Researchers have successfully used gene therapy to treat two young children with ADA-SCID, a rare form of SCID that requires regular injections of the bovine form of ADA enzyme. The new method involves removing bone marrow cells and engineering them to produce healthy immune cells, offering a potentially lower-risk alternative to bone ...
Researchers combine a gene that shuts off angiogenesis with a nanoparticle that selectively targets cancer tumor cells, effectively cutting off their blood supply and killing the tumor. This approach shows strong regression of large tumors in every system tested.
Research suggests that personality disorders change over time, with certain traits increasing in severity as individuals age. A 12-year follow-up study found that anxious and obsessive personality traits became more pronounced in patients, while flamboyant tendencies decreased.
A study of 219 patients with non-metastatic colon cancer found that laparoscopy-assisted colectomy (LAC) reduced perioperative morbidity, shortened hospital stays, and prolonged cancer-related survival. LAC was associated with a 60% lower risk of tumour relapse compared to open colectomy.
A new gene therapy protocol has successfully treated a child born without an immune system, reversing severe combined immunodeficiency. The procedure improved genetically altered stem cells, giving them a biological advantage and allowing them to prevail over the abnormal cells.
A single gene on the X chromosome, AGTR2, has been linked to mental retardation. The discovery could lead to new therapies and insights into normal brain development.
A previously unrecognized function of myeloperoxidase has been identified, affecting vasculature through a pathway independent of chlorine bleach production. This discovery may lead to the development of new drugs to treat inflammatory vascular diseases and conditions like septic shock.
A study by NIH/National Institute on Drug Abuse found that integrated medical and substance abuse treatment significantly increased patient continuation rates. Over half of patients who received comprehensive care entered outpatient substance abuse programs, compared to just 2.4% of those receiving standard care.
Researchers at Clemson University have identified a single gene, AGTR2, that may trigger mental retardation in males when it is abnormal. The study found mutations in eight male patients with unexplained mental retardation, offering new insights into the causes of brain development disorders.
Researchers at CWRU have developed a new cancer treatment using dual-release kinetics, which could potentially allow for more effective and safest local drug therapy. The device is designed to work in synergy with image-guided thermal ablation and aims to reduce exposure of normal tissues to drugs while increasing the dosage to the tum...
A new study suggests that taking aspirin three or more times a week for six months may reduce the risk of developing non-small cell lung cancer in women. However, larger studies are needed to confirm these findings and determine the optimal dose due to potential side effects like gastrointestinal bleeding.
Lee's research found that zeolites expand as fluid from the surrounding medium is squeezed into their tiny pores under great pressure, leading to potential applications as 'molecular sponges'. The discovery was made possible by using a technique called powder diffraction at Brookhaven's National Synchrotron Light Source.
A study found that people with type 2 diabetes experienced increased oscillatory potentials after dark adaptation, which decreased with oxygen inhalation. The researchers suggest that diabetic patients might benefit from a modified night-time illumination cycle during sleep to reduce oxygen consumption in the retina.
Researchers at the University of Washington discovered that fluid forces in the human body help invasive bacteria, such as E. coli, thrive and adhere to surfaces. This finding has significant medical implications, including the potential for improved biomedical device safety and a better understanding of urinary tract infections.
A study of 144 physicians found that treating substance-abusing patients leads to lower professional satisfaction rates compared to caring for patients with hypertension. The findings suggest that addressing physician dissatisfaction in drug abuse treatment may improve patient outcomes.
Researchers have designed rough-surfaced, fuzzy polymers to mesh with neurons, improving contact with brain tissue. The polymers' unique surface can fine-tune electrical signal conduction, enabling more efficient neural communication for brain-computer interfaces.
Researchers conducted two studies on venlafaxine XR, a SNRI medication, for social anxiety disorder (SAD) treatment. The results showed significant reductions in SAD symptoms as early as four or six weeks after treatment began, with continued improvements through week 12.
Researchers have found a new piece of the gene expression puzzle, revealing how histone proteins interact with each other and with other molecules to regulate gene activity. The discovery sheds light on potential causes of male infertility and highlights the complex mechanisms at play in chromatin.
The AT1-receptor blocker Atacand significantly reduces non-fatal strokes in elderly patients with mild hypertension while maintaining cognitive function. Lowering blood pressure also shows no significant increase in cognitive decline or dementia risk.
This study found that paclitaxel- and carboplatin-based regimens can prolong survival of patients with advanced non-small cell lung cancer, with two-year survival rates similar to those achieved at one year with best supportive care. However, three-drug regimens were slightly more toxic and did not provide additional benefits.
A study by the NIH/National Institute on Drug Abuse found that active cocaine users had significantly lower adherence rates to antiretroviral therapy, leading to a higher risk of viral suppression failure. The study suggests that interventions should include assessing and treating cocaine use in patients with HIV infection.
Researchers discovered that degradation of SDF-1 protein is crucial for stem cell mobilization in bone marrow transplants. G-CSF growth factor triggers this process by reducing SDF-1 levels, allowing stem cells to flow into the bloodstream. The findings may lead to improved collection of stem cells for clinical transplantations.
Researchers found that gene swapping in mice leads to pro-B cell lymphomas, with amplifications of c-myc and IgH genes arising from chromosome translocations. The study uncovered a new mechanism for cancer formation involving the DNA-snipping enzyme RAG.
A study of 219 patients with non-metastatic colon cancer found that laparoscopy-assisted colectomy (LAC) reduced tumour relapse and death from all causes by 60% and 50%, respectively. LAC also resulted in shorter hospital stays and lower perioperative morbidity compared to open colectomy.
A new study found that the continuous stitching technique significantly reduced pain in women with perineal damage after childbirth. The method also resulted in fewer suture removals within three months compared to interrupted suturing. This could lead to cost savings and improved outcomes for patients.
A study of 373 intravenous drug users found significant reductions in emergency department use among those using needle-exchange programs, including Hispanics, men, and those with mental illness. The study suggests that needle-exchange-based health care services can reduce emergency department use among high-risk IDUs.