Researchers found that omega-6 fatty acids can stimulate cell growth in prostate cancer cells by activating the production of cPLA2 and COX2 enzymes. A diet high in omega-6 fatty acids may contribute to increased risk of prostate cancer, while a new class of drugs targeting cPLA2 could offer a safer alternative to existing treatments.
A study by Linda Teplin et al found that over one quarter of individuals with severe mental illness were victims of violent crime in the past year, nearly 17% for completed violence. The authors recommend systematic screening and monitoring, skill-based prevention programs, and policy-level changes to address this public health problem.
A new study reveals that insulin therapy preserves endothelial function in critically ill patients, improving oxygen supply to cells. This finding opens doors for novel treatments and progress in intensive care medicine.
The study found that hemodialysis was more beneficial for patients with cardiovascular disease, while peritoneal dialysis was better suited for healthier patients. The findings suggest that choosing the right dialysis treatment can impact mortality rates.
A recent study found that adolescent girls who experienced violence are more likely to perpetrate violent acts, with the highest risk at age 14. The research also suggests that improving community safety can help reduce violent behavior among these girls.
Researchers have identified 141 distinct proteins in the healthy human cornea, including classical blood proteins and anti-angiogenic factors. This comprehensive protein study may lead to future therapeutics for various corneal disorders, improving clinical classifications and potentially generating artificial corneas for transplantation.
A new analysis of existing studies reveals that individuals with overweight or obesity are at a higher risk of experiencing GERD symptoms, erosive esophagitis, and esophageal cancer. In contrast, researchers found no significant difference in mortality rates between patients undergoing peritoneal dialysis or hemodialysis for end-stage ...
Researchers investigate Akt1's impact on cardiac function, finding it can enhance cardiac function after heart failure but also contribute to maladaptive effects. A new gene therapy approach successfully treats severe combined immunodeficiency (SCID) in mice, offering promising implications for its treatment.
Researchers found a significant risk factor for early respiratory failure following stem cell transplantation: patients with low lung function test scores prior to treatment. The study analyzed 2,852 patients who received allogeneic transplants between 1990 and 2001.
Researchers have discovered that monarch butterflies use specialized UV photoreceptors in their eyes to guide their long-distance migration. The butterflies' biological clock also plays a crucial role, with input from both the light-detecting navigation sensors and brain clock combining to provide direction.
Researchers at UTMB discovered that oxidative stress from pollen is as important as antigen exposure in triggering severe respiratory inflammation. Antioxidant substances may help forestall allergy or asthma attacks, and longer-lived antioxidants could be effective in treatment and prevention.
Researchers found that older patients with newly diagnosed diabetes are considered a high-risk group for developing pancreatic cancer. The study, conducted by the Mayo Clinic College of Medicine, included 2,122 patients aged 50 and older who were diagnosed with diabetes between 1950 and 1995.
Using RoboLase, Australian scientists successfully performed sub-cellular surgery on a laser microscope system in California, demonstrating the potential for remote medical procedures. The technology enabled researchers to collaborate without traveling to a single laboratory site, paving the way for increased global scientific collabor...
The TIMSS 1999 Video Study found that while countries exhibit unique teaching patterns, there is also significant global convergence in classroom methods. This suggests that teachers from different countries can recognize familiar practices and be surprised by their differences.
The JAK/STAT signaling pathway is a crucial regulator of cell growth and survival in various organisms. Research at the Cold Spring Harbor Laboratory has shed light on the molecular mechanisms underlying this pathway.
Researchers halt Phase IIB/IIIA clinical trial of heparinase I due to higher incidences of negative side effects, including bleeding and infections. The study's lead author emphasizes the need for further research to develop an effective alternative to protamine.
A study by Mayo Clinic found that 72% of discharged patients couldn't list their medications or 58% couldn't recall their diagnosis. Dr. Friedman recommends improving communication through language, practicality, and time to avoid noncompliance.
Researchers discovered a new protein, CBP21, that speeds up chitin degradation by breaking down its structure. This discovery has potential applications in combating fungi and producing biofuels.
According to a survey of 180 Ph.D. recipients in Earth and space sciences, the vast majority (87%) found work in their field, earning commensurate or slightly higher salaries than in 2001 and 2002. Most graduates were employed in academia, with positive attitudes towards their employment situation and challenging yet relevant work.
Researchers discovered that monkeys perceive vibration frequency by analyzing neuronal firing patterns, particularly in the first 250 milliseconds. The findings suggest a complex process where attention to the initial response dominates perception, with subsequent firings becoming less significant.
Residential injuries are a major cause of death in US children and teens, with the majority being preventable. A study found that fatal residential injuries decreased by 22% between 1985-1997, but disparities persist due to socioeconomic factors.
Key findings highlight the importance of including women in clinical trials due to differences in response to drug therapy, such as higher levels of adverse reactions and varying mortality rates. This lack of data affects treatment strategies, with many drugs prescribed to women adapted from studies conducted mainly in men.
Dr. Gragoudas is being recognized for his groundbreaking work on protein beam irradiation and photodynamic therapy for intraocular melanoma and neovascular age-related macular degeneration. He has made significant contributions to the clinical practice of ophthalmology, particularly in the study of retinal vascular diseases.
A study found that 43% of women prefer female endoscopists, with 87% willing to wait for a female doctor and 14% willing to pay more. This preference may hinder colon cancer screening among women, emphasizing the need for targeted prevention programs.
Researchers discover that amphetamines can alter movement independently of dopamine, opening up new directions in the search for anti-Parkinsonian drugs. The findings suggest that drugs with similar chemical attributes might offer useful alternatives to current therapies.
Recent studies using transgenic mice have shown that overactive Akt1 can lead to cardiac dysfunction and hypertrophy. In contrast, Akt1 is critical for adaptive angiogenesis in the heart after ischemia. The research highlights the importance of understanding Akt1's role in regulating cardiovascular function.
A recent study reveals that symbiotic bacteria, such as Blochmannia, exhibit exceptional genomic stability despite rapid protein evolution. Genome sequencing of the black carpenter ant mutualist revealed that all shared genes were completely conserved in both genomes, indicating a striking lack of genetic change over millions of years.
A Stanford study found that surgically closing a woman's peritoneum after a C-section significantly reduces the risk of abdominal adhesions. The research suggests that this long-held practice may not be necessary and could even offer benefits in terms of reducing post-operative pain.
A study published in Developmental Cell reveals that connective tissue holding a cancer cell in place degrades, allowing it to spread to other parts of the body. The researchers identified a specific pathway critical for cancer cell activity, which could lead to more effective drug therapies with reduced side effects.
Researchers discovered that Arf gene restricts blood vessel growth in the eye during embryonic development, preventing excessive growth and associated cancers. This finding may lead to new therapies for persistent hyperplastic primary vitreous and anticancer drugs.
Researchers have developed a way to engineer an alternative outer covering for the measles virus, allowing it to recognize and target only cancerous cells. The 'virus in stealth' approach uses pieces from an animal virus that cannot infect humans to disguise the measles virus, enabling it to evade the immune system and reach tumors.
Researchers at Stanford University have developed a nanotech-laser treatment that uses carbon nanotubes to selectively kill cancer cells, bypassing normal body tissue. The technique involves coating the nanotubes with folate molecules to target diseased cells, and shining near-infrared light on them to induce heat and destruction.
Researchers identify NF-Ya as a master-regulatory gene controlling stem-cell division programs. Overexpressing NF-Ya increases stem cell production by ten- to twenty-fold.
A growing number of older adults suffer from mental disorders, with one-third experiencing a mental disorder at any given time. The University of Rochester Medical Center has received a NIMH Training grant to support postdoctoral researchers in developing skills for independent research.
A new study has identified older Americans with new-onset diabetes as a high-risk group for pancreatic cancer. The research found that patients with type 2 diabetes are at a significantly higher risk of developing pancreatic cancer compared to those without the condition, highlighting the need for early detection and screening.
Scientists discover that cyclin D1, overproduced in half of all breast cancers, can disrupt BRCA1's normal role as a cancer inhibitor. Cyclin D1 interferes with BRCA1 function by occupying the same binding site on estrogen receptor alpha, negating its tumor suppressor role.
The study found that wolf exclusion led to a 10-fold increase in elk populations, resulting in decreased beaver lodge construction and disappearance of songbirds dependent on willow habitat. The findings support the role of large predators in conservation and restoration strategies.
Researchers have identified new amphibian species through genetic analysis and bioacoustic tools, contrary to the assumption that taxonomic inflation is driving species discoveries. This finding underscores the importance of continued exploration and conservation efforts in this endangered vertebrate group.
A study of adolescents aged 12-18 found that body image concerns and media influence play a significant role in supplement use. Nearly 20% of teens reported using supplements to improve muscle mass or definition, with creatine and protein powders being the most commonly used products.
Researcher Elizabeth Loftus found that people can be led to believe they got sick as children from specific unhealthy foods, resulting in reduced appeal as adults. Participants showed a similar tendency to avoid the food after believing they had a negative experience.
A recent study published in Obstetrics & Gynecology found that babies born at night have a 12-16% increase in neonatal mortality, accounting for almost 10% of all neonatal deaths in California. This increased risk is attributed to various factors, including potential complications during delivery and reduced access to healthcare services.
A new technique using a customized gene chip can rapidly detect genetic changes in neuroblastoma tumors, helping doctors predict treatment outcomes and guide therapy. The approach may also be adapted for other types of cancer with DNA changes important to their prognosis.
Researchers have discovered a potential new target for cannabis-derived drugs to treat inflammatory bowel disease (IBD), which causes inflammation in the gastrointestinal tract. Cannabis-based medicines could help heal the gut lining, alleviating symptoms such as pain and weight loss.
Recent research has shed light on the mechanisms underlying Wnt signaling in polarized cell divisions. The study reveals that Wnt signaling regulates cell fate and tissue organization by controlling the asymmetric division of stem cells.
A Swedish meta-analysis of 47 scientific studies found clear patterns across thousands of people who went on to be diagnosed with Alzheimer's. The study showed marked preclinical deficits in global cognitive ability, episodic memory, and executive functioning, but no impairment in primary memory.
Researchers at UT Southwestern Medical Center have developed a new gene silencing technique that targets chromosomal DNA to shut down gene expression in cultured cells. By blocking the ability of chromosomal DNA to be copied into RNA and made into proteins, this approach offers a promising strategy for treating and curing disease.
Physicists at the University of Pennsylvania have created a functional electronic circuit using nanotubes, overcoming a major hurdle in the race to create nanotube-based electronics. The researchers used liquid suspensions of carbon nanotubes to create circuits by dipping semiconductor chips into the solution.
A global expert group recommends developing a Global Health and Nursing Equity Index to guide performance assessments and inform distribution of foreign aid. The group also advocates for strategic partnerships, international credentialing, and targeted investment in nursing education to stem the crisis.
Researchers found that riluzole, a glutamate modulating agent, reduced symptoms in 35% of patients with OCD. The study suggests that riluzole may represent a novel treatment intervention for certain anxiety and mood disorders.
A new study by Michigan Medicine found that a simple written-reminder system can reduce urinary catheter use by 7.6% and lead to a significant decrease in hospital-acquired infections. The system's cost is estimated to be lower than the savings it generates, with potential tens of thousands of dollars in annual savings.
Scientists on a remote expedition are working from a Seattle command center while exploring the Lost City vent field, which includes an 18-story vent taller than any seen before. Researchers aim to determine if microbes thrive in mantle rocks and could discover new life forms.
Researchers identified 80 genes involved in flower development, shedding light on the regulation of floral organ identity and patterning. The gene trap technique provided a powerful tool for examining gene expression and function, revealing novel insights into floral development.
Researchers reassess the Hayward fault threat to San Francisco, predict space weather by watching the Sun, and discover a rock-solid source for Martian methane. A large shaking vehicle study found the Hayward fault is angled at 70 degrees to the east, potentially leading to unexpected earthquakes.
Researchers discovered that specific genes allow motor proteins to work together, enabling efficient transport in cilia. This finding provides insight into the molecular mechanisms underlying various human diseases linked to cilia defects.
Researchers discovered that calcium fills a small structure in cells, forcing muscles to relax when full. This understanding can help doctors treat patients more accurately with the body's natural mechanisms.
A recent study found that HIV therapy success rates are similar between developed and non-developed countries, with a general success rate of 60% after 12-18 months on treatment. People in developing countries who received free ART drugs showed a 30% higher rate of success than those who had to pay for their medication.
Researchers tested a new software called R-CAST in a military command-and-control simulation, where human teams made incorrect decisions under pressure. The software improved team performance by sharing information and identifying key information quickly, enabling humans to maintain acceptable decision-making levels.
Researchers at Brown University have solved a crucial part of the SAP97 protein's structure, allowing them to develop a molecule that can inhibit it. This breakthrough could lead to effective treatments for cardiac and neurological diseases, including learning and memory disorders and drug addiction.
A new study has identified a protein called DOCK180 that senses chemicals inducing cell migration. This finding may lead to treatments halting cancer metastasis and immune disorders like arthritis and asthma by inhibiting inappropriate cell movement.
Molecular machines can now be driven individually using an electric current, allowing for controlled operation. This breakthrough enables the use of molecular machines in applications such as computing, sensors and bioengineering.