Articles tagged with Discovery Research
A novel machine-learning model uses artificial neural networks to analyze protein sequence data, providing detailed information on protein structure, function and evolutionary features. The model can be used to design new proteins with desired functions and predict the future sequence evolution of proteins in living organisms.
The UK Biobank has released a vast tranche of new genetic data linked to detailed health records, offering an unprecedented resource for understanding human biology and aiding therapeutic discovery. The data includes novel loss of function associations with large effects on disease risk, such as between PIEZO1 and varicose veins.
A research team has successfully computed millions of highly accurate atomic data for neodymium ions, enabling studies of the origin of precious metals like gold and platinum. The findings show that the light of a kilonova, emitted by neutron star mergers, contains abundant heavy elements.
Researchers discovered an ancient species of Old World monkey, filling a gap in the fossil record. The findings suggest that Alophia may have fed on hard objects like fruits and seeds, leading to the evolution of bilophodonty.
A new program aims to address this fear by providing patients with accurate information about treatment options and reducing the stigma around seeking help. The study found that nearly half of adults who die by suicide saw a primary care clinician within a month prior to their deaths.
Longitudinal cohort studies provide an excellent learning environment for early researchers, offering high-quality data and mentorship opportunities. These studies, such as the Framingham Heart Study, can help investigators launch their careers by publishing research with higher impact and gaining valuable experience.
New research by University of British Columbia shows LGBTQ Americans dispersing and diversifying their living spaces beyond traditional gayborhoods. The study reveals a range of emerging neighborhoods catering to specific subgroups within the LGBTQ community, including queer communities of color and same-sex couples with children.
Scientists have discovered a 25-million-year-old palm fossil in central Tibet, pushing back the formation of the Tibetan Plateau by millions of years. The discovery suggests that the region was once much flatter than previously thought, with lakes and subtropical vegetation, before becoming a plateau around 2-3 million years ago.
According to Binghamton University professor Nina Flanagan, a positive mindset is crucial for maintaining a productive work environment in the healthcare field. Negativity can spread from leaders if not addressed.
Researchers at the University of Southampton are launching a study to improve condom use and tackle STIs among young men in the UK. The study will examine whether online or face-to-face education sessions lead to better outcomes in reducing chlamydia rates among 2,200 men aged 16-25.
A new study by Dr. Margaret McCarthy's Lab reveals that male sex steroids play a key role in shaping brain development, particularly in the amygdala, which controls emotions and social behaviors. The research shows that testosterone eliminates newborn cells in males, while females' cells differentiate into glial cells.
A Southwest Research Institute-led team of scientists have discovered a lack of very small Kuiper Belt objects with crater counts on Pluto's satellite Charon indicating fewer impactors smaller than 1 mile in diameter than predicted. This finding has deep implications for our understanding of the solar system's origin and evolution.
Researchers have developed a blood test that can predict kidney transplant rejection up to two months in advance. By monitoring seven immune genes, doctors may be able to intervene before damage occurs, improving patient outcomes and organ lifespan.
A recent NSF CAREER Award recipient aims to develop trustworthy machine learning from untrusted models, with a focus on safeguarding complex systems that piggyback on less-than-trustworthy technology. The grant will support work in creating tools to verify model safety and detect abnormal phenomena throughout the system's lifecycle.
The Proteomic Skin Atlas maps human skin molecules and functions, shedding light on skin diseases like psoriasis and eczema. Researchers hope to accelerate research and develop new treatments for the 3,000 known skin diseases.
A new UNLV study finds that the quality of fruits and vegetables at dollar stores is comparable to traditional grocery store produce. The research team championed channel blurring, which benefits budget-conscious shoppers by increasing access to healthy, affordable food options.
The collection of over 1,700 animal and plant specimens from Sir Charles Lyell's era provides insight into volcano formation and palaeontology. The data is now easily searchable for researchers worldwide.
Researchers at VCU have developed a technique to observe subtle changes in clusters of matter, shedding light on their catalytic properties and potential applications in drug discovery. This breakthrough enables the study of molecules on nanoclusters in real-time, revealing fast-paced configuration and position changes.
Researchers can create synthetic networks that satisfy differential privacy requirements, enabling broader sharing of confidential data for scientific discovery. These altered datasets capture most statistical features from the original network, making them suitable for various researchers.
Genevera Allen, a Rice University statistician, emphasizes the need for machine learning systems to question their predictions and assess uncertainty. She argues that current ML techniques often rely on uncorroborated data-driven discoveries, leading to reproducibility issues in fields like precision medicine.
Researchers have discovered that a material designed to absorb all light of a specific color demands the waves be synchronized as well. By adjusting parameters, they were able to create a coherent perfect absorber with two overlapping modes, increasing versatility and flexibility in tailoring the material's properties.
The discovery of Mnyamawamtuka moyowamkia provides new clues to the evolution of ecosystems on the African continent during the Cretaceous period. The dinosaur, a member of the titanosaur sauropod family, has a unique heart-shaped tail that sheds light on its evolutionary history.
Newly discovered fossilized tracks suggest that multicellular organisms could be 1.5 billion years older than previously thought, with origins dating back to 2.1 billion years ago. This discovery has sparked debate and skepticism among researchers, who are exploring alternative explanations for the early emergence of complex life.
A recent study published in the Journal of Biomechanics used advanced MRI techniques to track wrist bone movement in 18 individuals, revealing gender-based differences. The researchers found that while individual left and right wrists are similar, there are distinct differences between male and female wrists.
A new species of softshell turtle, Pelodiscus variegatus, has been discovered in northeastern Indochina. The species is characterized by dark blotches on its shell and has a critically endangered conservation status due to its limited range and high exploitation rates.
A pilot project by Springer Nature and BCRF enables researchers to make their datasets accessible alongside published articles. Dedicated Research Data Editors will help authors draft descriptions and deposit datasets in a journal data repository.
Researchers from NYU Abu Dhabi have identified a new frog species on Bibita Mountain in southwestern Ethiopia, characterized by its slender body, long legs, and golden coloration. The discovery highlights the importance of assessing biodiversity in remote areas and underscores the potential for numerous unknown species to exist.
A new study by Cass Business School academic Dr Ruben van Werven has identified four key language strategies used by influential entrepreneurs to connect with investors. These strategies include implying a point without making it, presenting the imagined future as a reality, being explicit about the current situation, and supporting th...
A team of researchers has found a novel function for the signaling molecule TRADD, which was previously considered dispensable. Without RIPK1 protein, having two copies of the TRADD gene or no copies results in cell death, while one copy promotes survival. This discovery sheds light on regulating cell death and survival pathways.
A case study documents a highly malignant bone tumor in a 240-million-year-old stem-turtle from the Triassic period. The appearance of the tumor conforms with present-day periosteal osteosarcoma in humans, providing valuable insights into the history of cancer in tetrapod evolution.
Researchers at George Washington University found that decentralized systems perform better when individual parts are less capable, as overly smart components lead to overcorrections and mistakes. This discovery has potential applications in company structure, autonomous vehicles, AI algorithms, and even biological evolution.
The Brazilian Reproducibility Initiative, launched in 2018, aims to repeat experiments from published articles originating from Brazil to estimate the country's research reproducibility. The project will assess over 60-100 experiments across multiple laboratories.
Researchers at the University of Chichester and Leuven discovered that Roy Lichtenstein had a complex and collaborative dynamic with comics creators. The artist's work significantly shaped comics publications, and cartoonists praised each other's work.
Researchers from NIMS and Hokkaido University discovered that proton transfer in electrochemical reactions is governed by the quantum tunneling effect, revealing a novel physical process. This breakthrough may accelerate basic research leading to highly efficient electrochemical energy conversion systems based on quantum mechanics.
Researchers will have access to a virtual cohort of 1.4 million individuals through the Common Infrastructure for National Cohorts in Europe, Canada and Africa (CINECA). The project aims to accelerate disease research and improve treatment effectiveness by analyzing genetic, physical and lifestyle data.
A randomised controlled trial involving over 2,700 couples found that the new IVF technique PICSI did not significantly improve success rates for male infertility, with a success rate of around one in four couples. However, it did reduce miscarriages by 39% compared to standard ICSI treatment.
A clinical trial found e-cigarettes to be almost twice as effective as nicotine replacement treatments in helping smokers quit. The study, funded by the National Institute for Health Research, involved 886 smokers and found that e-cigarette users were more likely to achieve abstinence and experience a reduction in smoking urges.
A research team led by Professor Jaeheung Cho has found a new active intermediate synthesized in the oxidation process using biomimetic catalysts and artificial oxidants. This discovery clarifies the oxidation mechanism and clears the long-standing debate on the role of metal-iodosylbenzene intermediates.
The OCTN2 transporter plays a vital role in maintaining carnitine homeostasis, and its deficiency can cause severe muscle pathology. The OCTN1 transporter is associated with inflammatory diseases, such as Crohn's disease, and may have anti-inflammatory properties.
MU researchers create an artificial intelligence system to quarantine cyberattackers, providing a temporary distraction to allow for a more sophisticated defensive strategy. This approach aims to exploit the psychological aspect of cyberattacks, making attackers believe their efforts are successful.
Researchers have made the largest individual record within the genus Gyrinophilus and the Plethodontidae family in the United States. The discovery is reexamining growth limits of cave-obligate salamanders in harsh environments, highlighting the hospitability of underground ecosystems.
Researchers developed an AI-powered method to correct errors in single-cell RNA sequencing, enabling precise data for every cell. The algorithm, called kBET, quantifies differences between experiments and facilitates comparison of correction results.
This special collection showcases the potential of 3D cell culture technology in accelerating basic research, drug discovery, and drug development. Human induced pluripotent stem cells (iPSCs) provide optimized systems for disease modeling, compound pharmacology, and toxicology.
A study from Gero longevity company shows that quitting smoking can lead to rejuvenation that can be monitored by a mobile phone app. The app uses AI algorithm trained on physical activity signals to estimate biological age and track its reversion after smoking cessation.
Researchers at the University of Tokyo have discovered how plants detect odor molecules by binding to transcriptional co-repressors, changing gene expression. This understanding may lead to new ways of influencing plant behavior, such as altering crop quality or deterring pests.
Henry Sauermann's research on crowd science, a field that involves public participation in scientific projects, has been recognized with the 2018 Nelson Prize. The prizewinning paper introduced a conceptual framework to understand and classify such projects.
A new rapid blood test for tuberculosis (TB) has been found to be substantially more accurate than existing tests, enabling doctors to quickly detect or rule out TB infection. The test, developed at Imperial College London, could save the NHS over £2 million per year by stopping the use of existing, inadequate tests.
Molecules can switch between magnetic and non-magnetic forms dynamically, enabling applications like efficient solar cells and quantum computing. The researchers found this process occurs in half a picosecond, far faster than initially believed.
A recent study published in Scientific Reports found that smokers demonstrate a higher aging ratio and are predicted to be twice as old as their chronological age compared to nonsmokers. The study used blood biochemistry and artificial intelligence to analyze the impact of smoking on biological age.
Newly discovered regulatory proteins differ significantly from mouse immune cells, offering new possibilities for treating immune-mediated diseases like multiple sclerosis and rheumatoid arthritis. Human T cell regulation has special characteristics that require further study to advance translational research.
Researchers have discovered that the GREB1 gene amplifies androgen receptor output in human prostate cancer cells, contributing to antiandrogen resistance. Inhibiting GREB1 converts high-AR output cells to low-output states, improving enzalutamide treatment effectiveness.
Researchers have discovered a new mechanism underlying the control of gene expression in all living organisms. Transcriptional pausing by RNA polymerase provides a 'roadblock' to help regulate gene expression levels, which could aid our understanding of antibacterial drugs and future synthetic gene design.
A novel 'palette effect' mechanism allows locusts to switch between green and black coloring in response to different environments. The discovery reveals a red pigment complex acts as a switch to coordinate the insects' color changes, providing an adaptive response to population density.
A University of Oxford study reveals that genomic research has been limited by a lack of diversity, with most subjects from the UK, US, and Iceland. The study analyzed nearly 4,000 scientific studies between 2005 and 2018, finding that ancestral diversity has stalled and non-white groups are under-represented.
A Texas A&M engineering team uses machine learning and AI to develop an autonomous framework for discovering new materials. The system can adaptively pick the best models to find optimal materials, reducing the time and cost of research.
Researchers developed Structural Unsupervised Viewlets Models (SUVMs) to recognize object categories, inspired by brain's unsupervised learning ability. The SUVMs performed well on the face dataset but underperformed on airplane images.
A recent report from a joint effort between researchers and experts has provided guidelines for defining the quality of uncultivated virus genomes. The new standards aim to improve the analysis and characterization of these viruses, which are increasingly being identified through genome sequencing and analyses.
Researchers have discovered the oldest known plant virus, a 1,000-year-old virus from ancient corncobs at an Ancestral Puebloan ruin in Arizona. The discovery reveals that chrysoviruses can persist in plants for long periods and may confer potential benefits to the plant.
SourceData from EMBO is an open platform that makes research data directly searchable, while BioStudies aggregates the data files linked to a specific publication or project. This integrated workflow enables authors to make their published data openly accessible and easy to find.
A new study by MIT researchers finds that compiling massive, anonymized datasets about people's movement patterns can make it easier to discern users' identities. The study shows how merging different types of location-stamped data can lead to a high matchability success rate, increasing the possibility of deanonymizing real user data.