Articles tagged with Dementia
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Researchers develop QC-01-175, a molecular tool that clears abnormal tau protein from human neurons, providing a new approach for studying disease progression and potential therapeutic benefits. The findings suggest targeted protein degradation technology can be used to transform a protein binder into a functional molecule with pharmac...
A new state-of-the-art sleep unit has opened at the University of East Anglia, pioneering research will investigate the link between sleep and dementia. The unit aims to determine whether treating sleep disturbances early on could help slow down the progression of Alzheimer's disease.
A study found a link between fewer reproductive years and an increased risk of dementia in women. Women with shorter total reproductive years had a higher risk of developing dementia, particularly those who started menstruating later or went through menopause earlier.
Researchers at OHSU test video chat to stave off dementia in seniors, showing promise in improved cognitive tests. Social isolation is a major problem for seniors, and this study aims to identify healthy but isolated individuals and see if regular conversation can prevent age-related cognitive decline.
A new study found that controlling high blood pressure in mid-life patients with atrial fibrillation can reduce dementia risk by up to 15%. The study analyzed data from over 196,000 patients and found that lowering systolic blood pressure to 120-129 mmHg was associated with lower dementia risk.
Dementia caregivers want robots to support positive moments and alleviate emotional stress through tasks like answering repeated questions, managing daily schedules, and providing reminders. The researchers are now building high-tech prototypes based on the initial low-tech prototypes designed by caregivers.
A robot-guided video game has been developed to get older adults learning and working together, staving off dementia. The game's goal is to encourage physical movement and social interaction, addressing isolation a key contributor to dementia progression.
A new study found that catheter ablation significantly reduces the risk of dementia and stroke in patients with atrial fibrillation and carotid arterial disease compared to medication treatment. Researchers identified 5,786 patients and found that ablation made a significant difference in those with both conditions.
Chronic periodontitis may increase the risk of developing dementia by 6%, according to a recent study published in the Journal of the American Geriatrics Society. The research suggests that preventing and treating periodontitis could lead to a reduced risk of dementia.
Dorothee Dormann's work reveals similarities in ALS and FTD pathogenesis, highlighting the role of protein FUS in disease progression. Her research aims to identify molecular targets for therapy and explore common mechanisms with other neurodegenerative diseases.
A large study of over 8,200 adults found no association between midlife diet quality and later risk of dementia. The study followed participants for nearly 25 years, but repeated assessments of diet quality during midlife didn't show any significant link to subsequent risk for dementia.
FAU's Dementia Prevention Initiative aims to identify novel biomarkers and peripheral predictors of disease, enabling personalized evaluation and prevention plans. The $3 million grant will enable researchers to follow patients for three years, share data with other investigators, and provide training.
Scientists at Northwestern University have discovered that an existing therapy used to treat Alzheimer's disease may also be effective for patients with Primary Progressive Aphasia (PPA), a type of dementia that destroys language. The study found that individuals with PPA exhibit the same loss of cholinergic neurons and axons in the fo...
A study of 800 Swedish women found that those with high levels of mental activities like reading, singing, and gardening were 46% less likely to develop Alzheimer's disease. Women who were physically active also had a reduced risk of developing dementia, with a 52-56% lower risk compared to inactive participants.
A Swedish study of 800 women found that those with a high level of mental and physical activities had a lower risk of developing dementia. Mental activities included reading, playing instruments, singing in a choir, and gardening, while physical activity ranged from light walking to regular intense exercise.
Researchers at Kaunas University of Technology developed a computer game for dementia carers, offering immersive scenarios to build knowledge and skills. The game is freely available online, providing a hands-on approach to train caregivers in dealing with the challenges of dementia care.
A study by the University of Helsinki found that insufficient sleep is associated with changes in DNA methylation in gene regulatory elements related to the nervous system development pathway. This indicates a potential link between chronic sleep deprivation and long-term health risks.
A new study published in Neurology suggests that education does not play a significant role in when the disease starts or how fast it progresses. Researchers found an association between higher education and better thinking and memory skills at the start of the study, but this did not translate to slower cognitive decline.
A large UK population-based study found no association between the antidepressant trazodone and a reduced risk of dementia. Researchers analyzed data from over 15 million patients and compared them with users of other antidepressants, but found higher incidence rates among trazodone users.
The American Geriatrics Society recommends excluding feeding tube preference from Physician Order for Life-Sustaining Treatment (POLST) forms due to research showing that they harm patients with dementia. PEG tubes can increase discomfort and agitation, leading to restraints and bedsores.
Research found differences in gut microbiota between patients with and without dementia, with higher levels of ammonia and indole associated with increased dementia risk. Lower levels of beneficial Bacteroides organisms were also observed in dementia patients.
A study published in Communications Biology found that chronic conditions like cancer and diabetes share common underlying mechanisms with aging. The researchers analyzed genetic data from over 300,000 people and identified 12 genetic loci associated with healthy life expectancy.
The Alzheimer's Association has awarded funding for the SPRINT MIND 2.0 Study, which aims to investigate intensive blood pressure treatment and its impact on reducing dementia risk. The study will continue to follow up trial participants with two years of additional assessment.
The SPRINT MIND trial found that intensive lowering of systolic blood pressure did not significantly reduce dementia risk, but had a measurable impact on mild cognitive impairment. The study demonstrated that intensive blood pressure control is safe for the brain and may offer avenues for prevention.
A clinical trial led by Wake Forest School of Medicine found that intensive control of blood pressure significantly reduced the risk of developing mild cognitive impairment (MCI) in older people. MCI is a precursor to early dementia and increases the risk of dementia progression, but reversion to normal cognition is possible.
A randomized clinical trial involving 9,400 adults with hypertension found that intensive blood pressure control did not significantly reduce the risk of probable dementia. Early study termination and fewer than expected cases of dementia may have limited the power to detect a difference.
A UK study found lower cognitive scores and earlier dementia diagnoses in Asian and Black patients compared to White patients. The research highlights the need for tailored prevention initiatives and early diagnosis across ethnic groups.
Research suggests that frailty makes older adults more susceptible to Alzheimer's dementia, regardless of brain changes. The study found a significant association between frailty and cognitive decline, suggesting that maintaining function and independence may help reduce dementia risk.
A Danish population-based study found that vital exhaustion, a state of emotional suffering and somatic symptoms, is associated with a higher risk of dementia later in life. The study, published in IOS Press, suggests that addressing psychological risk factors may be crucial in preventing dementia.
A study found that moving more, even simple routine physical activity like housework, can protect the brain from damage and preserve memory and thinking skills. The study looked at 454 older adults and found that those who moved more had better thinking and memory skills compared to those who didn't.
The new AI system uses machine learning algorithms to identify early symptoms of urinary tract infections in people with dementia. This allows for earlier treatment and reduction in hospitalizations, according to researchers at the University of Surrey.
A recent study published in Neurology found that older adults who engage in regular physical activity may maintain better thinking and memory skills despite having brain lesions or biomarkers linked to dementia. The study, conducted by Rush University Medical Center, compared cognition test results and activity data for 454 older adult...
Regenstrief Institute researcher Malaz Boustani advocates for Medicare payment for team-based care, which improves patient outcomes and reduces costs. Collaborative care models, including the Aging Brain Care model, have shown effective results in managing dementia and related dementias.
The My Brain Robbie campaign aims to fill an educational gap in dementia prevention by providing public health education for children aged 6-12. The project uses an animated video and free resources to teach eight simple steps to keep brains healthy, connecting with modifiable risk factors for cognitive decline.
Researchers identified five distinct subtypes of insomnia, each with unique characteristics and underlying brain mechanisms. These findings have significant implications for treatment effectiveness and the prevention of depression, offering a new direction in understanding this complex mental disorder.
A European research project aims to uncover the physiological pathways underlying neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, and Down syndrome, which are linked by evolving dementia. The HEROES project seeks to develop biomarkers for dementia progression and explore new therapeutic approaches.
A Swedish study found a significant correlation between dementia and ischemic stroke, with patients dying from IS having a higher mortality rate compared to those who did not have IS. The study also highlights the importance of accurate death certificate diagnoses, particularly for deaths reported outside Swedish hospitals.
Researchers have identified a single mutation in the MAPT gene as the culprit behind inherited frontotemporal dementia, leading to impaired communication between brain neurons and neurodegeneration. The study offers new potential treatment targets for both this condition and Alzheimer's disease.
The new guidelines aim to support doctors in assessing and managing patients with dementia who drive. Key findings indicate that many people with dementia are safe to drive in the early stages, but making the decision to stop can be difficult.
A study found that female veterans with traumatic brain injury (TBI), post-traumatic stress disorder (PTSD), or depression are more likely to develop dementia than their counterparts without these conditions. Women with PTSD were about 80% more likely, while those with depression were about 70% more likely to develop dementia.
The five-year study will investigate the use of electroconvulsive therapy (ECT) to treat severe agitation and aggression in people with Alzheimer's disease. Researchers will compare ECT treatment plus standard therapies to standard therapies alone for individuals with moderate-to-severe Alzheimer's dementia.
A recent study reveals a significant increase in worldwide dementia cases over the past 26 years, with the number of people suffering from Alzheimer's disease and other dementias rising to 43.8 million in 2016. This represents a 117% growth, attributed to both aging and global population growth.
A UCLA-led research team has identified two major groups of genes involved in mutations that result in an overproduction of tau protein, a hallmark of progressive dementia. The study suggests that these genetic processes may be targetable with experimental drugs.
Researchers found that quick cognitive assessments can be wrong, with varying biases based on factors like education, age, ethnicity, and living conditions. This study highlights the need for more accurate and unbiased methods to detect dementia in primary care settings.
Research found that lung disease, including restrictive and obstructive conditions, is associated with a greater risk of developing dementia. The study analyzed data from over 14,000 participants and found that low lung function was linked to an increased risk of dementia.
A study in the Journal of the American Osteopathic Association notes that elderly gun owners with dementia are at a high risk of suicide and accidental shootings. The authors argue that public policy, such as red flag laws, can help mitigate this risk by removing firearms from patients with cognitive impairment.
New research published in the Canadian Medical Association Journal found that trazadone is associated with a comparable risk of falls and major osteoporotic fractures to atypical antipsychotics. This finding challenges the assumption that trazodone is a safer alternative for treating behavioral symptoms in seniors with dementia.
A study found that a training programme for caregivers in care homes improves the lives of residents with dementia, reducing agitation and hospital admissions. The programme, known as WHELD, cost £660 per resident to achieve significant improvements, saving up to £4,000 per home.
Researchers used diffusion tensor imaging to assess white matter health and found that individuals who went on to experience cognitive decline had significantly more signs of damage. The study predicted cognitive decline with 89% accuracy, rising to 95% when focusing on specific brain areas.
A recent study published in JAMA Neurology reveals that adults with Down syndrome are more likely to die from dementia, highlighting the importance of studying disease progression and potential treatments for this population. The study, which included 211 adults, found that 70% of those who died had dementia.
A new study by the University of Exeter found that most people living with dementia also have at least one additional chronic health condition. The study, led by Professor Linda Clare, highlights the need for better care planning and support to deal with multiple conditions in a more integrated way.
Breakdowns in brain's blood vessels linked to Alzheimer's disease and vascular dementia, potentially leading to earlier diagnosis and intervention through biomarkers, exercise, and targeted treatments. Age-related loss of brain lymphatic function also plays a role in neurodegeneration.
Researchers from Regenstrief Institute and Indiana University Center for Aging Research develop IN-PEACE to improve dementia care and reduce caregiver stress through state-of-the-art symptom management. The initiative provides support by nurses and social workers to both patients and their family caregivers.
Two UTA social work professors, Noelle Fields and Ling Xu, have received a $459,994 NIH grant to develop an intervention program for African American dementia caregivers. The SCP Plus program aims to reduce caregiver burden and stress while increasing the well-being of caregivers.
A £2.7 million study is developing a person-centred package of care in GP surgeries, focusing on the introduction of one dementia expert to link to the rest of the patient's clinical team. The programme aims to improve the experience of care and promote positive mental and physical wellbeing.
A recent study published by the American Society of Nephrology found a strong link between acute kidney injury and an increased risk of developing dementia. Patients with acute kidney injury had a 7.0% vs. 2.3% chance of developing dementia, highlighting the potential long-term cognitive consequences of AKI.
A University of Bath team has biochemically characterised the protein produced by the C9orf72 gene, revealing it to be a guanine nucleotide exchange factor (GEF) that regulates molecules called RABs. This understanding is crucial in developing treatments and potentially a cure for neurodegenerative diseases ALS and FTD.
A new study published in Frontiers in Aging Neuroscience suggests a causal link between herpes viruses and Alzheimer's disease, with antiviral drugs drastically reducing the risk of senile dementia in patients with severe herpes infections.
A large study published in The BMJ found that pre-eclampsia is associated with an increased risk of later dementia, particularly vascular dementia. Women with a history of pre-eclampsia were more than three times as likely to develop vascular dementia compared to those without the condition.
A new study from the University of Pittsburgh has identified arterial stiffness as a key risk factor for dementia in older adults. The researchers found that individuals with high arterial stiffness readings were 60% more likely to develop dementia over a 15-year period.