Researchers found a decline in genetic diversity in Tasman Bay's New Zealand snapper population, starting from the 1950s when it began to be commercially fished. The 'virgin' population showed a significant decline in six of seven microsatellite loci, raising concerns about the sustainability of commercial fishing industries.
Panek and his research team have discovered a process that leads to an almost pure form of 'handed' tetrahydropyridine, a component found in many drugs. The molecule's unusual chemical properties can control a reaction's three-dimensional orientation.
A Cornell University biochemist has developed a strategy to make tumor cells more sensitive to retinoic acid, reducing required doses and enhancing its anticancer activity. By introducing CRABP-II, a naturally occurring protein, researchers can boost RA's ability to inhibit breast cancer cell proliferation.
Zhang has discovered ways to use small catalysts to assemble chiral molecules, accelerating drug discovery and lowering prices. This method is crucial for AIDS drugs, particularly protease inhibitors, which generated $147 billion last year.
A review of physician communication found that female primary care physicians engage in more patient-centered and emotional talk compared to their male counterparts. Medical visits with female physicians were also longer, averaging 23 minutes per patient. The study suggests room for improvement in both genders' communication styles.
Researchers developed a model predicting increased cancer cure rates by 15-70% using genetic radiotherapy, combining radiation and viral infection. The technique makes tumor cells more sensitive to x-rays, potentially leading to improved treatment outcomes.
A study of internal tobacco industry documents reveals that companies profited from both tobacco and nicotine replacement therapies, undermining efforts to combat smoking addiction. Researchers argue that such financial conflicts of interest should be made public to ensure greater corporate responsibility.
Researchers identified 15 BCR-ABL mutations that cause resistance to Gleevec, a common treatment for chronic myeloid leukemia. These mutations alter the enzyme's flexibility and conformation, making it difficult for the drug to bind and inhibit its activity.
A Wayne State and Virginia chemist has won a national award for his work on developing anti-parasitic compounds by mimicking the structure of sugar molecules. Researchers have learned that these molecules serve as 'ID tags' on cell surfaces, which can be used to identify target tissues and prevent infections.
A study by Oregon State University has found that changing children's attitudes towards TV violence may be easier than directly changing their viewing habits. The program, called Project REViEW, teaches kids to become television detectives and analyze logical and illogical consequences of TV events.
Luesch will receive the $45,000 fellowship to investigate new cancer drugs at The Scripps Research Institute. He completed his Ph.D. work this summer at the University of Hawaii at Manoa under Richard E. Moore, Ph.D., and will join Peter G. Schultz, Ph. D.
A new study found sertraline to be both safe and effective in treating depression among hospitalized heart patients. The trial showed a 23% reduction in life-threatening cardiovascular events, although not statistically significant, indicating potential benefits of sertraline for this population.
Grubbs's specialty is designing catalysts that can selectively target specific parts of molecules, critical for making pharmaceuticals. The award recognizes his work on improving the precision and control of these catalysts.
The Osteoarthritis Initiative will recruit 5,000 participants aged 50+ at high risk for knee osteoarthritis. The project aims to establish a natural history database for osteoarthritis, allowing researchers to identify potential new disease targets and develop tools for understanding disease progression.
The DuPont team developed the BAX system, which detects harmful bacteria like E. coli and Salmonella in just five hours, reducing reporting time by one to two days.
Researchers from DSM High Performance Fibers have developed a super-strong polyethylene fiber called Dyneema, which provides maximum protection at minimal weight. The material is used in armored gear, safety products, and sports equipment, offering significant contributions to protecting human lives.
Richard W. Rees, a Wilmington researcher, has been awarded the Hero of Chemistry title by the American Chemical Society for his work on laminated safety glass technology that protects people from flying glass shards and other debris in explosions.
A recent Mayo Clinic study found that patients classified as optimists reported better physical and mental functioning, and scored higher on quality-of-life assessments. Researchers believe this may be due to the long-term health implications of explanatory style, an assessment of patients' attitudes towards life.
Researchers will investigate how wetland landscape, circulation features, and restoration strategies affect fecal pollution levels. The study aims to resolve the controversy over whether coastal wetlands generate or filter out fecal pollution, with potential implications for beach water quality and habitat preservation.
A Harvard chemist has developed molecular mimics that rival the complexity of nature using innovative cell screening techniques. The approach involves attaching a natural protein to a fluorescent tag and then screening molecules for their ability to perturb cellular processes.
A study by Georgetown University researchers found that initially recommended drug dosages are often too high, which can lead to unnecessary overdosing. This discrepancy has significant implications for patient safety and healthcare costs. Further research is needed to address the issue of dose-selection in drug development.
A new study has shown that patients with mesothelioma, a cancer caused by asbestos exposure, can survive for up to 13-14 months when treated with the drug combination of pemetrexed and carboplatin. This is an improvement over previous treatments, which only offered a six-to-eight-month survival rate.
A St. Louis chemist has won a national award for developing innovative materials, including durable ship coatings that repel barnacles without polluting the environment. Her research also explores degradable polymers for medical applications, such as transporting cancer drugs to their targets.
James R. Moran, a fellow at Solutia Inc., has developed a laminated safety glass that can absorb blast pressure and energy, protecting people from flying glass shards and debris in explosions. This technology was recognized by the American Chemical Society's Heroes of Chemistry program for its contribution to improving public safety.
Joullie's groundbreaking work with didemnins, compounds isolated from marine animals showing anticancer properties, has made significant contributions to understanding their structures and enhancing their activity against tumors. Her innovative approach and problem-solving skills have been recognized with the Arthur C. Cope Scholar Award.
A meta-analysis found that female primary care physicians engage in more partnership behaviors, positive talk, and psychosocial question asking compared to male counterparts. Medical visits with female physicians were about 10% longer than those with male physicians.