A study published in Critical Care found that severe sepsis affects around 5% of cancer patients hospitalized in the US, resulting in a mortality rate nearly five times higher than non-cancer patients. Early antibiotic treatment could significantly improve cancer survival rates.
Researchers at The Burnham Institute have determined the crystal structure of the anthrax-cell binding complex, offering new leads for the discovery of antitoxins. This breakthrough also provides insights into using anthrax toxin as an anti-tumor agent, with potential applications in treating cancer.
Researchers solved the puzzle of the molecular structure of the protective antigen protein and CMG2 bound together, providing clearer targets for shutting down the anthrax toxin's entry into cells. This detailed image also points to a potential new tumor treatment using a genetically modified anthrax toxin.
Scientists used gene therapy to deliver RNA that silenced the disease-causing SCA1 gene in mice with spinocerebellar ataxia 1, preventing neurodegeneration. The approach also protected brain cells from destruction and prevented protein clump buildup.
A meta-analysis of 293 studies found that stress affects immunity in distinct ways, with short-term stress boosting natural immunity but chronic stress weakening it. Chronic stress is particularly damaging, especially for older or sick individuals, while acute time-limited stressors enhance quick energy-efficient responses.