Articles tagged with Dementia
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Researchers are developing sophisticated methods to understand Alzheimer's disease mechanisms and predict its onset before symptoms appear. The five-year study aims to pinpoint factors leading to cognitive decline in relation to beta-amyloid proteins.
Researchers will investigate brain aging and Alzheimer's using advanced bio imaging technology on a representative sample of 1,310 Tsimane adults. The project aims to understand the relationship between vascular health and Alzheimer's risk.
The Canadian Foundation for Innovation provides a $1.8 million grant to Baycrest's Rotman Research Institute (RRI) to upgrade its MRI and MEG machines, enabling researchers to pursue unique ways to protect brain health during aging and prevent dementia.
Researchers analyzed 56 high-quality studies on dementia to identify gaps in knowledge, focusing on caregiver behavior, environment, and progression of disease. The study aims to inform treatment design and interventions to reduce behavioral and psychological symptoms in dementia patients.
Researchers discovered that LSD1 removal in adult mice induces changes in gene activity similar to Alzheimer's disease. LSD1 protein is also perturbed in human brain samples with Alzheimer's and FTD, suggesting it as a central player in these neurodegenerative diseases.
A Swedish registry study found that dementia patients with stroke can receive thrombolysis treatment without increased risk of brain haemorrhage or death. However, those over 80 may experience worse functional outcomes and be more likely to be discharged to nursing homes.
A first-of-its-kind study found that frontotemporal degeneration (FTD) causes substantial economic burden on patients and caregivers, with combined annual costs of $119,654. The study revealed significant impact on household income and quality of life, with most patients forced to leave the labor force during their prime earning years.
A study published by the American Academy of Neurology found that high blood pressure in women's 40s is associated with a 65% increased risk of dementia. Women who developed high blood pressure in their 40s were 73% more likely to develop dementia than those with stable blood pressure throughout their 30s and 40s.
Up to two thirds of people with Alzheimer's disease experience psychotic episodes, linked to faster cognitive decline and accelerated death rates. New approaches to clinical trials aim to develop effective non-drug interventions to alleviate symptoms without adverse outcomes.
A long-term study of 3,000 adults found that those who couldn't identify four out of five common odors were more than twice as likely to develop dementia. The study's lead author notes that the sense of smell is closely connected with brain function and health.
A research team led by DGIST Professor Moon Cheil has identified the reason behind olfactory dysfunction in patients with early-stage Alzheimer's disease. The study reveals that a toxic protein called beta-amyloid accumulates in the peripheral nervous system, specifically in the olfactory epithelium, leading to olfactory failure.
A comprehensive study from Florida State University found no evidence that personality changes occur before the onset of mild cognitive impairment or dementia. Researchers analyzed data from over 2,000 individuals and discovered that personality traits remained stable even in the years leading up to clinical diagnosis.
A recent study published in Neurology found that both high and low levels of magnesium in blood may increase the risk of developing dementia. The research involved 9,569 participants who were followed for eight years, with those having high or low magnesium levels showing a 30% higher risk of dementia compared to the middle group.
A new study by Duke-NUS Medical School found that Alzheimer's patients with CeVD exhibit different brain network changes compared to those without CeVD, suggesting distinct underlying pathology. This finding may improve diagnosis, treatment, and management of neurodegenerative disorders.
Researchers found that individuals with frontotemporal dementia were physically aggressive earlier and exhibited more severe behavior towards strangers compared to those with Alzheimer's disease. The study of 281 deceased patients revealed a significant difference in the manifestation of aggression between the two groups.
Researchers found patients with FTD showed thinning of outer retina compared to control subjects. The degree of retinal thinning was worse in those with lower cognition scores.
Researchers at the University of Nottingham found that contagious yawning is triggered automatically by primitive reflexes in the primary motor cortex. Their study showed that individuals' propensity for contagious yawning is determined by cortical excitability and physiological inhibition, with limited ability to resist yawns.
A study published in Neurology found that less REM sleep and longer sleep latency are associated with a higher risk of developing dementia. Research followed 321 participants over 12 years, revealing a nine percent increase in all-cause dementia risk for each percentage reduction in REM sleep.
A new study published in Neurology suggests that people who get less rapid eye movement (REM) sleep may have a greater risk of developing dementia. The researchers found a link between lower percentages of REM sleep and an increased risk of dementia, with every percent reduction resulting in a 9% increase in dementia risk.
Researchers developed an algorithm using AI and big data to recognize dementia signatures two years before onset from a single amyloid PET scan. The tool could improve patient care and accelerate treatment research into Alzheimer's disease.
A recent study by McLean Hospital researchers highlights the need for better security and privacy measures in health apps designed for dementia patients. The paper found that many apps collect user-generated content without adequate protection, posing a risk to patients' sensitive information. Clinicians are urged to educate themselves...
A new study estimates that families of individuals with dementia incur $184,500 greater in lifetime care costs compared to those without dementia. Reducing symptoms by 10% can lower lifetime costs by $3,880 and $680, respectively.
A new simulation study shows that dementia can more than double the healthcare expenditure of aging individuals, with the majority of the financial burden falling on family members. The total average cost to care for a person with dementia was $321,000 over five years, compared to $137,280 without dementia.
Researchers detect granulins inside cells for the first time, suggesting a potential FTD treatment strategy by targeting lysosomal function. The discovery may have therapeutic potential for Alzheimer's disease and Parkinson's disease as well.
A recent study found that 44% of nursing home residents with dementia were taking PIMs at admission, and many stopped or started these medications during their stay. The researchers suggest a person-centered approach to discontinuing PIMs, especially for frail older adults.
Greater intraindividual reaction time variability was found to predict shorter survival times in older adults, independent of cognitive decline. The study used computerized reaction time tests to measure participants' responses and found that increased variability was associated with a higher risk of mortality.
A cohort of 861 adults aged 70-90 years showed that greater reaction time variation predicted all-cause mortality. The findings suggest that reaction time variability could be an independent marker for predicting shorter time to death, even when accounting for other risk factors.
Researchers stopped FUS protein clumping using phosphorylation, a natural cellular process that increases protein charge and repels aggregation. The findings could have positive implications for treating ALS and dementia.
Researchers found that people with high blood pressure variability are more likely to develop dementia and Alzheimer's disease. Home monitoring of blood pressure may be a useful tool for assessing future dementia risk.
A large NIH-funded study found that middle-aged Americans with vascular health risk factors such as diabetes and high blood pressure are more likely to develop dementia later in life. The study analyzed data from 15,744 participants over 25 years and found a strong link between midlife vascular health and the risk of developing dementia.
A University of California San Diego study found that moderate alcohol consumption is associated with reduced mortality and greater chances of remaining cognitively healthy into older age. Among men and women aged 85+, individuals who consumed 'moderate to heavy' amounts of alcohol were twice as likely to be cognitively healthy than no...
Research by the University of Stirling found that hospital patients with dementia and other causes of confusion have inferior treatment outcomes and longer stays. This study is the first large population-based study to prove this, affecting over one-third of older hospital admissions.
A study published in JAMA Neurology found that individuals born in high stroke mortality states have a higher risk of developing dementia. Black participants had the highest risk, with cumulative 20-year dementia risks at age 65 being 30.13% compared to 21.8% for those not born in high stroke mortality states.
A recent study published in the British Journal of Anaesthesia has found that delirium after surgery is associated with a significant increase in dementia risk in elderly patients. Researchers analyzed data from over 2,000 patients and found that those who developed postoperative delirium were three times more likely to suffer permanen...
Researchers developed a new, non-invasive method called transcranial magnetic stimulation (TMS) to distinguish between Alzheimer's disease and frontotemporal dementia. The technique accurately diagnosed the conditions with 90% accuracy in most cases.
A five-year research programme is improving care for patients living with dementia in hospitals. Distractions during drug rounds can hinder treatment, but the involvement of family or carers can be hugely beneficial. The study's findings aim to create and implement specific care pathways that acknowledge differences in dementia present...
A high proportion of former NFL players had neuropathological evidence of CTE, with 110 out of 111 players diagnosed. The study also found a link between CTE and previous football participation, with severe pathology more common among professional players.
Childhood dementia, an inherited disorder affecting brain metabolism, shows promise in treating with immunomodulators. Inflammation of the brain is a key feature, and drugs like fingolimod and teriflunomide have shown therapeutic effects in mouse models.
The first Lancet Commission on Dementia Prevention and Care identifies powerful tools to prevent dementia. Nonmedical interventions such as social contact and exercise can reduce the incidence of dementia by up to 20% in early life and 15% in late life, according to a new report.
A new report models the impact of nine risk factors on dementia, including education, hearing loss, and smoking, and estimates that removing these factors could prevent 35% of all dementia cases. Increasing education in early life, reducing hearing loss, and stopping smoking are identified as key interventions.
A study of 13,864 participants found no convincing evidence linking PPI use to increased dementia risk. The research suggests that PPIs are safe for patients who require them for long-term treatment, and benefits may outweigh risks.
A large-scale trial found that goal-oriented therapy significantly improves people's ability to engage in important daily tasks and maintain independence. The therapy, which involves setting and achieving individual goals, shows promising results for supporting individuals with early-stage dementia to live fulfilling lives.
Researchers at Cardiff University have discovered two new genes that increase a person's risk of developing Alzheimer's disease. The findings build on previous research identifying 24 susceptibility genes and provide insights into the mechanisms underlying the disease.
A large-scale trial found that person-centered activities combined with one hour of social interaction per week can improve the lives of people with dementia in care homes. The approach also saves money compared to standard care.
Researchers will use PET scans and MRI to detect harmful chemical build-up and measure brain structure, with a focus on 40-65 year olds. The project hopes to develop ways to intervene before irreversible damage is done.
A new clinical trial will assess the effectiveness of improvisational dance in improving gait and balance problems associated with cognitive impairment and memory loss, as well as reducing apathy and depression. The 12-week program will be divided into four groups, including dance with social engagement and dance only.
Researchers review three cases of delayed-onset PTSD in patients with dementia, highlighting the importance of recognizing early life trauma. Clinicians can differentiate between PTSD and BPSD by considering a patient's unique narrative and history of previous trauma.
A new study found that offering the New York University Caregiver Intervention (NYUCI) program to eligible Minnesota Medicaid enrollees could save $40.4 million over 15 years, with increased net savings of $52.2 million via video teleconferencing.
A retrospective cohort study of over 40,000 TBI patients found a significant increase in dementia risk after moderate-to-severe traumatic brain injury. Those with mild TBI had a 1.6% diagnosis rate, while those with moderate-to-severe TBI had a 3.5% diagnosis rate, highlighting the increased risk in middle-aged individuals.
By 2040, over 1.2 million people will live with dementia in England and Wales, mainly due to longer lifespans. The incidence of new cases is declining, but overall prevalence is expected to rise substantially.
A study of over 40,000 Finnish adults with TBI found a significant link between TBI and dementia in working-age adults. The risk of dementia among TBI survivors remains high even years after the injury, suggesting that TBI may trigger a process leading to dementia.
A new technology called Ambient Activity aims to treat the cause of dementia behaviors rather than just symptoms. The device uses personalized content such as photos, games, music, and more to engage patients and promote meaningful physical, mental, and social engagement.
A new study from the University of California, Berkeley found that dementia patients tend to die sooner when cared for by family members with depression or anxiety. The study tracked 176 patients and their caregiver mental health over several years, revealing a strong link between patient survival and caregiver well-being.
Research published in The Journal of the American Osteopathic Association finds that off-label antipsychotic medications increase mortality rates in elderly people with dementia. Non-drug interventions like behavior management and sensory stimulation show promise as effective alternatives.
The World Health Organization predicts 135.5 million dementia cases by 2050, yet all neurodegenerative diseases are incurable. This Special Focus issue addresses challenges and advancements in therapy.
A new guide, Ensuring a Smooth Journey, aims to make air travel simpler and less stressful for people with dementia. The guide provides step-by-step advice on navigating Brisbane Airport's terminals, including planning and preparing for trips, managing at the airport, and choosing seats.
Florida Atlantic University has received a $1 million grant to establish the Comprehensive Center for Brain Health, which will focus on reducing risk of neurodegenerative diseases through personalized prevention plans. The center aims to identify individualized strategies to build a better brain as people age.
Research found no link between proton pump inhibitors and increased risk of dementia in people 75-years-old or older. However, frequent PPI use was associated with higher rates of depression, heart disease, and other health conditions. Regular PPI use also showed a decreased risk of cognitive decline.
Researchers at Scripps Florida and collaborators have won a $7.2 million grant to develop new RNA-based treatments for ALS and frontotemporal dementia. The project aims to create small-molecule drug candidates that target the root cause of these diseases.
The new Dementia with Lewy Bodies Consortium will centralize research efforts and create a national, coordinated registry for clinical data. Researchers aim to find DLB biomarkers to improve diagnosis and treatment of patients with this disease.