Articles tagged with Dementia
Researchers found that nursing home residents with advanced dementia who undergo surgical repair for hip fractures have a lower mortality rate compared to those managed with palliative care. These patients also experience less pain and fewer pressure ulcers.
A study of over 350,000 US veterans found that even mild traumatic brain injuries (TBI) without a loss of consciousness were associated with increased dementia risk. The risk was also elevated for patients with moderate to severe TBIs.
The study found that nearly 4.7 million adults had Alzheimer's in 2010, expected to grow to 13.8 million by 2050. The researchers emphasize the importance of conversations about gun ownership with families and physicians, balancing safety concerns with individual rights.
Researchers tracked over 350,000 veterans and found a significant link between concussion and dementia, with concussion alone doubling the risk. The study suggests that traumatic brain injury may hasten neurodegenerative conditions by inducing or accelerating abnormal protein accumulation.
A recent study sheds light on the role of inflammation in dementia and Alzheimer's disease, suggesting that inflammation is a major cause rather than just a consequence. The research found that many genes linked to dementia regulate susceptibility and response to inflammatory damage.
A new smart home prototype named DRESS helps people with dementia dress themselves through automated assistance, enabling them to maintain independence and dignity. The system uses sensors, image recognition, and guided assistance to track progress during the dressing process.
Research suggests a link between moderate to severe mid-life anxiety and later life dementia, with potential benefits from non-pharmacological therapies such as mindfulness and meditation. The findings support previous evidence of mental illness being associated with dementia in older age.
Researchers found that music activates the salience network of the brain, which remains relatively functioning in individuals with Alzheimer's disease. The study suggests that personalized music programs may be an alternative route for communicating with patients who have lost contact with their environment.
Researchers linked cognitive function levels to crash risk in older drivers without dementia, finding lower cognitive function increases the risk of motor vehicle crashes. Depression also increased the risk for these drivers.
A new study found that long-term use of anticholinergic antidepressants and medications for bladder conditions increases the risk of dementia. The research analyzed over 40,000 patients and compared them to 283,933 people without dementia.
A UK study found a link between long-term use of certain anticholinergic drugs and an increased risk of dementia in patients over 45. The study suggests that clinicians should avoid prescribing these drugs to older patients due to potential cognitive effects.
A large study has found that anticholinergic drugs, commonly prescribed for depression and incontinence, are associated with an increased risk of dementia. The study analyzed over 27 million prescriptions and found a significant link between the use of these medications and dementia diagnosis.
A new guide from QUT's Dementia Centre aims to prepare those who care for people with dementia to cope during natural disasters. The Preparing for a Natural Disaster Guide highlights the increased risks faced by carers of people with dementia, including exacerbated symptoms and potential harm.
A UCL-led study found that hospitals are more likely to diagnose dementia in patients who have been admitted for another reason. However, missed diagnoses persist, with one-third of people with dementia discharged without recognition, highlighting the need for better record-sharing and culturally appropriate assessments.
A recent study indicates that dementia is being diagnosed later in life and lived for a shorter period, with possible contributing factors such as reduced stroke risk and increased vaccination rates. Researchers suggest other causes, including lower pollution levels and better nutrition, may also play a role.
San Diego County has received a $1.3 million NIH grant to advance Alzheimer's research, aiming to find a treatment or cure for the disease. The funding will support a team of scientists in identifying prototype drugs that can bind to and modulate TREM2, a gene known to correlate with increased risk of developing late-onset Alzheimer's.
A new computer programme assesses whole brain deterioration and predicts cognitive function after stroke up to ten times more accurately than current methods. The 'brain health index' can quantify visible brain injury from cerebral small vessel disease and brain atrophy, giving early warning of risk of future cognitive decline.
A new study by LMU researchers reveals that the aggregation of FUS protein is a central component of ALS and FTD. In healthy nerve cells, FUS is transported into the nucleus where it regulates DNA and RNA processing, but in neurons affected by ALS and FTD, its transport is compromised, leading to cytoplasmic aggregation.
A Portland State University research team published an interactive diagram and web-based presentation in Frontiers in Neurology, revealing the complex nature of mild traumatic brain injury (TBI). The causal-loop diagram shows how specific variables interact to influence concussion recovery.
A new study found that higher levels of education during childhood significantly decrease the risk of dementia and Alzheimer's disease in older African Americans. This association is particularly strong for those who grew up in low-income rural areas.
The anthology explores dementia-associated apathy research, neural system effects on late-life depression, and adopting new models of care. It also proposes solutions to accelerate change in science, practice, training, and public policy.
A USC study found that individuals with a college education have a lower risk of developing dementia and living with it for longer periods. The research suggests that targeting chronic diseases like hypertension and diabetes may delay dementia onset but ultimately increase the number of people living with dementia at older ages.
A new study led by University of Arizona cognitive scientist Aneta Kielar found that people with primary progressive aphasia, a rare dementia, can recruit intact areas of the brain to decipher sentences. This brain compensation offers hope for developing targeted treatments for PPA.
A nationwide study of 2.8 million people over 36 years found that sustaining a traumatic brain injury (TBI) is associated with an increased risk of developing both dementia and Alzheimer's disease. The risk of dementia increased with the number and severity of injuries, even a single mild TBI.
A large study found a significant link between traumatic brain injury (TBI) and dementia, with the risk increasing by 24% in individuals with TBI history. The study also found that the severity and number of TBIs were associated with increased dementia risk.
A large study found that controlling blood pressure with antihypertensive medications can significantly reduce the risk of dementia in older African-American men and women. The research suggests that good blood pressure control at any age is crucial for preventing cognitive decline.
Researchers at McGovern Medical School are studying how protein deposits in the brain can trigger dementia and stroke. Akihiko Urayama's team is examining the brain's clearance system, while Louise McCullough's team is investigating the gut-brain connection.
Researchers have identified genetic links between ALS and frontotemporal dementia, suggesting that treatments for one may also work for the other. The study found common genetic variations associated with both disorders, including those near the MAPT gene and BNIP1.
Long-term use of antiepileptic drugs is associated with a higher risk of developing Alzheimer's disease and dementia. Cognitive-impairing antiepileptic drugs increase the risk by 20% for Alzheimer's and 60% for dementia, with dose dependence observed.
Researchers investigated the association between angiotensin-converting enzyme (ACE) polymorphisms and cognitive change in late-onset Alzheimer's disease dementia. They found that ACE inhibitors slowed cognitive decline independently of blood pressure variations, particularly for APOE4- carriers with specific ACE genotypes. No function...
A new study by UCSF researchers has identified two previously unrecognized genetic risks associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. The findings suggest that these diseases share genetic similarities, but differ in their impact on brain function.
A University of Delaware researcher is studying a naturally occurring dietary supplement, nicotinamide riboside (NR), to boost nicotinamide adenine dinucleotide (NAD+) levels and potentially treat age-related cardiovascular dysfunction. The study aims to improve physiological function in humans by reversing age-related declines in NAD+.
A new University of Bristol study reveals that two types of nicotinic receptors play distinct roles in long-term memory retrieval and encoding. The study suggests that drugs targeting individual nicotinic receptors could lead to more effective therapies for dementia.
A recent study published in the Journal of the American Geriatrics Society found that older adults with slower walking speeds may be at increased risk for developing dementia. The research examined data from nearly 4,000 participants and discovered a strong link between slower walking speed and higher risk of dementia.
Research identifies poor attention and decision-making skills as linked to walking slowly and experiencing falls in older adults with dementia. Certain brain training methods may help improve mobility and prevent falls by addressing cognitive function issues.
A recent study found that neglectful behaviors are widespread among English care home staff, despite efforts to provide person-centered care. The survey of 1,544 staff revealed that many witnessed residents being left waiting for care or having insufficient time for food.
Salk Institute scientists have developed a CRISPR-based tool called CasRx that targets RNA to correct protein imbalances in cells from dementia patients. The tool showed 80% effectiveness in rebalancing tau protein levels, opening up new avenues for treating RNA and protein-related diseases.
David A. Bennett's work in memory loss research has led to significant advancements in treating and preventing Alzheimer's disease and related disorders. The study's findings are shared globally to develop therapy and identify resilience characteristics.
Researchers identified five essential themes for consistent and supported care transitions, including preparing individuals with dementia and their caregivers, evaluating preferences and goals, and creating inter-professional collaborative team environments. The findings suggest that person-centered care is crucial for achieving outcom...
Women with high physical fitness at middle age were nearly 90% less likely to develop dementia decades later. The study found that highly fit women developed dementia an average of 11 years later than moderately fit women.
A recent study using CRISPR-Cas9 technology identified new genes that may hasten neuron death in ALS and FTD patients. The researchers found that genes controlling cell movement and protein assembly were potential partners in DPR toxicity, suggesting novel therapies for ALS.
A global study of DNA samples from 520,000 individuals identified 22 new genetic risk factors for stroke, according to researchers. The findings are significant as they will increase potential targets for stroke drug development and provide valuable insights into dementia research.
Researchers discover FUS plays a crucial role in the microRNA-mediated gene silencing system, which regulates cellular activity. Disruption of this system may contribute to neurodegenerative diseases like ALS and FTD. The study suggests that FUS facilitates guiding and targeting of messenger-RNAs by microRNAs.
Four neuroscientists, including Christian Haass, receive the Brain Prize for their work on the genetic and molecular bases of Alzheimer's disease. Their research has revolutionised understanding of the changes in the brain that lead to Alzheimer's, with potential implications for diagnosis, treatment, and prevention.
A new study from UT Southwestern Medical Center found a correlation between traumatic brain injury and early-onset Alzheimer's disease. People who sustained concussions were diagnosed with dementia on average 2 1/2 years earlier than those without TBI.
Researchers studied angiogenin's entry into central nervous system cells to better understand its role in brain diseases like ALS and dementia. The study found that angiogenin uptake has multiple biochemical pathways, revealing a more intricate mechanism than initially thought.
Researchers found that older adults with dementia are at increased risk for serious problems like falls and delirium during hospital stays. The study suggests that special discharge planning for people with dementia is crucial in reducing readmission rates.
Research reveals that individuals with Alzheimer's disease who die from the condition itself tend to have less hospitalization and ICU stays compared to those who die from other causes. This contrasts with those who receive fewer palliative care services during their final months.
A new study shows that a creative couples' intervention significantly improves communication in people with Alzheimer's and their caregivers. The 10-week program increased facilitative communication in caregivers and sociable communication in care receivers, leading to better understanding, intimacy, and reduced conflict.
A new study reveals a significant increase in dementia risk among adults born with congenital heart disease, with a 60% increased risk compared to the general population. The risk was even higher for those under 65 years old, with a 160% increase.
A new e-Health platform has been developed to support healthy aging and prevent cardiovascular disease and dementia in the elderly. The HATICE trial involves over 2,500 participants aged 65 or older and aims to reduce risk factors through lifestyle changes and interactive guidance.
A nationwide observational study of over one million adults with dementia found that alcohol use disorders are the most important preventable risk factors for dementia. Chronic heavy drinking was linked to 57% of early-onset dementia cases, highlighting the need for screening and treatment interventions.
A new study published in Neurology suggests that individuals who do not recognize their own memory problems are nearly threefold more likely to develop dementia within two years. This lack of awareness is associated with impaired brain metabolic function and higher rates of amyloid deposition, a protein linked to Alzheimer's disease.
Pimavanserin has been found to effectively reduce psychosis symptoms in people with Alzheimer's disease without the damaging effects of other antipsychotics. The research, published in Lancet Neurology, shows a significant improvement in psychotic symptoms without sedation or falls, which are common side-effects of current treatments.
Researchers found that people born with heart defects in Denmark had a 60% higher risk of dementia compared to the general population, with those diagnosed before age 65 facing an even greater risk. The study's findings suggest that continued monitoring and management may be necessary for individuals born with congenital heart defects.
Researchers developed a rapid test to diagnose Parkinson's and dementia with Lewy bodies using cerebral spinal fluid samples. The test showed high accuracy in detecting these diseases within two days, outperforming related assays.
A study found that older adults with positive beliefs about aging have a lower risk of developing dementia compared to those with negative views. The protective effect was even observed among individuals carrying the high-risk APOE E4 gene variant.
A new study led by Yale University found that positive beliefs about old age can significantly reduce the risk of developing dementia. Among APOE ε4 carriers, who are at high risk of dementia, those with positive attitudes had a nearly 50% lower risk of developing the disease.
A large-scale trial found that upskilling care home staff to deliver person-centred care, combined with just one hour of social interaction per week, significantly improves quality of life and reduces agitation and aggression in people with dementia. The approach also saves money compared to standard care.
USC researchers found that nearly 50% of dementias begin with damaged gatekeeper cells, leading to small vessel disease and white matter disease. Controlling fibrinogen levels may reverse or slow white matter disease in a mouse model.