ACTOS, an insulin sensitizer, is shown to improve diabetic dyslipidemia components when administered in combination with other diabetes therapies. The study found significant increases in average and peak LDL and HDL particle size, accompanied by a decrease in particle density.
Jennie Hunter-Cevera is a renowned microbiologist who has made significant contributions to the field through her innovative techniques for isolating and screening microorganisms. Her work has led to the discovery of new species, enzymes, and products, including antimicrobial, anticancer, and novel herbicidal properties.
In the 16th century, identity badges were issued to the poor as a stamp of approval and to prevent begging. The badges were designed to distinguish those deemed deserving from unworthy individuals. By the late 17th century, badging became compulsory in England, with penalties for those who refused to wear them.
Ferré-D'Amaré's groundbreaking research on RNA crystallization and ribozymes has significantly advanced the understanding of molecular structures in living organisms. He developed new techniques to obtain RNA crystals, enabling detailed studies of RNA-protein interactions and biochemical functions.
Rosmarin developed a new probe, the C-probe, to detect bacterial infections more accurately. This innovation has great promise for rapidly diagnosing serious infections like meningitis and improving patient outcomes.
The study reveals that strong magnetic fields accelerate particles near the speed of light, radiating as gamma rays. The research suggests a new mechanism for gamma-ray burst formation, potentially resolving long-standing scientific debates.
Researchers at Ohio State University have made a breakthrough in understanding how cells package DNA, with implications for cancer research and new therapies. A newly discovered protein, Hif1p, works with an enzyme complex to add histone proteins to DNA, forming chromatin.
Caroline Mohr, a leading expert in clinical microbiology, has won the 2004 Scherago-Rubin Award from the American Society for Microbiology. Her work involves identifying and classifying microorganisms, including gram-negative bacilli, and evaluating automated systems used to identify these bacteria.
Campbell's work on bacteriophage lambda demonstrated the relationship between its genome and host, leading to key findings in genetic and biochemical studies of site-specific recombination. His extensive contributions also include discovery of nonsense mutations, bacterial gene regulation, and microbial population dynamics research.
Jay Levy's research has significantly impacted our understanding of HIV and the immune system, leading to major breakthroughs in antiviral responses. His work has also improved the safety of blood products for hemophiliacs and shed light on the role of plasmacytoid dendritic cells in HIV infection.
Weissfeld's work on policy issues has had a significant impact on the profession of clinical microbiology. She chairs ASM's Professional Affairs Committee and serves on various committees reviewing legislation affecting microbiology laboratory practice.
Weinstein is recognized for his landmark articles on laboratory detection of bacterial and fungal infections, as well as his contributions to clinical decision-making in infectious disease medicine. He has also served on editorial boards of several journals and holds prestigious fellowships.
Vazquez-Torres is a leading researcher studying how Candida and Salmonella cause disease, and how the body fights off these pathogens. He has discovered new pathways by which cells can sample the intestinal lumen, migrate to the spleen, and trigger systemic immune responses.
A study of 160 pregnant women with genetic risk factors for thrombophilia found that enoxaparin significantly reduced pregnancy loss compared to low-dose aspirin. Women taking enoxaparin had a normal live birth rate of 86% and healthy newborns, while those on aspirin suffered more pregnancy losses.
The Mayo Clinic researchers have invented a nontoxic molecular probe that targets the brain regions containing amyloid plaques, enabling high-resolution MRI images in live mice and potentially human patients. The probe may also be used to evaluate new Alzheimer's therapies and provide early diagnosis.
A new measurement method and microenvironment evaluation technique have been developed to study spinal cord nerve regeneration. The findings extend earlier Mayo Clinic research, showing that a biodegradable scaffold can support axon growth under different experimental conditions.
A study reported in Journal of the American Dietetic Association found that between 1973-74 and 1993-94, the percentage of children eating a school lunch declined from 89.7% to 78.2%, while eating dinners prepared outside the home increased from 5.4% to 19%.
Jorge Escalante-Semerena has supervised 21 Ph.D. students, many of whom have won awards and fellowships. He is renowned for helping students gain recognition for their work, while also being a productive researcher focusing on cobalamin biosynthesis.
Researchers at MGH Cancer Center found that specific gene mutations in the EGFR gene predict responsiveness to Iressa, a targeted therapy that causes tumors to shrink significantly. The discovery will help determine which patients benefit from Iressa and potentially lead to new targeted therapies.
A recent study by Dr. Edward Scott and colleagues found that donor cells containing a Y chromosome were present in the brains of three women up to 6 years after bone marrow transplantation. This suggests that bone marrow could be used as a therapeutic source of readily harvestable cells for nerve cell regeneration.
King Chung's research shows that combining hearing aid technologies with cochlear implants reduces background noise, enhances speech understanding, and improves sound quality. Cochlear implant users prefer conditions with advanced hearing aid preprocessing.
Researchers use a NASA WB-57 research jet to examine icy cirrus clouds, aiming to understand their warming and cooling effects on Earth's climate. The Middle Latitude Cirrus Experiment gathers detailed information to improve computer simulations of future climate change.
HIV-infected women are 3.9 times more likely to have HPV infection at the outset of the study, and smoking significantly increases this risk. Smoking and HIV infection may each alter the natural history of HPV infection to heighten tumor risk.
Researchers have discovered a molecule called ppGpp that plays a crucial role in regulating bacterial gene expression and survival. When amino acid levels are low, ppGpp accumulates and shuts down protein synthesis, allowing the cell to go dormant until conditions improve.
Researchers identified a 23-gene signature that can predict disease recurrence in Dukes' B colon cancer patients with high accuracy. The study's findings have significant implications for personalized therapy decisions and could lead to improved patient outcomes.
Researchers have discovered a way to convert adult bone marrow cells into brain stem cells, which could potentially restore functioning in individuals with Alzheimer's disease. The process eliminates ethical and logistical issues associated with fetal tissue use and allows for quick conversion within a few weeks.
Researchers have successfully performed heart biopsies using arm catheterization, a promising new option for patients. The procedure showed no major complications and allowed patients to be discharged quickly.
Researchers studied 87 women with epilepsy and found that nearly 40% experience catamential patterns where seizures fluctuate with menstrual cycles. Progesterone lozenges may help reduce seizure frequency and severity during monthly hormonal changes.
Researchers developed a novel method to pinpoint rapidly evolving genes in pathogens, revealing potential drug targets for tuberculosis and malaria. The technique analyzes genome sequences to identify genes under selective pressure, allowing for the discovery of previously unknown genes.
Researchers linked mid-life heart disease risk factors to increased dementia risk later in life. The study of over 11,000 participants found that those with four key risk factors had nearly three times the chance of developing dementia compared to those with none. Presence of each risk factor added a 20-40% greater risk for developing ...
The report evaluates nine effective programs and eleven that warrant further research, highlighting the importance of defined outcomes, sustained commitment, personalization, challenging content, engaged adults, and educators' roles. These design principles aim to increase participation in STEM fields among underrepresented groups.
A recent study found that height loss of between 2-3 inches increases the risk of hip osteoporosis by nearly fourfold. Researchers suggest a simple evaluation of height can help physicians decide whether patients should undergo a bone density scan to check for osteoporosis.
A study published in Cell found that genetic defects in Nkx2-5 lead to progressive heart failure by degrading the electrical wiring of the heart, particularly the atrioventricular node. The researchers also identified a growth-factor gene called BMP-10 as a key contributor to this process.
A South African study found that women experiencing gender-based violence are more likely to contract HIV due to abusive partners imposing risky sexual practices. The research highlights the need for effective interventions to address social constructions of masculinity and intimate partner violence in relation to HIV risk.
Research found a direct correlation between viral levels in blood and semen, with acutely infected individuals being hyper-infectious before symptoms occur. Transmission rates during heterosexual sex are likely to be much higher than previously thought during this period.
A team of archaeologists has unearthed conclusive evidence of early humans' control over fire in Eurasia, dating back to the Acheulian culture. The discovery, made at the Benot Ya'aqov site in Israel, reveals that ancient humans used fire for cooking and warmth, significantly impacting their diet and survival.
Researchers at PTC Therapeutics have discovered a new biochemical pathway that controls cell growth modulation. This finding has significant implications for the development of therapeutics targeting cancer cells, which rely on deregulated translation to grow uncontrollably.
The article highlights the need for investment in human resources to respond to global health crises, particularly in sub-Saharan Africa. Human resources for health are essential for achieving better health outcomes, and donors can support these developments by acknowledging their importance.
Scientists at Georgia Tech Research Institute are developing a non-destructive radar system to detect mold behind walls, which can emit harmful compounds and cause serious health issues. The goal is to create a handheld prototype that can map mold and help contractors pinpoint damaged areas.
Experts question whether Europe can achieve ambitious environmental goals for children due to limited action taken. Prioritizing specific areas with clear disease causation and high burden is recommended.
Researchers at University of Pittsburgh successfully used suspension culture systems to promote follicular growth in rats and mice, showing promise for preserving ovarian fertility after cancer treatment. The study's findings suggest a promising step towards conserving fertility for cancer patients.
Researchers found a high correlation between EGFR mutations and sensitivity to gefitinib therapy in lung cancer patients, particularly in women and non-smokers. The study also revealed significant differences in response rates between Japanese and American patients, suggesting genetic variation plays a crucial role in drug effectiveness.
A study found that black men with prostate cancer are more likely to die from the disease due to delayed or inadequate care, particularly those without other diagnosed illnesses. The researchers suggest that cultural and social factors contribute to this disparity.
Researchers at Emory University Health Sciences Center have identified a genetic sequence for the anti-bacterial protein Escapin found in sea slugs. The protein prevents bacteria from growing on surfaces, making it a potential solution for preventing biofilm formation and associated problems.
Researchers at SLU School of Medicine discovered a new drug, Cinacalcet, that successfully treated hyperparathyroidism, a common side effect of kidney disease. The treatment works by fooling the parathyroid glands into thinking calcium levels are higher than they actually are.
A recent study published in the American Journal of Public Health found that periodontitis is more prevalent among older blacks than whites or Mexican-Americans, regardless of income or education levels. The researchers suggest historical factors such as unequal opportunities contribute to this disparity.
Researchers pinpoint CO2 sources, geological and terrestrial sinks, and transport requirements in Virginia. The project aims to reduce greenhouse gases and mitigate global warming by developing technologies for removing carbon from the atmosphere.
Researchers create 'quantum dots' in gallium arsenide to harness electrons' spin for logic gates and potential quantum computing applications. The tiny dots could enable faster, smaller computer chips with enhanced data security.
Researchers at Harvard Medical School have discovered a new target for human papillomaviruses, which could lead to specific antiviral drugs for treating precancerous cervical lesions. By blocking the protein BRD4, they prevented infected mouse cells from becoming cancerous.
Researchers found that patients with certain EGFR gene mutations in non-small cell lung cancer (NSCLC) respond well to treatment with Iressa, a kinase blocker. The study identifies the potential for screening patients for these mutations to predict treatment response and benefits ethnic populations differently.
Regime shifts occur when changes in ocean conditions, such as warming, affect plankton production and propagate up the food chain. Overfishing can also force a regime shift, changing population dynamics of an entire ecosystem.
A study of 304 young adult users found that friends were the most important source of information about MDMA, followed by websites like DanceSafe.org. Younger and more educated users relied on the internet for information, while parents, mainstream media, and radio were considered less accurate sources.
A study suggests that regular doses of cranberry juice or tablets can reduce the risk of female urinary tract infections (UTIs) by up to 50% in sexually active adult women. Cranberry juice's effectiveness in treating existing UTI cases is still unknown, but it offers a potential natural alternative to antibiotics.
A Penn State study has found that six domestic oils provided adequate corrosion protection for concrete bridge tendons in various test environments. The top-performing products from the study, including Citgo Cutting Oil NC 205 and Shell/Texaco Dromus ABD, will undergo further testing to examine their bond and ultimate flexural capacity.
Researchers discovered a genetic mutation that causes retinitis pigmentosa by interfering with cell development in the retina's capillaries. Understanding this mechanism could lead to new treatments for the disease.
Researchers have identified a set of six genes that correlate with survival in diffuse large B-cell lymphoma, including LMO2, BCL6, and CCND2. The findings suggest that molecular profiling may help refine prognoses for this difficult-to-treat blood cancer.
A recent study by American Academy of Neurology found that patients taking pergolide for Parkinson's disease have a higher risk of developing valvular heart disease. Eighty-nine percent of pergolide-treated patients showed some degree of valvular insufficiency, with increased risks in the mitral and aortic valves.
The Northwestern Memorial Hospital is testing a stomach 'pacemaker' system that reduces hunger and helps obese patients lose weight. The system, manufactured by Transneuronix, uses electrical stimulation to induce feelings of fullness.
A new study from the Mayo Clinic found that pyridostigmine improves standing blood pressure without increasing blood pressure when lying down, offering a safe treatment option for patients with orthostatic hypotension. The study involved 29 patients who were satisfied with the drug's effects, with 17 taking it as their primary treatment.
A recent study found that men who served in the military were 60% more likely to develop ALS than men who did not serve. The study also revealed that military service prior to the Gulf War was associated with an increased risk of ALS, suggesting a potential link between military service and the development of this debilitating disease.