Researchers have identified a biological pathway for a potent molecule, IL-10, that can delay rejection of transplanted organs by preventing blood-vessel deterioration. The study used rat models and found that a single muscular injection of IL-10 could provide long-term therapeutic effects.
A study found that male mouse fetuses exposed to estrogenic chemicals developed more ducts in their prostate and narrowed urethras, raising concerns for human health. The researchers used low doses of ethinylestradiol and bisphenol A, which are commonly found in oral contraceptives and plastics.
The Hox gene complex has been rearranged differently in several Drosophila species, but their expression and function are conserved. The research suggests that Hox gene clustering is a result of evolutionary history rather than functional necessity.
The FDA approved clofarabine for pediatric patients with relapsed or refractory ALL, built on years of effective use of pre-1980 drugs and adaptable for adult use later. Researchers say this approval is crucial for giving children access to new anti-cancer drugs.
Researchers developed an Interactive Scanning Electron Microscope (iSEM) system to simulate the capabilities of a $200,000 analytical instrument in classrooms. Students can measure and analyze objects in detail, simulating real-world experiments previously only accessible to graduate students.
A study of NYC public school children found a high proportion had a probable mental disorder six months after the 9/11 attack. The severity of exposure was related to disorder rates, with family exposure being a stronger factor than direct exposure.
Researchers identified 18 genes that predict which patients will respond to Hepatitis C treatment, offering a potential simple blood test for early diagnosis. The study found that these genes are key to the body's ability to eliminate the virus.
A six-week cycling study found that regular exercise activates hundreds of genes in young, healthy men, some linked to diabetes and cardiovascular disease. The study also showed that individuals who improved their performance most activated more genes in the muscles, a phenomenon not previously seen.
New research reveals that accumulated liver lipids originate from serum fatty acids, newly produced fatty acids within the liver, and dietary fatty acids. The study also highlights the potential role of endocannabinoids in regulating liver metabolism and appetite control. Additionally, a companion paper explores the relationship betwee...
Researchers used two-photon microscopy to visualize thymocyte migration in intact thymuses. The study found that positively selected T cells follow a clear directional course to the medulla, suggesting long-range signaling cues guide this process.
The HealthGrades Patient Safety in American Hospitals Study found that top-performing hospitals had 267,151 fewer patient safety incidents and 48,417 fewer deaths compared to the bottom 10%. Hospital-acquired infections were a significant contributor to these differences.
A Neandertal femur found in France suggests that the transition from Middle Paleolithic to Upper Paleolithic marked a shift to greater mobility among humans. Close competition for food and space persisted with hyenas during this period, indicating a more complex human landscape.
A new research program aims to create advanced nanotechnologies to analyze plaque formation on the molecular level and detect it at early stages. The program will focus on detecting plaque and pinpointing its genetic causes with three types of nanostructured probes.
The study found that obesity prevalence increased by 276% in the highest income group, compared to 144% in lower-income groups. Obesity rates are now similar across all income categories, with the lowest and highest groups experiencing rapid increases.
A survey of parents with non-medical exemptions found that 69% cited vaccine harm as a reason for exemption. Parents with exempt children reported lower trust in government and medical sources, while also expressing more confidence in alternative medicine professionals.
The Alliance for Microbicide Development and the Global Campaign for Microbicides will receive grants to support science and policy research, public education, and advocacy. The funding will help develop evidence-based policies for microbicide R&D and investments.
Researchers at UT Southwestern Medical Center have discovered a novel anti-leukemia drug, PD166326, that is nearly 100 times more potent than the current treatment, Gleevec. The study shows the new drug effectively inhibits mutated enzyme activity and reduces white blood cell count in mice with leukemia.
Metal stents have been shown to be a safe and effective treatment for bile duct obstructions caused by pancreatic cancer. The study found that 90% of patients had open stents after three months and 80% after one year, with minimal complications.
A new study found no association between hormonal contraceptive use and changes in CD4+ cell count or viral load suppression after initiating HAART. Continuous HAART use significantly improved HIV disease progression outcomes, with increased CD4+ counts and undetectable viral loads.
A randomized trial of 202 participants showed a 23% reduction in all-cause mortality, a 30% reduction in cardiovascular disease mortality, and a 49% reduction in cancer mortality. The study found that Transcendental Meditation reduces risk factors for heart disease and other chronic disorders.
A new study found that peginterferon-alfa-2b with ribavirin was well-tolerated and yielded a sustained viral response in 59% of children with chronic hepatitis C. Patients infected via needle or with normal liver enzyme levels responded better to treatment.
A University of California, San Diego team discovered a receptor-ligand pair that plays a critical role in the final step of blood vessel formation, allowing newly constructed vessels to 'lock' together. Inhibiting this integrin protein may starve tumors and combat cancer.
A new study reveals that E.coli bacteremia affects up to 53,000 non-institutionalized seniors each year, with a significant risk of septic shock and death. Researchers suggest developing a vaccine could save many lives, but currently, there is no similar vaccine available.
In archaea, a specialized enzyme uses RNA as a guide to pseudouridylate specific RNA molecules. This modification impacts the stability, localization, and translation efficiency of target RNAs.
Exercise therapy has a small beneficial effect on chronic low back pain but no impact on shorter-term pain, according to two new studies. A plant-based low-fat diet is also better at lowering LDL cholesterol levels than a similar diet without veggies.
Researchers found that high oxygen levels can weaken a protective mechanism triggered by hypoxia, leading to increased lung damage. The study suggests that therapeutic activators targeting the A2AR signaling pathway may mitigate these effects.
A five-year study aims to investigate why coyotes are becoming more aggressive in urban and suburban areas of New York state, with researchers seeking ways to prevent conflicts with humans. The study will also survey public attitudes and behaviors relating to coyotes, as well as develop methods to induce fear without harm.
Scientists have discovered an enzyme that suppresses heart cell replication, and by inhibiting it, they can enable heart cells to proliferate. This breakthrough could lead to new strategies for regenerating tissue after heart attacks and may be a more practical alternative to stem-cell therapy.
A new strategy, developed by the University of Toronto Joint Centre for Bioethics, aims to integrate and value ethical decision-making in healthcare. The 'hub and spokes' model assigns a central ethics resource to share knowledge and guidance with frontline employees, promoting accountability and sustainability.
Research suggests that daily acetaminophen use is associated with a higher prevalence of asthma and chronic obstructive pulmonary disease (COPD), as well as decreased lung function. In contrast, vitamin C supplementation during pregnancy can limit the negative effects of nicotine on fetal lung tissue.
A new study estimates that polluted O.C. beaches result in significant healthcare costs, affecting both locals and tourists. The research, conducted by UCI researchers, provides policymakers with a valuable tool for evaluating the cost-benefit of cleaning up coastal waters.
A new study found that MPAA ratings fail to predict the frequency of violence in individual films, with PG and R ratings containing a wide range of violent acts. The study suggests that objective content descriptions and measures of explicit violence are better indicators of big screen violence.
Researchers found that high levels of oxygen can exacerbate lung inflammation in mice by triggering the release of adenosine, a molecule that protects against tissue damage. The study suggests that adenosine substitutes may be useful in preventing lung damage in patients with acute lung inflammation.
Researchers identified genes required for stem cell function and regeneration in planarians, providing insights into human development and health. The study used RNA interference to analyze gene function in intact animals and on proliferation of adult stem cells.
Research by A. Saari Csallany suggests that repeated heating of polyunsaturated oils for frying can lead to the accumulation of toxic compounds like HNE. The study aims to determine the optimal lower temperature for oil heating to prevent HNE formation and its related diseases.
A study by Vanderbilt University researchers found that inhibiting COX-1 slowed the growth of epithelial ovarian tumors in a mouse model. This breakthrough suggests targeting COX-1 as a novel approach to prevent and treat ovarian cancer.
A new study found that computerized risk stratification tools, like ACI-TIPI, may not accurately diagnose heart attacks in patients from different ethnicities. The researchers compared the tool's performance in a mixed-race US population and an Asian population in Singapore.
A study found that socially isolated men have higher levels of inflammatory markers, including interleukin-6, which are linked to cardiovascular disease. The researchers suggest that social connections may be beneficial for heart health and that men with lower social involvement have the highest levels of IL-6.
A study found that lonely college students have a weaker immune response to the flu shot, with sparse social ties and feelings of loneliness independently contributing to poorer immunity. Chronic loneliness can predict poor health and well-being, and may be linked to stress and impaired health behaviors.
A review of 71 studies found that well-motivated, younger patients with no loss of consciousness are less likely to suffer from postconcussional syndrome. The majority of patients recover completely within three to six months, but some predictors include female gender and being involved in a lawsuit.
Research shows that vitamin C can help prevent smoking-related lung development problems in unborn babies. The study found that vitamin C dosed during pregnancy may improve lung air flow and reduce adverse outcomes.
This May 2005 Ophthalmology journal issue presents multiple research findings on various ophthalmic conditions, including temporal arteritis, isolated optic atrophy, diabetic retinopathy, and uveitis. Key studies explore the management of neurological disorders and treatment outcomes for patients with these conditions.
Researchers found that motexafin gadolinium creates oxidative stress in tumor cells, increasing metallothionein production and inhibiting thioredoxin reductase. This leads to cell death via disruption of critical enzymes needed for cell survival and replication.
Researchers tracked Alu elements in primate genomes, finding a 20-million-year period of quiescence followed by rapid expansion. The 'stealth driver' model suggests that low-activity Alu elements contribute to human-specific retrotransposition activity.
Iraq's higher education system has been severely damaged, with 5/6ths of institutions destroyed, and the country needs $1 million in infrastructure repairs. The UN University proposes a National Commission to transform the system, addressing issues like teacher training, research funding, and international connectivity.
A recent study by the American Academy of Ophthalmology reveals that many glaucoma patients fail to take their medication properly, with up to half delaying refills or missing doses. This non-adherence can lead to increased hospital admissions and lost productivity, resulting in significant economic costs worldwide.
A Columbia University/University of Iowa study reveals that inherited variations in the Factor H gene may trigger age-related macular degeneration through inflammation and immune responses. Researchers found that targeting molecules involved in immune system response could lead to powerful new therapies for treating and preventing AMD.
Chronic exposure to discrimination may increase the risk of cardiovascular disease in African-American women, according to a study. The research found that higher levels of perceived discrimination were associated with greater calcium buildup in the arteries, highlighting the importance of addressing this stressor for heart health.
Researchers discovered significant differences in lipoprotein sizes and subclasses among severely obese white and black children, indicating higher cardiovascular risk for the former group. This study emphasizes the importance of addressing obesity-related health disparities in childhood.
Researchers found that a fiber supplement significantly decreased LDL and increased HDL cholesterol levels in people with type 2 diabetes. The study suggests an alternative treatment option for those unable or unwilling to take statins.
Scientists at the Cold Spring Harbor Laboratory have identified a retroviral resistance gene that can help prevent HIV and other retroviruses from infecting cells. The discovery opens up new possibilities for developing treatments and therapies.
In some species, egg orientation influences embryonic development, leading to differences in cell fate and patterning. This phenomenon highlights the importance of spatial cues during early developmental stages.
Researchers found that a personalized physical exercise and Mediterranean-style diet plan improved vascular structure and function in volunteers with pre-clinical cardiovascular disease risk factors. Average VO2 max increased by 3.2 mL/min/kg, while body weight decreased significantly.
A recent study by the Life Course Socio-Economic Status (LCSES) study found that male combat veterans are more likely to be heavy drinkers and smokers compared to non-veterans and non-combat veteran controls. The researchers also discovered that older men with distant combat exposure had higher odds of obesity and physical inactivity.
Researchers at Cold Spring Harbor Laboratory developed a functional brain model with 1 million neurons and 16 terabytes of storage. This achievement marks a major breakthrough in neural networking, enabling faster processing speeds and increased computational power.
A new study found that combat veterans are more likely to be heavy smokers and drinkers, while also experiencing lower physical inactivity compared to non-veterans. The research suggests that combat exposure may exert long-term adverse effects on cardiovascular risks.
The photoelectric effect, first explained by Einstein in 1905, has become a crucial tool for understanding the properties of matter. The new issue of New Journal of Physics features research on hot electrons and high-temperature superconductors, demonstrating its relevance to tailored electronic materials.
A study found that exposure to traffic emissions at menarche (first menstrual period) and first birth was associated with increased breast cancer risk in premenopausal and postmenopausal women, respectively. The findings support the hypothesis that early-life exposures contribute to breast cancer risk.
PNNL's ecological dock design reduces harm to nearshore marine life, while a new system tracks juvenile salmon behavior, aiding restoration of critical habitats. The lab also developed a cost-effective nanomaterial to remove mercury from industrial wastes, significantly reducing production costs.
A new study confirms the Earth's energy is out of balance, with more energy absorbed from the sun than emitted back to space. The imbalance, measured at 0.85 watts per meter squared, will cause an additional 0.6 degrees Celsius warming by the end of this century.