Scientists create microscision technique that uses gas to bombard skin with tiny crystals, creating invisible conduits for drug delivery. The new method is shown to be effective in administering local anaesthesia without causing pain, making it a promising alternative to traditional needles.
Researchers at Imperial College London have discovered a link between chromosome 'caps' and the prediction of rare bone marrow diseases. The study found that shorter telomeres in chromosomes can indicate an increased risk of disease severity and early onset, providing a potential new mechanism for understanding disease anticipation.
Researchers discovered a novel screening approach that identified a compound, GS4012, which suppresses a genetic mutation in zebrafish embryos. The compound promotes vascular growth and may have implications for diseases such as heart attack, stroke or injury.
Research reveals that stress triggers a hormonal response that modifies immune system function, leading to increased vulnerability to mental and physical diseases. Stress can create long-term damage by initiating an inflammatory state in the body, which can lead to chronic diseases such as depression and coronary artery disease.
Dr. Bissell's research reveals that the cellular microenvironment plays a crucial role in gene expression and cell behavior. She discovered that malignant cells can be reverted to a normal phenotype through manipulation of the extracellular matrix.
Researchers have discovered biomarkers for ALS in cerebrospinal fluid, which could enable rapid diagnosis and prompt treatment. These biomarkers have high sensitivity and specificity, and may be used to monitor drug effectiveness in clinical trials.
Researchers have discovered that a brain electrical signal can predict an individual's visual working memory capacity, which varies from 1.5 to 5 objects. The study found that the signal levels off when the number of objects exceeds the subject's capacity, while those with higher capacity show large increases in brain activity.
A study at the University of Texas M. D. Anderson Cancer Center found that Tibetan yoga improved sleep quality and reduced need for sleep medication in lymphoma patients. Despite no differences in other quality of life measures, the brief 7-week study suggests potential benefits of Tibetan yoga as a stress-reducer in cancer patients.
A study by the Infectious Diseases Society of America found that HIV drugs from developing countries meet US standards for active ingredient levels. Bioequivalency studies are still necessary to ensure efficacy and safety, according to lead author Dr. Scott Penzak.
Researchers found that about 20% of un diagnosed participants were at risk for diabetes and 3.4% were diabetic. Shelter residents had lower hemoglobin A1c levels than those screened elsewhere, suggesting better health outcomes.
Scientists have made a groundbreaking discovery about DNA crossover during meiosis, which is crucial for sexual reproduction. The new findings suggest that the decision to make a crossover or non-crossover recombination is made much earlier than previously thought, shedding light on the molecular basis of this process.
A team of astronomers at Penn State used the Hobby-Eberly Telescope to detect a cometlike body falling onto a massive, very young star. The infall, which occurred about 3200 years ago, provided dramatic spectral variations in the star's light. This discovery sheds light on planetary formation and the evolution of massive star systems.
Lyncean Technologies announces a tabletop synchrotron light source, Compact Light Source, to boost scientific productivity and enable new medical imaging techniques. The Compact Light Source is a breakthrough in X-ray technology developed on licensed technology from Stanford Linear Accelerator Center.
Most long-stay nursing home residents spend a significant amount of time in bed, even in facilities with low restraint levels. The study estimates that typical residents in high-restraint homes spend 19-20 hours in bed daily.
Researchers at Berkeley Lab have developed a way to image and digitally restore mechanical audio recordings, such as shellac phonograph discs. This technology enables the mass digitization of thousands of blues, classical, jazz, and spoken word recordings in the Library of Congress's archives.
A high-fat fast-food breakfast causes a surge in inflammatory factors in the blood stream, overwhelming the body's natural anti-inflammatory mechanisms. Repeated exposure may lead to chronic inflammation and increase the risk of heart disease.
Scientists have quantified the transport of carbon from surface waters to the deep ocean in response to iron fertilization. The study found that while iron fertilization can enhance carbon flux and reduce atmospheric carbon dioxide levels, the quantities removed are no greater than natural plankton blooms, making it a limited solution.
Researchers at Johns Hopkins Medicine found that mesenchymal stem cell shape is a critical factor in determining which type of cell they will become. By using micropatterning technology, the team showed that spherical stem cells efficiently transform into fat cell precursors, while those allowed to stretch and flatten move closer to be...
The American Society for Microbiology has recognized Hopkins Marine Station's dedication to microbiology research and education. The station has served as Stanford University's marine biology research and education facility since 1892, offering a popular summer course on microbiology.
A study found that when doctors spend at least 10 minutes with patients, inquire about immunizations before exams, have four staff members, and hold down waiting room time, over 90% of patients are properly vaccinated. Critical path analysis revealed the full sequence of events was more powerful than individual activities.
Researchers at New York Medical College are exploring bacterial antibiotic resistance in salmon aquaculture and developing new diagnostic tests for Lyme disease. The studies aim to improve understanding of the diseases and test new methods for prevention and control.
A study published in JAMA found a significant link between delirium in ICU patients and increased mortality rates. The researchers also highlighted the economic burden of treating delirium in ICUs, estimating costs ranging from $4 billion to over $20 billion nationwide.
A study of Pentagon personnel found that nearly 21 percent experienced mental health symptoms, including generalized anxiety and depression, following the 9/11 attacks. The researchers also discovered that a significant portion of those at high risk for mental health problems sought counseling after the attack.
No-till farming reduces carbon emissions by retaining humus in the soil, preventing erosion and promoting healthy crop production. By adopting no-till practices, farmers can sequester up to 300 million tons of soil carbon annually, potentially delaying the need for fossil fuels.
Researchers developed a new method to speed up the search for genes involved in complex medical conditions. By substituting one chromosome at a time, they can detect gene locations with greater accuracy and efficiency. This breakthrough has the potential to accelerate the discovery of disease-causing genes and lead to new treatments.
The American Physiological Society awarded 55 minority travel fellowships to facilitate participation of underrepresented students in EB 2004, attracting over 11,000 scientists annually. The fellowships, supported by NIDDK and NIGMS grants, provide funds for transportation, meals, lodging, and meeting registration.
Atom-scale images reveal the preferred location of atoms in silicon nitride ceramic, matching theoretical calculations. This breakthrough enables researchers to predict and manipulate material structure, leading to tougher and stronger ceramic materials for advanced applications.
A new study provides support for the ancient origin of the MT visual center in primates, suggesting it evolved early in primate evolution. The researchers used optical imaging to analyze the brain structure of a small nocturnal primate called the galago and found similarities with monkey brains.
Pre-teens and middle school students are the best targets for smoking prevention programs. The study found that nearly half of teens aged 11-18 have tried smoking at least once, with most being early experimenters who smoked fewer than 25 cigarettes in their lifetime.
Musicians may experience skin problems due to prolonged contact with instruments, particularly those using rosin, nickel, or other materials. Changing instrument components or adjusting playing positions can help alleviate these conditions.
Robotic Carbon Explorers tracked fertilized waters with over four-fold plankton growth, contrary to expectations that lack of silicates would limit growth. The study suggests a significant role for iron in fixing carbon dioxide in the ocean.
The team aims to maximize biodiversity on the site, addressing issues of re-introduction of native plants and animals, habitat fragmentation, and invasive species control. The park will be built by August 2008 for the Games' enjoyment and education, complementing Beijing's cultural sites.
Researchers at NCAR/University of Colorado Denver aim to create a system that sends real-time maps and predictions of wildfires to frontline firefighters. The team will use supercomputers, satellite and sensor monitoring, and meteorology to develop tools to warn firefighters about wildfire behavior.
A study found that HIV-positive US military personnel who received a smallpox vaccine between 2002-2003 showed no negative effects. The researchers suggest exempting HIV-infected individuals from vaccination during outbreaks, but consider weakened vaccines for immunocompromised people in the future.
Researchers have identified SSX-2, a promising target for cancer vaccines, and found that patients mount their own immunological responses against cancer cells expressing the protein. A new early-phase clinical trial is underway to assess the safety and efficacy of an SSX-2-based vaccine.
Researchers at the University of North Carolina identified the role of the K1 gene in tumor cell growth and metastasis, potentially leading to new treatment options. The study found that the K1 gene initiates cancerous processes by up-regulating growth factors and breaking down supporting tissue.
Researchers at MIT have developed a technique that uses focused microwave energy to kill early-stage breast cancer cells, reducing the need for additional surgery. The treatment has shown promising results, with women experiencing a 43% reduction in cancer cells found close to surgical margins.
Researchers have identified two specific brain areas activated when people make mental state judgments, shedding light on the neural basis of everyday theory of mind. This finding may help develop interventions for individuals with autism who struggle with social skills and mental state decoding.
A new study found that sacral nerve stimulation significantly reduces the number of weekly episodes of incontinence, from 16 to 3-2 per week after one-two years. The technique also shows an improvement in quality-of-life scores and is a safe option for patients with intact or repaired anal sphincters.
A UCLA study found that providing Head Start parents with easy-to-understand health-care guidance can lead to significant reductions in emergency room and clinic visits, resulting in cost savings for Medicaid. The study showed a 48% reduction in unnecessary ER visits and a 37.5% decrease in clinic visits for routine illnesses.
The subpolar gyre's weakening trend is attributed to heat exchanges from the ocean to the atmosphere playing a bigger role. This study, published on Science Express Web site, found Labrador Sea water warmed during the 1990s, reducing contrast with warmer southern latitudes and driving ocean circulation.
The SuperWASP facility is now operational, generating vast amounts of data to discover thousands of new planets around nearby stars. Data from the facility will lead to exciting progress in areas of astronomy, including the discovery of exoplanets and early detection of variable objects.
Polar mesospheric clouds have been found to remove nearly all meteoric iron, a process similar to the depletion of the ozone layer. Laboratory experiments and computer modeling revealed that ice particles on the surfaces of these clouds efficiently uptake iron atoms, causing a local depletion in the metal layer.
Researchers at Argonne National Laboratory have created a 3D map of diesel particles, revealing their varying shapes depending on engine speed and load. The findings provide clues to designing cleaner engines, with potential applications for reducing emissions and mitigating health problems.
A year-long study found that postmenopausal women who exercised regularly had significantly lower serum estrogen levels and a reduced risk of breast cancer. The exercise program resulted in a 16.7% reduction in free serum estradiol, a key female sex steroid.
Researchers have identified a potential DNA marker, SFRP2, that can be used to detect colorectal cancer in stool samples with high sensitivity and specificity. This breakthrough could lead to earlier detection and treatment of the disease.
Researchers have identified a novel gene linked to familial Parkinson's disease, revealing a new pathway for therapeutic treatment. The discovery places mitochondrial function at the centre of Parkinson's research, particularly in relation to oxidative stress and brain cell degeneration.
Four researchers are recognized for their work on normal lung development, RhoA's role in blood vessel disruption, and cardiovascular regulation. Their research aims to improve mortality and morbidity associated with premature birth and related conditions.
Dr. Ballard and his team will map the ship and conduct scientific analyses of its deterioration, assessing the impact of manmade factors on natural decay. They'll also study microbial research and examine the effects of tiny microbes on the ship's hull.
A team of researchers has received a $2 million NSF grant to create an advanced system that predicts wildfire behavior and progression. The system will use data from sensors, satellite monitoring, and mathematical theory to provide minute-by-minute predictions for firefighters.
Dr. Magdi Yacoub will receive the ISHLT Lifetime Achievement Award for his pioneering work in heart recovery using support devices. His approach, known as 'bridge to recovery,' has broadened the usage of heart assist devices and improved patient outcomes.
A study confirmed that alcohol intake is associated with an increased risk of gout, with beer and liquor showing a stronger link than moderate wine consumption. The Health Professionals Follow-up Study found that men who consumed more than 50 grams of alcohol daily had a 2.5 times higher risk of developing gout.
Researchers at Moss Landing Marine Laboratories have conducted an experiment that revealed iron fertilization can trigger massive phytoplankton blooms in the Southern Ocean. These blooms consume vast amounts of carbon dioxide, which is then potentially removed from the atmosphere, suggesting a potential solution to global warming.
Researchers developed a preoperative diagnostic test that uses gene expression to distinguish between benign and malignant thyroid carcinoma. The test has the potential to improve diagnosis accuracy and treatment outcomes for patients with thyroid cancer.
A new hypothesis suggests that autoimmunity is triggered by insufficient immune stimulation, leading to a decrease in T cells and an overactive expansion of the remaining population. This condition, known as lymphopenia, can cause diseases like Type 1 diabetes and rheumatoid arthritis.
A 12-year study found that drinking alcohol increases the risk of gout, with daily consumption between 30-50g increasing risk by 2.5 times. Beer consumption was linked to the strongest association, while wine showed no increased risk.
Archaeologists discovered perforated shells at Blombos Cave, dated to 75,000 years ago, which were likely strung as beads. This finding supports the theory that modern human behavior developed gradually throughout the Middle Stone Age.
The Madison/Swanson and Steamboat Lumps marine reserves in the Gulf of Mexico have been given a new life after a two-year extension. Larger fish with greater egg-producing potential were found within the protected sites than outside them, indicating the reserves are working as designed.
A new strain of Salmonella enterica serotype choleraesuis has been isolated that is resistant to all commonly used antimicrobials, including ceftriaxone and ciprofloxacin. Constant surveillance is needed to prevent further spread of this multidrug-resistant bacterium.
The American Physiological Society awarded 12 Distinguished Lecturers in 2004, including Christine Seidman, Robin Davisson, and Kevin Fitzgerald. The awards recognize outstanding research achievements in various fields of physiology.