A new investigational transplant drug called LEA29Y has been shown to selectively block the co-stimulatory signal that triggers an immune response, thereby preventing organ rejection and preserving kidney function. This approach avoids the toxic side effects associated with current immunosuppressant medications like cyclosporine.
A study found celecoxib safe for short-term use in patients with cirrhosis, whereas naproxen harms renal function. Celecoxib did not affect kidney function, while naproxen reduced glomerular filtration rate and increased serum creatinine levels.
A new study reveals that referrals to palliative care come too late to improve quality of life for cancer patients. Researchers surveyed 318 family members and found that only 48% thought referral timing was appropriate, while most believed care was given too late.
The new test can identify babies born with Severe Combined Immunodeficiency (SCID), a life-threatening illness, early on, allowing for effective treatment. The test uses dried blood samples from newborns, providing the first accurate and high-throughput screen for immune deficiencies.
A joint environmental monitoring system was established between Hungary and Slovakia to assess the dam's impact on the Danube River. The authors recommend integrating this system with regional monitoring structures to achieve sustainable management of shared water resources.
A study led by Drs. Dennis R. Burton and Ian A. Wilson identified the specific amino acids on gp41 that 4E10 interacts with, revealing its unique ability to target a conserved region near the surface of the virus. This research advances the quest for an HIV-1 vaccine, providing valuable insights into broadly neutralizing antibodies.
The NYU Child Study Center will provide the 8-week Life Enrichment Program to address persistent needs of children of uniformed personnel and their caregivers. The program aims to decrease distress, increase energy and confidence, improve parent-child relationships, and increase social support for surviving spouses.
USC researchers have found that flawed hardware can be tolerable in various applications, such as graphics and accounting. They've developed simple test structures to determine attributes of erroneous performance, enabling cost-efficient testing and prediction.
A recent UCLA study published in the American Journal of Public Health found that people's drinking habits decrease with age, with an average decline of 9-11% per decade. The study used data from the National Health and Nutrition Examination Survey to track changes in drinking behavior over time.
The pharmaceutical industry is struggling with declining productivity and increasing R&D costs, prompting the need for innovative solutions. Personalized medicine offers a promising approach by targeting drugs to individuals likely to respond well, while regional development and cluster formation can foster collaboration and competitiv...
Researchers at UT Southwestern have identified a protein called HIF-2a, which may help treat premature blindness caused by retinopathy of prematurity. The study found that controlling this protein could prevent or treat ROP before it happens, offering new hope for premature babies.
The new guidelines, developed by a team of leading experts in child psychiatry, provide evidence-based recommendations for treating children and adolescents with bipolar disorder. The guidelines emphasize the importance of using multiple medications to stabilize moods and promote recovery.
Researchers at Thomas Jefferson University have discovered a protein called CD36 that may play a key role in the development of diabetic kidney disease. The study found that CD36 is present in specific cells and can trigger self-directed cell death or apoptosis, leading to progressive kidney failure.
Researchers have discovered three new bacterial species, Wolbachia wAna, wSim, and wMoj, in the genomes of Drosophila fruit flies. The discovery was made by scanning raw genomic data from the Trace Archive, a public repository of sequencing projects.
A new diagnostic technique, conformation-dependent immunoassay (CDI), is being considered as the standard approach for brain biopsies of patients suspected of having prion disease. The study found that CDI detected prions in 100% of samples studied, while traditional tests failed to detect them in a high proportion of cases.
Men who were most physically active at start of study cut their risk by 50 percent, while strenuous activity in early adult life reduced risk by 60 percent. Physical activity was also linked to lower risk in women, although this relationship was not statistically significant.
The Joint United Nations Programme on AIDS and the American Association for the Advancement of Science are promoting global health partnerships to accelerate HIV/AIDS vaccine research. Collaborations between governments, industry, and multilateral organizations can make a substantial difference in advancing vaccine development.
A study by the University of Washington found that more than half of high school seniors (56%) were employed in the spring of their final year, mostly in minimum-wage jobs. These students often worked long hours and for low pay, which can impact their ability to balance work and academic responsibilities.
Bees' brains process scents in a complex system that correlates with behavioral responses, suggesting a species-specific code for odor recognition. The study's findings improve understanding of animal perception and memory, paving the way for further research.
Researchers found diverse surface materials, including hydrated minerals, which suggest water was common on Mars. The study suggests areas like Syrtis Major, Valles Marineris, and Terra Meridiani are strong candidates for future Mars missions.
Researchers debate the ethics of commercial cord blood banking, citing logistical difficulties and low probabilities of use. While some argue for private sector involvement, others raise concerns about exploiting emotional vulnerabilities of parents for financial gain.
According to Pinstrup-Andersen, failing to address Africa's devastating poverty will exacerbate global instability and push millions towards terrorism. The consequences of malnutrition and environmental degradation in Africa will have far-reaching effects on worldwide security.
Researchers found that tumors developing secondary resistance to Tarceva and Iressa had an additional EGFR mutation, rendering the drugs ineffective. The discovery highlights the need for alternative targeted therapies for patients with KRAS mutations.
Dr. Brooks' research highlights the link between biodiversity decline and emerging human and wildlife diseases, such as West Nile Virus and avian flu. He argues that understanding parasite life cycles is crucial to preventing these diseases.
A study of 34,133 patients found that only 55.7% received antimicrobials within an hour before incision, while 9.6% started treatment more than four hours post-incision. The results highlight opportunities to improve the use of antimicrobial prophylaxis to prevent surgical site infections.
A bird IQ test, developed by Dr. Lefebvre, ranks species based on their innovative feeding behaviors observed in the wild. The study found that birds with greater behavioral flexibility and larger forebrains are more successful in new environments.
Scientists discovered that birch pollen extracts inhibit a protein that normally blocks allergic reactions, leading to increased sensitivity in allergy-prone individuals.
Researchers found that genetic diversity of the Mlabri is significantly lower than other agriculture-based hill tribes, indicating a severe population reduction around 500-1000 years ago. This reverts previous assumptions that contemporary hunter-gatherer groups represent pre-agricultural human populations.
People with migraine are 43% more likely to be smokers and have high cholesterol, while those with aura symptoms are more likely to have high blood pressure and history of stroke or heart disease. The study suggests a shared predisposition toward both conditions.
A new study by University Hospital of Geneva suggests that cell phone images can be used to visualize and diagnose leg wounds remotely. The researchers evaluated the use of cell phones to take images of leg ulcers, transmit them to experts, and receive diagnoses, with high levels of agreement between remote and in-person evaluations.
Scientists have discovered a gene responsible for an insect's sense of smell, which is highly conserved across four different species, including pests that target crops and human health. This finding could lead to the development of new pesticides and disease-controlling insect repellents by targeting the insects' sense of smell.
Researchers found comparable weight loss results in patients over 60 compared to those under 60 undergoing laparoscopic Roux-en-Y gastric bypass surgery. Both age groups also experienced significant reductions in obesity-related diseases, such as high blood pressure and diabetes.
Scientists discover that tubeworms release waste sulfate to stimulate sulfide-producing microbes, enabling their remarkable 250-year lifespan. This symbiotic relationship helps the worms thrive in deep-sea environments where nutrients are scarce.
Scientists adapted a molecular biology technique called mass spectrometry-based genotyping to quickly detect and analyze the SARS virus from clinical samples. This breakthrough provides valuable information on transmission routes and containment policies.
Researchers have discovered that an ancient olfaction protein is shared by many insects, including fruit flies, medflies, and mosquitoes. This finding suggests a high degree of evolutionary conservation of the protein's function in detecting odors, which could be exploited for developing novel pest control methods.
Researchers at Stanford have developed a computer model that incorporates imaging data and can predict patient outcomes with increased accuracy. The model, which factors in the flexibility of veins and arteries, has shown promising results in large-animal studies, predicting flow after an aortic graft within 10%.
The study analyzed a dataset of 107 plants and animals, showing that the opportunity for selection to act on a gamete can influence recombination rates. The researchers found that strong selection on female gametes could lead to lower recombination rates in females.
Researchers found that genetic variation in bitter taste receptors affects how people perceive bitterness, with some having heightened sensitivity and others being insensitive. This study expands our understanding of individual differences in taste perception and may lead to new insights into the role of bitter compounds in human health.
Scientists found that tumors from six patients with non-small cell lung cancer who initially responded to gefitinib or erlotinib but relapsed carried activating mutations in the EGFR gene. The resistant tumor cells also carried a second mutation in the EGFR gene, which causes resistance to these drugs.
A new international treaty aims to address the global management of publicly funded health R&D, prioritizing diseases with a high burden such as tuberculosis and leishmaniasis. The treaty would provide a binding framework for redirecting knowledge and scientific expertise towards priority needs.
Researchers used mirror neurons to study human behavior and found that these cells can predict the intentions behind actions. This suggests a deeper level of understanding and prediction in human social interactions.
A study by UCLA neuroscientists found that pre motor mirror neuron areas of the brain can ascribe intentions to actions when presented within a context. This expansion of knowledge supports imitation-based treatments for autism and similar disorders, which may improve social interaction skills.
Carla Gomes and Bart Selman have developed new techniques to tackle combinatorial problems, such as airline scheduling and chess, by finding key variables that can be fixed in advance. These approaches exploit the structure of real-world problems, allowing computers to find faster solutions.
Dr. Piero Rinaldo calls for improved newborn screening due to inconsistent use of existing technology and variability in quality parameters. He highlights the success of secondary analysis in reducing false positives and improving screening value.
A new study reveals that a secreted signaling protein called Wnt10b stimulates the growth of bone cells and inhibits fat cell development, leading to increased bone mass and density in mice. The research also shows that Wnt10b protects against bone loss from aging or estrogen deficiency.
Susan Bryant, a leading researcher in limb regeneration, was elected a 2005 Association for Women in Science fellow for her efforts to increase women faculty at UCI. Her work led to a significant increase in the percentage of women recruited to tenure-track positions across campus.
Researchers propose an equitable antiretroviral allocation strategy to ensure fair access to the life-saving drugs. The strategy considers the population's geographic distribution, healthcare facilities, and treatment goals, aiming to maximize epidemic reduction while minimizing disparities.
Researchers found that a person's specific allele of a single bitter-taste-receptor gene determines their perceptual sensitivity to PTC and related compounds. This suggests that genetic variations play a dominant role in determining individual differences in bitter-taste perception.
Researchers propose a new method to detect OSAS in patients with snoring, using medical history and routine physical examination. A study of 101 patients found that these methods were insufficient to distinguish between snorers and those with OSAS.
Researchers found that the number of vertebrae in cloned carp-goldfish fish was determined by the goldfish's egg cytoplasm, not its genetic code. The study suggests a
Despite advances in molecular biology, microbes have outpaced pharmaceutical companies in developing resistance to antibiotics. Dr. Julian Davies highlights over 300 known genes that confer resistance, and notes the need for a deeper understanding of microbial evolution.
Researchers found a psychiatric rate of 5.27% among emergency department patients, significantly lower than national prevalence rates. The study identified significant disparities in psychiatric diagnoses between Caucasians and African Americans.
The panel discussion highlights concerns over funding cuts for environmental research programs, including NASA's Earth Science program and the Climate Change Science Program. The scientists warn that these cuts will have a significant impact on graduate student training and the nation's economic competitiveness.
The new version boasts improved translation quality, speed improvements of 5-10 times over previous versions, and enhanced multi-processor capabilities. This upgrade enables faster automation of the translation process, saving customers time and money.
Research demonstrates that the sympathetic nervous system mediates bone resorption through a receptor on bone cells, which is required for osteoporosis development. Preventing this effect could lead to the prevention of osteoporosis. Drugs like beta blockers show promise in reducing fractures and may be repurposed to target bone health.
A study of over 4,500 Finnish men found that boys taller between birth and 1 year had higher earnings in adulthood. Those who grew slowly as infants were less likely to achieve higher education levels, suggesting a link between physical growth and economic outcomes.
Researchers found that mice lacking type VI collagen developed osteoarthritis at a rate five times greater than those with a functioning gene. The study provides new insights into the role of type VI collagen in cartilage health and its impact on osteoarthritis development.
Hatfull, a Pitt professor, discusses ways to make research experiences available to students at all stages of education. He has turned high school students into
A study found that air pollution increases the risk of heart attacks and strokes by thickening blood, a process triggered by particulate matter. Exposure to pollutants boosted inflammatory activity and promoted clotting factors in cells, suggesting a potential link between air pollution and cardiovascular disease.
Manuel Ares has developed a teaching exercise for undergraduate biology classes that helps students resolve conflicts in scientific data and apply processes used by scientists. The exercise involves laboratory experiments, literature searches, and presentations to develop a model of the system.