Researchers at Joslin Diabetes Center have identified genetic regions involved in autoimmune diseases, including type 1 diabetes. The study found a chromosomal region where T-cells were given the green light to attack beta cells, leading to insulitis and later type 1 diabetes.
A study by Dr. Max Schanzenbach finds that the Feeney Amendment's constraints on federal judges were unnecessary to keep prison sentences between offenders similar, as federal sentencing practices did not change appreciably over the relevant time period.
The researchers designed a microfluidic fuel cell that functions without a physical barrier to separate the fuel and oxidant, utilizing laminar flow instead. This design offers several advantages, including fewer parts and simpler design, as well as compatibility with alkaline chemistry.
A study of 292 health care professionals found that a family history of substance use disorder, major opioid use, and coexisting psychiatric disorders significantly increased the risk of relapse. The study suggests that intensive monitoring and tailored treatment plans can help prevent relapse among high-risk healthcare professionals.
A new study suggests that family physicians can effectively use a definitive blood test to screen for actual allergies in patients with hay fever or allergic rhinitis. The test evaluates the reaction of Immunoglobulin E (IgE) to specific allergens, such as pollen from grass and trees.
Researchers at Emory University Health Sciences Center have identified a new tumor suppressor gene, ATBF1, which inhibits cell proliferation. This finding suggests that ATBF1 may play a role in the development of prostate cancer and potentially other types of cancers.
Researchers found that phagocytes reduce IL-23 production after ingesting apoptotic neutrophils, leading to decreased inflammatory response. Abnormal neutrophils with impaired migration resulted in elevated IL-23 and IL-17 levels.
Researchers developed new methods for diagnosing cancer based on genomic DNA analysis, which detects changes in chromatin structure and cell interaction with the microenvironment. These findings may lead to the design of new cancer therapeutic agents.
Researchers find that moderate light exposure causes complete retinal degeneration within a month, but lower levels cause slower and reversible damage. This study provides new insights into the interaction of genetics and environment in causing eye disease and suggests potential treatments for preventing blindness.
Researchers discovered that targeting mutant B-Raf protein can prevent the spread of melanoma and halt tumor growth. Lowering mutant B-Raf activity reduced melanoma development in human cells, providing a potential breakthrough for treating this aggressive form of skin cancer.
The new guidelines emphasize the importance of timely thrombolysis and PCI, with a focus on reducing delays in treatment. They also highlight the benefits of primary PCI over thrombolysis in certain situations.
A study found that 76% of women would be willing to accept a cervical cancer vaccine for themselves, while 67% of mothers with daughters would consent to have their child vaccinated. The main reasons for non-acceptance were unknown side effects and the belief that minors are not sexually active.
Researchers used the FDA's MAUDE database to analyze cochlear implant complications and trends over two periods. They found device failure was the most commonly reported complication, with a significant decrease in malfunction from pre-1998 to 2002.
A new study published in the Journal of Clinical Investigation suggests that low-dose aspirin therapy may be a viable treatment option for pre-eclampsia during pregnancy. The research team created a mouse model that mimics low-dose aspirin therapy and found no significant complications, paving the way for further treatment options.
A Boston University team found an association between naturally high levels of blood cholesterol and improved mental functioning, including visual organization, memory, attention, and concentration. However, the benefits were modest and did not outweigh the risks of heart disease and stroke associated with high cholesterol.
Asthma sufferers experience worsened symptoms when infected with the common cold virus, as their cells replicate more extensively and fail to produce interferon-beta, a potent anti-viral protein. This defect leads to increased pro-inflammatory molecule secretion, recruiting asthma-inducing cells into the lungs.
Researchers discovered that bacteria's pili induce changes in host gene expression, keeping host cells alive longer. The study found that artificial mechanical pull on the host cell membrane triggers a signaling cascade to affect host gene expression.
A new online self-help technology is being launched to tackle eating disorders, particularly bulimia nervosa. The computer-based package aims to provide accessible treatment options for adolescents and young adults affected by the condition.
The new Local-Electrode Atom-Probe (LEAP) tomograph allows researchers to study the nanostructure and chemical composition of materials at an unprecedented level. By analyzing the structure and chemical identity of steel, scientists can design stronger materials with improved properties.
Most cancer survivors can return to work after treatment, but a minority face ongoing problems requiring comprehensive support services. The study found that similar numbers of men and women stop working during treatment, with the lowest rates among those with certain types of cancer.
Researchers at Imperial College London have solved the structure of the Foot-and-Mouth Disease Virus enzyme, revealing its atomic details and potential target for anti-viral drugs. The discovery could lead to the development of a vaccine that can be administered quickly to control outbreaks.
A study of 54 patients with ALD who underwent liver transplants found that those who resumed alcohol consumption had significantly lower 10-year survival rates compared to abstinent patients. Higher mortality rates among relapse group were attributed to increased risk of cancers and cardiovascular events.
UCSF scientists Joseph DeRisi and Kevan Shokat have made significant contributions to understanding infectious diseases like SARS and malaria, and are now working to develop new treatments. Their research focuses on protein kinases, which play a crucial role in cell signaling and disease development.
The Manhattan Tobacco Cessation Center grant aims to promote systematic screening and counseling for all tobacco users. The program will decrease smoking rates, improve health outcomes, and save lives by linking smokers to evidence-based treatment through partnerships with healthcare providers.
Scientists at Los Alamos National Laboratory have developed a novel method for detecting fingerprints based on the chemical elements present in fingerprint residue. The technique, known as micro-X-ray fluorescence, detects sodium, potassium, and chlorine elements that are often present in human fingerprints.
A recent study found that hospitals are more willing to partner with quality improvement organizations (QIOs), with over 90% reporting QIO interventions had a positive impact. QIOs provide educational materials, benchmark data, and hospital performance data, leading to improved quality of care.
Researchers study electron hopping in magnetic materials to understand macroscopic effects and predict material properties. Techniques like inelastic x-ray scattering reveal energy needed for electron movement, which could lead to optimized spintronics and innovative technologies.
The US healthcare system exhibits both strengths and failings, with private market competition driving inequality, inefficiency, and high costs. Researchers explore the role of corporate interests in shaping health care markets, organizational forces, and clinical practice guidelines.
Researchers have developed a new technology that analyzes breath to detect cytokines, proteins released by cells during an infection. In studies on pigs and human-exhaled breath samples, they were able to identify elevated cytokine levels in infected individuals before visible symptoms appeared.
HHMI has tapped two Long Island researchers, Scott Lowe and Gregory Hannon, as among the nation's most promising scientists. The Institute is investing over $300 million in their research over the next seven years.
Dr. Waldemar Debinski has developed a novel treatment approach for glioblastoma, the most aggressive form of brain cancer, by targeting specific receptors on cancer cells. The therapy combines a form of interleukin-13 with a toxin that kills cancer cells without damaging healthy tissue.
Researchers have identified materials with high charge mobility, crucial for flexible displays and electronic devices. By studying single crystal structures, scientists can now assess intrinsic electronic properties without external factors affecting results.
Researchers found conditions unfavorable for methane gas hydrate formation in the northern Gulf of Mexico due to salt domes and hot sediments. The study suggests deposits may be thin or non-existent, contradicting previous estimates.
A new study reveals that valproate poses a greater birth-defect risk than previously thought, with major malformations occurring in 10.7% of infants born to women taking the medication, compared to 2.9% for other anticonvulsants and 1.6% for non-users.
A study by the University of Manchester found that wearers who slept in hydrogel lenses were five times more likely to develop keratitis than those sleeping in silicone hydrogel lenses. Silicone hydrogels are now recommended as a safer option for extended wear.
Aptamers may have therapeutic effects against cancer by blocking RET downstream signaling events. The study uses whole-cell SELEX to identify macromolecules with potential therapeutic effects against other transmembrane receptors involved in tumorigenesis.
Scientists propose that light's origin is tied to tiny violations of Einstein's relativity, which can be tested experimentally. This new view holds promise for alternative understanding of light's behavior in various environments, including empty space and gravitational fields.
The study found that LC16m8, an attenuated smallpox vaccine, had a 100% take rate and was well-tolerated with no cardiac toxicity detected. This breakthrough offers hope for introducing a safer and more effective smallpox vaccine to the US market.
A simple intervention using UV filter photos increased sun protection during incidental exposure, with 37% of participants reporting sunless tanner use. The study also found that the intervention led to more friends and family being informed about UV damage and sun protection.
Listeria uses host cell lipids to move within cells and spread through the body. The bacteria hijack the host cell's actin cytoskeleton using two membrane lipids, PIP2 and PIP3, which are essential for their movement.
Gray wolves help regulate elk populations, providing a steady food source for scavengers like bears and eagles during severe winters. The study highlights the importance of wolves in mitigating the effects of climate change on ecosystems.
A new study has found that the use of budesonide reduces the risk of asthma-related events by 40% in children. The study, which involved nearly 2,000 children with mild persistent asthma, showed that earlier treatment with budesonide resulted in fewer exacerbations and improved lung function.
A study on lamotrigine found a 2.9% risk of birth defects, similar to the general population, while valproic acid had a 12.5% risk when used with other epilepsy drugs. Researchers emphasize the importance of controlling seizures and planning carefully to minimize risks during pregnancy.
A study found that 11 out of 23 children with severe abdominal pain improved after psychological support, highlighting the dangers of 'healthcare consumerism' when parents lack insight into their child's symptoms. The authors suggest that robust systems are needed to protect children and healthcare professionals from these effects.
A new technique using high-density porous polyethylene grafts has shown substantial improvement in straightening the middle third of the nose, even in cases with previous rhinoplasty. The procedure is safe, effective, and reliable, providing long-term stability and reducing future scar contracture or trauma.
The world's largest freshwater wetland is under unprecedented pressure from economic development, alterations of its water courses, and conversion to other land uses. Climate change poses a significant threat to the Pantanal's ecosystem, biodiversity, and species composition.
The Institute for OneWorld Health has been awarded $7.3 million by the Skoll Foundation to develop new, affordable medicines for infectious diseases in developing countries. The award recognizes the organization's innovative business model and its commitment to creating lasting improvements in complex social problems.
Researchers at PNNL have developed a new solid chemical material that can release hydrogen almost 100 times faster than conventional methods. The nanophase material achieves this high rate of hydrogen release at a lower temperature, making it an attractive option for sustainable hydrogen storage.
A retrospective cohort study found that early treatment with nebulized ICS reduced hospitalization rates among young children with asthma. The study evaluated 11,407 patients and showed that those receiving initial therapy had lower exacerbation rates.
Researchers solved the three-dimensional crystal structure of CD14, providing insights into its binding to LPS. The receptor has a large hydrophobic pocket that accommodates various ligands, including LPS and other microbial products.
The TEL2 gene cooperates with MYC to increase the risk of precancerous B lymphocytes becoming cancerous. This cooperation leads to a mutation inactivating p53, allowing abnormal cells to multiply uncontrollably. The study suggests that TEL2 should be considered a diagnostic marker and/or a target for novel drugs to treat B-cell lymphoma.
A new influenza vaccine developed using insect cells can produce a strong immune response in humans and may be scaled up for commercial manufacture. This rapid method uses a purified concentration of hemagglutinin to elicit an immune response against specific flu strains.
Researchers have found that black holes in 10 dimensions behave like fluids with near-zero viscosity, which is lower than water. This discovery could revolutionize our understanding of the behavior of matter and energy at extreme temperatures and densities.
A study of 47 female motorway toll-booth operators and 27 office workers found that exposure to traffic exhausts caused significant DNA damage, as indicated by elevated levels of urinary 8-OHdG. The researchers conclude that environmental levels should be curbed to protect people's health.
A new University of Alberta study confirms that pre-school children living in poverty do not benefit from welfare-to-work reforms. The study found that family environment scores for low-income families were worse than for non-poor families, and that low income still had an independent effect on the children's school readiness.
A study of liver transplant patients with hepatitis C found that donor age does not impact long-term survival rates. Instead, maintenance azathioprine was associated with improved overall and 3-month survival rates, suggesting a complex relationship between immunosuppression and disease progression.
Researchers at PNNL have developed a process to convert corn into isosorbide, which can improve the properties of plastic materials. The technology has the potential to reduce the amount of petroleum necessary to make plastics and create new jobs for rural economies.
Scientists at Rockefeller University have discovered a key event in the maturation of sperm that is extremely sensitive and could be targeted to improve fertility or develop a male contraceptive. The research found that mice missing a gene called Septin 4 are sterile, with sperm defects similar to human conditions like 'droplet sperm',
Researchers have found that nisin can effectively neutralize both anthrax and Bacillus cereus spores. The natural antimicrobial peptide has been shown to remain dormant on treated spores, preventing germination and disease in mice. Further development of nisin-based formulations for human skin decontamination is underway.
A year-long study found that new generation silicone hydrogel lenses significantly reduce the risk of severe keratitis, a type of eye infection. Those wearing traditional hydrogel lenses were five times more likely to develop severe keratitis when sleeping in their lenses.