Articles tagged with Dementia
A new diagnostic definition for Functional Cognitive Disorder (FCD) has been established, allowing researchers to better characterise the condition and its prognosis. The criteria also hold promise for strengthening research into dementia by identifying patients for trials.
Baycrest researchers are studying the effects of COVID-19 and social isolation on cognitive health, finding a potential link between respiratory symptoms and decreased oxygen to the brain. The study aims to identify factors predicting dementia development in older adults.
A new study proves that the McKee CTE staging scheme accurately represents the progression of tau pathology in CTE, correlating with clinical dementia and age at death. Researchers found five brain regions with increasing p-tau pathology that conform to CTE stage, age, and years of football play.
A new study published in Neurology found that people who experience a sudden drop in systolic blood pressure when standing up may be at higher risk of developing dementia years later. The study also showed that controlling these blood pressure drops could be a promising way to help preserve people's thinking and memory skills as they age.
The Dementia Friendly Church programme has had a significant impact, improving interactions between church attendees and people with dementia. The project involves making practical changes to church layouts, worship, and hospitality to create 'friendly spaces' for those living with dementia.
Researchers have identified measurable Alzheimer's risk factors in adolescents and young adults, emphasizing the need for early interventions targeting heart health and education. Studies found that high blood pressure, diabetes, and poor educational quality are associated with worse late-life cognition, particularly in African Americans.
A new report from the Lancet Commission identifies 12 modifiable risk factors that can delay or prevent 40% of dementia cases. These include reducing excessive alcohol intake, limiting air pollution, and promoting physical activity throughout life.
Experts identify 12 modifiable risk factors that can be targeted throughout life to delay or prevent dementia. The report highlights the potential for preventive measures to reduce dementia risk, particularly in low- and middle-income countries.
A study of 8,275 participants found that those with severe gum disease had twice the risk for mild cognitive impairment or dementia. People with minimal tooth loss and mild gum disease were no more likely to develop thinking problems than those with no dental issues.
A phase 3 trial found pimavanserin to be effective in reducing psychotic symptoms in people with dementia, regardless of underlying dementia subtype or severity. The treatment works differently than other antipsychotics, showing promise for improving the lives of those affected by psychosis.
Two studies indicate that WTC responders are at risk for developing dementia, with reduced gray matter thickness in the brain consistent with neurodegenerative conditions. Researchers found protein changes in blood consistent with Alzheimer's disease in responders with PTSD and mild cognitive impairment.
Research reveals flu vaccinations can reduce Alzheimer's incidence by up to 17%, with pneumococcal vaccination showing a similar protective effect. Vaccination also found to reduce mortality in people with dementia.
Research finds concussion associated with increased risk of developing ADHD, mood and anxiety disorders, dementia and Parkinson's disease. Concussions upsets brain function and blood flow, potentially leading to long-term consequences.
A recent study found that over 40% of hospitalizations among older adults with dementia were for potentially preventable conditions, such as pneumonia and heart failure. The study's lead author emphasized the importance of addressing sepsis and implementing patient-centered programs to improve outpatient care.
A new Boston University School of Public Health and School of Medicine study finds that genetic risk factors for dementia can be lowered by improving cardiovascular health. Participants with a high genetic risk score were 2.6 times more likely to develop dementia, but those with good cardiovascular health were half as likely.
Research identified 21 evidence-based suggestions for preventing Alzheimer's disease, with a focus on vascular risk factors and lifestyle modifications. Targeting factors such as cognitive activity, high blood pressure, depression, diabetes, and stress may help reduce the risk of developing Alzheimer's disease.
Researchers found that high genetic risk scores, including apolipoprotein E ε4, increase dementia risk by 2.6 times, while favorable cardiovascular health reduces the risk by 0.45 times.
A UCSF study found that older adults with retained senses of hearing, vision, and touch have half the risk of developing dementia compared to those with marked sensory decline. The study tracked over 1,800 participants in their seventies for up to 10 years, revealing a stronger association between olfaction and lower dementia risk.
Researchers discovered that individuals with Alzheimer's disease and dementia experience more severe delirium and increased risk of hospitalization compared to those without ADRD. Targeted strategies can help prevent or reduce delirium severity, particularly in patients with ADRD.
Research reveals that many caregivers of individuals with Alzheimer's and Related Dementias (ADRD) lack guidance on firearm safety, despite high rates of accidental shootings. The study emphasizes the need for healthcare providers to address firearm safety in the context of ADRD, providing routine counseling and access to resources.
Researchers have identified a new biomarker, asymmetric dimethylarginine (ADMA), associated with cognitive decline in old age. The study found that ADMA levels were linked to decline in cognitive performance assessments after four years.
Research suggests that antioxidant treatment after acute ischemic stroke could delay the onset of Alzheimer's dementia by reducing oxidative stress and promoting mitochondrial function. Studies have shown promising results with molecules like edaravone and nerinetide, but more research is needed to confirm these findings.
A new study published in Neurology suggests that deep brain stimulation for Parkinson's disease does not significantly increase the risk of developing dementia. Researchers found that factors such as age, hallucinations, and cerebral hemorrhage during surgery were associated with a higher risk of dementia.
A new study will test a training model for primary care nurses to improve the lives of dementia patients by enhancing assessment, management, and coordination of care. The researchers aim to reduce emergency room visits, health care costs, and improve quality of life for patients and caregivers.
A recent study by the University of Kentucky's Sanders-Brown Center on Aging has identified a previously under-recognized form of dementia, quadruple misfolded proteins (QMP), linked to TDP-43 proteinopathy. The study found that about 20% of participants with dementia had QMP, resulting in the most severe dementia cases.
Researchers at the Allen Institute in Seattle are building a high-resolution map of Alzheimer's disease by comparing brain cells across patients with different stages of the disease. By identifying specific neurons and cell types affected by the progressive disorder, they aim to find new drug targets and potential therapies.
Researchers propose that elevated pulse pressure in blood traveling to the brain can cause inflammation, oxidative stress, and cellular dysfunction, leading to brain damage and cognitive decline. The study suggests reducing elevated pulse pressure could prove synergistic with other therapeutic approaches to treat dementia.
Research links inflammatory bowel disease (IBD) to a doubled risk of developing dementia, with diagnoses occurring 7 years earlier. The study suggests that an imbalance in gut bacteria and chronic inflammation may contribute to cognitive decline.
A new study published in the International Journal of Epidemiology found that obesity is associated with a higher risk of dementia, with women facing a 39% increased risk. The study suggests that weight management could play a significant role in reducing this risk.
New Zealand centenarians exhibit low rates of chronic diseases such as diabetes, depression, and hypertension. Socially active participants showed similar patterns across age groups, while exercise improved health without significant effects on ageing.
The Vietnam Era Twin Study of Aging will continue to follow and document risk factors for cognitive and brain aging in 1,600 male twins. The study aims to identify early signs of Alzheimer's disease and mild cognitive impairment.
A study found that an undergraduate service-learning course using music and filmmaking helped students connect with people with dementia, share unique stories, and process new experiences. The creative approach has the potential to humanize dementia and motivate a new generation of healthcare professionals.
A new UCL-led study found that repetitive negative thinking is linked to cognitive decline and increased risk of Alzheimer's disease. The research, published in Alzheimer's & Dementia, suggests that psychological tools like mindfulness or meditation may help reduce dementia risk.
The new app, called neureka, uses brain games and self-reflection challenges to collect data on mental health and dementia research. It aims to identify modifiable risk factors for disorders of the mind and capture complex datasets to develop individualized understanding of brain health.
A $2.6M NIH award will examine how sex differences impact cognitive impairment and dementia, with a focus on the brain vascular system. The project aims to uncover personalized molecular targets for therapy and improve treatment of dementia.
Researchers have developed an antibody that can accurately detect and quantify toxic amyloid-beta oligomers, a hallmark of Alzheimer's disease. This discovery could lead to improved diagnostic methods and ultimately help monitor the progression of the disease.
NUI Galway research shows that taking blood pressure medications can reduce the risk of developing dementia and cognitive impairment by 7%, and cognitive decline also by 7% over a four-year period. The study highlights the critical importance of controlling blood pressure in maintaining brain health, combined with a healthy lifestyle.
Researchers found that individuals with higher cardiovascular risk burdens experienced faster declines in episodic memory and working memory, as well as smaller hippocampal volumes. Maintaining heart health may be key to preventing cognitive decline, according to the study's findings.
A study of 7,000 adults aged 65 found that those with dementia and poor vision experience significant limitations in self-care, mobility, and household activities. The research highlights the need for better support systems to address these challenges.
An undergraduate course curriculum combined music, filmmaking, and reflective writing to help students connect with people living with dementia. More than half of the students continued engaging with participants after the course, highlighting the potential of arts and music courses in shaping perceptions about dementia.
A study of 2,800 people aged 50 and older found that low intake of flavonoid-rich foods was linked to a higher risk of developing Alzheimer's disease. Consuming more berries, apples, and tea may help prevent the condition, with even small amounts providing benefits.
A team of Emory scientists compared the most common inherited form of amyotrophic lateral sclerosis and frontotemporal dementia with spinocerebellar ataxia type 36. They discovered that protein products can poison cells in one disease but not the other, providing new insights into their pathological mechanisms.
Systematic reviews evaluate cognitive tests for Alzheimer's disease, biomarkers for neuropathologic Alzheimer disease, and prescription drugs for cognitive dysfunction. The findings suggest that certain brief cognitive tests are highly sensitive for distinguishing clinical Alzheimer-type dementia from normal cognition.
A new review study found that three tests - amyloid PET, FDG-PET, and MRI - are highly accurate in distinguishing between Alzheimer's disease and other causes of dementia. These tests show promise in improving diagnosis, but more study is needed for standardization.
A new tool measures quality of life in people with dementia by assessing five key domains: physical health, mood, memory, living situation, and ability to do fun activities. The tool reveals that living situation is the most important contributor to quality of life, followed by the ability to engage in fun activities.
Researchers found that telehealth services using videoconferences can save travel time, equip families with strategies to promote independence, and reduce costs for non-pharmacologic interventions. The study provides evidence-based information and skills to support people with dementia and their care partners.
A new study published in Neurology suggests that combining highly processed meats with starches and snacks like cookies and cakes may raise the risk of dementia. Researchers found that people with dementia were more likely to eat these foods together, while those without dementia had a greater variety of healthier food options.
A new online calculator predicts the risk of death and long-term care admission for patients with dementia based on simple questions at diagnosis. The study found that older age, male sex, and organ failure are key predictors of mortality and institutionalization.
An observational study of 1,000 older women found a significant association between visual impairment and an increased risk of dementia. The study suggests that addressing visual impairment could be an important prevention strategy for reducing dementia risk.
An observational study of 2,900 older residents found that long-term air pollution exposure increases the risk of developing dementia. Cardiovascular disease may contribute to this association by increasing blood flow and oxygenation to the brain, leading to neurodegenerative changes.
A study at Karolinska Institutet found that long-term exposure to air pollution is associated with an increased risk of dementia. The researchers also found that cardiovascular disease plays a key role in this association, and that reducing emissions can help mitigate the risk.
A large study published in Neurology found that taking a low-dose aspirin daily does not reduce the risk of thinking and memory problems caused by mild cognitive impairment or probable Alzheimer's disease. The study involved 19,114 participants and was supported by various funding sources.
A standardized dementia test has been adapted for use in seven Indian languages, enabling accurate diagnosis and mild cognitive impairment detection. The study found high diagnostic accuracy, making it a valuable tool for future cross-national research studies.
A growing body of evidence suggests that antioxidant treatment in acute ischemic stroke may delay the onset of Alzheimer's dementia. Oxidative stress plays a major role in the pathogenesis of AD, and antioxidants have shown promise in animal models and some clinical trials.
Research from the University of Cambridge found a link between inflammation and protein build-up in various types of dementia. The study suggests that neuroinflammation is a common factor across different neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease.
A study by Hiroshima University found that financial literacy is key to understanding existing legal and social services for people with dementia. Financially literate individuals are more aware of systems like adult guardianship and civil trust, which can help prevent misuses of power and ensure continued economic participation.
A blood test measuring phosphorylated tau 181 (pTau181) shows promise in detecting Alzheimer's disease and mild cognitive impairment. The test's accuracy surpasses existing methods, offering a potential solution for early diagnosis and treatment.
A new study published in JAMA Network Open found that declines in both memory and gait speed are associated with an increased risk of dementia in adults 60 and older. The observational meta-analysis included six studies with over 8,700 participants from the US and Europe.
A new study by UCL researchers has found a link between iron accumulation in the brain and cognitive decline in people with Parkinson's disease. The study used advanced MRI techniques to detect iron deposits in different brain regions, revealing associations with poor memory and thinking scores.
The number of people with dementia in Europe is estimated to almost double by 2050, from 7.9 million to 14.3 million, according to a new report by Alzheimer Europe. The prevalence of dementia has decreased in recent years, but this trend is expected to reverse unless better treatments and prevention strategies are developed.