Articles tagged with Laboratories
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Dr. Jeffrey Friedman of Rockefeller University identified leptin as the 'satiety factor' behind obesity and type 2 diabetes, shedding light on chemical and genetic factors involved in the condition. The discovery has opened possibilities for future pharmaceutical treatments, influencing research worldwide.
A new study finds nearly a doubling of illegal fishing in the Northeast multispecies groundfish fishery, with 12-24% annual harvest taken illegally. The study recommends a 'smart compliance policy' to combat noncompliance and protect fish stocks.
The article describes a new approach for targeted mutagenesis in Drosophila melanogaster using ChIP-Seq analysis. The SIRT method combines homologous recombination, site-specific integration, and bacterial recombineering to facilitate efficient genetic variants at specific loci. This novel technique enables researchers to investigate g...
Theoretical work by SLAC researchers reveals two methods for detecting true muonium's formation and decay in electron-positron accelerators. These methods use relativistic effects to create a stable signature, making observation of the exotic atom feasible. The discovery has the potential to reveal new forms of matter.
Researchers found that confined spaces lead to greater variety seeking, as people diversify their choices. In crowded stores, customers tend to choose unfamiliar and unique brands.
A recent study found that women have a more powerful innate immune system than men due to the presence of estrogen. Estrogen blocks an enzyme called Caspase-12, which prevents the inflammatory process, making women more resistant to infection.
Researchers at NIST conducted experiments on wind-driven fires in high-rise buildings, finding that conditions can quickly spread smoke, heat, and gases through hallways and stairwells. Techniques such as blocking windows with fire-resistant materials and using 'floor below nozzle' systems showed promise in reducing hazardous conditions.
The May issue of Cold Spring Harbor Protocols features a set of methods to analyze protein complexes, including Blue-Native PAGE and differential in-gel electrophoresis. Additionally, researchers can generate viral vectors using adenovirus technology for efficient gene delivery.
Jindong Chen, a VARI researcher, has been awarded the AACR Scholar-in-Training Award for his presentation on Birt-Hogg-Dubé (BHD) syndrome and its relation to kidney tumors. This award recognizes groundbreaking cancer research and is highly competitive among applicants.
Physicists at Ames Laboratory have demonstrated that the superconductivity mechanism in iron-arsenide superconductors is unique compared to all other known classes of superconductors. The team found a power-law variation of London penetration depth, suggesting electron pairing different from any other known superconductor.
Gary Borisy, MBL director and CEO, has been elected to the National Academy of Sciences for his distinguished contributions to cell biology. He is a pioneer in the field, having discovered protein tubulin and provided insights into chromosome movement, cell motility, and microtubule dynamics.
Grapevine flowers' fragrance comes from pollen grains stored in anthers, contrary to common perception that petals produce perfume. The scent serves as a defense mechanism to protect male reproductive tissues from predatory insects.
Dr. Kathy M. Chun, Director of Cytogenetics and Molecular Genetics at North York General Hospital, is the recipient of the 2009 Signature Genomic Laboratories Travel Award. The award recognizes outstanding young researchers in medical genetics and covers travel costs to the ACMG meeting.
This article provides optimization strategies for polymerase chain reaction (PCR) and a method for loading individual cells with fluorescent probes via patch pipettes. The techniques are described in detail, including touchdown PCR and hot-start PCR, and their applications in neuroscience research.
A study of 65 female commercial sex workers found that remote screening using tampon-based self-collection was easy and preferred over traditional methods. The method proved to be more accurate in detecting gonorrhoea and Chlamydia, with a higher number of cases identified compared to traditional tests.
Whitehead Institute member Peter Reddien has been awarded an Early Career Scientist position by the Howard Hughes Medical Institute (HHMI), providing him with a six-year funded research program. He will investigate regeneration in planaria flatworms, a project that aligns with HHMI's goals to support innovative and creative science.
A new measurement standard for vitamin D may lead to better bone health, particularly in children, women, and the elderly. The standard, developed by NIST and NIH, will enable more accurate and reliable vitamin D measurements in blood samples.
The renewal of the European Associated Laboratory Agreement establishes a France-Israel laboratory of neuroscience, fostering joint research projects and collaborative publications. The new agreement aims to promote brain research opportunities in Europe amidst calls for boycotting Israeli academia.
Researchers investigated coral skeleton formation and found systematic compositional variations, complicating paleoenvironmental change proxies. Meanwhile, a study on Venus' vortices revealed similarities with terrestrial hurricanes, potentially aiding atmospheric superrotation understanding.
Two new methods are featured in Cold Spring Harbor Protocols: a rapid, reversible method for studying protein stability using small molecules, and a combined technique for identifying proteins that mediate long-range chromosomal interactions. These methods provide new tools for investigating protein function and chromatin structure.
Researchers found that consumers' quality expectations were initially misled by biasing cues, but they learned from these mistakes and made more accurate judgments in subsequent purchases. The study suggests marketers should rethink their strategies for misleading consumers with false attributes, as it may backfire on repeat purchases.
Researchers found that combining DHEA with red clover isoflavones increased testosterone production and reversed androgenic effects in prostate cells. The study suggests a potential cancer prevention effect of herbal supplements like DHEA, warranting further research.
A research model has shown that training people to avoid falls by exposing them to unstable situations can help them maintain their balance on a slippery floor. The study found that trained subjects were better at controlling the landing foot and unconsciously changed their gait, reducing the risk of falling.
Researchers at UC Davis have discovered a new class of drugs that can reduce heart swelling and reverse heart failure. The study, led by cardiologist Nipavan Chiamvimonvat and entomologist Bruce Hammock, found that the enzyme soluble epoxide hydrolase plays a key role in the development of cardiac hypertrophy.
Researchers find that stretching facial skin during speech affects perceived sound, linking production and perception. The study contributes to understanding the relationship between speech perception and production.
A study led by Professor Derry Roopenian found that a blocked protein called Interleukin 21 prevents systemic lupus erythematosus (SLE) in mice. The researchers also demonstrated the importance of IL21 signaling in SLE progression, suggesting that interrupting this process could be an effective therapeutic option for human SLE patients.
Two protocols, one for DNA repair homologous recombination and another for sumoylation of proteins, are featured in CSH Protocols. These methods provide a biochemical means to dissect the mechanisms of molecular processes involved in DNA repair and post-translational modification.
The Rockefeller University Center for Clinical and Translational Science has awarded grants to university investigators to conduct early studies in translational science. These studies may lead to improvements in human health if successful.
Researchers found that most respondents reported improved mood after a good cry, but some felt worse or no improvement. Criers who received social support experienced the most significant improvements in mood. The study highlights the complexities of crying behavior and its physical and emotional effects.
WPI will support teaching and research programs in fire protection engineering with the new facility. The university is home to the world's leading graduate program in fire protection engineering.
A new study in Journal of Consumer Research uncovers a strategy for releasing consumers from 'regret lock' after missing a sale. By offering alternative sales on similar products, retailers can increase purchase likelihood and market share.
Simple clinical and laboratory tests can identify low-risk stomach bleed patients who can be safely managed as outpatients. This approach reduces hospital admissions by 71% without adverse effects on patient care.
Scientists have successfully grown two native bushy species, Genista versicolor and Reseda complicata, to suggest new mechanisms for restoring vegetation in the ski resort. The study aims to improve germination and growth percentages of these species using different vegetable growth regulators.
A balance between large research groups and individual scientists is optimal for success, according to a novel theory by Adrian Bejan. Successful research groups grow naturally and contribute to the whole, while solitary thinkers have flourished throughout history due to science being good for society.
The journal Cold Spring Harbor Protocols presents two articles detailing experimental culture methods for cells from the immune system and the nervous system. These protocols enable researchers to isolate and grow specialized cells like macrophages and cerebellar granule neurons, facilitating studies on their functions and interactions.
In a groundbreaking study, researchers have identified a common variant in the GRM7 gene as being associated with susceptibility to glutamate excitotoxicity and hearing loss. The findings could lead to treatments that bring relief to millions of people worldwide suffering from age-related hearing loss.
Biological damage caused by declining calcium levels is causing widespread transformation of aquatic food webs in boreal lakes in North America. The phenomenon, known as 'aquatic osteoporosis,' affects many lake-dwelling organisms, including water fleas, and has important management implications.
Researchers used computer modeling and experimentation to investigate how cracks grow at low speeds in silicon, finding rearrangements of atoms associated with ductile materials can occur near the crack tip. This instability can lead to macroscopic changes in the path of the crack, leaving behind ridges on the crack surface.
Emory University's new Human Health: Molecules to Mankind (M2M) program trains students in both laboratory and population sciences, aiming to create a comprehensive approach to understanding human health. The program partners researchers from schools of medicine, public health, and other institutions.
Using a novel combination of technologies, researchers identified 13 previously unknown tumor suppressor genes that, when mutated, can lead to liver cancers. These findings may provide new avenues for cancer therapy and have implications for understanding the molecular causes of the disease.
The journal features two articles with detailed instructions for setting up experimental culture systems. These methods allow researchers to study and manipulate developing cells and tissues in the laboratory, enabling the identification of neural progenitor cells and the analysis of cell migration between organs during development.
The Rutgers University Cell and DNA Repository has received two major NIH awards to support investigations into the genetics of mental disorders, metabolic diseases, and digestive health. The funds will enable researchers to study the genetic causes of complex diseases such as autism, bipolar disorder, and diabetes.
The University of Warwick is acquiring over 200 plastinated body parts from Germany for its medical school, a £400,000 investment in anatomy education. These specimens will be used by students to understand human anatomy and develop surgical skills.
Researchers have identified a stable, modifiable virus capable of withstanding harsh conditions and can be used as a nanobuilding block. The virus particles are ideal for producing materials on the nanometre scale and can be modified spatially controlled.
Researchers from Georgia Tech, University of Dayton, and others develop a stronger, more practical dry adhesive inspired by gecko feet. The new material creates directionally-varied adhesive force, with a gripping ability nearly three times that of real geckos.
Scientists will explore chemical reactions in extreme space conditions using a new research center combining laboratory experiments, theoretical studies, and radio-telescope observations. The Center for Chemistry of the Universe aims to expand our understanding of molecule formation that may seed young planets with life.
A team of researchers argues that current publication practices create an extreme imbalance between the abundance of supply and limited venues for publication, leading to unrepresentative results. This distortion affects the broader scientific community, as only a small proportion of research findings are selected for publication.
Researchers at Cold Spring Harbor Laboratory found that a splicing factor called SF2/ASF targets known cancer-related proteins, leading to the disruption of cellular processes. Understanding these complex molecular interactions may lead to new approaches for cancer treatment.
Researchers found that juvenile bluefin tuna from both regions return to their birthplace to spawn, contradicting previous assumptions about fish migration patterns. This study has significant implications for managing bluefin tuna fisheries in the Mediterranean and North Atlantic.
The use of multiple model organisms is expanding due to decreasing genome sequencing costs and advancing gene expression manipulation techniques. Emerging model organisms, such as planarians and snapdragons, are being introduced to the laboratory, enabling comparison and refinement of existing models.
A recent study published in Genome Research found that ultraconserved elements, identical between humans and animals, play a crucial role in the natural evolution of species. These elements account for less than 2% of the human genome but are essential for the survival of many species.
A new study published in the Journal of Nutrition has found that consuming moderate amounts of dark chocolate (6.7 grams per day) can lower the risk of heart attack by significantly reducing inflammation and cardiovascular disease. The study, which enrolled over 20,000 participants, suggests that this amount of dark chocolate is associ...
Researchers may develop new treatments for diseases like multiple sclerosis, rheumatoid arthritis, and sepsis by understanding the role of fibrin in blood coagulation. The NIH grant will support a four-year study to identify how cytokines regulate fibrin levels.
Researchers at Georgia Institute of Technology have developed a prosthetic vein valve to replace damaged valves in people with chronic venous insufficiency. The valve has shown promise in preclinical trials, demonstrating biocompatibility and performance similar to natural body tissue.
Researchers at the University of Notre Dame have made significant discoveries about bacterial cell wall recycling. The study reveals that a specific enzyme, M1tB, plays a crucial role in breaking down the cell wall, leading to pro-inflammatory events associated with bacterial infections.
MIT researchers have developed a technique called amplitude spectroscopy that can characterize the properties of artificial atoms used in quantum computing. This approach enables the study of quantum entities over broad frequency ranges, which is essential for understanding and engineering atomic-scale devices.
This study investigates the 3D rupture conformations of a surface fault under biaxial compression, revealing three stages of crack growth and introducing the concept of anti-wing cracks. The results provide fundamental understanding of surface fault propagation and have significant implications for future studies on active fault movement.
Researchers develop powerful tool for investigating gene function using siRNA and lentiviral vectors. The method enables long-term down-regulation of specific target genes in various cell types, facilitating cancer cell biology studies.
Researchers at the Salk Institute have identified two signaling pathways activated in response to exercise that converge to increase endurance. They discovered a drug, GW1516, that simultaneously triggers both pathways, turning laboratory mice into long-distance runners and conferring many exercise benefits.
Researchers have successfully differentiated pluripotent stem cells from a patient with ALS into motor neurons and glia featuring an ALS genotype, offering new avenues for drug discovery and understanding the disease process.