-small cell lung cancer. The treatment, which includes an adaptive boost plan, showed promising results in improving progression-free survival and reducing toxic side effects.
A nationwide cohort study found that COVID-19 survivors exhibit lower all-cause mortality and congestive heart failure but higher acute myocarditis and deep vein thrombosis risks. Younger, non-vaccinated patients with preexisting cardiovascular risk factors face elevated cardiovascular complications.
A clinical trial showed that an extract of Boswellia, a plant used in traditional medicine for centuries, has anti-proliferative effects against breast cancer. The study found a statistically significant reduction in tumor proliferation compared to non-treated patients, suggesting potential anti-cancer activity in humans.
Researchers at Kennedy Krieger and Boston Children's Hospital have discovered a new way to decrease early seizure likelihood among infants with Sturge-Weber Syndrome. Presymptomatic treatment involving anti-seizure medication and low-dose aspirin improves neurologic outcomes.
Researchers created a single-cell atlas of the human placenta, revealing changes in gene expression patterns among cell types. The study found that cells most affected by labor were in chorioamniotic membranes and generated inflammatory signaling.
A new special issue of Calcified Tissue International & Musculoskeletal Research sheds light on sarcopenia's pathogenesis, clinical implications, and therapeutic targets. Researchers have made significant progress in evaluating, managing, and developing interventions for this condition.
Researchers found that reducing stimulant use was associated with significant improvement in measures of health and recovery among people with stimulant use disorder. This suggests that a more nuanced perspective on measuring treatment success may be beneficial.
A nationwide Danish study found a slightly increased risk of arrhythmia in patients taking medical cannabis for chronic pain. The risk was more than twice that of those not receiving cannabis, with the largest increases observed in older adults and those with pre-existing cardiovascular conditions.
Researchers unveiled a previously unknown effect of PG545 in ovarian cancer cells, inducing DNA damage and promoting autophagic degradation of RAD51. This breakthrough could aid in selecting the most appropriate treatments for ovarian cancer patients with PARPi resistance.
Researchers at Nemours Children's Health discovered that injecting neuroblastoma tumors with Zika virus shrank or eliminated those tumors in mice, suggesting a potential new therapy. The study showed promising results, with complete tumor elimination and no recurrence after four weeks of follow-up.
Researchers have found that the BCG vaccine can enhance innate immunity in individuals with dormant immune cells, predicting a positive response to vaccination. Trained immunity responders exhibited increased production of inflammatory mediators after vaccination.
Researchers at the University of Cincinnati are testing a new tongue exercise approach to improve swallowing function in stroke patients. The trial aims to provide concrete evidence-based recommendations for treating dysphagia, a common post-stroke complication that can have significant impacts on patients' health and quality of life.
A combination of 11 proteins can predict long-term disability outcomes in multiple sclerosis, making it possible to tailor treatments to individual patients. The study identified a specific protein, neurofilament light chain, as a reliable biomarker for disease activity.
The European Commission has awarded €38 million to further develop EBRAINS, a digital ecosystem for neuroscientific research. The project aims to establish a new standard for brain atlases and push forward digital twin approaches.
A new study introduces a machine learning-aided non-invasive imaging technique that can rapidly visualize liver fat distribution, enabling early diagnosis and treatment of liver diseases. The method uses near-infrared hyperspectral imaging and machine learning to differentiate between types of lipids in the liver.
A new computational model, IRMMa, predicts personalized prognosis for newly diagnosed multiple myeloma patients based on tumor genomics and treatments. The model improves on previous prognostic tools by taking into account individualized risk and distinct subtypes of the disease.
A new, universal definition of acute pediatric critical illness has been reached by consensus among researchers and clinicians from 40 countries. The definition focuses on the patient's status rather than resource availability, enabling global research and potentially leading to improvements in patient outcomes.
Researchers have identified a gene that links deafness to cell death in the inner ear, creating new opportunities for preventing hearing loss. The discovery suggests that UPR-blocking drugs could prevent deafness caused by loud noise exposure or aging.
The rural South region has alarming rates of heart disease, obesity, and chronic obstructive pulmonary disease (COPD), with some areas having 19% higher heart failure rates than urban areas. A unique mobile exam unit is being used to conduct health exams and gather data on the social determinants of health in these communities.
A study of nearly 900 patients found that delayed or missed diagnoses contributed to temporary or permanent harm in three-quarters of cases. Improving diagnostic tools and techniques could reduce errors by up to 40%, according to researchers.
The American Heart Association has made significant medical advancements over the past 100 years, including the development of artificial heart valves and implantable pacemakers. The organization continues to work towards health equity, with a focus on removing barriers to healthcare for diverse populations.
A team of scientists used functional near-infrared spectroscopy (fNIRS) to measure brain activity in two key visual regions, the lateral occipital complex (LOC) and fusiform face area (FFA). The study found that fNIRS successfully measured LOC activity but had limitations in detecting FFA activity due to its depth. This research has th...
A recent study published by the Mayo Clinic found that an AI-enabled digital stethoscope can detect peripartum cardiomyopathy, a potentially life-threatening condition, more accurately than regular care. The researchers identified twice as many cases using the AI-powered tool.
A new study found that fentanyl-laced prescription pills are driving a surge in overdose deaths among high school age adolescents in the US. The death rate for this group has increased to 5.2 per 100,000, with Arizona and Colorado experiencing rates double the national average.
A phase III study found that selpercatinib significantly improves cancer progression-free survival in patients with NSCLC and RET gene translocations. The therapy also demonstrated efficacy in treating intracranial lesions, a common challenge in advanced NSCLC.
Researchers used OCTA to visualize retinal blood vessel changes in migraine patients during and between attacks. Blood flow decreases were found, with asymmetrical flow correlated to headache pain side.
Cancer immunotherapy can cause severe colitis due to hyper-activated immune T cells and deleted regulatory T cells. Researchers at Michigan Medicine have identified a new mouse model that develops colitis after treatment with antibodies used for tumor immunotherapy, revealing the mechanism behind this side effect.
A major new study has found a significant link between hearing loss and the development of dementia. People with severe hearing loss are at a higher risk, with a 20% increased likelihood of developing dementia compared to those with normal hearing.
Researchers developed nanosensors that can be inhaled and detected in urine, offering a potential alternative to CT scans for early lung cancer detection. The diagnostic system shows high specificity and sensitivity in detecting stage 1 or 2 lung tumors.
Researchers at Boston University's Center for Neurorehabilitation have made two important advances that may help people with Parkinson's disease walk more smoothly. Wearable soft robotic apparel and a music-based technology were tested in studies, showing promising results in increasing walking duration and distance.
A research team developed a novel blood test called desNIPT to screen pregnant women for genetic diseases in their unborn children. The test has demonstrated effectiveness in identifying alterations in fetal genes, similar to invasive procedures like chorionic villus sampling or amniocentesis.
The Colorado Center for Personalized Medicine has hit a major milestone of returning clinical genetic results to over 30,000 patients, making it a leader in providing personalized patient care. The center is also studying pharmacogenomics and providing results to guide drug selection and dosing.
Researchers from UC San Francisco have found that Paxlovid treatment does not reduce the risk of developing long COVID. They also discovered a higher proportion of individuals with acute symptoms rebounding after treatment, and those who took Paxlovid were just as likely to develop severe Long COVID symptoms as those who did not.
Researchers found that mutations in IDO2 can affect dopamine release and lead to ASD-like behaviors. IDO2 KO mice exhibited changes in microglia populations, which may contribute to synaptic abnormalities.
Cancer stem cell-derived exosomes (CSC-Exos) are essential for communication between CSCs and other cells in the tumor microenvironment, contributing to cancer progression. The editorial highlights their potential as a novel clinical tool for diagnosis, prognosis, prevention of tumor recurrence, and therapeutic strategy
A new study found that patients treated at community cancer centers have poorer survival rates compared to those at academic medical centers. The study analyzed data from over 20,000 patients with HPV-related oropharyngeal squamous cell cancers.
Researchers found that higher levels of omega-3 fatty acids in the blood plasma were associated with better lung function and longer survival without needing a lung transplant. This was consistent regardless of smoking history or cardiovascular disease.
Researchers found that infants with enlarged perivascular spaces have a 2.2 times greater chance of developing autism compared to those with the same genetic risk. The study also indicates that these infants are more likely to experience sleep problems seven to ten years after diagnosis.
A large clinical study led by Linköping University found no difference in the risk of severe complications between breast milk-based and cow's milk-based enrichment for extremely preterm infants. The study included 228 infants and found that both groups had a similar incidence of necrotising enterocolitis, sepsis, and death.
GFH009 inhibits tumor growth and induces apoptosis in various HHM-derived cell lines. The compound's mechanism of action involves rapid 'on-off' inhibition of CDK9, which exerts a proapoptotic effect on cancer cells.
A study by Mass General Brigham found that daily learning tests can detect Alzheimer's disease-related changes in memory among cognitively normal older adults. The test, called BRANCH, was completed over seven days on a smartphone, revealing diminished learning curves associated with elevated amyloid levels.
The researchers designed a capsule about the size of a multivitamin, powered by a small battery, which vibrates to activate mechanoreceptors in the stomach. This activation stimulates hormone release patterns similar to those following a meal, reducing food intake and slowing weight gain by 40 percent.
A new study from the University of Pennsylvania School of Medicine found that mailing signed orders to patients with cirrhosis led to a significant increase in liver cancer screenings. The study involved over 500 patients and showed that 55% completed their screening within six months, compared to just 27% in the control group.
Researchers found that baseline amyloid burden and brain health are stronger predictors of Alzheimer's progression than age alone. The study also showed that individuals with higher amyloid levels developed dementia two years earlier than those without.
Recent urology treatment studies have improved the reporting of harms in randomized trials, addressing adverse events, side effects, and complications. The analysis found a significant increase in reporting harms criteria from 2012 to 2020, with more than three-fourths of items addressed by 2020.
A recent study found that doxycycline prophylaxis did not prevent bacterial sexually transmitted infections (STIs) among cisgender women, despite being prescribed to 18% of participants. The study also revealed high rates of antibiotic-resistant gonorrhea, which may be due to low adherence and limited treatment options.
The inability to burp, known as retrograde cricopharyngeus dysfunction (R-CPD), significantly impacts daily life, causing symptoms like abdominal bloating, flatulence, and difficulty vomiting. Participants reported feeling embarrassed, anxious, and depressed due to R-CPD, highlighting the need for increased awareness and identification.
Researchers at the University of Cincinnati's Lindner Center of HOPE have developed a novel approach to treating depression using spinal cord stimulation. The study found that electrical stimulation of the spinal cord decreased depressive symptoms and showed therapeutic potential.
Researchers from Brazil discuss the management of refractory or relapsed classic Hodgkin lymphoma in adults, highlighting novel agents such as brentuximab vedotin and immunotherapy. The Brazilian healthcare system's constraints are also considered when making treatment decisions.
Recent studies suggest that gamma brain wave stimulation can yield beneficial effects on brain function, disease pathology, and cognitive function in patients with Alzheimer's disease. Various cells beyond neurons are involved in mediating these effects.
Researchers are leveraging AI/ML to improve health outcomes, but human judgment is still crucial for model selection and data quality. Explainable AI can enhance transparency and acceptance in clinical practice.
The AGA releases its first comprehensive evidence-based guideline for managing pouchitis, a complication of ulcerative colitis surgery. The guideline recommends treatment with antibiotics and multi-strain probiotics to prevent recurrent pouchitis.
Researchers found that less than two percent of patients in Medicaid and commercially insured plans received Z-codes to document Social Determinants of Health. The study highlights the need for improved tracking and documentation of SDOH in healthcare settings, with recommendations for policy changes and provider education.
A phase-one human clinical trial shows that Omadacycline causes a distinctly different effect on the gut microbiome than Vancomycin, making it a safe drug option for patients at high risk for C diff infection. The antibiotic achieves high concentrations in the gut quickly, reducing the risk of long-term colonization.
The study identifies FAM53C as a cytosolic-anchoring inhibitory binding protein of the kinase DYRK1A, regulating its activity and cellular location. This finding may provide potential clinical insights into treating Down syndrome and related diseases.
Flori Corpodean, a postdoctoral researcher at Pennington Biomedical, has been selected as the sole recipient of the 2024 Resident Research Award. She is exploring how the brain and intestinal tract communicate through her research on altered nutrient delivery.