Articles tagged with Dementia
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Researchers at Temple University Health System have discovered a way to reverse memory deficits and tau pathology in mice with dementia. By administering a drug that blocks leukotriene formation, they were able to improve spatial learning and working memory in treated animals.
Researchers from Kumamoto University analyzed over 107 Alzheimer's patients and found that face-saving responses are a common communication pattern in the disease. The study suggests that these responses may indicate conflicted feelings about questions that patients cannot answer correctly.
A study of Japanese adults aged 60 found that short and long daily sleep durations were risk factors for dementia and premature death. Participants with optimal sleep duration (5-6.9 hours) had a lower risk of dementia and death compared to those with shorter or longer sleep durations.
A new study from the University of Surrey has developed AI-powered technology to monitor the wellbeing of people with dementia. This innovative system uses IoT devices installed in homes to detect potential health issues early on, preventing hospital admissions and improving care outcomes.
Researchers found that proxies more accurately predict length of life left and are less likely to agree to burdensome treatments for residents believed to have less than 6 months left. This discovery was published in the Journal of the American Medical Association Internal Medicine.
A new study published in the Australasian Journal on Ageing found that people with dementia are more likely to wander and become lost, resulting in potentially life-threatening outcomes. The researchers recommend implementing a 'Silver Alert' system, similar to Amber Alerts for missing children, to minimize this risk.
Researchers from the University of Würzburg have discovered a new role for stress granules in the formation and elimination of these structures. The study found that ZFAND1 protein is necessary for normal clearance of stress granules, which can lead to neurodegenerative diseases like ALS and FTD if not properly eliminated.
A large-scale study has identified three new genes linked to the risk of Alzheimer's disease, shedding light on the mechanisms underlying the condition. The findings, published in Translational Psychiatry, are based on genetic data from over 300,000 people and could pave the way for new approaches to treating the disease.
A study published in The BMJ found that a moderate to high intensity exercise program improved physical fitness in individuals with mild to moderate dementia. However, the program did not slow cognitive decline or improve daily activities. Researchers suggest exploring other forms of exercise and considering potential negative effects ...
A nationally representative sample of older English adults found that wealth in late life is associated with increased dementia risk. The study suggests that individuals with fewer financial resources are at higher risk for dementia.
Research from University College London reveals that older adults with fewer financial resources are more likely to develop dementia. The study analyzed data from over 6000 adults and found a significant link between socioeconomic factors and dementia incidence.
Machine learning has detected small vessel disease, a common cause of stroke and dementia, in CT scans more accurately than current methods. The software can identify and measure the severity of SVD, enabling clinicians to administer better treatments and predict patients' likelihood of developing dementia.
Researchers found that inheriting a variation in the PM20D1 gene increases the risk of developing Alzheimer's disease, making it an excellent candidate for clinical prevention trials. The study highlights the importance of international scientific collaboration and multidisciplinary research to tackle complex diseases like dementia.
A simple visual screening tool, VAT, shows increased predictive value for dementia risk when combined with MMSE score declines. The tool may help identify older adults at increased risk of developing dementia.
Research from Intermountain Medical Center reveals that carotid artery disease and atrial fibrillation significantly increase a patient's chances of developing dementia due to restricted blood flow to the brain. The study stresses the need for physicians to monitor and screen patients for both diseases, especially those with risk factors.
Researchers found changes in hippocampal neurons early after alpha-synuclein aggregates appear, suggesting potential therapeutic treatments to halt or reverse cognitive impairments. The study suggests defects in pre- and post-synaptic functions, indicating plasticity in the neurons.
The study found that good relationships, social engagement, and everyday functioning are linked to better quality of life for people with dementia. Factors such as poor mental or physical health, agitation, and unmet needs are associated with lower quality of life.
Researchers found that TDP-43 and DISC1 protein clusters disrupt dendritic local translation, leading to abnormal cell function and behavior. The study provides a new insight into the molecular mechanisms underlying psychiatric symptoms in neurodegenerative diseases.
Researchers identified new combinations of risk factors linked to increased dementia risk, including age, marital status, lower BMI, and less sleep at mid-life. The study suggests that modifiable risk factors may be targeted for prevention and early intervention.
Researchers tracked over 350,000 veterans and found a significant link between concussion and dementia, with concussion alone doubling the risk. The study suggests that traumatic brain injury may hasten neurodegenerative conditions by inducing or accelerating abnormal protein accumulation.
Researchers found that nursing home residents with advanced dementia who undergo surgical repair for hip fractures have a lower mortality rate compared to those managed with palliative care. These patients also experience less pain and fewer pressure ulcers.
A study of over 350,000 US veterans found that even mild traumatic brain injuries (TBI) without a loss of consciousness were associated with increased dementia risk. The risk was also elevated for patients with moderate to severe TBIs.
The study found that nearly 4.7 million adults had Alzheimer's in 2010, expected to grow to 13.8 million by 2050. The researchers emphasize the importance of conversations about gun ownership with families and physicians, balancing safety concerns with individual rights.
A recent study sheds light on the role of inflammation in dementia and Alzheimer's disease, suggesting that inflammation is a major cause rather than just a consequence. The research found that many genes linked to dementia regulate susceptibility and response to inflammatory damage.
A new smart home prototype named DRESS helps people with dementia dress themselves through automated assistance, enabling them to maintain independence and dignity. The system uses sensors, image recognition, and guided assistance to track progress during the dressing process.
Research suggests a link between moderate to severe mid-life anxiety and later life dementia, with potential benefits from non-pharmacological therapies such as mindfulness and meditation. The findings support previous evidence of mental illness being associated with dementia in older age.
Researchers found that music activates the salience network of the brain, which remains relatively functioning in individuals with Alzheimer's disease. The study suggests that personalized music programs may be an alternative route for communicating with patients who have lost contact with their environment.
Researchers linked cognitive function levels to crash risk in older drivers without dementia, finding lower cognitive function increases the risk of motor vehicle crashes. Depression also increased the risk for these drivers.
A new study found that long-term use of anticholinergic antidepressants and medications for bladder conditions increases the risk of dementia. The research analyzed over 40,000 patients and compared them to 283,933 people without dementia.
A UK study found a link between long-term use of certain anticholinergic drugs and an increased risk of dementia in patients over 45. The study suggests that clinicians should avoid prescribing these drugs to older patients due to potential cognitive effects.
A large study has found that anticholinergic drugs, commonly prescribed for depression and incontinence, are associated with an increased risk of dementia. The study analyzed over 27 million prescriptions and found a significant link between the use of these medications and dementia diagnosis.
A new guide from QUT's Dementia Centre aims to prepare those who care for people with dementia to cope during natural disasters. The Preparing for a Natural Disaster Guide highlights the increased risks faced by carers of people with dementia, including exacerbated symptoms and potential harm.
A UCL-led study found that hospitals are more likely to diagnose dementia in patients who have been admitted for another reason. However, missed diagnoses persist, with one-third of people with dementia discharged without recognition, highlighting the need for better record-sharing and culturally appropriate assessments.
A recent study indicates that dementia is being diagnosed later in life and lived for a shorter period, with possible contributing factors such as reduced stroke risk and increased vaccination rates. Researchers suggest other causes, including lower pollution levels and better nutrition, may also play a role.
San Diego County has received a $1.3 million NIH grant to advance Alzheimer's research, aiming to find a treatment or cure for the disease. The funding will support a team of scientists in identifying prototype drugs that can bind to and modulate TREM2, a gene known to correlate with increased risk of developing late-onset Alzheimer's.
A new computer programme assesses whole brain deterioration and predicts cognitive function after stroke up to ten times more accurately than current methods. The 'brain health index' can quantify visible brain injury from cerebral small vessel disease and brain atrophy, giving early warning of risk of future cognitive decline.
A new study by LMU researchers reveals that the aggregation of FUS protein is a central component of ALS and FTD. In healthy nerve cells, FUS is transported into the nucleus where it regulates DNA and RNA processing, but in neurons affected by ALS and FTD, its transport is compromised, leading to cytoplasmic aggregation.
The anthology explores dementia-associated apathy research, neural system effects on late-life depression, and adopting new models of care. It also proposes solutions to accelerate change in science, practice, training, and public policy.
A USC study found that individuals with a college education have a lower risk of developing dementia and living with it for longer periods. The research suggests that targeting chronic diseases like hypertension and diabetes may delay dementia onset but ultimately increase the number of people living with dementia at older ages.
A Portland State University research team published an interactive diagram and web-based presentation in Frontiers in Neurology, revealing the complex nature of mild traumatic brain injury (TBI). The causal-loop diagram shows how specific variables interact to influence concussion recovery.
A new study found that higher levels of education during childhood significantly decrease the risk of dementia and Alzheimer's disease in older African Americans. This association is particularly strong for those who grew up in low-income rural areas.
A new study led by University of Arizona cognitive scientist Aneta Kielar found that people with primary progressive aphasia, a rare dementia, can recruit intact areas of the brain to decipher sentences. This brain compensation offers hope for developing targeted treatments for PPA.
A large study found a significant link between traumatic brain injury (TBI) and dementia, with the risk increasing by 24% in individuals with TBI history. The study also found that the severity and number of TBIs were associated with increased dementia risk.
A nationwide study of 2.8 million people over 36 years found that sustaining a traumatic brain injury (TBI) is associated with an increased risk of developing both dementia and Alzheimer's disease. The risk of dementia increased with the number and severity of injuries, even a single mild TBI.
Researchers investigated the association between angiotensin-converting enzyme (ACE) polymorphisms and cognitive change in late-onset Alzheimer's disease dementia. They found that ACE inhibitors slowed cognitive decline independently of blood pressure variations, particularly for APOE4- carriers with specific ACE genotypes. No function...
A new study by UCSF researchers has identified two previously unrecognized genetic risks associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. The findings suggest that these diseases share genetic similarities, but differ in their impact on brain function.
A large study found that controlling blood pressure with antihypertensive medications can significantly reduce the risk of dementia in older African-American men and women. The research suggests that good blood pressure control at any age is crucial for preventing cognitive decline.
Researchers at McGovern Medical School are studying how protein deposits in the brain can trigger dementia and stroke. Akihiko Urayama's team is examining the brain's clearance system, while Louise McCullough's team is investigating the gut-brain connection.
Researchers have identified genetic links between ALS and frontotemporal dementia, suggesting that treatments for one may also work for the other. The study found common genetic variations associated with both disorders, including those near the MAPT gene and BNIP1.
Long-term use of antiepileptic drugs is associated with a higher risk of developing Alzheimer's disease and dementia. Cognitive-impairing antiepileptic drugs increase the risk by 20% for Alzheimer's and 60% for dementia, with dose dependence observed.
A University of Delaware researcher is studying a naturally occurring dietary supplement, nicotinamide riboside (NR), to boost nicotinamide adenine dinucleotide (NAD+) levels and potentially treat age-related cardiovascular dysfunction. The study aims to improve physiological function in humans by reversing age-related declines in NAD+.
A new University of Bristol study reveals that two types of nicotinic receptors play distinct roles in long-term memory retrieval and encoding. The study suggests that drugs targeting individual nicotinic receptors could lead to more effective therapies for dementia.
Research identifies poor attention and decision-making skills as linked to walking slowly and experiencing falls in older adults with dementia. Certain brain training methods may help improve mobility and prevent falls by addressing cognitive function issues.
A recent study published in the Journal of the American Geriatrics Society found that older adults with slower walking speeds may be at increased risk for developing dementia. The research examined data from nearly 4,000 participants and discovered a strong link between slower walking speed and higher risk of dementia.
A recent study found that neglectful behaviors are widespread among English care home staff, despite efforts to provide person-centered care. The survey of 1,544 staff revealed that many witnessed residents being left waiting for care or having insufficient time for food.
Researchers identified five essential themes for consistent and supported care transitions, including preparing individuals with dementia and their caregivers, evaluating preferences and goals, and creating inter-professional collaborative team environments. The findings suggest that person-centered care is crucial for achieving outcom...
Salk Institute scientists have developed a CRISPR-based tool called CasRx that targets RNA to correct protein imbalances in cells from dementia patients. The tool showed 80% effectiveness in rebalancing tau protein levels, opening up new avenues for treating RNA and protein-related diseases.
David A. Bennett's work in memory loss research has led to significant advancements in treating and preventing Alzheimer's disease and related disorders. The study's findings are shared globally to develop therapy and identify resilience characteristics.
Women with high physical fitness at middle age were nearly 90% less likely to develop dementia decades later. The study found that highly fit women developed dementia an average of 11 years later than moderately fit women.
A recent study using CRISPR-Cas9 technology identified new genes that may hasten neuron death in ALS and FTD patients. The researchers found that genes controlling cell movement and protein assembly were potential partners in DPR toxicity, suggesting novel therapies for ALS.