Articles tagged with Clinical Research
A groundbreaking clinical trial found that hip-focused physical therapy outperforms spine-focused therapy in reducing disability from low back pain in adults aged 60-85. The study's results suggest a tailored approach can lead to faster improvements in low back pain disability, walking speed, and chair-rise performance.
A $2 million three-year grant from the U.S. Department of Commerce will create a regional incubator for life sciences startups in South Carolina, providing them with expertise, resources, and networking opportunities.
Researchers found that colon cancer screenings reduce cancer rates by about 0.5 percent, doubling previous estimates of a quarter of a percentage point. This effect is twice the impact of just being invited to screen, suggesting that actual screening rather than just the offer makes a difference.
A recent study published in EBioMedicine found that yellow fever virus causes myocardial fibrosis, cardiomyocyte hypertrophy, and vascular endothelium alterations, leading to cardiac conduction system disruption. The research provides new insights into the pathogenesis of YF-associated heart injury.
Zarbio and Georgia State University scientists propose a framework for understanding Alzheimer's disease, linking molecular mechanisms, beta-amyloid biomarkers, and diagnosis. The Amyloid Degradation Toxicity Hypothesis resolves long-standing paradoxes in AD research.
A study by the University of Sydney and University of Warwick found large gaps in evidence regarding opioid medicines for cancer pain. Non-opioid medicines, including aspirin, may be as effective as opioids for background cancer pain.
A new study at Columbia University Mailman School of Public Health found that patients generate more actionable and creative ideas when explicitly invited to share them. The research offers a rigorously tested methodology for eliciting creative ideas from patients, which can be used to improve healthcare delivery and quality improvement.
A phase II clinical trial found that psilocybin-assisted therapy significantly reduced depressive symptoms in adults with cancer and major depression. Participants who received the therapy experienced a decrease in depression severity scores, with 80% showing sustained responses to treatment.
Researchers revisited melatonin's effects on cancer in mice, finding that nighttime administration inhibits chemically induced mammary tumor development. The study highlights the importance of timing in using this freely available compound for cancer prevention and treatment.
Researchers have identified sST2 and suPAR in the blood of dengue patients, which could accurately predict patients at risk of severe dengue. The test kits would improve patient outcomes by distinguishing between non-life-threatening cases and severe dengue, requiring hospitalization.
A world-first brain stimulation treatment is being developed to treat symptoms of Parkinson's disease and epilepsy using ultrasound technology. The endovascular focused ultrasound technique could significantly improve the quality of life for thousands of people living with neurological diseases.
Researchers have discovered a new control mechanism that drives the maturation of human stem cell-derived heart muscle cells, providing fresh insight into cardiac regenerative therapy and disease modeling. The study identifies RBFox1 as a key intrinsic regulator of heart muscle cell maturation.
Researchers from Tokyo University of Science developed a novel, low-cost hydrogel using seaweed extract that prevents wound expansion and promotes healing. The hydrogel demonstrates significantly lower adhesion and swelling compared to conventional hydrogels, making it an excellent alternative for treating skin wounds.
Researchers discovered a novel therapeutic target BAMBI that suppresses immune cells, reducing the effectiveness of radiation therapy and inducing therapy resistance in cancer patients. BAMBI's expression is associated with improved survival rates, suggesting it as a promising approach to overcome radiation therapy resistance.
Researchers discovered the potential role of oxygen levels and HIF1A gene in determining nucleus pulposus cell behavior, particularly its implications on lipid metabolism. The study may inform novel therapeutic approaches for Intervertebral Disc Degeneration.
Researchers have developed a spinal cord stimulation technology that restores sensation, improves function, and reduces phantom limb pain after trans-tibial amputation. The study showed significant improvements in balance control and gait stability, with an average 70% reduction in phantom limb pain.
Researchers at Johns Hopkins Medicine have identified six protein markers that can predict and manage acute kidney injury (AKI), a condition marked by serious inflammation. The study's findings offer hope for non-invasive assessments of AKI, potentially reducing the need for invasive kidney biopsies.
A five-year study called RHYTHM-B will test innovative strategies to improve hypertension outcomes for Black patients. The research team will enroll 780 non-Hispanic Black patients and compare two interventions: remote self-management support and in-person care.
A recent study found that human induced pluripotent stem cell-derived cardiomyocytes interact negatively with myofibroblasts, leading to electrical instability and arrhythmogenic potential. Blocking Interleukin-6 signalling reduced these negative effects, suggesting a promising therapeutic strategy for safe regenerative treatments.
The National Cardiogenic Shock Initiative study demonstrates a 71% survival rate for patients treated with the new protocol, which involves rapid initiation of mechanical circulatory support and right heart catheterization. This significant improvement in survival rates is expected to save thousands of lives each year.
A comprehensive review of targeted therapies for lupus nephritis discusses the challenges of current treatments and proposes strategies to overcome obstacles. Recent advancements in B-cell targeting and alternative approaches such as CAR-T cells are highlighted.
A joint study by Medical University of South Carolina and Clemson University found that teleconsent, a remote consenting method, is the preferred approach for clinical trial participation. This method eliminates travel costs and improves real-time communication between researchers and participants, increasing trust and understanding.
A study found childhood cancer survivors have twice the risk of developing prediabetes as the general public, increasing their risk of life-threatening diseases. Lifestyle interventions may help reduce this risk and improve their life expectancy.
Researchers found that blocking cholesterol production prevented progression of serrated-type intestinal tumors in mice, suggesting a potential new strategy for treating these aggressive cancers. The study's findings support the use of cholesterol-lowering drugs to prevent or treat these tumors.
A U of M-led study introduces an innovative genetic engineering method that avoids cost and safety concerns associated with viral vectors. The method combines CRISPR-Cas9 precision genome editing and a novel DNA integration mechanism, integrating large DNA sequences into human T-cells with high efficiency.
Researchers have developed an AI-powered algorithm that can detect the risk of atrial fibrillation (AFib) with high accuracy, even in people with infrequent AFib episodes. This new tool has the potential to reduce the incidence of stroke and heart failure by identifying patients at increased risk and guiding targeted interventions.
A new study reveals disparities in the diagnosis and treatment of Lyme disease between Black and White patients. Black patients were more likely to have advanced stages of Lyme disease when clinically diagnosed, and experience a longer time before receiving antibiotic treatment.
A large study of over 9,000 pregnant people found that cannabis exposure during pregnancy is associated with a composite measure of unhealthy pregnancy outcomes, including low birth weight. Higher levels of cannabis exposure were also linked to higher risks of complications.
Researchers at UVA Health System created an 'atlas of atherosclerosis' revealing critical processes that form harmful plaque buildup. The study provides unprecedented insights into atherosclerosis and its impact on coronary artery disease, heart attacks, and strokes.
Researchers at Johns Hopkins Medicine used liquid biopsies to monitor changes in circulating tumor DNA and detect immune cell expansions, predicting patient responses to immunotherapies and detecting early signs of toxic side effects. The test showed significant associations with progression-free and overall survival.
Miniaturized electrochemical sensors offer low-cost, time-efficient analysis and high specificity and sensitivity for toxic heavy metal detection. However, limitations in selectivity, detail, and interference by foreign species hinder on-site analysis.
Researchers found that patients who scheduled their own mammograms through an online patient portal had a 13 percentage point increase in screening completions. This simple intervention doubled the number of mammogram completions, resulting in approximately 4,500 more people getting screened.
Researchers developed a method to measure microvascular changes in the skin using AI and optoacoustic imaging technology, enabling non-invasive assessment of diabetes severity. The study identified 32 significant changes in blood vessels, which can be used to monitor disease progression.
A recent study published in JNCCN found that patients from underrepresented groups treated with first-line immunotherapy for advanced Non-Small Cell Lung Cancer (NSCLC) showed similar survival outcomes as their White counterparts. The study analyzed data from 248 patients and highlighted the need for more diverse patient representation...
A phase 3 trial found that tirzepatide promotes additional weight loss and preserves metabolic health when continued, but discontinuation leads to significant weight regain. Researchers suggest chronic treatment may be necessary for sustained weight loss and improved cardiometabolic risk factors.
A new study led by Dr. Mikkael Sekeres found that patients with a common form of acute myeloid leukemia reported better quality of life when treated with quizartinib, which targets the FLT3-ITD mutation. The study also showed minimal side effects and improved survival rates compared to those who didn't receive the drug.
A study evaluated sleep tracking performance of various wearable devices against a reference system, considering user needs. Non-EEG wearables showed superior performance for healthy individuals who want to monitor sleep habits.
A new study finds that analyzing surgical lymphatic fluid for HPV DNA can predict cancer recurrence and guide treatment decisions. The test was found to be more sensitive than traditional methods, detecting high-risk patients who may be missed by standard tools.
Research found elevated risks between intimate partner violence and childhood sexual abuse and various health conditions. Intimate partner violence was associated with increased risk of major depressive disorders, maternal abortion, and alcohol misuse, while childhood sexual abuse linked to increased risk of self-harm and alcohol use.
A systematic review has identified 29 primary risk factors associated with long-term arm morbidities following breast cancer treatments. The main risk factors include removal of lymph nodes, high body mass index, mastectomy, radiation therapy, chemotherapy, infection, and trauma to the affected arm.
A phase III trial has found that personalised treatment for chronic lymphocytic leukaemia (CLL) can improve survival and remission rates. The trial showed that individualising therapy based on regular blood tests significantly improved progression-free and overall survival in patients with previously untreated CLL.
A Phase I clinical trial of AT101, a new CAR T cell therapy targeting CD19 through a distinct binding mechanism, has shown a 100% complete response rate in patients with relapsed or refractory B cell non-Hodgkin's lymphoma. The treatment was found to be safe with manageable side effects and is expected to build upon the effectiveness o...
Researchers at University of Cincinnati Cancer Center present Phase 2 clinical trial results for a new BTK inhibitor treatment that offers potential for improved efficacy and safety in chronic lymphocytic leukemia. The study also explores the use of IRAK4 inhibitors to target acute myeloid leukemia cells, with promising results.
A small molecule drug compound has shown promise in treating multiple sclerosis by targeting the glutamate system, reducing MS-like symptoms and repairing damaged myelin. The results come from a CAMH-led pre-clinical study published in Science Advances.
The new robotic replica, called RRV, can mimic healthy and diseased states, allowing scientists to test cardiac devices and therapies. The model can also be used to study the effects of mechanical ventilation on the right ventricle and develop strategies to prevent right heart failure.
Researchers discuss recent advances in blood-based liquid biopsies for prostate cancer interrogation, highlighting key biomarkers like CTCs, ctDNA, and exosomes. The studies suggest that these approaches can aid in predicting tumor recurrence, improving treatment response, and evaluating prognosis.
Gene therapy treatments can prompt an adverse immune reaction when the body mistakenly perceives the treatment as a viral threat. Researchers have identified a critical pathway in the liver that triggers this response, but also found a way to block it, paving the way for safer and more precise gene therapy options.
New research found that less than five minutes of daily physical activity can be beneficial for people living with inoperable lung cancer, reducing mortality rates by 60% compared to those who were largely inactive. Healthcare providers should investigate a person's levels of physical activity in early management of the disease.
A new study by researchers at University College London found that reducing oxygen levels for critically ill children on mechanical ventilators can lead to better outcomes, including reduced days spent on machines supporting organs. This approach has the potential to improve outcomes and reduce healthcare costs globally.
Researchers found that BCMA-positive extracellular vesicles (EVs) in plasma levels correlated with myeloma patient responses to belantamab-mafodotin therapy. High EV levels preceded FLC progression and were associated with mafodotin-induced eryptosis.
Researchers developed novel PDAC organoids that resemble the unique tumor microenvironment, enabling effective screening of anticancer drugs. The study used patient-derived cells and hiPSC-derived mesenchymal cells to create two distinct organoid types, one with strong chemo-resistance capabilities.
A large-scale genome study of over 50,000 patients and 900,000 controls has identified 25 genetic markers associated with peptic ulcers, which may lead to new population-specific treatments. The study also found a link between Helicobacter pylori and peptic ulcer disease.
Researchers at the University of Turku found that bexmarilimab therapy alters macrophage behavior to promote anti-tumor immune defense. The therapy was well-tolerated and stabilized disease progression in patients with advanced-stage cancer, inducing tumor-associated macrophage and lymphocyte activation.
A new stem cell treatment using mRNA technology from COVID-19 vaccines has shown promise in regenerating liver tissue, potentially reversing chronic and acute liver diseases. The treatment stimulates the natural repair mechanism of the liver by activating specific receptors on stem cells.
Researchers validate a new Japanese version of the implementation leadership scale to promote evidence-based practice in Japan. The scale measures strategic leadership demonstrated by nurse managers and staff nurses in implementing evidence-based practices.
Researchers leverage AI to analyze healthcare data and identify new targets for effective therapies and accelerate drug development in aging research. AI can tailor cancer treatment more precisely to individual patients' unique aging profiles, optimizing treatment outcomes and minimizing risks.
A new study published in the Journal of Nutrition found that consuming whole food omnivorous meals with lean beef resulted in significantly higher muscle protein synthesis rates compared to isocaloric and isonitrogenous vegan meals. The research, conducted on healthy older adults, demonstrated a 47% increase in muscle protein synthesis...
The TAF/EVG fast-dissolving vaginal insert is being evaluated in a Phase 1 study to determine its safety and user acceptability. The study aims to assess the product's effectiveness as an on-demand HIV prevention method for women, particularly those who do not want or can't use daily PrEP or long-acting products.
Research found a correlation between early negative life events, orbitofrontal cortex thinning, and later depressive symptoms in young adults. A higher burden of negative life events and accelerated thinning of the region were associated with increased depressive symptoms.
Imetelstat, a telomerase inhibitor, successfully treated anaemia in MDS patients for up to one year, reducing the need for red blood cell transfusions. The drug offers a novel mechanism of action for patients with lower-risk MDS who do not respond to standard treatment.