Functional rhinoplasty techniques improve nasal airway function by addressing septal deviation, valve collapse and turbinate hypertrophy. Surgical procedures significantly reduce patient scores indicating improved nasal obstruction severity, with similar rates of improvement seen across different techniques.
A new study published in PLOS Pathogens suggests that doxycycline can reduce the pathology of lymphatic filariasis by targeting Wolbachia bancrofti. The treatment shows promise as an ameliorating option for individuals with adult worms, potentially providing relief from debilitating swelling and genital areas.
Researchers at Northwestern University have found that hematopoietic stem cells can transform into a wide variety of tissue types, not just blood cells. Additionally, the elasticity of a stem cell's environment plays a major role in determining its growth, with softer environments producing nerve-like cells and more rigid environments ...
A recent analysis found that over 17% of adults in the US reported trouble sleeping or insomnia, with 4.5% using complementary and alternative medicine (CAM) to treat their condition. The most common types of CAM used were biologically based therapies and mind-body therapies.
A specific taste receptor, Gr66a, has been identified as responsible for the detection of caffeine's bitter taste in fruit flies. The receptor plays a crucial role in mediating caffeine's perception and is also involved in the processing of other methylxanthines.
Researchers at MIT have identified a class of chemical molecules that preserve the metallic properties of carbon nanotubes, enabling them to be assembled and manipulated without losing conductivity. This breakthrough has potential applications in detectors, sensors, and optoelectronics.
Researchers at UCSD School of Medicine have reconstructed the signaling pathways that regulate activation of glycoprotein IIb-IIIa, a critical receptor in platelet function. The study provides a powerful tool for studying therapeutic targets and developing new antithrombotic drugs.
Research reveals that a specific receptor gene's variation affects perception of bitter compounds in plants, such as glucosinolates found in broccoli. This study supports the idea that evolution shaped human taste preferences to avoid thyroid-inhibiting compounds.
A global study has shown a clear association between kidney cancer incidence rates and proximity to the equator, suggesting that UVB exposure triggers vitamin D production. Countries near the equator have lower kidney cancer rates, while those farther away have higher rates, indicating a potential protective effect of sunlight exposure.
Stevens Professor K.P. Subbalakshmi receives a NSF Cyber Trust Program grant to develop secure low-power wireless technology through error-resilient encryption and power-adaptive design.
Researchers at Mayo Clinic found that the protein p120 catenin can both suppress and promote metastasis, depending on its interaction with cadherin proteins. The study suggests that a future designer drug could block the beginning of metastasis or stop it once it starts.
Researchers identified risk factors associated with hearing loss in children with bacterial meningitis, including Streptococcus pneumoniae meningitis. Length of hospitalization, seizures, and cerebrospinal fluid protein levels were significant predictors for hearing loss.
Individuals with sleep-related breathing disorders are significantly more likely to develop depression, especially those with moderate or worse disorders. The study found a dose-response association between sleep-related breathing disorder and depression, suggesting a causal link between the conditions.
A computer model of the stomach revealed a narrow path, dubbed the Magenstrasse, where food exits rapidly and particles are processed differently. This discovery may explain observed high variability in drug initiation time and have important implications for drug delivery and digestion.
Physicists at Brown University used magnetic fields to manipulate gravity and study paramecium behavior in water. The study found that by altering the gravitational force, paramecia swam differently under high gravity, zero gravity, or even reverse gravity conditions.
A study of 161 African-Americans with type 2 diabetes found that poor sleep quality and quantity were associated with higher HbA1c levels, indicating poorer blood glucose control. The results suggest that optimizing sleep duration and quality may improve glucose control in patients with type 2 diabetes.
Astronomers have discovered a small brown dwarf star orbiting a Sun-like star with a planet, revealing a new class of coldest brown dwarfs called T dwarfs. The team also found another smaller brown dwarf in the same system, which may be the youngest known T dwarf, providing a snapshot of early brown-dwarf development.
A national survey of 31,044 adults found that approximately 4.5% of those with insomnia reported using complementary and alternative medicine (CAM) to treat their condition. CAM therapies were used by 65% of respondents who sought biological methods, such as herbal medicines and diet interventions.
Researchers found that bluegill sunfish larvae preferentially associate with the odor of siblings they've never encountered before. This ability provides compelling evidence for the use of kin recognition through a process in which individuals match their own physical characteristics to those of others.
A New York City analysis found that non-HIV-related deaths among people with AIDS increased by 32.8% from 1999 to 2004, with underlying causes including substance abuse and cardiovascular disease. The study suggests a shift in healthcare models to address physical and mental health needs is necessary to reduce these deaths.
Physiologic Communications is developing an implantable biosensor that can detect physiologic and chemical changes with faster accuracy than current methods. This 'living chip' has the potential to revolutionize disease monitoring by providing real-time data to physicians and enabling timely interventions.
Researchers have invented an optical on-off switch that can replace electrical wiring on airplanes with fiber optics for controlling elevators, rudders, and other flight-critical elements. This technology also has potential applications on highways as a 'weigh-in-motion' sensor for measuring the weight of fast-moving commercial trucks.
A recent survey of 4,193 New York City men found that nearly 10% of those identifying as straight reported having sex with at least one man. This group was more likely to be from minority racial or ethnic groups, foreign-born, and married. They were also less likely to get tested for HIV or use condoms during last sexual encounter.
A new study published in The Journal of Physiology shows that short bursts of intense exercise can produce similar results to traditional endurance training. This type of high-intensity interval training may be a viable option for individuals with limited time, improving muscle health and performance despite lower overall training volume.
Researchers have developed a new method to study materials under extreme conditions, revealing the evolution of high-strain-rate plasticity. The technique combines molecular dynamics simulations with experimental data from laser experiments, providing insights into metal deformation and material strength.
A new supplement provides essential information on preconception care, emphasizing the importance of women's health before pregnancy. The supplement covers topics such as folic acid supplements, vaccinations, and screening for HIV, as well as measures to avoid harmful substances like alcohol and anti-epileptic drugs.
Researchers found that bird moms alter the birth order of eggs to shield sons from mites, speeding up their growth and survival. This strategy allows both males and females to thrive despite increased mortality risk from parasites.
A new research project in China aims to develop robust scientific guidelines for safe levels of copper and nickel in Chinese soils. The project will combine data from various sources, including European Union and Australian research programs, to explain toxicity across a wide range of environments.
Researchers found that plasmaspheric drainage plumes can overload the dayside reconnection site, reducing solar wind coupling and influencing auroral activity. Climate models also predict increased carbon emissions due to rising temperatures, especially in southern regions of the US. Additionally, remote wind forcing played a role in t...
Researchers have characterized a gutless worm that relies on microbial specialists for energy production, waste handling, and transportation through marine sediments. The unique partnership involves the worm providing housing and nutrients to microbes in exchange for essential services.
Patients with allergic rhinitis experience more difficulty sleeping and sleep disorders compared to those without allergies. Allergic rhinitis affects about 20-50% of the population, contributing to snoring, breathing problems, and sleep apnea.
Researchers have found that a class of cancer drugs can restore skeletal muscle mass and prevent decline in muscular dystrophy. Treatment with histone deacetylase inhibitors like Trichostatin A improved muscle function and resistance to degeneration in dystrophic mice.
A study found that GAVI funding significantly increased childhood vaccine coverage in countries with less than 65% initial coverage, raising it to around 65%. However, countries with higher initial coverage showed no improvement. The estimated cost per child immunized was under $14, close to GAVI's original estimates.
Researchers at The Wistar Institute have determined the three-dimensional structure of a key two-molecule complex involved in long-term gene storage, primarily in non-growing cells. This discovery provides important insights into how cells protect genes that could trigger cancers and other disorders.
The International Society for Heart and Lung Transplantation releases comprehensive global guidelines for managing heart failure patients prior to transplantation. The guidelines aim to enhance patient care, optimize outcomes, and improve resource allocation.
Researchers enhanced donor lungs using clinical maneuvers, increasing transplant procedures without compromising recipient function. The San Antonio Lung Transplant protocol improved lung procurement rates by up to 50%, reducing lengthy wait times and potentially eliminating deaths among patients awaiting lung transplantation.
Researchers developed uniform tungsten trimers on titanium dioxide, offering insights into metal oxide catalysts. The nanostructures reveal consistent alignment and uniform size, making them ideal for fundamental reactivity studies.
Half of registered nurses report chronic interference of work with their home lives, impacting personal health and ability to provide quality care. Work-family conflict can exacerbate the nursing shortage and lower job satisfaction.
A Northwestern University study finds that the kouprey, Southeast Asia's 'forest ox,' is unlikely to be a wild species due to its genetic similarity to a domesticated breed. The researchers believe it may have originated from a domestic hybrid between banteng and zebu cattle.
Researchers at The Wistar Institute have identified a single molecule required for genome compaction in spores and sperm, a process critical for passing genetic information to offspring. Compaction helps protect the genome from damage and is essential for maintaining fertility in higher organisms.
A new study suggests that taking rosiglitazone, a medication for type 2 diabetes, can prevent the disease in people at high risk. The three-year trial found that this combination reduced the risk by about two-thirds, preventing around 144 cases of diabetes per 1000 people.
Researchers at Thomas Jefferson University have discovered a new way to sidestep gleevec resistance in leukemia cells. By reactivating the protein C/EBP-alpha, they found that leukemia development is halted. This discovery could lead to new treatment strategies for leukemias resistant to gleevec and other cancers.
Patients can self-report muscle weakness, fatigue, cognitive problems, and mood changes associated with statin use on a new web site. The site aims to gather information on side effects and provide education on minimizing health risks.
The University of Miami Rosenstiel School has received a total of $1 million in NOAA grants to improve hatchery and offshore aquaculture technology. The program aims to develop ecologically sustainable aquaculture practices with minimal environmental impact.
Newly discovered behavior in cancer cells reveals a toggle switch that enables them to morph into highly mobile cells, invade other tissues, and adapt comfortably. This understanding could lead to finding ways to stop metastasis, the most deadly trait of cancer.
A University of Pittsburgh study reveals that weight concerns can decrease a woman's motivation to remain smoke-free postpartum. Women who were confident in their ability to control their weight without smoking were more motivated to stay abstinent.
A new test, OncoPlan, has been developed to predict which breast cancer patients are likely to benefit from chemotherapy. The test measures the levels of two proteins that play a role in cancer growth and survival.
A potential diagnostic marker indicates anti-angiogenic drugs' effectiveness by measuring a decrease in circulating endothelial cells. Anti-angiogenic drugs target tumor blood vessels, starving them of oxygen and nutrients.
Researchers at NIST and NC State University found that Prozac can interfere with freshwater mussels' reproductive cycle. The study, which examined fluoxetine's effect on native mussels, raises concerns about potential health impacts for humans and animals due to continuous exposure to pharmaceuticals in waterways.
A new study found that IPF patients who can cover less than 680 feet during the six-minute walk test are four times more likely to die. The test's accuracy was found to be superior to other measures, such as forced vital capacity percent (FVC%).
Researchers at Ohio State University have made a groundbreaking discovery on how water molecules interact with proteins, revealing that they slow down to connect with proteins. The study provides an early result in explaining essential biological functions like protein folding and enzyme catalysis.
A new candidate biomarker, galectin-3, has been identified as a potential marker for heart failure diagnosis and prognosis. Elevated levels of this inflammatory protein can help diagnose heart failure and identify patients at risk of dying within 60 days.
Prisons in the US are woefully ill-prepared for a flu pandemic, putting the public at risk. Nearly 85% of prisoners will be released within a year, carrying diseases like HIV and tuberculosis with them.
Researchers found a unique genetic mutation that makes people susceptible to herpes simplex virus-1, leading to viral encephalitis. The study challenges current thinking on how genes work with infections, providing new insights into the immune system's response to pathogens.
Scientists used holotomography to study arabidopsis seed's internal structures, discovering a network of voids that may store oxygen for efficient germination. The technique reveals the seed's three-dimensional organization and circulation system, opening new research avenues.
In a study led by Johns Hopkins Medicine, researchers discovered that patients with chronic sinusitis who failed to respond to treatment had severely decreased immune function and lower production of key proteins. The findings suggest new treatment targets for this condition affecting an estimated 32 million Americans.
Scientists sequenced the first complete tree genome, poplar, to develop sustainable plantation forestry and biofuels production. The research identified over 45,000 protein-coding genes and 93 genes associated with cellulose production.
Panic disorder affects up to 5% of the population, causing recurrent anxiety attacks and agoraphobia. Anti-depressants and cognitive-behavioural therapy (CBT) are effective treatments, but less than half of those in need receive care due to barriers such as diagnosis difficulties and insurance coverage issues.
The Ames Laboratory will collaborate with Iowa State University and Sandia National Laboratory to develop software that enables access to three of the world's most important computational chemistry codes. The project aims to accelerate scientific discovery in areas such as energy, climate change, and materials science.
Researchers found that slow theta oscillations tune into high-gamma waves, allowing areas of the brain to coordinate activity and transmit information. This coupling enables top-down executive processes like attention and memory to be connected to low-level perceptions and actions.